Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production

Experimental and Molecular Medicine

Volumn 39, Issue 2, 2007, Pages 230-238

  Lee, Seon Jin ^a   Namkoong, Seung ^a   Ha, Kwon Soo ^a   Nam, Woo Dong ^a   Kwon, Young Guen ^b   Lee, Hansoo ^a   Yoon, Eun Young ^c   Chang, Dong Jo ^c   Kim, Soon Ok ^c   Kim, Young Myeong ^a  

^a Kangwon National University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Suwon University   (South Korea)

Author keywords

Colchicine; Cytokines; Immunosuppressive agents; Inflammation; T lymphocytes, helper inducer; Transplantation, homologous

Indexed keywords

COLCHICINE; COLCHICINE DERIVATIVE; CT 20006; CT 20007; CT 20015; CT 20032; CT 20087; CT 20126; CYCLOSPORIN A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG SYNTHESIS; FEMALE; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; SKIN ALLOGRAFT; TH1 CELL; TH2 CELL;

MUS;

EID: 34247645082     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2007.26     Document Type: Article

References (23)

1. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T-lymphocytes. Nature 1996;383:787-93
2. Benagiano M, Azzurri A, Ciervo A, Amedei A, Tamburini C, Ferrari M, Telford JL, Baldari CT, Romagnani S, Cassone A, D'Elios MM, Del Prete G. T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc Natl Acad Sci USA 2003;100:6658-63
3. Calcagni E, Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann N Y Acad Sci 2006;1069:62-76
4. Ford HR, Hoffman RA, Tweardy DJ, Kispert P, Wang S, Simmons RL. Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation 1991;51:656-61
5. Furukawa H, Oshima K, Tung T, Cui G, Laks H, Sen L. Liposome-mediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts. J Immunol 2005;174:6983-92
6. Gahm C, Holmin S, Rudehill S, Mathiesen T. Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine. Acta Neurochir (Wien) 2005;147:1071-84
7. Hoffman RA, Ascher NL, Jordan ML, Migliori RJ, Simmons RL. Characterization of natural killer activity in sponge matrix allografts. J Immunol 1988;140:1702-10
8. Holan V, Krulova M, Pindjakova J, Zajicova A. The role of macrophages and nitric oxide in the effector phase of allotransplantation reaction. Ann Transplant 2001;6:44-6
9. Holan V, Pindjakova J, Krulova M, Neuwirth A, Fric J, Zajicova A. Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism. Transplantation 2006;81:1708-15
10. Krulova M, Zajicova A, Fric J, Holan V. Alloantigen-induced, T-cell-dependent production of nitric oxide by macrophages infiltrating skin allografts in mice. Transpl Int 2002;15:108-16
11. Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, Lee SK, Kim YM. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IκB kinase-dependent NF-κB activation. Mol Cells 2003;16:97-105
12. Matsue H, Yang C, Matsue K, Edelbaum D, Mummert M, Takashima A. Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation. J Immunol 2002;169:3555-64
13. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57
14. Ostermann D, Perico N, Imberti O, Barbui C, Bontempelli M, Remuzzi G. Colchicine allows prolonged survival of highly reactive renal allograft in the rat. J Am Soc Nephrol 1993;4:1294-9
15. Oswald IP, Gazzinelli RT, Sher A, James SL. IL-10 synergizes with IL-4 and TGF-β to inhibit macrophage cytotoxic activity. J Immunol 1992;148:3578-82
16. Saeed SA, Integlia MJ, Pleskow RG, Calenda KA, Rohrer RJ, Dayal Y, Grand RJ. Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis. Pediatr Transplant 2006;10:730-5
17. Schmidt-Weber CB, Alexander SI, Henault LE, James L, Lichtman AH. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement. J Immunol 1999;162:238-44
18. Schuerwegh AJ, Dombrecht EJ, Stevens WJ, Van Offel JF, Bridts CH, De Clerck LS. Influence of pro-inflammatory (IL-1α, IL-6, TNF-α, IFN-γ) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthritis Cartilage 2003;11:681-7
19. Smith JM, Nemeth TL, McDonald RA. Current immunosuppressive agents: efficacy, side effects, and utilization. Pediatr Clin North Am 2003;50:1283-300
20. Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A. The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol 1996;8:688-93
21. Tan M, Di Carlo A, Liu SQ, Tector AJ, Tchervenkov JI, Metrakos P. Hepatic sinusoidal endothelium upregulates IL-1α, IFN-γ, and iNOS in response to discordant xenogeneic islets in an in vitro model of xenoislet transplantation. J Surg Res 2002;102:229-36
22. Worrall NK, Lazenby WD, Misko TP, Lin TS, Rodi CP, Manning PT, Tilton RG, Williamson JR, Ferguson TB. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med 1995;181:63-70
23. Wu CJ, Lovett M, Wong-Lee J, Moeller F, Kitamura M, Goralski TJ, Billingham ME, Starnes VA, Clayberger C. Cytokine gene expression in rejecting cardiac allografts. Transplantation 1992;54:326-32