Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity

PLoS ONE

Volumn 2, Issue 12, 2007, Pages

  Torres, Marcela ^a,b   Fernandez Fuentes, Narcis ^a,c   Fiser, András ^a   Casadevall, Arturo ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AUTOANTIGEN; GLUCURONOXYLOMANNAN; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 18B7; ANTIGEN; HYBRID PROTEIN;

ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; EQUILIBRIUM CONSTANT; GLYCOSYLATION; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION; KINETICS; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; THERMODYNAMICS; ANIMAL; ANTIGEN ANTIBODY REACTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOLOGY; MOUSE;

FILOBASIDIELLA NEOFORMANS; MURINAE; MUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; HUMANS; IMMUNOGLOBULINS; KINETICS; MICE; MODELS, MOLECULAR; RECOMBINANT FUSION PROTEINS; THERMODYNAMICS;

EID: 44949129913     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001310     Document Type: Article

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