Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts

Biochemical Journal

Volumn 412, Issue 3, 2008, Pages 435-445

  Jensen, Maja ^a   Palsgaard, Jane ^a   Borup, Rehannah ^b   De Meyts, Pierre ^a,b,c   Schäffer, Lauge ^c  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Gene expression profiling; Insulin mimetic peptide; L6 myoblasts; Mitogen activated protein kinase pathway (MAPK pathway); Mitogenicity; Signalling

Indexed keywords

AMINES; BINDING ENERGY; BIOACTIVITY; BIOMIMETICS; CELL GROWTH; CELL PROLIFERATION; COMPUTER NETWORKS; DRUG THERAPY; GENE EXPRESSION; GENES; INSULIN; IRIDIUM; LIGANDS; MICROFLUIDICS; PEPTIDES; TECHNOLOGY;

(PL) PROPERTIES; BINDING AFFINITIES; DIFFERENT EFFECTS; GENE EXPRESSION PROFILING; HYPOGLYCAEMIC; IN-CELL; IN-VIVO; INITIATION (ELECTRIC DISCHARGES); INSULIN RECEPTOR (IR); INSULIN-LIKE GROWTH FACTOR (IGF); MICROARRAY TECHNOLOGIES; MITOGEN-ACTIVATED-PROTEIN-KINASE (MAPK); MITOGENICITY; MYOBLASTS; RECEPTOR (IR); RECEPTOR ACTIVATION; RECEPTOR SIGNALLING; REGULATED GENES; SIGNALLING CASCADES; SYNTHETIC PEPTIDES;

HORMONES;

INSULIN; INSULIN RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN S597; SYNTHETIC PEPTIDE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INTERACTION; MICROARRAY ANALYSIS; MITOGENESIS; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION; INSULIN; MAP KINASE SIGNALING SYSTEM; MYOBLASTS; PEPTIDES; RATS; RECEPTOR, INSULIN; TRANSFECTION;

EID: 45349103168     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080279     Document Type: Article

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