메뉴 건너뛰기




Volumn 74, Issue 1, 2008, Pages 14-21

Xenotransplantation: Where are we in 2008?

Author keywords

Acute humoral rejection; Hyperacute rejection; Infection; Pig; Transgenic; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CHIMERIC ANTIBODY;

EID: 45249088523     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.135     Document Type: Short Survey
Times cited : (55)

References (64)
  • 1
    • 34247238869 scopus 로고    scopus 로고
    • Kidney and pancreas transplantation in the United States, 1996-2005
    • Andreoni KA, Brayman KL, Guidinger MK et al. Kidney and pancreas transplantation in the United States, 1996-2005. Am J Transplant 2007; 7: 1359-1375.
    • (2007) Am J Transplant , vol.7 , pp. 1359-1375
    • Andreoni, K.A.1    Brayman, K.L.2    Guidinger, M.K.3
  • 2
    • 45249095991 scopus 로고    scopus 로고
    • Richmond, VA. Available at
    • UNOS. United Network for Organ Sharing: Richmond, VA. Available at http://www.unos.org.
  • 3
    • 45249085896 scopus 로고    scopus 로고
    • Eurotransplant International Foundation, The Netherlands. Available at
    • Eurotransplant International Foundation. Leiden, The Netherlands. Available at http://www.transplant.org.
    • Leiden
  • 4
    • 0032523166 scopus 로고    scopus 로고
    • The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
    • Lin SS, Weidner BC, Byrne GW et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 1998; 101: 1745-1756.
    • (1998) J Clin Invest , vol.101 , pp. 1745-1756
    • Lin, S.S.1    Weidner, B.C.2    Byrne, G.W.3
  • 5
    • 0030661679 scopus 로고    scopus 로고
    • Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy
    • Kobayashi T, Taniguchi S, Neethling FA et al. Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy. Transplantation 1997; 64: 1255-1261.
    • (1997) Transplantation , vol.64 , pp. 1255-1261
    • Kobayashi, T.1    Taniguchi, S.2    Neethling, F.A.3
  • 6
    • 0037090845 scopus 로고    scopus 로고
    • Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors
    • Schuurman HJ, Pino-Chavez G, Phillips MJ et al. Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors. Transplantation 2002; 73: 1146-1151.
    • (2002) Transplantation , vol.73 , pp. 1146-1151
    • Schuurman, H.J.1    Pino-Chavez, G.2    Phillips, M.J.3
  • 7
    • 0035863070 scopus 로고    scopus 로고
    • A human CD46 transgenic pig model system for the study of discordant xenotransplantation
    • Diamond LE, Quinn CM, Martin MJ et al. A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 2001; 71: 132-142.
    • (2001) Transplantation , vol.71 , pp. 132-142
    • Diamond, L.E.1    Quinn, C.M.2    Martin, M.J.3
  • 8
    • 0035668542 scopus 로고    scopus 로고
    • Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection
    • Niemann H, Verhoeyen E, Wonigeit K et al. Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection. Transplantation 2001; 72: 1898-1906.
    • (2001) Transplantation , vol.72 , pp. 1898-1906
    • Niemann, H.1    Verhoeyen, E.2    Wonigeit, K.3
  • 9
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park KW et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089-1092.
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 10
    • 0041366004 scopus 로고    scopus 로고
    • Pathology of xenograft rejection: A commentary
    • Schuurman HJ, Cheng J, Lam T. Pathology of xenograft rejection: a commentary. Xenotransplantation 2003; 10: 293-299.
    • (2003) Xenotransplantation , vol.10 , pp. 293-299
    • Schuurman, H.J.1    Cheng, J.2    Lam, T.3
  • 11
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • Yamada K, Yazawa K, Shimizu A et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32-34.
    • (2005) Nat Med , vol.11 , pp. 32-34
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3
  • 12
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • Kuwaki K, Tseng YL, Dor FJ et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29-31.
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 13
    • 28644446730 scopus 로고    scopus 로고
    • Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
    • Chen G, Qian H, Starzl T et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298.
    • (2005) Nat Med , vol.11 , pp. 1295-1298
    • Chen, G.1    Qian, H.2    Starzl, T.3
  • 14
    • 33745842254 scopus 로고    scopus 로고
    • Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL
    • Jin R, Greenwald A, Peterson MD et al. Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL. J Immunol 2006; 177: 1289-1295.
    • (2006) J Immunol , vol.177 , pp. 1289-1295
    • Jin, R.1    Greenwald, A.2    Peterson, M.D.3
  • 15
    • 33947394796 scopus 로고    scopus 로고
    • Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity
    • Lilienfeld BG, Crew MD, Forte P et al. Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity. Xenotransplantation 2007; 14: 126-134.
    • (2007) Xenotransplantation , vol.14 , pp. 126-134
    • Lilienfeld, B.G.1    Crew, M.D.2    Forte, P.3
  • 16
    • 33746899704 scopus 로고    scopus 로고
    • Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D
    • Lilienfeld BG, Garcia-Borges C, Crew MD et al. Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D. J Immunol 2006; 177: 2146-2152.
    • (2006) J Immunol , vol.177 , pp. 2146-2152
    • Lilienfeld, B.G.1    Garcia-Borges, C.2    Crew, M.D.3
  • 17
    • 33846185825 scopus 로고    scopus 로고
    • Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
    • Wang H, VerHalen J, Madariaga ML et al. Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2007; 109: 836-842.
    • (2007) Blood , vol.109 , pp. 836-842
    • Wang, H.1    VerHalen, J.2    Madariaga, M.L.3
  • 18
    • 85047692190 scopus 로고    scopus 로고
    • Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    • Dwyer KM, Robson SC, Nandurkar HH et al. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest 2004; 113: 1440-1446.
    • (2004) J Clin Invest , vol.113 , pp. 1440-1446
    • Dwyer, K.M.1    Robson, S.C.2    Nandurkar, H.H.3
  • 19
    • 14344264156 scopus 로고    scopus 로고
    • Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance
    • Sykes M, Shimizu I, Kawahara T. Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance. Transplantation 2005; 79: S28-S29.
    • (2005) Transplantation , vol.79
    • Sykes, M.1    Shimizu, I.2    Kawahara, T.3
  • 20
    • 34547838855 scopus 로고    scopus 로고
    • Global unresponsiveness as a mechanism of natural killer cell tolerance in mixed xenogeneic chimeras
    • Kawahara T, Rodriguez-Barbosa JI, Zhao Y et al. Global unresponsiveness as a mechanism of natural killer cell tolerance in mixed xenogeneic chimeras. Am J Transplant 2007; 7: 2090-2097.
    • (2007) Am J Transplant , vol.7 , pp. 2090-2097
    • Kawahara, T.1    Rodriguez-Barbosa, J.I.2    Zhao, Y.3
  • 21
    • 0033572777 scopus 로고    scopus 로고
    • Thymic transplantation in miniature swine. I. Development and function of the 'thymokidney'
    • Yamada K, Shimizu A, Ierino FL et al. Thymic transplantation in miniature swine. I. Development and function of the 'thymokidney'. Transplantation 1999; 68: 1684-1692.
    • (1999) Transplantation , vol.68 , pp. 1684-1692
    • Yamada, K.1    Shimizu, A.2    Ierino, F.L.3
  • 22
    • 0034653832 scopus 로고    scopus 로고
    • Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients
    • Yamada K, Shimizu A, Utsugi R et al. Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients. J Immunol 2000; 164: 3079-3086.
    • (2000) J Immunol , vol.164 , pp. 3079-3086
    • Yamada, K.1    Shimizu, A.2    Utsugi, R.3
  • 23
    • 34250820410 scopus 로고    scopus 로고
    • Xenotransplantation: Current status and a perspective on the future
    • Yang YG, Sykes M. Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol 2007; 7: 519-531.
    • (2007) Nat Rev Immunol , vol.7 , pp. 519-531
    • Yang, Y.G.1    Sykes, M.2
  • 24
    • 0036240402 scopus 로고    scopus 로고
    • Xenotransplantation: Past achievements and future promise
    • Dwyer KM, Cowan PJ, d'Apice AJ. Xenotransplantation: past achievements and future promise. Heart Lung Circ 2002; 11: 32-41.
    • (2002) Heart Lung Circ , vol.11 , pp. 32-41
    • Dwyer, K.M.1    Cowan, P.J.2    d'Apice, A.J.3
  • 25
    • 10644296310 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Progress toward the clinic
    • McGregor CG, Teotia SS, Byrne GW et al. Cardiac xenotransplantation: progress toward the clinic. Transplantation 2004; 78: 1569-1575.
    • (2004) Transplantation , vol.78 , pp. 1569-1575
    • McGregor, C.G.1    Teotia, S.S.2    Byrne, G.W.3
  • 26
    • 24644482765 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival
    • McGregor CG, Davies WR, Oi K et al. Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005; 130: 844-851.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 844-851
    • McGregor, C.G.1    Davies, W.R.2    Oi, K.3
  • 27
    • 0035034212 scopus 로고    scopus 로고
    • The immunological barrier to xenotransplantation
    • Cascalho M, Platt JL. The immunological barrier to xenotransplantation. Immunity 2001; 14: 437-446.
    • (2001) Immunity , vol.14 , pp. 437-446
    • Cascalho, M.1    Platt, J.L.2
  • 28
    • 33645963970 scopus 로고    scopus 로고
    • T-cell responses during pig-to-primate xenotransplantation
    • Davila E, Byrne GW, LaBreche PT et al. T-cell responses during pig-to-primate xenotransplantation. Xenotransplantation 2006; 13: 31-40.
    • (2006) Xenotransplantation , vol.13 , pp. 31-40
    • Davila, E.1    Byrne, G.W.2    LaBreche, P.T.3
  • 29
    • 33644829825 scopus 로고    scopus 로고
    • Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
    • Cardona K, Korbutt GS, Milas Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304-306.
    • (2006) Nat Med , vol.12 , pp. 304-306
    • Cardona, K.1    Korbutt, G.S.2    Milas, Z.3
  • 30
    • 33644831338 scopus 로고    scopus 로고
    • Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    • Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303.
    • (2006) Nat Med , vol.12 , pp. 301-303
    • Hering, B.J.1    Wijkstrom, M.2    Graham, M.L.3
  • 31
    • 0034669957 scopus 로고    scopus 로고
    • Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice
    • Ohdan H, Swenson KG, Kruger Gray HS et al. Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice. J Immunol 2000; 165: 5518-5529.
    • (2000) J Immunol , vol.165 , pp. 5518-5529
    • Ohdan, H.1    Swenson, K.G.2    Kruger Gray, H.S.3
  • 32
    • 35948933472 scopus 로고    scopus 로고
    • Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells
    • Li S, Yan Y, Lin Y et al. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells. Blood 2007; 110: 3926-3935.
    • (2007) Blood , vol.110 , pp. 3926-3935
    • Li, S.1    Yan, Y.2    Lin, Y.3
  • 33
    • 0028406899 scopus 로고
    • Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28
    • Murray AG, Khodadoust MM, Pober JS et al. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1: 57-63.
    • (1994) Immunity , vol.1 , pp. 57-63
    • Murray, A.G.1    Khodadoust, M.M.2    Pober, J.S.3
  • 34
    • 0028889431 scopus 로고
    • Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
    • Yamada K, Sachs DH, DerSimonian H. Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 1995; 155: 5249-5256.
    • (1995) J Immunol , vol.155 , pp. 5249-5256
    • Yamada, K.1    Sachs, D.H.2    DerSimonian, H.3
  • 35
    • 22844451603 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T cells suppress anti-porcine xenogeneic responses
    • Porter CM, Bloom ET. Human CD4+CD25+ regulatory T cells suppress anti-porcine xenogeneic responses. Am J Transplant 2005; 5: 2052-2057.
    • (2005) Am J Transplant , vol.5 , pp. 2052-2057
    • Porter, C.M.1    Bloom, E.T.2
  • 36
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen
    • Kuwaki K, Knosalla C, Dor FJ et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am J Transplant 2004; 4: 363-372.
    • (2004) Am J Transplant , vol.4 , pp. 363-372
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.J.3
  • 37
    • 30144442608 scopus 로고    scopus 로고
    • Vascularized thymic lobe transplantation in a pig-to-baboon model: A novel strategy for xenogeneic tolerance induction and T-cell reconstitution
    • Yamamoto S, Lavelle JM, Vagefi PA et al. Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation 2005; 80: 1783-1790.
    • (2005) Transplantation , vol.80 , pp. 1783-1790
    • Yamamoto, S.1    Lavelle, J.M.2    Vagefi, P.A.3
  • 38
    • 33746931587 scopus 로고    scopus 로고
    • Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: In vivo and in vitro analyses
    • Fudaba Y, Spitzer TR, Shaffer J et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant 2006; 6: 2121-2133.
    • (2006) Am J Transplant , vol.6 , pp. 2121-2133
    • Fudaba, Y.1    Spitzer, T.R.2    Shaffer, J.3
  • 39
    • 0035876364 scopus 로고    scopus 로고
    • T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3- galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism
    • Ohdan H, Yang YG, Swenson KG et al. T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3- galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Transplantation 2001; 71: 1532-1542.
    • (2001) Transplantation , vol.71 , pp. 1532-1542
    • Ohdan, H.1    Yang, Y.G.2    Swenson, K.G.3
  • 40
    • 12344328358 scopus 로고    scopus 로고
    • Porcine hematopoietic progenitor cell transplantation in nonhuman primates: A review of progress
    • Tseng YL, Sachs DH, Cooper DK. Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress. Transplantation 2005; 79: 1-9.
    • (2005) Transplantation , vol.79 , pp. 1-9
    • Tseng, Y.L.1    Sachs, D.H.2    Cooper, D.K.3
  • 41
    • 2342640825 scopus 로고    scopus 로고
    • Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism
    • Lan P, Wang L, Diouf B et al. Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood 2004; 103: 3964-3969.
    • (2004) Blood , vol.103 , pp. 3964-3969
    • Lan, P.1    Wang, L.2    Diouf, B.3
  • 42
    • 0031965879 scopus 로고    scopus 로고
    • Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period
    • Itescu S, Kwiatkowski P, Artrip JH et al. Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period. Hum Immunol 1998; 59: 275-286.
    • (1998) Hum Immunol , vol.59 , pp. 275-286
    • Itescu, S.1    Kwiatkowski, P.2    Artrip, J.H.3
  • 43
    • 0030461046 scopus 로고    scopus 로고
    • T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection
    • Candinas D, Belliveau S, Koyamada N et al. T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection. Transplantation 1996; 62: 1920-1927.
    • (1996) Transplantation , vol.62 , pp. 1920-1927
    • Candinas, D.1    Belliveau, S.2    Koyamada, N.3
  • 44
    • 26844546175 scopus 로고    scopus 로고
    • Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D
    • Forte P, Lilienfeld BG, Baumann BC et al. Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D. J Immunol 2005; 175: 5463-5470.
    • (2005) J Immunol , vol.175 , pp. 5463-5470
    • Forte, P.1    Lilienfeld, B.G.2    Baumann, B.C.3
  • 45
    • 0031463438 scopus 로고    scopus 로고
    • Contribution of activated macrophages to the process of delayed xenograft rejection
    • Lin Y, Vandeputte M, Waer M. Contribution of activated macrophages to the process of delayed xenograft rejection. Transplantation 1997; 64: 1677-1683.
    • (1997) Transplantation , vol.64 , pp. 1677-1683
    • Lin, Y.1    Vandeputte, M.2    Waer, M.3
  • 46
    • 0029152790 scopus 로고
    • The main infiltrating cell in xenograft rejection is a CD4+ macrophage and not a T lymphocyte
    • Wallgren AC, Karlsson-Parra A, Korsgren O. The main infiltrating cell in xenograft rejection is a CD4+ macrophage and not a T lymphocyte. Transplantation 1995; 60: 594-601.
    • (1995) Transplantation , vol.60 , pp. 594-601
    • Wallgren, A.C.1    Karlsson-Parra, A.2    Korsgren, O.3
  • 47
    • 0037372892 scopus 로고    scopus 로고
    • T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts
    • Yi S, Hawthorne WJ, Lehnert AM et al. T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J Immunol 2003; 170: 2750-2758.
    • (2003) J Immunol , vol.170 , pp. 2750-2758
    • Yi, S.1    Hawthorne, W.J.2    Lehnert, A.M.3
  • 48
    • 0034674421 scopus 로고    scopus 로고
    • Role of CD47 as a marker of self on red blood cells
    • Oldenborg PA, Zheleznyak A, Fang YF et al. Role of CD47 as a marker of self on red blood cells. Science 2000; 288: 2051-2054.
    • (2000) Science , vol.288 , pp. 2051-2054
    • Oldenborg, P.A.1    Zheleznyak, A.2    Fang, Y.F.3
  • 49
    • 34247568865 scopus 로고    scopus 로고
    • Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages
    • Ide K, Wang H, Tahara H et al. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 2007; 20: 5062-5066.
    • (2007) Proc Natl Acad Sci USA , vol.20 , pp. 5062-5066
    • Ide, K.1    Wang, H.2    Tahara, H.3
  • 50
    • 33845994431 scopus 로고    scopus 로고
    • Coagulation and the xenograft endothelium
    • Cowan PJ. Coagulation and the xenograft endothelium. Xenotransplantation 2007; 14: 7-12.
    • (2007) Xenotransplantation , vol.14 , pp. 7-12
    • Cowan, P.J.1
  • 51
  • 52
    • 20244380021 scopus 로고    scopus 로고
    • Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function
    • Byrne GW, Schirmer JM, Fass DN et al. Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function. Am J Transplant 2005; 5: 1011-1020.
    • (2005) Am J Transplant , vol.5 , pp. 1011-1020
    • Byrne, G.W.1    Schirmer, J.M.2    Fass, D.N.3
  • 53
    • 33845939353 scopus 로고    scopus 로고
    • Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival
    • Byrne GW, Davies WR, Oi K et al. Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival. Transplantation 2006; 82: 1787-1791.
    • (2006) Transplantation , vol.82 , pp. 1787-1791
    • Byrne, G.W.1    Davies, W.R.2    Oi, K.3
  • 54
    • 10044240662 scopus 로고    scopus 로고
    • Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
    • Chen D, Weber M, McVey JH et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004; 4: 1958-1963.
    • (2004) Am J Transplant , vol.4 , pp. 1958-1963
    • Chen, D.1    Weber, M.2    McVey, J.H.3
  • 55
    • 33747115379 scopus 로고    scopus 로고
    • The transgenic expression of human CD39 on murine islets inhibits clotting of human blood
    • Dwyer KM, Mysore TB, Crikis S et al. The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation 2006; 82: 428-432.
    • (2006) Transplantation , vol.82 , pp. 428-432
    • Dwyer, K.M.1    Mysore, T.B.2    Crikis, S.3
  • 56
    • 33744749536 scopus 로고    scopus 로고
    • Is xenotransplantation of vascularized organs just too hard?
    • d'Apice AJ. Is xenotransplantation of vascularized organs just too hard? Xenotransplantation 2006; 13: 182-185.
    • (2006) Xenotransplantation , vol.13 , pp. 182-185
    • d'Apice, A.J.1
  • 57
    • 33750095969 scopus 로고    scopus 로고
    • Selected physiologic compatibilities and incompatibilities between human and porcine organ systems
    • Ibrahim Z, Busch J, Awwad M et al. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation 2006; 13: 488-499.
    • (2006) Xenotransplantation , vol.13 , pp. 488-499
    • Ibrahim, Z.1    Busch, J.2    Awwad, M.3
  • 58
    • 0031907868 scopus 로고    scopus 로고
    • Uncertainty in xenotransplantation: Individual benefit versus collective risk
    • Bach FH, Fishman JA, Daniels N et al. Uncertainty in xenotransplantation: individual benefit versus collective risk. Nat Med 1998; 4: 141-144.
    • (1998) Nat Med , vol.4 , pp. 141-144
    • Bach, F.H.1    Fishman, J.A.2    Daniels, N.3
  • 59
    • 4344669147 scopus 로고    scopus 로고
    • Xenotransplantation: Infectious risk revisited
    • Fishman JA, Patience C. Xenotransplantation: infectious risk revisited. Am J Transplant 2004; 4: 1383-1390.
    • (2004) Am J Transplant , vol.4 , pp. 1383-1390
    • Fishman, J.A.1    Patience, C.2
  • 60
    • 0036187971 scopus 로고    scopus 로고
    • Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine
    • Oldmixon BA, Wood JC, Ericsson TA et al. Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J Virol 2002; 76: 3045-3048.
    • (2002) J Virol , vol.76 , pp. 3045-3048
    • Oldmixon, B.A.1    Wood, J.C.2    Ericsson, T.A.3
  • 61
    • 7944223995 scopus 로고    scopus 로고
    • Position paper of the Ethics Committee of the International Xenotransplantation Association
    • Sykes M, D'Apice A, Sandrin M. Position paper of the Ethics Committee of the International Xenotransplantation Association. Transplantation 2004; 78: 1101-1107.
    • (2004) Transplantation , vol.78 , pp. 1101-1107
    • Sykes, M.1    D'Apice, A.2    Sandrin, M.3
  • 62
    • 34548321344 scopus 로고    scopus 로고
    • Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways
    • Cardona K, Milas Z, Strobert E et al. Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. Am J Transplant 2007; 7: 2260-2268.
    • (2007) Am J Transplant , vol.7 , pp. 2260-2268
    • Cardona, K.1    Milas, Z.2    Strobert, E.3
  • 63
    • 33750061886 scopus 로고    scopus 로고
    • International inventory of xenotransplantation practices in humans
    • Buhler L, Sgroi A, Sykes M et al. International inventory of xenotransplantation practices in humans. Xenotransplantation 2006; 13: 482.
    • (2006) Xenotransplantation , vol.13 , pp. 482
    • Buhler, L.1    Sgroi, A.2    Sykes, M.3
  • 64
    • 16244394500 scopus 로고    scopus 로고
    • Commentary: World Health Assembly resolution 57.18 on xenotransplantation
    • Sykes M. Commentary: World Health Assembly resolution 57.18 on xenotransplantation. Transplantation 2005; 79: 636-637.
    • (2005) Transplantation , vol.79 , pp. 636-637
    • Sykes, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.