Cyclin D3 immunoreactivity in follicular lymphoma is independent of the t(6;14)(p21.1;q32.3) translocation or cyclin D3 gene amplification and is correlated with histologic grade and Ki-67 labeling index

International Journal of Cancer

Volumn 112, Issue 1, 2004, Pages 71-77

  Pruneri, Giancarlo ^a   Valentini, Stefano ^a   Fabris, Sonia ^c   Del Curto, Barbara ^a   Laszlo, Daniele ^a   Bertolini, Francesco ^a   Martinelli, Giovanni ^a   Leocata, Pietro ^d   Viale, Giuseppe ^a,b   Neri, Antonino ^c  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Cyclin D3; Fluorescence in situ hybridization; Follicular lymphoma; Immunohistochemistry; Ki 67; P27; Skp2

Indexed keywords

CYCLIN D3; KI 67 ANTIGEN; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2;

ADULT; ARTICLE; CENTROMERE; CHROMOSOME 6; CHROMOSOME 6P; CHROMOSOME ARM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYCLIN D3 GENE; DISEASE SEVERITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE; GENE AMPLIFICATION; GENE PROBE; GENE TRANSLOCATION; HISTOPATHOLOGY; HUMAN; HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISOCHROMOSOME; LABELING INDEX; MALE; PREVALENCE; PRIORITY JOURNAL; TRISOMY; TUMOR;

ADULT; AGED; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 6; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; FEMALE; GENE AMPLIFICATION; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; KI-67 ANTIGEN; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; NEOPLASM STAGING; S-PHASE KINASE-ASSOCIATED PROTEINS; TRANSLOCATION, GENETIC; TRISOMY; TUMOR SUPPRESSOR PROTEINS;

EID: 4544267841     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20354     Document Type: Article

References (46)

1. Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 2001;1:222-31.
2. 1phase progression. Genes Dev 1999;13:1501-12.
3. Sgambato A, Cittadini A, Faraglia B, Weinstein IB. Multiple functions of p27(Kip1) and its alterations in tumor cells: a review. J Cell Physiol 2000;183:18-27.
4. Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H. p27(Kip 1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 1999;9:661-4.
5. Chiarle R. Fan Y, Piva R, Boggino H, Skolnik J, Novero D, Palestro G, De Wolf-Peeters C, Chilosi M, Pagano M, Inghirami G. S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase. Am J Pathol 2002;160:1457-66.
6. Lim MS, Adamson A, Lin Z, Perez-Ordonez B, Jordan RC, Tripp S, Perkins SL, Elenitoba-Johnson KS. Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index. Blood 2002;100:2950-6.
7. Shaughnessy J Jr, Gabrea A, Qi Y, Brents L, Zhan F, Tian E, Sawyer J, Barlogie B, Bergsagel PL, Kuehl M. Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma. Blood 2001;98:217-23.
8. Sonoki T, Harder L, Horsman DE, Karran L, Taniguchi I, Willis TG, Gesk S, Steinemann D, Zucca E, Schlegelberger B, Sole F, Mungall AJ. et al,. Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 2001;98:2837-44.
9. Chen Q, Lin J, Jinno S, Okayama H. Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation. Oncogene 2003;22:992-1001.
10. Bentz M, Werner CA, Dohner H, Joos S, Earth TF, Siebert R, Schroder M, Stilgenbauer S, Fischer K, Moller P, Lichter P. High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma. Blood 1996;88:1437-44.
11. Hough RE, Goepel JR, Alcock HE, Hancock BW, Lorigan PC, Hammond DW. Copy number gain at 12q12-14 may be important in the transformation from follicular lymphoma to diffuse large B cell lymphoma. Br J Cancer 2001;84:499-503.
12. Stokke T, DeAngelis P, Smedshammer L, Galteland E, Steen HB, Smeland EB, Delabie J, Holte H. Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma. Br J Cancer 2001;85:1900-13.
13. Viardot A, Moller P, Hogel J, Werner K, Mechtersheimer G, Ho AD, Ott G, Earth TF, Siebert R, Gesk S, Schlegelberger B, Dohner H, et al. Clinicopathologic correlations of genomic gains and losses in follicular lymphoma. J Clin Oncol 2002;20:4523-30.
14. Martinez-Climent JA, Alizadeh AA, Segraves R, Blesa D, Rubio-Moscardo F, Albertson DG, Garcia-Conde J, Dyer MJ, Levy R, Pinkel D, Lossos IS. Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. Blood 2003;101:3109-17.
15. Doglioni C, Chiarelli C, Macri E, Dei Tos AP, Meggiolaro E, Dalla Palma P, Barbareschi M. Cyclin D3 expression in normal, reactive and neoplastic tissues. J Pathol 1998;185:159-66.
16. Teramoto N, Pokrovskaja K, Szekely L, Polack A, Yoshino T, Akagi T, Klein G. Expression of cyclin D2 and D3 in lymphoid lesions. Int J Cancer 1999;81:543-50.
17. Moller MB, Nielsen O, Pedersen NT. Cyclin D3 expression in non-Hodgkin lymphoma: correlation with other cell cycle regulators and clinical features. Am J Clin Pathol 2001;115:404-12.
18. Wong SC, Chan JK, Lee KC, Hsiao WL. Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast. J Pathol 2001;194:35-42.
19. Filipits M, Jaeger U, Pohl G, Stranzl T, Simonitsch I, Kaider A, Skrabs C, Pirker R. Cyclin D3 is a predictive and prognostic factor in diffuse large B-cell lymphoma. Clin Cancer Res 2002;8:729-33.
20. Nathwani BN, Harris NL, Weisenburger D, Isaacson PG. Piris MA, Berger F, Muller-Hermelink HK, Swerdlow SH. Follicular lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Tumours of the haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001. 162-7.
21. Husson H, Carideo EG, Neuberg D, Schultze J, Munoz O, Marks PW, Donovan JW, Chillemi AC, O'Connell P, Freedman AS. Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood 2002;99:282-9.
22. Pruneri G, Mazzarol G. Manzotti M, Viale G. Monoclonal proliferation of germinal center cells (incipient follicular lymphoma) in an axillary lymph node of a melanoma patient. Hum Pathol 2001;32:1410-3.
23. Pruneri G, Fabris S, Fasani R, Del Curto B, Capella C, Pozzi B, Motta T, Andreola S, Ferreri AJM, Ponzoni M, Viale G, Neri A. Immuno-reactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation. J Pathol 2003;200:596-601.
24. Pruneri G, Fabris S, Baldini L, Carboni N, Zagano S, Colombi MA, Ciceri G, Lombardi L, Rocchi M, Buffa R, Maiolo AT, Neri A. Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14). Am J Pathol 2000;156:1505-13.
25. Starostik P, Greiner A, Schultz A, Zettl A, Peters K, Rosenwald A, Kolve M, Muller-Hermelink HK. Genetic aberrations common in gastric high-grade large B-cell lymphoma. Blood 2000;95:1180-7.
26. Siu LL, Wong KF, Chan JK, Kwong YL. Comparative genomic hybridization analysis of natural killer cell lymphoma/leukemia: recognition of consistent patterns of genetic alterations. Am J Pathol 1999;155:1419-25.
27. Squire J, Phillips RA, Boyce S, Godbout R, Rogers B, Gallie BL. Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization. Hum Genet 1984;66:46-53.
28. Martineau M, Clark R, Farrell DM, Hawkins JM, Moorman AV, Seeker-Walker LM. Isochromosomes in acute: lymphoblastic leukaemia: i(21q) is a significant finding. Genes Chromosomes Cancer 1996;17:21-30.
29. Ladanyi M, Parsa NZ, Offit K, Wachtel MS, Filippa DA, Jhanwar SC. Clonal cytogenetic abnormalities in Hodgkin's disease. Genes Chromosomes Cancer 1991;3:294-9.
30. Palanisamy N, Abou-Elella AA, Chaganti SR, Houldsworth J, Offit K, Louie DC, Terayu-Feldstein J, Cigudosa JC, Rao PH, Sanger WG, Weisenburger DD, Chaganti RS. Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma. Genes Chromosomes Cancer 2002;33:114-22.
31. Scaravaglio P, Saglio G, Geuna M, Palestre G, Guglielmelli T, Rege-Cambrin G. Isochromosome 6p and deletion of 6q characterize two related cytogenetic clones in a patient with immunoblastic lymphoma. Cancer Genet Cytogenet 1995;81:179-81.
32. Tien HF, Su IJ, Tang JL, Liu MC, Lee FY, Chen YC, Chuang SM. Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas. Br J Haematol 1997;97:621-5.
33. White AD, Clark RE, Jacobs A. Isochromosome (6p) in Waldenstrom's macroglobulinemia. Cancer Genet Cytogenet 1992:58:89-91.
34. Ott MM, Bartkova J, Bartek J, Durr A, Fischer L, Ott G, Muller-Hermelink HK, Kreipe H. Cyclin D1 expression in mantle cell lymphoma is accompanied by downregulation of cyclin D3 and is not related to the proliferative activity. Blood 1997;90:3154-9.
35. Sanchez-Beato M, Camacho FI, Martinez-Montero JC, Saez AI, Villuendas R, Sanchez-Verde L, Garcia JF, Piris MA. Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression: p27/KIP1-cyclin D3 colocalization in tumor cells. Blood 1999;94:765-472.
36. Klein U, Tu Y, Stolovitzky GA, Keller JL, Haddad J Jr, Miljkovic V, Cattoretti G, Califano A, Dalla-Favera R. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci USA 2003;100:2639-44.
37. Llanos M, Alvarez-Arguelles H, Aleman R, Oramas J, Diaz-Flores L, Batista N. Prognostic significance of Ki-67 nuclear proliferative antigen, bcl-2 protein, and p53 expression in follicular and diffuse large B-cell lymphoma. Med Oncol 2001;18:15-22.
38. Ito Y, Takeda T, Wakasa K, Tsujimoto M, Matsuura N. Expression and possible role of cyclin D3 in human pancreatic adenocarcinoma. Anticancer Res 2001;21:1043-8.
39. Florenes VA, Faye RS, Maelandsmo GM, Nesland JM, Holm R. Levels of cyclin D1 and D3 in malignant melanoma: deregulated cyclin D3 expression is associated with poor clinical outcome in superficial melanoma. Clin Cancer Res 2000;6:3614-20.
40. Oliver RJ, MacDonald DG. G1 cyclins in oral epithelial dysplasia. J Oral Pathol Med 2001;30:80-6.
41. Pruneri G, Mazzarol G, Fabris S, Del Curto B, Bertolini F, Neri A, Viale G. Cyclin D3 immunoreactivity in gastrointestinal stromal tumors is independent of cyclin D3 gene amplification and is associated with nuclear p27 accumulation. Mod Pathol 2003;16:886-92.
42. Kauzman A, Li SQ, Bradley G, Bell RS, Wunder JS, Kandel R. Cyclin alterations in giant cell tumor of bone. Mod Pathol 2003;16:210-8.
43. Barnouin K, Fredersdorf S, Eddaoudi A, Mittnacht S, Pan LX, Du MQ, Lu X. Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. Oncogene 1999;18:6388-97.
44. Senderowicz AM. Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer Chemother Pharmacol 2003;52(Suppl 1):S61-73.
45. Senderowicz AM, Headlee D, Stinson SF, Lush RM, Kalil N, Villalba L, Hill K, Steinberg SM, Figg WD, Tompkins A, Arbuck SG, Sausville EA. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 1998;16:2986-99.
46. Tan AR, Headlee D, Messmann R, Sausville EA, Arbuck SG, Murgo AJ, Melillo G, Zhai S, Figg WD, Swain SM, Senderowicz AM. Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. J Clin Oncol 2002;20:4074-82.