Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain

British Journal of Pharmacology

Volumn 126, Issue 7, 1999, Pages 1634-1638

  Fraser, Caroline M ^a   Sills, Graeme J ^a   Forrest, Gerard ^a   Thompson, George G ^a   Brodie, Martin J ^a  

^a WESTERN INFIRMARY   (United Kingdom)

Author keywords

Anti epileptic drugs; Epilepsy; Glutamine synthetase

Indexed keywords

1 METHYL 1,2 DIPHENYLETHYLAMINE; AMMONIA; ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; FELBAMATE; GABAPENTIN; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

EID: 0032939556     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702472     Document Type: Article

References (30)

1. CARL, G.F., BLACKWELL, L.K., BARNETT, F.C., et al. (1993). Manganese and epilepsy: Brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats. Epilepsia, 34, 441-446.
2. CHEUNG, H., KAMP, D. & HARRIS, E. (1992). An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res., 13, 107-112.
3. COOPER, A.J.L., VERGARA, F. & DUFFY, T.D. (1983). Cerebral glutamine synthetase. In: Glutamine, Glutamate and GABA in the central nervous system. (ed.) Hertz, L., Kvamme, E., McGeer, E.G. & Schousboe, A. pp. 77-93. New York: Alan R. Liss.
4. DICHTER, M.A. & BRODIE, M.J. (1996). New antiepileptic drugs. New Engl. J. Med., 334, 1583-1590.
5. ELGER, C.E., BAUER, J., SCHERRMANN, J. & WIDMAN, G. (1998). Aggravation of focal epileptic seizures by antiepileptic drugs. Epilepsia, 39 (suppl 2): S15-S18.
6. FRASER, C.M., SILLS, G.J., FORREST, G., THOMPSON, G.G. & BRODIE, M.J. (1998). Effects of antiepileptic drugs on glutamine synthetase activity in mouse brain. Epilepsia, 39 (suppl 2), 99.
7. LAMING, P.R., COSBY, S.L. & O'NEILL, J.K. (1989). Seizures in the mongolian gerbil are related to a deficiency in cerebral glutamine synthetase. Comp. Biochem. Physiol., 94, 399-404.
8. LOISEAU, P. (1998). Do antiepileptic drugs exacerbate seizures? Epilepsia, 39, 2-4.
9. MARTINEZ-HERNANDEZ, A., BELL, K.P. & NORENBERG, M.D. (1977). Glutamine synthetase: Glial localization in brain. Science, 195, 1356-1358.
10. MEISTER, A. (1974). Glutamine synthetase of mammals. In The Enzymes Vol. 10. (ed.) Boyer, P.D. pp. 699-754. London: Academic Press.
11. MEISTER, A. (1980). Catalytic mechanism of glutamine synthetase; overview of glutamine metabolism. In: Glutamine: Metabolism, Enzymology and Regulation. (ed.) Mora, J. & Palacios, R. pp. 1-40. London: Academic Press.
12. MURPHY, J.M., MOTIWALA, R. & DEVINSKY, O. (1991). Phenytoin intoxication. South. Med. J., 84, 1199-1204.
13. NOLAN, P.M., PHELAN, P.P. & REGAN, C.M. (1985). The effect of sodium valproate on brain glutaminase and glutamine synthetase. IRCS Med. Sci., 13, 873-874.
14. NORENBERG, M.D. (1979). The distribution of glutamine synthetase in the rat central nervous system. J. Histochem. Cytochem., 27, 756-762.
15. NORENBERG, M.D. & MARTINEZ-HERNANDEZ, A. (1979). Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res., 161, 303-310.
16. OSORIO, I., BURNSTINE, T.H., REMLER, B., MANON-ESPAILLAT, R. & REED, R.C. (1989). Phenytoin-induced seizures: A paradoxical effect at toxic concentrations in epileptic patients. Epilepsia, 30, 230-234.
17. PERUCCA, E., GRAM, L., AVANZINI, G. & DULAC, O. (1998). Antiepileptic drugs as a cause of worsening seizures. Epilepsia, 39, 5-17.
18. PETERS, E.L. & TOWER, D.B. (1959). Glutamic acid and glutamine metabolism in cerebral cortex after seizures induced by methionine sulphoximine. J. Neurochem., 5, 80-90.
19. PHELAN, P., REGAN, C., KILTY, C. & DUNNE, A. (1985). Sodium valproate stimulates the particulate form of glutamine synthetase in rat brain. Neuropharmacology, 24, 895-902.
20. PISHAK, M.R. & PHILLIPS, A.T. (1979). A modified radioisotopic assay for measuring glutamine synthetase activity in tissue extracts. Anal. Biochem., 94, 82-88.
21. ROGAWSKI, M.A. & PORTER, R.J. (1990). Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev., 42, 223-286.
22. SELLINGER, O.Z., SCHATZ, R.A., PORTA, R. & WILENS, T.E. (1984). Brain methylation and epileptogenesis: The case of methionine sulfoximine. Ann. Neurol., 16, S115-S120.
23. SILLS, G.J., LEACH, J.P., FRASER, C.M., FORREST, G., PATSALOS, P.N. & BRODIE, M.J. (1997). Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. Eur. J. Pharmacol., 325, 35-40.
24. SWANSON, R.A., SHIRAISHI, K., MORTON, M.T. & SHARP, F.R. (1990). Methionine sulphoximine reduces cortical infarct size in rats after middle cerebral artery occlusion. Stroke, 21, 322-327.
25. TROUPIN, A.S. & OJEMANN, L.M. (1975). Paradoxical intoxication -A complication of anticonvulsant administration. Epilepsia, 16, 753-758.
26. WAMIL, A.W., CHEUNG, H., HARRIS, E.W. & MCLEAN, M.J. (1996). Remacemide HCl and its metabolite, FPL 12495AA, limit action potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture. Epilepsy Res., 23, 1-14.
27. WANIEWSKI, R.A. & MARTIN, D.L. (1986). Exogenous glutamate is metabolized to glutamine and exported by rat primary astrocyte cultures. J. Neurochem., 47, 304-313.
28. WANIEWSKI, R.A. (1992). Physiological levels of ammonia regulate glutamine synthesis from extracellular glutamate in astrocyte cultures. J. Neurochem., 58, 167-174.
29. WHITE, H.S., YEN-CHOW, Y.C., CHOW, S.Y., KEMP, J.W. & WOODBURY, D.M. (1985). Effects of phenytoin on primary glial cell cultures. Epilepsia, 26, 58-68.
30. WOLFF, D.L., KERRICK, J.M., RARICK, J., LEPPIK, I.E. & GRAVES, N.M. (1994). Post-market felbamate use in the refractory epilepsy population. Epilepsia, 35 (suppl 8), 32.