Unusual intercalation of acridin-9-ylthiourea into the 5′-GA/TC DNA base step from the minor groove: Implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate

Nucleic Acids Research

Volumn 31, Issue 14, 2003, Pages 4138-4146

  Baruah, Hemanta ^a   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (ACRIDIN 9 YLAMINO)ETHYL] 1,3 DIMETHYLTHIOUREA; ACRIDINE DERIVATIVE; ADENINE; ANTINEOPLASTIC AGENT; CYTOSINE; CYTOTOXIC AGENT; DNA; DNA BASE; GUANINE; INTERCALATING AGENT; LIGAND; NUCLEOTIDE; OLIGONUCLEOTIDE; PLATINUM; THIOUREA DERIVATIVE; THYMINE; UNCLASSIFIED DRUG; OLIGODEOXYRIBONUCLEOTIDE; THIOUREA;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CALCULATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA ADDUCT; DNA DRUG COMPLEX; DRUG BINDING; DRUG CONJUGATION; DRUG SPECIFICITY; DRUG STRUCTURE; ENERGY; EQUILIBRIUM DIALYSIS; EXPERIMENTATION; INTERCALATION COMPLEX; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; BASE PAIRING; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; THERMODYNAMICS;

ACRIDINES; BASE PAIRING; BASE SEQUENCE; BINDING, COMPETITIVE; DNA; DNA ADDUCTS; INTERCALATING AGENTS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PLATINUM; THERMODYNAMICS; THIOUREA;

EID: 0242380625     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg465     Document Type: Article

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