Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15

European Journal of Immunology

Volumn 34, Issue 7, 2004, Pages 2022-2031

  Loser, Karin ^a   Mehling, Annette ^a   Apelt, Jenny ^a   Ständer, Sonja ^a   Andres, Pietro G ^b   Reinecker, Hans Christian ^b   Eing, Bodo R ^a   Skryabin, Boris V ^a   Varga, Georg ^a   Schwarz, Thomas ^a,d   Beissert, Stefan ^a,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

HSV infection; IL 15; T lymphocytes; Transgenic mice; Vaccination

Indexed keywords

HAPTEN; INTERLEUKIN 15; KERATIN; VIRUS ANTIBODY; ALLERGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTACT ALLERGY; CONTROLLED STUDY; GENE OVEREXPRESSION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; IMMUNE RESPONSE; IMMUNITY; IN VIVO STUDY; INFECTION RESISTANCE; KERATINOCYTE; LANGERHANS CELL; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; SENSITIZATION; SKIN DEFECT; T LYMPHOCYTE; TRANSGENIC MOUSE; VIRUS IMMUNITY; WILD TYPE; ANIMAL; ANTIGEN PRESENTATION; BLOOD; CONTACT DERMATITIS; CYTOLOGY; GENE EXPRESSION; GENETICS; HELPER CELL; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHENOTYPE; PHYSIOLOGY; SKIN; VIROLOGY;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ANTIGEN PRESENTATION; DERMATITIS, CONTACT; GENE EXPRESSION; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNITY, NATURAL; IMMUNOLOGIC MEMORY; INTERLEUKIN-15; KERATINOCYTES; LANGERHANS CELLS; MICE; MICE, TRANSGENIC; PHENOTYPE; SKIN; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 4544227402     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324785     Document Type: Article

References (24)

1. Waldmann, T. A. and Tagaya, Y., The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 1999. 17: 19-49.
2. Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S. and Ma, A., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998. 9: 669-676.
3. Kennedy, M. K., Glaccum, M., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C. R. et al., Reversible defects in natural killer and memory CD8 T cell lineages in interleukin-15-deficient mice. J. Exp. Med. 2000. 191: 771-780.
4. Fehniger, T. A., Suzuki, K., Ponnappan, A., VanDeusen, J. B., Cooper, M. A., Florea, S. M., Freud, A. G., Robinson, M. L., Durbin, J. and Caligiuri, M. A., Fatal leukemia in interleukin-15 transgenic mice follows early expansion in natural killer and memory phenotype CD8+ T cells. J. Exp. Med. 2001. 193: 219-231.
5. Bamford, R. N., Battiata, J. D., Burton, J. D., Sharma, H. and Waldmann, T. A., Interleukin(IL)-15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 1996. 93: 2897-2902.
6. Onu, A., Pohl, T., Krause, H. and Bulfone-Paus, S., Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J. Immunol. 1997. 158: 255-262.
7. Blauvelt, A., Asada, H., Klaus-Kovtun, V., Altman, D. J., Lucey, D. R. and Katz, S. I., Interleukin-15 mRNA is expressed by keratinocytes, Langerhans cells, and blood-derived dendritic cells and is down-regulated by ultraviolet B irradiation. J. Invest. Dermatol. 1996. 106: 1047-1052.
8. Mohamadzadeh, M., Berard, F., Essert, G., Chalouni, C., Pulendran, B., Davoust, J., Bridges, G., Palucka, A. K. and Banchereau, J., Interleukin-15 skews monocyte differentiation into dendritic cells with features of Langerhans cells. J. Exp. Med. 2001. 194: 1013-1019.
9. Rückert, R., Asadullah, K., Seifert, M., Budagian, V. M., Arnold, R., Trombotto, C., Paus, R. and Bulfone-Paus, S., Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J. Immunol. 2000. 165: 2240-2250.
10. Hayday, A., Theodoridis, E., Ramsburg, E. and Shires, J., Intraepithelial lymphocytes: exploring the third way in immunology. Nat. Immunol. 2001. 2: 997-1003.
11. Carding, S. R. and Egan, P. J., γδ T cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2002. 2: 336-345.
12. Saitou, M., Sugai, S., Tanaka, T., Shimouchi, K., Fuchs, E., Narumiya, S. and Kakizuka, A., Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 1995. 374: 159-162.
13. Beissert, S., He, H.-T., Hueber, A.-O., Lelluch, A. O., Metze, D., Mehling, A., Luger, T. A., Schwarz, T. and Grabbe, S., Impaired cutaneous immune responses in Thy-1-deficient mice. J. Immunol. 1998. 161: 5296-5302.
14. Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J. and Marrack P., Control of homeostasis of CD8+ T cells by opposing cytokines. Science 2000. 288: 675-678.
15. Bulfone-Paus, S., Ungureanu, D., Pohl, T., Lindner, G., Paus, R., Rückert, R., Krause, H. and Kunzendorf, U., Interleukin-15 protects from lethal apoptosis in vivo. Nat. Med. 1997. 3: 1124-1128.
16. Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., Nishiyama, Y. and Yoshikai, Y., A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology 2000. 275: 57-66.
17. Ohteki, T., Suzue, K., Maki, C., Ota, T. and Koyasu, S., Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2001. 2: 1138-1143.
18. Howie, S., Norval, M. and Maingay J., Exposure to low-dose ultraviolet irradiation suppresses delayed-type hypersensitivity to herpes simplex virus in mice. J. Invest. Dermatol. 1986. 86: 125-128.
19. Akiba, H., Kehren, J., Ducluzeau, M. T., Krasteva, M., Horand, F., Kaiserlian, D., Kaneko, F. and Nicolas, J. F., Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic T cells inducing keratinocyte apoptosis. J. Immunol. 2002. 68: 3079-3087.
20. Armitage, R. J., Macduff, B. M., Eisenman, J., Paxton, R. and Grabstein, K. H., IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 1995. 154: 483-490.
21. Allan, R. S., Smith, C. M., Belz, G. T., van Lint, A. L., Wakim, L. M., Heath, W. R. and Carbone, F. R., Epidermal viral immunity induced by CD8α dendritic cells but not by Langerhans cells. Science 2003. 301: 1925-1928.
22. Stanley, M. A., Imiquimod and the imidazoquinolones: mechanism of action and therapeutical potential. Clin. Exp. Dermatol. 2002. 27: 571-577.
23. Gunzer, M., Weishaupt, C., Planelles, L. and Grabbe, S., Two-step negative enrichment of CD4+ and CD8+ T cells from murine spleen via nylon wool adherence and an optimized antibody cocktail. J. Immunol. Methods 2001. 258: 55-63.
24. Mehling, A., Loser, K., Varga, G., Metze, D., Luger, T. A., Schwarz, T., Grabbe S. and Beissert, S., Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J. Exp. Med. 2001. 194: 615-628.