Common molecular mechanisms regulating fetal bone formation and adult fracture repair

Bone Regeneration and Repair: Biology and Clinical Applications

Volumn , Issue , 2005, Pages 45-55

  Miclau, Theodore ^a   Schneider, Richard A ^a   Frank Eames, B ^a   Helms, Jill A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 45249099043     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1385/1-59259-863-3:045     Document Type: Chapter

References (60)

1. Schneider, R. A. and Helms, J. A. (1998) Development and regeneration of the musculoskeletal system. Curr. Opin. Orthop. 9, 20-24. (Pubitemid 29049276)
2. Ferguson, C., Alpern, E., Miclau, T., and Helms, J. A. (1999) Does adult fracture repair recapitulate embryonic skeletal formation? Mech. Dev. 87(1-2), 57-66. (Pubitemid 29428086)
3. Iwasaki, M., Le, A. X., and Helms, J. A. (1997) Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis. Mech. Dev. 69(1-2), 197-202. (Pubitemid 28064957)
4. Sandberg, M. M., Aro, H. T., and Vuorio, E. I. (1993) Gene expression during bone repair. Clin. Orthop. 289, 292-312. (Pubitemid 23124826)
5. Vortkamp, A., Pathi, S., Peretti, G. M., Caruso, E. M., Zaleske, D. J., and Tabin, C. J. (1998) Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech. Dev. 71(1-2), 65-76. (Pubitemid 28153519)
6. Hammerschmidt, M., Brook, A., and McMahon, A. P. (1997) The world according to hedgehog. Trends Genet. 13(1), 14-21. (Pubitemid 27062504)
7. Riddle, R. D., Johnson, R. L., Laufer, E., and Tabin, C. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75(7), 1401-1416. (Pubitemid 24021914)
8. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., and Tabin, C. (1994) Sonic hedgehog and FGF-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79(6), 993-1003.
9. Hurle, J. M., Ganan, Y., and Macias, D. (1989) Experimental analysis of the in vivo chondrogenic potential of the interdigital mesenchyme of the chick leg bud subjected to local ectodermal removal. Dev. Biol. 132(2), 368-374. (Pubitemid 19107506)
10. Kawakami, Y., Ishikawa, T., Shimabara, M., et al. (1996) BMP signaling during bone pattern determination in the developing limb. Development 122(11), 3557-3566. (Pubitemid 26395997)
11. Akiyama, H., Chaboissier, M. C., Martin, J. F., Schedl, A., and De Crombrugghe, B. (2002) The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16(21), 2813-2828. (Pubitemid 35253149)
12. Bi, W., Deng, J. M., Zhang, Z., Behringer, R. R., and De Crombrugghe, B. (1999) Sox9 is required for cartilage formation. Nat. Genet. 22(1), 85-89. (Pubitemid 29214811)
13. Zákány, J. and Duboule, D. (1999) Hox genes in digit development and evolution. Cell Tissue Res. 296(1), 19-25. (Pubitemid 29179368)
14. Peichel, C. L., Prabhakaran, B., and Vogt, T. F. (1997) The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Development 124(18), 3481-3492. (Pubitemid 27470032)
15. Goff, D. J. and Tabin, C. J. (1997) Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124(3), 627-636. (Pubitemid 27092428)
16. Capdevila, J., Tsukui, T., Rodríquez Esteban, C., Zappavigna, V., and Izpisúa Belmonte, J. C. (1999) Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 4(5), 839-849.
17. Hall, B. K. and Miyake, T. (2000) All for one and one for all: condensations and the initiation of skeletal development. Bioessays 22(2), 138-147. (Pubitemid 30092080)
18. Merino, R., Rodriguez-Leon, J., Macias, D., Gañan, Y., Economides, A. N., and Hurle, J. M. (1999) The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126(23), 5515-5522. (Pubitemid 30015943)
19. Hall, B. K. and Miyake, T. (1995) Divide, accumulate, differentiate: cell condensation in skeletal development revisited. Int. J. Dev. Biol. 39(6), 881-893. (Pubitemid 26097613)
20. Wright, E., Hargrave, M. R., Christiansen, J., et al. (1995) The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat. Genet. 9(1), 15-20.
21. Ng, L. J., Wheatley, S., Muscat, G. E., et al. (1997) SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev. Biol. 183(1), 108-121. (Pubitemid 27157837)
22. Lefebvre, V., Huang, W., Harley, V. R., Goodfellow, P. N., and De Crombrugghe, B. (1997) SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1 (II) collagen gene. Mol. Cell Biol. 17(4), 2336-2346. (Pubitemid 27133320)
23. Zhang, P., Jimenez, S. A., and Stokes, D. G. (2003) Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by sox9. J. Biol. Chem. 278(1), 117-123. (Pubitemid 36043552)
24. Liu, Y., Li, H., Tanaka, K., Tsumaki, N., and Yamada, Y. (2000) Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2 (XI) collagen gene. J. Biol. Chem. 275(17), 12712-12718. (Pubitemid 30241422)
25. Healy, C., Uwanogho, D., and Sharpe, P. T. (1999) Regulation and role of Sox9 in cartilage formation. Dev. Dyn. 215(1), 69-78. (Pubitemid 29215705)
26. Brunet, L. J., McMahon, J. A., McMahon, A. P., and Harland, R. M. (1998) Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280(5368), 1455-1457. (Pubitemid 28264842)
27. Zimmerman, L. B., De Jesús-Escobar, J. M., and Harland, R. M. (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86(4), 599-606. (Pubitemid 26299491)
28. Duprez, D., Bell, E. J., Richardson, M. K., et al. (1996) Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57(2), 145-157. (Pubitemid 26252549)
29. Hall, B. K. and Miyake, T. (1992) The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat. Embryol. (Berl.) 186(2), 107-124.
30. Francis-West, P. H., Abdelfattah, A., Chen, P., et al. (1999) Mechanisms of GDF-5 action during skeletal development. Development 126(6), 1305-1315. (Pubitemid 29182125)
31. Storm, E. and Kingsley, D. (1996) Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein BMP family. Development 122(12), 3969-3979. (Pubitemid 27033891)
32. Zhao, Q., Eberspaecher, H., Lefebvre, V., and De Crombrugghe, B. (1997) Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev. Dyn. 209(4), 377-386. (Pubitemid 27328464)
33. Bi, W., Huang, W., Whitworth, D. J., et al. (2001) Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc. Natl. Acad. Sci. USA 98(12), 6698-6703. (Pubitemid 32538279)
34. Bitgood, M. J. and McMahon, A. P. (1995) Hedgehog and BMP genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172(1), 126-138.
35. Ferguson, C. M., Miclau, T., Hu, D., Alpern, E., and Helms, J. A. (1998) Common molecular pathways in skeletal morphogenesis and repair. Ann. NY Acad. Sci. 857(5), 33-42. (Pubitemid 28526254)
36. Helms, J. A., Alpern, E. J., and Ferguson, C. (1998) Indian hedgehog signaling in embryonic skeletal morphogenesis and adult repair. Orthopaedic Research and Education Foundation Grant.
37. Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M., and Tabin, C. J. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273(5275), 613-622. (Pubitemid 26262108)
38. St-Jacques, B., Hammerschmidt, M., and McMahon, A. P. (1999) Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13(16), 2072-2086. (Pubitemid 29407348)
39. Byrd, N., Becker, S., Maye, P., et al. (2002) Hedgehog is required for murine yolk sac angiogenesis. Development 129(2), 361-372. (Pubitemid 34863803)
40. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89(5), 747-754. (Pubitemid 27516177)
41. Otto, F., Thornell, A. P., Crompton, T., et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89(5), 765-771. (Pubitemid 27516179)
42. Mundlos, S., Otto, F., Mundlos, C., et al. (1997) Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89(5), 773-779. (Pubitemid 27516180)
43. Komori, T., Yagi, H., Nomura, S., et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89(5), 755-764. (Pubitemid 27516178)
44. Sato, M., Morii, E., Komori, T., et al. (1998) Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Oncogene 17(12), 1517-1525. (Pubitemid 28472756)
45. Somerman, M. J., Prince, C. W., Sauk, J. J., Foster, R. A., and Butler, W. T. (1987) Mechanism of fibroblast attachment to bone extracellular matrix: role of a 44 kilodalton bone phosphoprotein. J. Bone Miner. Res. 2(3), 259-265.
46. Reinholt, F. P., Hultenby, K., Oldberg, A., and Heinegård, D. (1990) Osteopontin-a possible anchor of osteoclasts to bone. Proc. Natl. Acad. Sci. USA 87(12), 4473-4475.
47. Miyauchi, A., Alvarez, J., Greenfield, E. M., et al. (1991) Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J. Biol. Chem. 266(30), 20369-20374. (Pubitemid 21908468)
48. Jiménez, M. J., Balbín, M., López, J. M., Alvarez, J., Komori, T., and López-Otín, C. (1999) Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell. Biol. 19(6), 4431-4442. (Pubitemid 29242017)
49. Solheim, E. (1998) Growth factors in bone. Int. Orthop. 22(6), 410-416. (Pubitemid 29103437)
50. Gerber, H., Vu, T., Ryan, A. M., Kowalski, J., Werb, Z., and Ferrara, N. (1999) VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5, 623-628. (Pubitemid 29289424)
51. Risau, W. (1997) Mechanisms of angiogenesis. Nature 386(6626), 671-674. (Pubitemid 27193480)
52. Neufeld, G. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22. (Pubitemid 29038270)
53. Haigh, J. J., Gerber, H. P., Ferrara, N., and Wagner, E. F. (2000) Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development 127(7), 1445-1453. (Pubitemid 30232595)
54. Probst, A. and Spiegel, H. U. (1997) Cellular mechanisms of bone repair. J. Invest. Surg. 10(3), 77-86. (Pubitemid 27296667)
55. Carter, D. C. and Giori, N. J. (1991) Effect of mechanical stress on tissue differentiation in the bony implant bed. University of Toronto Press. Toronto.
56. Carter, D. R., Beaupré, G. S., Giori, N. J., and Helms, J. A. (1998) Mechanobiology of skeletal regeneration. Clin. Orthop. Related Res. 82(355 Suppl), S41-S55.
57. Minet, E., Michel, G., Remacle, J., and Michiels, C. (2000) Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review). Int. J. Mol. Med. 5(3), 253-259.
58. Thompson, Z., Miclau, T., Hu, D., and Heims, J. A. (2002) A model for intramembranous bone healing during fracture repair. J. Invest. Med. 50(1), 83A.
59. Tay, B. K., Le, A. X., Gould, S. E., and Helms, J. A. (1998) Histochemical and molecular analyses of distraction osteogenesis in a mouse model. J. Orthop. Res. 16(5), 636-642. (Pubitemid 28512446)
60. Sandell, L. J., Sugai, J. V., and Trippel, S. B. (1994) Expression of collagens I, II, X, and XI and aggrecan mRNAs by bovine growth plate chondrocytes in situ. J. Orthop. Res. 12(1), 1-14. (Pubitemid 24070783)