Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3799-3801

  Ma, Zhidong ^a   Saluta, Gilda ^b   Kucera, Gregory L ^b   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Acridine; DNA targeted agents; Lung cancer; Platinum

Indexed keywords

1 [2 (ACRIDIN 9 YLAMINO)ETHYL] 1,3 DIMETHYLTHIOUREA; [[2 (ACRIDINE 4 CARBOXAMIDO)ETHYL](METHYL)AMINO] (METHYLAMINO)METHANIMINIUM CHLORIDE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; GUANIDINE; PLATINUM; TERT BUTYL [[2 (ACRIDINE 4 CARBOXAMIDO) ETHYL] (METHYL)AMINO] (METHYLAMINO) METHYLENECARBAMATE; THIOUREA;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GUANIDINE; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PLATINUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA;

EID: 44949212198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.043     Document Type: Article

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