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Volumn 1132, Issue , 2008, Pages 157-162

How promiscuity promotes tolerance: The case of myasthenia gravis

Author keywords

Autoimmune regulator; Central tolerance; Promiscuous gene expression; Thymic epithelial cells

Indexed keywords

AUTOANTIGEN; AUTOIMMUNE REGULATOR PROTEIN; CHOLINERGIC RECEPTOR; INSULIN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN;

EID: 45249124322     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1405.026     Document Type: Conference Paper
Times cited : (10)

References (30)
  • 1
    • 4544258485 scopus 로고    scopus 로고
    • Self-representation in the thymus: An extended view
    • &
    • Kyewski, B. & J. Derbinski. 2004. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4 : 688 698.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 688-698
    • Kyewski, B.1    Derbinski, J.2
  • 2
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • &
    • Kyewski, B. & L. Klein. 2006. A central role for central tolerance. Annu. Rev. Immunol. 24 : 571 606.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 3
    • 28444438159 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity
    • &
    • Peterson, P. & L. Peltonen. 2005. Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity. J. Autoimmun. 25 (Suppl 49 55.
    • (2005) J. Autoimmun. , vol.25 , pp. 49-55
    • Peterson, P.1    Peltonen, L.2
  • 4
    • 34249717868 scopus 로고    scopus 로고
    • Lessons on immune tolerance from the monogenic disease APS1
    • &
    • DeVoss, J.J. & M.S. Anderson. 2007. Lessons on immune tolerance from the monogenic disease APS1. Curr. Opin. Genet. Dev. 17 : 193 200.
    • (2007) Curr. Opin. Genet. Dev. , vol.17 , pp. 193-200
    • Devoss, J.J.1    Anderson, M.S.2
  • 5
    • 33751513054 scopus 로고    scopus 로고
    • Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    • DeVoss, J. et al. 2006. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J. Exp. Med. 203 : 2727 2735.
    • (2006) J. Exp. Med. , vol.203 , pp. 2727-2735
    • Devoss, J.1
  • 6
    • 34248372524 scopus 로고    scopus 로고
    • Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
    • Gavanescu, I. et al. 2007. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc. Natl. Acad. Sci. USA 104 : 4583 4587.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4583-4587
    • Gavanescu, I.1
  • 7
    • 0037383758 scopus 로고    scopus 로고
    • Aire regulates negative selection of organ-specific T cells
    • Liston, A. et al. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4 : 350 354.
    • (2003) Nat. Immunol. , vol.4 , pp. 350-354
    • Liston, A.1
  • 8
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells
    • Aschenbrenner, K. et al. 2007. Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells. Nat. Immunol. 8 : 351 358.
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1
  • 9
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski, J. et al. 2005. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202 : 33 45.
    • (2005) J. Exp. Med. , vol.202 , pp. 33-45
    • Derbinski, J.1
  • 10
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 : 1395 1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 11
    • 0017408627 scopus 로고
    • Intrathymic pathogenesis and dual genetic control of myasthenia gravis
    • &
    • Wekerle, H. & U.P. Ketelsen. 1977. Intrathymic pathogenesis and dual genetic control of myasthenia gravis. Lancet 1 : 678 680.
    • (1977) Lancet , vol.1 , pp. 678-680
    • Wekerle, H.1    Ketelsen, U.P.2
  • 12
    • 0023189057 scopus 로고
    • Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study
    • Schluep, M. et al. 1987. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann. Neurol. 22 : 212 222.
    • (1987) Ann. Neurol. , vol.22 , pp. 212-222
    • Schluep, M.1
  • 13
    • 34147128054 scopus 로고    scopus 로고
    • Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity
    • &
    • Taubert, R., J. Schwendemann & B. Kyewski. 2007. Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. Eur. J. Immunol. 37 : 838 848.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 838-848
    • Taubert, R.1    Schwendemann, J.2    Kyewski, B.3
  • 14
    • 34548151158 scopus 로고    scopus 로고
    • An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
    • Giraud, M. et al. 2007. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448 : 934 937.
    • (2007) Nature , vol.448 , pp. 934-937
    • Giraud, M.1
  • 15
    • 0026467592 scopus 로고
    • Pathogenetic significance of fetal-type acetylcholine receptors on thymic myoid cells in myasthenia gravis
    • Geuder, K.I. et al. 1992. Pathogenetic significance of fetal-type acetylcholine receptors on thymic myoid cells in myasthenia gravis. Dev. Immunol. 2 : 69 75.
    • (1992) Dev. Immunol. , vol.2 , pp. 69-75
    • Geuder, K.I.1
  • 16
    • 1542500767 scopus 로고    scopus 로고
    • Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus
    • Bruno, R. et al. 2004. Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus. J. Neuroimmunol. 149 : 147 159.
    • (2004) J. Neuroimmunol. , vol.149 , pp. 147-159
    • Bruno, R.1
  • 17
    • 0035145379 scopus 로고    scopus 로고
    • Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit
    • Navaneetham, D. et al. 2001. Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit. Muscle Nerve 24 : 203 210.
    • (2001) Muscle Nerve , vol.24 , pp. 203-210
    • Navaneetham, D.1
  • 18
    • 0034857910 scopus 로고    scopus 로고
    • Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
    • &
    • Klein, L., B. Roettinger & B. Kyewski. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31 : 2476 2486.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2476-2486
    • Klein, L.1    Roettinger, B.2    Kyewski, B.3
  • 19
    • 34548863119 scopus 로고    scopus 로고
    • Myasthenia gravis thymus: Complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status
    • Leite, M.I. et al. 2007. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. Am. J. Pathol. 171 : 893 905.
    • (2007) Am. J. Pathol. , vol.171 , pp. 893-905
    • Leite, M.I.1
  • 20
    • 34147106416 scopus 로고    scopus 로고
    • Aire-ing self antigen variability and tolerance
    • Holmdahl, R. 2007. Aire-ing self antigen variability and tolerance. Eur. J. Immunol. 37 : 598 601.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 598-601
    • Holmdahl, R.1
  • 21
    • 16244418695 scopus 로고    scopus 로고
    • Genetic lesions in T-cell tolerance and thresholds for autoimmunity
    • Liston, A. et al. 2005. Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunol. Rev. 204 : 87 101.
    • (2005) Immunol. Rev. , vol.204 , pp. 87-101
    • Liston, A.1
  • 22
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
    • &
    • Chentoufi, A.A. & C. Polychronakos. 2002. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51 : 1383 1390.
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 23
    • 85047689216 scopus 로고    scopus 로고
    • Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
    • Thebault-Baumont, K. et al. 2003. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J. Clin. Invest. 111 : 851 857.
    • (2003) J. Clin. Invest. , vol.111 , pp. 851-857
    • Thebault-Baumont, K.1
  • 24
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese, A. et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15 : 293 297.
    • (1997) Nat. Genet. , vol.15 , pp. 293-297
    • Pugliese, A.1
  • 25
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis, P. et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet. 15 : 289 292.
    • (1997) Nat Genet. , vol.15 , pp. 289-292
    • Vafiadis, P.1
  • 26
    • 0033740378 scopus 로고    scopus 로고
    • Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ
    • &
    • Lew, A., W.J. Rutter & G.C. Kennedy. 2000. Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ. Proc. Natl. Acad. Sci. USA 97 : 12508 12512.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12508-12512
    • Lew, A.1    Rutter, W.J.2    Kennedy, G.C.3
  • 27
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd, J.A. et al. 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39 : 857 864.
    • (2007) Nat. Genet. , vol.39 , pp. 857-864
    • Todd, J.A.1
  • 28
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas, J. et al. 2005. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. 35 : 3343 3352.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 3343-3352
    • Haas, J.1
  • 29
    • 33746356813 scopus 로고    scopus 로고
    • Human regulatory T cells and their role in autoimmune disease
    • &
    • Baecher-Allan, C. & D.A. Hafler. 2006. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212 : 203 216.
    • (2006) Immunol. Rev. , vol.212 , pp. 203-216
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 30
    • 34547150491 scopus 로고    scopus 로고
    • What does the future hold for cell-based tolerogenic therapy?
    • Bluestone, J.A. et al. 2007. What does the future hold for cell-based tolerogenic therapy? Nat. Rev. Immunol. 7 : 650 654.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 650-654
    • Bluestone, J.A.1


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