Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: Implications for the molecular mechanism of the inhibition

Chemistry and Biology

Volumn 8, Issue 12, 2001, Pages 1209-1220

  Usui, Takeo ^c   Kojima, Sachiko ^b   Kidokoro, Shun Ichi ^b,d   Ueda, Kazunori ^c   Osada, Hiroyuki ^c   Sodeoka, Mikiko ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

^c RIKEN   (Japan)

^d NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Dual specificity protein phosphatase; Protein phosphatase inhibitor; RK 682; VHR

Indexed keywords

MAMMALIA;

ENZYME INHIBITOR; ERK PHOSPHATASE; H1 RELATED PROTEIN TYROSINE PHOSPHATASE; H1-RELATED PROTEIN-TYROSINE PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; RK 682;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DRUG DESIGN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

DIMERIZATION; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0035542857     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00089-8     Document Type: Article

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