Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection

Transplantation

Volumn 78, Issue 5, 2004, Pages 668-674

  Liu, Yulin ^a   Son, Ni Huiping ^a   Szabolcs, Matthias J ^a   Ma, Ninsheng ^b   Sciacca, Robert R ^a   Albala, Arline ^a   Edwards, Niloo ^b   Cannon, Paul J ^a  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Acute rejection; Apoptosis; Heart transplantation; Nitric oxide synthase 2; Poly(ADP ribose) synthase

Indexed keywords

3 AMINOBENZAMIDE; 3 NITROTYROSINE; 5 AMINOISOQUINOLINONE; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) METHYLARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL ISOLATION; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART MUSCLE CELL; HEART TRANSPLANTATION; INCUBATION TIME; INFLAMMATORY INFILTRATE; MACROPHAGE; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE CULTURE;

ACUTE DISEASE; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; ENZYME INHIBITORS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; ISOQUINOLINES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED LEW; RATS, INBRED WF; TRANSPLANTATION, HOMOLOGOUS;

EID: 4544232105     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000131662.01491.2E     Document Type: Article

References (23)

1. Yang X, Chowdhury N, Cai B, et al. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest 1994; 94(2): 714.
2. Worrall NK, Lazenby WD, Misko TP, et al. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med 1995; 181(1): 63.
3. Szabolcs M, Michler RE, Yang X, et al. Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase. Circulation 1996; 94(7): 1665.
4. Szabolcs MJ, Ravalli S, Minanov O, et al. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation 1998; 65(6): 804.
5. Szabolcs MJ, Ma N, Athan E, et al. Acute cardiac allograft rejection in nitric oxide synthase-2(-/-) and nitric oxide synthase-2(+/+) mice: effects of cellular chimeras on myocardial inflammation and cardiomyocyte damage and apoptosis. Circulation 2001; 103(20): 2514.
6. Szabolcs MJ, Sun J, Ma N, et al. Effects of selective inhibitors of nitric oxide synthase-2 dimerization on acute cardiac allograft rejection. Circulation 2002; 106(18): 2392.
7. Koglin J, Granville DJ, Glysing-Jensen T, et al. Attenuated acute cardiac rejection in NOS2 -/- recipients correlates with reduced apoptosis. Circulation 1999; 99(6): 836.
8. Pinsky DJ, Cai B, Yang X, et al. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta. J Clin Invest 1995; 95(2): 677.
9. Pinsky DJ, Aji W, Szabolcs M, et al. Nitric oxide triggers programmed cell death (apoptosis) of adult rat ventricular myocytes in culture. Am J Physiol 1999; 277(3 Pt 2): H1189.
10. Gilad E, Zingarelli B, Salzman AL, et al. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro. J Mol Cell Cardiol 1997; 29(9): 2585.
11. Szabo C. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic Biol Med 1996; 21(6): 855.
12. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271(5 Pt 1): C1424.
13. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57(2): 225.
14. McDonald MC, Mota-Filipe H, Wright JA, et al. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. Br J Pharmacol 2000; 130(4): 843.
15. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9(6): 587.
16. Zingarelli B, Cuzzocrea S, Zsengeller Z, et al. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc Res 1997; 36(2): 205.
17. Szabo C. Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock. Shock 1998; 9(5): 341.
18. Hasko G, Mabley JG, Nemeth ZH, et al. Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Mol Med 2002; 8(5): 283.
19. Ing DJ, Zang J, Dzau VJ, et al. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ Res 1999; 84(1): 21.
20. Valenzuela MT, Guerrero R, Nunez MI, et al. PARP-1 modifies the effectiveness of p53-mediated DNA damage response. Oncogene 2002; 21(7): 1108.
21. Wayman N, McDonald MC, Thompson AS, et al. 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5′-diphosphate ribose) polymerase, reduces myocardial infarct size. Eur J Pharmacol 2001; 430(1): 93.
22. Wesierska-Gadek J, Wojciechowski J, Schmid G. Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1. J Cell Biochem 2003; 89(6): 1260.
23. Ma N, Szabolcs MJ, Sun J, et al. The effect of selective inhibition of cyclooxygenase (COX)-2 on acute cardiac allograft rejection. Transplantation 2002; 74(11): 1528.