-
1
-
-
4544258485
-
Self-representation in the thymus: An extended view
-
&
-
Kyewski, B. & J. Derbinski. 2004. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4 : 688 698.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 688-698
-
-
Kyewski, B.1
Derbinski, J.2
-
2
-
-
33646165128
-
A central role for central tolerance
-
&
-
Kyewski, B. & L. Klein. 2006. A central role for central tolerance. Annu. Rev. Immunol. 24 : 571 606.
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 571-606
-
-
Kyewski, B.1
Klein, L.2
-
3
-
-
28444438159
-
Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity
-
&
-
Peterson, P. & L. Peltonen. 2005. Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity. J. Autoimmun. 25 (Suppl 49 55.
-
(2005)
J. Autoimmun.
, vol.25
, pp. 49-55
-
-
Peterson, P.1
Peltonen, L.2
-
4
-
-
34249717868
-
Lessons on immune tolerance from the monogenic disease APS1
-
&
-
DeVoss, J.J. & M.S. Anderson. 2007. Lessons on immune tolerance from the monogenic disease APS1. Curr. Opin. Genet. Dev. 17 : 193 200.
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 193-200
-
-
Devoss, J.J.1
Anderson, M.S.2
-
5
-
-
33751513054
-
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
-
DeVoss, J. et al. 2006. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J. Exp. Med. 203 : 2727 2735.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2727-2735
-
-
Devoss, J.1
-
6
-
-
34248372524
-
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
-
Gavanescu, I. et al. 2007. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc. Natl. Acad. Sci. USA 104 : 4583 4587.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4583-4587
-
-
Gavanescu, I.1
-
7
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston, A. et al. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4 : 350 354.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
-
8
-
-
34248598295
-
Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells
-
Aschenbrenner, K. et al. 2007. Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells. Nat. Immunol. 8 : 351 358.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 351-358
-
-
Aschenbrenner, K.1
-
9
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski, J. et al. 2005. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202 : 33 45.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
-
10
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson, M.S. et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 : 1395 1401.
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
-
11
-
-
0017408627
-
Intrathymic pathogenesis and dual genetic control of myasthenia gravis
-
&
-
Wekerle, H. & U.P. Ketelsen. 1977. Intrathymic pathogenesis and dual genetic control of myasthenia gravis. Lancet 1 : 678 680.
-
(1977)
Lancet
, vol.1
, pp. 678-680
-
-
Wekerle, H.1
Ketelsen, U.P.2
-
12
-
-
0023189057
-
Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study
-
Schluep, M. et al. 1987. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann. Neurol. 22 : 212 222.
-
(1987)
Ann. Neurol.
, vol.22
, pp. 212-222
-
-
Schluep, M.1
-
13
-
-
34147128054
-
Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity
-
&
-
Taubert, R., J. Schwendemann & B. Kyewski. 2007. Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. Eur. J. Immunol. 37 : 838 848.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 838-848
-
-
Taubert, R.1
Schwendemann, J.2
Kyewski, B.3
-
14
-
-
34548151158
-
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
-
Giraud, M. et al. 2007. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448 : 934 937.
-
(2007)
Nature
, vol.448
, pp. 934-937
-
-
Giraud, M.1
-
15
-
-
0026467592
-
Pathogenetic significance of fetal-type acetylcholine receptors on thymic myoid cells in myasthenia gravis
-
Geuder, K.I. et al. 1992. Pathogenetic significance of fetal-type acetylcholine receptors on thymic myoid cells in myasthenia gravis. Dev. Immunol. 2 : 69 75.
-
(1992)
Dev. Immunol.
, vol.2
, pp. 69-75
-
-
Geuder, K.I.1
-
16
-
-
1542500767
-
Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus
-
Bruno, R. et al. 2004. Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus. J. Neuroimmunol. 149 : 147 159.
-
(2004)
J. Neuroimmunol.
, vol.149
, pp. 147-159
-
-
Bruno, R.1
-
17
-
-
0035145379
-
Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit
-
Navaneetham, D. et al. 2001. Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit. Muscle Nerve 24 : 203 210.
-
(2001)
Muscle Nerve
, vol.24
, pp. 203-210
-
-
Navaneetham, D.1
-
18
-
-
0034857910
-
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
-
&
-
Klein, L., B. Roettinger & B. Kyewski. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31 : 2476 2486.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2476-2486
-
-
Klein, L.1
Roettinger, B.2
Kyewski, B.3
-
19
-
-
34548863119
-
Myasthenia gravis thymus: Complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status
-
Leite, M.I. et al. 2007. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. Am. J. Pathol. 171 : 893 905.
-
(2007)
Am. J. Pathol.
, vol.171
, pp. 893-905
-
-
Leite, M.I.1
-
20
-
-
34147106416
-
Aire-ing self antigen variability and tolerance
-
Holmdahl, R. 2007. Aire-ing self antigen variability and tolerance. Eur. J. Immunol. 37 : 598 601.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 598-601
-
-
Holmdahl, R.1
-
21
-
-
16244418695
-
Genetic lesions in T-cell tolerance and thresholds for autoimmunity
-
Liston, A. et al. 2005. Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunol. Rev. 204 : 87 101.
-
(2005)
Immunol. Rev.
, vol.204
, pp. 87-101
-
-
Liston, A.1
-
22
-
-
0036315824
-
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
-
&
-
Chentoufi, A.A. & C. Polychronakos. 2002. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51 : 1383 1390.
-
(2002)
Diabetes
, vol.51
, pp. 1383-1390
-
-
Chentoufi, A.A.1
Polychronakos, C.2
-
23
-
-
85047689216
-
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
-
Thebault-Baumont, K. et al. 2003. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J. Clin. Invest. 111 : 851 857.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 851-857
-
-
Thebault-Baumont, K.1
-
24
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese, A. et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15 : 293 297.
-
(1997)
Nat. Genet.
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
-
25
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
Vafiadis, P. et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet. 15 : 289 292.
-
(1997)
Nat Genet.
, vol.15
, pp. 289-292
-
-
Vafiadis, P.1
-
26
-
-
0033740378
-
Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ
-
&
-
Lew, A., W.J. Rutter & G.C. Kennedy. 2000. Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ. Proc. Natl. Acad. Sci. USA 97 : 12508 12512.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12508-12512
-
-
Lew, A.1
Rutter, W.J.2
Kennedy, G.C.3
-
27
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Todd, J.A. et al. 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39 : 857 864.
-
(2007)
Nat. Genet.
, vol.39
, pp. 857-864
-
-
Todd, J.A.1
-
28
-
-
27944499757
-
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
-
Haas, J. et al. 2005. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. 35 : 3343 3352.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 3343-3352
-
-
Haas, J.1
-
29
-
-
33746356813
-
Human regulatory T cells and their role in autoimmune disease
-
&
-
Baecher-Allan, C. & D.A. Hafler. 2006. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212 : 203 216.
-
(2006)
Immunol. Rev.
, vol.212
, pp. 203-216
-
-
Baecher-Allan, C.1
Hafler, D.A.2
-
30
-
-
34547150491
-
What does the future hold for cell-based tolerogenic therapy?
-
Bluestone, J.A. et al. 2007. What does the future hold for cell-based tolerogenic therapy? Nat. Rev. Immunol. 7 : 650 654.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 650-654
-
-
Bluestone, J.A.1
|