-
1
-
-
0026757845
-
The membranous skeleton: The role of cell condensations in vertebrate skeletogenesis
-
1. Hall BK, Miyake T: The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat Embryol (Berl), 1992, 186:107-124.
-
(1992)
Anat Embryol (Berl)
, vol.186
, pp. 107-124
-
-
Hall, B.K.1
Miyake, T.2
-
2
-
-
0031035441
-
Heritable diseases of the skeleton: Part i. Molecular insights into skeletal development-transcription factors and signaling pathways
-
2. Mundlos S, Olsen BR: Heritable diseases of the skeleton: part I. Molecular insights into skeletal development-transcription factors and signaling pathways. FASEB J 1997, 11:125-132.
-
(1997)
FASEB J
, vol.11
, pp. 125-132
-
-
Mundlos, S.1
Olsen, B.R.2
-
3
-
-
0029762378
-
The role of BMPs and GDFs in development of region-specific skeletal structures
-
3. King JA, Storm EE, Marker PC, Dileone RJ, Kingsley DM: The role of BMPs and GDFs in development of region-specific skeletal structures. Ann N Y Acad Sci 1996, 785:70-89.
-
(1996)
Ann N Y Acad Sci
, vol.785
, pp. 70-89
-
-
King, J.A.1
Storm, E.E.2
Marker, P.C.3
Dileone, R.J.4
Kingsley, D.M.5
-
4
-
-
0031906441
-
An extensive 3′ regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo
-
4. DiLeone R, Russell L, Kingsley D: An extensive 3′ regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics 1998, 148:401-408. This work adds to the growing evidence that BMPs are involved in many aspects of development, especially skeletogenesis. These authors identify the control sequences that regulate expression of the mouse Bmp5 gene in specific skeletal structures and soft tissues. These control sequences have remarkable specificity for particular components of the skeleton, rather than for cartilage and bone in general. Collectively, these findings indicate that the skeleton is generated by many independent domains of BMP expression, each being controlled by separate regulatory elements driving expression at specific anatomic locations.
-
(1998)
Genetics
, vol.148
, pp. 401-408
-
-
DiLeone, R.1
Russell, L.2
Kingsley, D.3
-
5
-
-
0030598829
-
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
-
5. Zimmerman LB, De Jesaus-Escobar JM, Harland RM: The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 1996, 86:599-606.
-
(1996)
Cell
, vol.86
, pp. 599-606
-
-
Zimmerman, L.B.1
De Jesaus-Escobar, J.M.2
Harland, R.M.3
-
6
-
-
0032523777
-
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
-
6. McMahon J, Takada S, Zimmerman L, Fan C, Harland R, McMahon A: Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 1998, 12:1438-1452. This paper demonstrates how proper embryonic patterning depends on a delicate balance between inductive signals and their specific antagonists. These authors show that Noggin, which encodes an antagonist of BMP, is necessary for normal development. Their data indicate that the normal patterning of the vertebrate neural tube and somites requires the inhibition of BMP signaling by Noggin.
-
(1998)
Genes Dev
, vol.12
, pp. 1438-1452
-
-
McMahon, J.1
Takada, S.2
Zimmerman, L.3
Fan, C.4
Harland, R.5
McMahon, A.6
-
7
-
-
0032577276
-
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
-
7. Brunet LJ, McMahon JA, McMahon AP, Harland RM: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 1998, 280:1455-1457.
-
(1998)
Science
, vol.280
, pp. 1455-1457
-
-
Brunet, L.J.1
McMahon, J.A.2
McMahon, A.P.3
Harland, R.M.4
-
8
-
-
0030481707
-
Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein BMP family
-
8. Storm E, Kingsley D: Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein BMP family. Development 1996, 122:3969-3979.
-
(1996)
Development
, vol.122
, pp. 3969-3979
-
-
Storm, E.1
Kingsley, D.2
-
10
-
-
0028837742
-
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
-
10. Bitgood MJ, McMahon AP: Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995, 172:126-138.
-
(1995)
Dev Biol
, vol.172
, pp. 126-138
-
-
Bitgood, M.J.1
McMahon, A.P.2
-
11
-
-
0029750190
-
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
-
11. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein [see comments]. Science 1996, 273:613-622.
-
(1996)
Science
, vol.273
, pp. 613-622
-
-
Vortkamp, A.1
Lee, K.2
Lanske, B.3
Segre, G.V.4
Kronenberg, H.M.5
Tabin, C.J.6
-
12
-
-
0032008025
-
Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
-
12. Vortkamp A, Pathi S, Peretti GM, Caruso EM, Zaleske DJ, Tabin CJ: Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 1998, 71:65-76. This investigation is an important contribution to our understanding of proteins that regulate bone development. These authors study the role of Indian hedgehog (Ihh) in chondrocyte differentiation. Most significantly, they find that the same molecules controlling endochondral ossification in embryos are also expressed during adult bone growth and fracture repair. These results suggest that such events are regulated by similar molecular mechanisms.
-
(1998)
Mech Dev
, vol.71
, pp. 65-76
-
-
Vortkamp, A.1
Pathi, S.2
Peretti, G.M.3
Caruso, E.M.4
Zaleske, D.J.5
Tabin, C.J.6
-
13
-
-
0030027059
-
Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
-
13. Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP: Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 1996, 10:301-312.
-
(1996)
Genes Dev
, vol.10
, pp. 301-312
-
-
Goodrich, L.V.1
Johnson, R.L.2
Milenkovic, L.3
McMahon, J.A.4
Scott, M.P.5
-
14
-
-
0029975823
-
Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb
-
14. Marigo V, Scott MP, Johnson RL, Goodrich LV, Tabin CJ: Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 1996, 122:1225-1233.
-
(1996)
Development
, vol.122
, pp. 1225-1233
-
-
Marigo, V.1
Scott, M.P.2
Johnson, R.L.3
Goodrich, L.V.4
Tabin, C.J.5
-
15
-
-
0030743317
-
Hedgehog and its patched-smoothened receptor complex: A novel signalling mechanism at the cell surface
-
15. Alcedo J, Noll M: Hedgehog and its patched-smoothened receptor complex: a novel signalling mechanism at the cell surface. Biol Chem 1997, 378:583-590.
-
(1997)
Biol Chem
, vol.378
, pp. 583-590
-
-
Alcedo, J.1
Noll, M.2
-
16
-
-
0031560935
-
Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signaling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
-
16. Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, et al.: Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signaling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun 1997, 235:142-147.
-
(1997)
Biochem Biophys Res Commun
, vol.235
, pp. 142-147
-
-
Akiyama, H.1
Shigeno, C.2
Hiraki, Y.3
Shukunami, C.4
Kohno, H.5
Akagi, M.6
-
17
-
-
0031020221
-
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
-
17. Mo R, Freer AM, Zinyk DL, Crackower MA, Michaud J, Heng HH, et al.: Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 1997, 124:113-123.
-
(1997)
Development
, vol.124
, pp. 113-123
-
-
Mo, R.1
Freer, A.M.2
Zinyk, D.L.3
Crackower, M.A.4
Michaud, J.5
Heng, H.H.6
-
18
-
-
0031406262
-
Expression of ihh, BMP6 and gli during skeletal morphogenesis
-
18. Iwasaki M, Le AX, Helms JA: Expression of ihh, BMP6 and gli during skeletal morphogenesis. Mech Dev 1997, 69:197-202.
-
(1997)
Mech Dev
, vol.69
, pp. 197-202
-
-
Iwasaki, M.1
Le, A.X.2
Helms, J.A.3
-
19
-
-
85038200408
-
Sonic hedgehog signaling in normal and abnormal craniofacial morphogenesis
-
Edited by Guggenheim B
-
19. Hu D, Helms JA: Sonic hedgehog signaling in normal and abnormal craniofacial morphogenesis. In Oral Biology at the Turn of the Century. Edited by Guggenheim B. 1998.
-
Oral Biology at the Turn of the Century
, pp. 1998
-
-
Hu, D.1
Helms, J.A.2
-
20
-
-
0021000325
-
Inhibition of neovascularization by a cartilage factor
-
20. Kuettner KE, Pauli BU: Inhibition of neovascularization by a cartilage factor. Ciba Found Symp 1983, 100:163-173.
-
(1983)
Ciba Found Symp
, vol.100
, pp. 163-173
-
-
Kuettner, K.E.1
Pauli, B.U.2
-
21
-
-
0028855604
-
Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: Dependence on extracellular matrix assembly
-
21. Descalzi Cancedda F, Melchiori A, Benelli R, Gentili C, Masiello L, Campanile G, et al.: Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. Eur J Cell Bioll 1995, 66:60-68.
-
(1995)
Eur J Cell Bioll
, vol.66
, pp. 60-68
-
-
Descalzi Cancedda, F.1
Melchiori, A.2
Benelli, R.3
Gentili, C.4
Masiello, L.5
Campanile, G.6
-
22
-
-
0029858774
-
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
-
22. Alexandre C, Jacinto A, Ingham PW: Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 1996, 10:2003-2013.
-
(1996)
Genes Dev
, vol.10
, pp. 2003-2013
-
-
Alexandre, C.1
Jacinto, A.2
Ingham, P.W.3
-
23
-
-
0028842821
-
The cDNA cloning and expression of the gene encoding rat gelatinase B
-
23. Okada A, Santavicca M, Basset P: The cDNA cloning and expression of the gene encoding rat gelatinase B. Gene 1995, 16:317-321.
-
(1995)
Gene
, vol.16
, pp. 317-321
-
-
Okada, A.1
Santavicca, M.2
Basset, P.3
-
24
-
-
0028223234
-
High expression of 92-kD type IV collagenase gelatinase B in the osteoclast lineage during mouse development
-
24. Reponen P, Sahlberg C, Munaut C, Thesleff I, Tryggvason K: High expression of 92-kD type IV collagenase gelatinase B in the osteoclast lineage during mouse development. J Cell Biol 1994, 124:1091-1102.
-
(1994)
J Cell Biol
, vol.124
, pp. 1091-1102
-
-
Reponen, P.1
Sahlberg, C.2
Munaut, C.3
Thesleff, I.4
Tryggvason, K.5
-
25
-
-
0013591444
-
The matrix metalloproteinase Gelatinase B null mice exhibit deficient growth plate angiogenesis and hypertrophic chondrocyte apoptosis
-
in press
-
25. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, et al.: The matrix metalloproteinase Gelatinase B null mice exhibit deficient growth plate angiogenesis and hypertrophic chondrocyte apoptosis. Cell 1998, in press. These researchers used targeted deletion of a metalloproteinase to illustrate the importance of vascularization in endochondral ossification of bone. The results emphasize the transition from mature to hypertrophic cartilage, the role of programmed cell death, and the eventual replacement of cartilage by bone using a variety of in vivo and in vitro techniques. In addition, their findings have an impact on our understanding of other genetic defects in which bone formation is altered.
-
(1998)
Cell
-
-
Vu, T.H.1
Shipley, J.M.2
Bergers, G.3
Berger, J.E.4
Helms, J.A.5
Hanahan, D.6
-
26
-
-
0029015278
-
Management of the compromised lower extremity
-
26. O'Brien P: Management of the compromised lower extremity. Can J Surg 1995, 38:218-220.
-
(1995)
Can J Surg
, vol.38
, pp. 218-220
-
-
O'Brien, P.1
-
27
-
-
0030666372
-
Cbfal, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
-
27. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, et al.: Cbfal, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development [see comments]. Cell 1997, 89:765-771.
-
(1997)
Cell
, vol.89
, pp. 765-771
-
-
Otto, F.1
Thornell, A.P.2
Crompton, T.3
Denzel, A.4
Gilmour, K.C.5
Rosewell, I.R.6
-
28
-
-
0030684749
-
Targeted disruption of Cbfal results in a complete lack of bone formation owing to maturational arrest of osteoblasts
-
28. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, et al.: Targeted disruption of Cbfal results in a complete lack of bone formation owing to maturational arrest of osteoblasts [see comments]. Cell 1997, 89:755-764.
-
(1997)
Cell
, vol.89
, pp. 755-764
-
-
Komori, T.1
Yagi, H.2
Nomura, S.3
Yamaguchi, A.4
Sasaki, K.5
Deguchi, K.6
-
29
-
-
15844412402
-
Increased bone formation in osteocalcin-deficient mice
-
29. Ducy P, C. Desbois C, Boyce B, Pinero G, Story B, Dunstan C, et al.: Increased bone formation in osteocalcin-deficient mice. Nature 1996, 382:448-452.
-
(1996)
Nature
, vol.382
, pp. 448-452
-
-
Ducy, P.1
C. Desbois, C.2
Boyce, B.3
Pinero, G.4
Story, B.5
Dunstan, C.6
-
30
-
-
0031832548
-
Genetics of skeletogenesis
-
30. Karsenty G: Genetics of skeletogenesis. Dev Genet 1998, 22:301-313.
-
(1998)
Dev Genet
, vol.22
, pp. 301-313
-
-
Karsenty, G.1
-
31
-
-
0030678549
-
Osf2/Cbfal: A transcriptional activator of osteoblast differentiation
-
31. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G: Osf2/Cbfal: a transcriptional activator of osteoblast differentiation [see comments]. Cell 1997, 89:747-754.
-
(1997)
Cell
, vol.89
, pp. 747-754
-
-
Ducy, P.1
Zhang, R.2
Geoffroy, V.3
Ridall, A.L.4
Karsenty, G.5
-
32
-
-
0032029929
-
In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues
-
32. Martin I, Padera RF, Vunjak-Novakovic G, Freed LE: In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues. J Orthop Res 1998, 16:181-189.
-
(1998)
J Orthop Res
, vol.16
, pp. 181-189
-
-
Martin, I.1
Padera, R.F.2
Vunjak-Novakovic, G.3
Freed, L.E.4
-
33
-
-
0031940290
-
The manipulated mesenchymal stem cells in regenerated skeletal tissues
-
33. Nevo Z, Robinson D, Horowitz S, Hasharoni A, Yayon A: The manipulated mesenchymal stem cells in regenerated skeletal tissues. Cell Transplant 1998, 7:63-70.
-
(1998)
Cell Transplant
, vol.7
, pp. 63-70
-
-
Nevo, Z.1
Robinson, D.2
Horowitz, S.3
Hasharoni, A.4
Yayon, A.5
-
34
-
-
0027973996
-
Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy
-
34. Bruder SP, Fink DJ, Caplan AI: Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994, 56:283-294.
-
(1994)
J Cell Biochem
, vol.56
, pp. 283-294
-
-
Bruder, S.P.1
Fink, D.J.2
Caplan, A.I.3
-
35
-
-
0026228558
-
Mesenchymal stem cells
-
35. Caplan AI: Mesenchymal stem cells. J Orthop Res 1991, 9:641-650.
-
(1991)
J Orthop Res
, vol.9
, pp. 641-650
-
-
Caplan, A.I.1
-
36
-
-
0030043654
-
Mechanical factors in bone growth and development
-
36. Carter DR, Van Der Meulen MC, Beauprae GS: Mechanical factors in bone growth and development. Bone 1996, 18(suppl 1):5-10.
-
(1996)
Bone
, vol.18
, Issue.SUPPL. 1
, pp. 5-10
-
-
Carter, D.R.1
Van Der Meulen, M.C.2
Beauprae, G.S.3
-
37
-
-
0013617648
-
Histochemical and molecular analyses of distraction osteogenesis in a mouse model
-
in press
-
37. Tay BKB, Le AX, Gould SE, Helms JA: Histochemical and molecular analyses of distraction osteogenesis in a mouse model. J Orthop Res 1997, in press.
-
(1997)
J Orthop Res
-
-
Tay, B.K.B.1
Le, A.X.2
Gould, S.E.3
Helms, J.A.4
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