Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: Differential requirements for the modulation of FGF-1 and FGF-2

Glycobiology

Volumn 10, Issue 11, 2000, Pages 1183-1192

  Pye, David A ^a,b   Vivès, Romain R ^a,b   Hyde, Patricia ^b   Gallagher, John T ^b  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Activity; FGF 1; FGF 2; Heparan sulfate; Oligosaccharides

Indexed keywords

CELL SURFACE RECEPTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; HEPARAN SULFATE; OLIGOSACCHARIDE; SUGAR; SULFATE; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOHYDRATE ANALYSIS; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; GROWTH STIMULATION; MITOGENESIS; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SULFATION;

ANIMALIA;

EID: 0033658646     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/10.11.1183     Document Type: Article

References (88)

1. Ability of different chemically modified heparins to potentiate the biological activity of heparin-binding growth factor 1: Lack of correlation with growth factor binding
2. Investigation of the ability of several naturally occuring and synthetic polyanions to bind to and potentiate the biological activity of acidic fibroblast growth factor
3. Ligand-induced transphosphorylation between different FGF receptors. EMBO J
4. X-Ray crystal structure of human acidic fibroblast growth factor
5. Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development
6. Structural comparison of fibroblast growth factor-specific heparan sulfates derived from a growing or differentiating neuroepithelial cell line
7. Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor
8. Acidic and basic fibroblast growth factor bind with differing affinity to the same heparan sulfate proteoglycan on BALB/c 3T3 cells: Implications for potentiation of growth factor action by heparin
9. Evidence that carboxyl-reduced heparin fails to potentiate acidic fibroblast growth factor activity due to an inability to interact with cell surface heparin receptors
10. The heparin-binding (fibroblast) growth factor family of proteins
11. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase
12. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue
13. Structural analysis of glycosaminoglycans derived from axonally transported proteoglycans in regenerating goldfish optic nerve
14. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
15. Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half-life
16. Developmental changes in heparan sulfate expression: In situ detection with mAbs
17. Specificity studies on the heparin lyases from Flavobacterium heparinum
18. Structure of a heparin-linked biologically active dimer of fibroblast growth factor
19. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
20. Characterization of novel sequences containing 3-O-sulfated glucosamine in glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain
21. Heparin structure and interactions with basic fibroblast growth factor
22. Age-dependent modulation of heparan sulfate structure and function
23. Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells
24. Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharides
25. Structure and function of heparan sulfate proteoglycans
26. Foam cell conversion of macrophages alters the biosynthesis of heparan sulfate
27. Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H
28. Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1. FGF-2 and FGF-4
29. Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2
30. Importance of 6-O-sulfate groups of glucosamine residues in heparin for activation of FGF-1 and FGF-2
31. Importance of 2-O-sulfate groups of uronate residues in heparin for activation of FGF-1 and FGF-2
32. Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro
33. An essential heparin-binding domain in the fibroblast growth factor receptor kinase
34. Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek
35. Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains
36. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3
37. Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: Development of a sensitive electrophoretic approach
38. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
39. More to ″heparin″ than anticoagulation
40. Examination of the substrate specificity of heparin and heparan sulfate lyases
41. Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor
42. Liver heparan sulfate structure. A novel molecular design
43. Domain structure of heparan sulfates from bovine organs
44. Nature of the interaction of heparin with acidic fibroblast growth factor
45. Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan
46. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property
47. High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells
48. Stabilization by heparin of acidic fibroblast growth factor mitogenicity for human endothelial cells in vitro
49. Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan
50. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
51. Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization
52. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern
53. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin and fibroblast growth factor
54. Basement-membrane heparan sulfate with high affinity for antithrombin synthesized by normal and transformed mouse mammary epithelial cells
55. Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans
56. Monomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activation
57. Molecular attributes of bovine aortic endothelial cell heparan sulfate
58. Heparan sulfate oligosaccharides require 6-O-Sulfation for promotion of basic fibroblast growth factor mitogenic activity
59. Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfate
60. The neurotrophic activity of fibroblast growth factor 1 (FGF1) depends on endogenous FGF1 expression and is independent of the mitogen-activated protein kinase cascade pathway
61. Distinct role of 2-O-, N- and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1
62. Selective reduction of 6-O-sulfation in heparan sulfate from transformed mammary epithelial cells
63. Differentiation-associated modulation of heparan sulfate structure and function in CaCo-2 colon carcinoma cells
64. Fine structure of heparan sulfate regulates syndecan-1 function and cell behavior
65. Engineering of fibroblast growth factor: Alteration of receptor binding specificity
66. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation and cell proliferation
67. Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis
68. Acidic and basic fibroblast growth factors are survival factors with distinctive activity in quiescent BALB/c 3T3 murine fibroblasts
69. FGF-1 is a heparin-independent mitogen for rat hepatocytes
70. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells
71. Human endothelial cells are chemotactic to endothelial cell growth factor and heparin
72. Human endothelial cells: Use of heparin in cloning and long-term
73. Molecular organization of heparan sulfate from human skin fibroblasts
74. Distribution of iduronate 2-sulfate residues in heparan sulfate. Evidence for an ordered polymeric structure
75. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate
76. Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons
77. Signal transduction by fibroblast growth factor receptor-4 (#FGFR-4). Comparison with FGFR-1
78. Fibroblast growth factor receptors have different signaling and mitogenic potentials
79. Molecular characterization of recombinant human acidic fibroblast growth factor produced in E.coli: Comparative studies with human basic fibroblast growth factor
80. Translocation of cytosol of exogenous, CAAX-tagged acidic fibroblast growth factor
81. Cells selected for high tumorigenicity or transformed by simian virus 40 synthesize heparan sulfate with reduced degree of sulfation
82. Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin
83. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family
84. Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle
85. Three-dimensional structures of acidic and basic fibroblast growth factors