Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity

Journal of Organic Chemistry

Volumn 73, Issue 12, 2008, Pages 4362-4369

  Patterson, Andrew W ^a   Peltier, Hillary M ^a   Ellman, Jonathan A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ALKYLATION; AMIDES; AMINATION; AMINES; AMINO ACIDS; BIOLOGICAL MATERIALS; CHEMICAL REACTIONS; HEALTH; HYDROCARBONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; STEREOCHEMISTRY; STEREOSELECTIVITY;

ACYL TRANSFER; AMERICAN CHEMICAL SOCIETY (ACS); AMIDE BONDS; BIOLOGICAL STUDIES; CHEMICAL EQUATIONS; HETERO CYCLES; HIGHLY EFFICIENT; N-ALKYLATION; N-METHYLATION; STEREO SELECTIVE SYNTHESIS; SYNTHESIS (OF CHIRAL IONIC LIQUIDS);

SYNTHESIS (CHEMICAL);

1,3 TETRAHYDROOXAZINE; HETEROCYCLIC COMPOUND; ISOLEUCINE; N METHYLTUBULYSIN DERIVATIVE; N METHYLTUBUVALINE; OXAZINE DERIVATIVE; TERT BUTANESULFINAMIDE;

ACYLATION; ALKYLATION; ARTICLE; CHEMICAL BOND; CYTOTOXICITY; DRUG SYNTHESIS; METHYLATION; REDUCTION; STEREOCHEMISTRY;

DRUG SCREENING ASSAYS, ANTITUMOR; MAGNETIC RESONANCE SPECTROSCOPY; OLIGOPEPTIDES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 45249085481     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo800384x     Document Type: Article

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