Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 8, 1996, Pages 1103-1105

  Hashimoto, Yukiya ^a   Otsuki, Yuko ^a   Odani, Atsuko ^a   Takano, Mikihisa ^a   Hattori, Haruo ^a   Furusho, Kenshi ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

CYP2C19; CYP2C9; pharmacokinetics; phenytoin; polymorphism

Indexed keywords

PHENYTOIN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; CLINICAL ARTICLE; DRUG EFFECT; DRUG ELIMINATION; DRUG METABOLISM; EPILEPSY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HETEROZYGOSITY; HUMAN; MALE; POLYMERASE CHAIN REACTION; STEADY STATE;

EID: 0029744762     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.1103     Document Type: Article

References (12)

1. Fritz S., Lindner W., Roots I., Frey B.M., and Küpfer, J. Pharmacol. Exp. Ther., 241, 615-622 (1987).
2. Inaba T., Pharmacol. Ther., 46, 341-347 (1990).
3. Goldstein J.A., Faletto M.B., Romkes-Sparks M., Sullivan T., Kitareewan S., Raucy J.L., Lasker J.M., and Ghanayem B.I., Biochemistry, 33, 1743-1752 (1994).
4. de Morais S.M.F., Wilkinson G.R., Blaisdell J., Nakamura K., Meyer U.A., and Goldstein J.A., J. Biol. Chem., 269, 15419-15422 (1994).
5. de Morais S.M.F., Wilkinson G.R., Blaisdell J., Meyer U.A., Nakamura K., and Goldstein J.A., Mol. Pharmacol., 46, 594-598 (1994).
6. Veronese M.E., Mackenzie P.I., Doecke C.J., McManus M.E., Miners J.O., and Birkett D.J., Biochem. Biophys. Res. Comm, 175, 1112-1118 (1991).
7. Veronese M.E., Doecke C.J., Mackenzie P.I., McManus M.E., Miners J.O., Rees D.L.P., Gasser R., Meyer U.A., and Birkett D.J., Biochem. J., 289, 533-538 (1993).
8. Wang S., Huang J., Lai M., and Tsai J., Pharmacogenetics, 5, 37-42 (1995).
9. Hashimoto Y., Koue T., Otsuki Y., Yasuhara M., Hori R., and Inui K., J. Pharmacokin. Biopharm., 23, 201-212 (1995).
10. Odani A., Hashimoto Y., Takayanagi K., Otsuki Y., Koue T., Takano M., Yasuhara M., Hattori H., Furusho K., and Inui K., Biol. Pharm. Bull., 19, 444-448 (1996).
11. Wrighton S.A., Stevens J.C., Becker G.W., and VandenBranden M., Arch. Biochem. Biophys., 306, 240-245 (1993).
12. Kaminsky L.S., de Morais S.M.F., Faletto M.B., Dunbar D.A., and Goldstein J.A., Mol. Pharmacol., 43, 234-239 (1993).