First synthetic method for the preparation of 6-unsubstituted-2,3-dihydro-1,3-oxazin-4-ones

Journal of Organic Chemistry

Volumn 61, Issue 10, 1996, Pages 3358-3361

  Bertolini, Giorgio ^a   Aquino, Mario ^a   Ferrario, Francesco ^a   Pavich, Gianfranco ^a   Zaliani, Andrea ^a   Sala, Alberto ^a  

^a Italfarmaco SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 OXAZINE DERIVATIVE; 2,3 DIHYDRO 3 [2 (NITROOXY) ETHYL] 1,3 BENZOXARIN 4 ONE; 2,3 DIHYDRO 3 [2 (NITROOXY) ETHYL] 1,3 OXAZIN 4 ONE DERIVATIVE; ILF 296; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DRUG SYNTHESIS; ISCHEMIA; NONHUMAN; RAT; REACTION ANALYSIS;

EID: 0029894891     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo952118h     Document Type: Article

References (9)

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6. According to semiempirical calculation (AM1), compound 9a was thermodynamically more stable than 8a by about 10 Kcal/mol.
7. Ferris, A. F.; McLean, K. W.; Marks, I. G.; Emmons, W. D. J. Am. Chem. Soc. 1953, 75, 4078.
8. Benedini, F.; Bertolini, G.; Ferrario, F.; Motti, A.; Sala, A.; Somenzi, F. J. Heterocyc. Chem. 1995, 32, 103.
9. Prepared by mixing the corresponding ethyl esters and ethanolamine at 70 °C for several hours. J. Org. Chem. 1996, 61, 3375-3387