Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 78, Issue 4-5, 2008, Pages 247-255

  Muzaffar, S ^a   Shukla, N ^a   Bond, M ^a   Sala Newby, G ^a   Angelini, G D ^a   Newby, A C ^a   Jeremy, J Y ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; APOCYNIN; CLOSTRIDIUM DIFFICILE TOXIN B; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; ILOPROST; NITRIC OXIDE DONOR; PROTEIN P47; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG RESEARCH; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SPECTROPHOTOMETRY; VASCULAR SMOOTH MUSCLE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; ILOPROST; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PROTEIN KINASE INHIBITORS; RAC1 GTP-BINDING PROTEIN; SUPEROXIDES; THROMBOXANE A2; TIME FACTORS;

EID: 44849143799     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2008.01.008     Document Type: Article

References (44)

1. Cai H., Griendling K.K., and Harrison D.G. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol. Sci. 24 (2003) 471-478
2. Shah A.M., and Channon K.M. Free radicals and redox signalling in cardiovascular disease. Heart 90 (2004) 486-487
3. Li J.M., and Shah A.M. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am. J. Physiol. 287 (2004) R1014-R1030
4. Muzaffar S., Shukla N., and Jeremy J.Y. Nicotinamide adenine dinucleotide phosphate oxidase: a promiscuous therapeutic target for cardiovascular drugs?. Trends Cardiovasc. Med. 15 (2005) 278-282
5. Muzaffar S., Jeremy J.Y., Angelini G.D., Stuart Smith K., and Shukla N. The role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries. Thorax 58 (2003) 598-604
6. Muzaffar S., Shukla N., Angelini G.D., and Jeremy J.Y. Nitroaspirins and SIN-1, but not aspirin, inhibit the expression of endotoxin- and cytokine-induced NADPH oxidase in vascular smooth muscle cells from pig pulmonary arteries. Circulation 110 (2004) 1140-1147
7. 2α in cultured porcine pulmonary artery vascular smooth muscle cells. Br. J. Pharmacol. 141 (2004) 488-496
8. Muzaffar S., Shukla N., Angelini G.D., and Jeremy J.Y. Superoxide "auto-augments" the formation of superoxide through upregulation of NADPH oxidase expression in porcine pulmonary artery endothellial cells: inhibition with iloprost. Eur. J. Pharmacol. 538 (2006) 108-114
9. phox and endothelial nitric oxide synthase in the pulmonary artery. Thorax 60 (2005) 305-313
10. phox expression in porcine pulmonary endothelial cells. Br. J. Pharmacol. 146 (2005) 109-117
11. 2 mimetic, U46619, in corpus cavernosal smooth muscle cells. Br. J. Urol. Int. 96 (2005) 423-427
12. Jeremy J.Y., Yim A.P., Wan S., and Angelini G.D. Oxidative stress, nitric oxide and vascular disease. Cardiovasc. Surg. 17 (2002) 324-327
13. Hordijk P.L. Regulation of NADPH oxidases: the role of Rac proteins. Circ. Res. 98 (2006) 453-462
14. Rimon G., and Rubin M. Regulation of a common, low-affinity binding site for primary prostanoids on bovine aortic endothelial cells. Biochim. Biophys. Acta 10 (1998) 289-296
15. Dostmann W.R., Taylor M.S., Nickl C.K., Brayden J.E., Frank R., and Tegge W.J. Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. Proc. Natl. Acad. Sci. USA 97 (2000) 14772-14777
16. Wu Y.J., Bond M., Sala-Newby G., and Newby A.C. A novel mechanism underlying the regulation of smooth muscle cell proliferation by the small GTPase Rac-1. Eur. Heart J. 27 Suppl. 1 (2006) 966
17. Bond M., Sala-Newby G.B., and Newby A.C. Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation. J. Biol. Chem. 279 (2004) 37304-37310
18. Wu Y.J., Bond M., Sala-Newby G., and Newby A.C. Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation. Circ. Res. 98 (2006) 1141-1150
19. Pelletier S., Julien C., Popoff M.R., Lamarche-Vane N., and Meloche S. Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. J. Cell Physiol. 204 (2005) 412-422
20. S. Muzaffar, N. Shukla, G.D. Angelini, J.Y. Jeremy, Acute inhibition of NADPH oxidase activity in vascular smooth muscle cells by nitric oxide, iloprost and hydrogen sulfide, Br. J. Pharmacol., 2007, in press (abstract).
21. Wung R.S., Ni C.W., and Wang D.L. ICAM-1 induction by TNFα and IL-6 is mediated by distinct pathways via Rac in endothelial cells. J. Biomed. Sci. 12 (2005) 91-101
22. Goya K., Otsuki M., Xu X., and Kasayama S. Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus. Metabolism 52 (2003) 192-198
23. Aljada A., Saadeh R., Assian E., Ghanim H., and Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J. Clin. Endocrinol. Metab. 85 (2000) 2572-2575
24. Christensen E.N., and Mendelsohn M.E. Cyclic GMP-dependent protein kinase Iα inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells. J. Biol. Chem. 281 (2006) 8409-8416
25. Purdy K.E., and Arendshorst W.J. Prostaglandins buffer ANG II-mediated increases in cytosolic calcium in preglomerular VSMC. Am. J. Physiol. Renal Physiol. 277 (1999) F850-F858
26. 1. Cardiovasc. Res. 71 (2006) 236-246
27. 1 mediates type I collagen-dependent MMP-2 activation. Role in cell invasion across collagen barrier. J. Biol. Chem. 276 (2001) 16248-16256
28. Kitahara M., Ichikawa M., Kinoshita T., Shiozawa S., Shigematsu H., and Komiyama A. Prostacyclin inhibits the production of MMP-9 induced by phorbol ester through protein kinase A activation, but does not affect the production of MMP-2 in Human cultured mesangial cells. Kidney Blood Press. Res. 24 (2001) 18-26
29. Eagleton M.J., Peterson D.A., Sullivan V.V., Roelofs K.J., Ford J.A., Stanley J.C., and Upchurch Jr. G.R. Nitric oxide inhibition increases aortic wall matrix metalloproteinase-9 expression. J. Surg. Res. 104 (2002) 15-24
30. Jacob A., Molkentin J.D., Smolenski A., Lohmann S.M., and Begum N. Insulin inhibits PDGF-directed VSMC migration via NO/cGMP increase of MKP-1 and its inactivation of MAPKs. Am. J. Physiol. Cell Physiol. 283 (2002) C704-C713
31. 1 activation. Circ. Res. 98 (2006) 480-489
32. Bulin C., Albrecht U., Bode J.G., Weber A.A., Schrör K., Levkau B., and Fischer J.W. Differential effects of vasodilatory prostaglandins on focal adhesions, cytoskeletal architecture, and migration in human aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 84-92
33. Chahdi A., Miller B., and Sorokin A. Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J. Biol. Chem. 280 (2005) 578-584
34. Brown J.H., Del Re D.P., and Sussman M.A. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ. Res. 98 (2006) 730-742
35. Fink A.N., Frishman W.H., Azizad M., and Agarwal Y. Use of prostacyclin and its analogues in the treatment of cardiovascular disease. Heart Dis. 1 (1999) 29-40
36. Miller M.R., and Megson I.L. Recent developments in nitric oxide donor drugs. Br. J. Pharmacol. 151 (2007) 305-321
37. Jeremy J.Y., Angelini G.D., Khan M., Mikhailidis D.P., Morgan R.J., Thompson C.S., Bruckdorfer K.R., and Naseem K.M. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc. Res. 46 (2000) 50-54
38. Jeremy J.Y., Rowe D., Emsley A.M., and Newby A.C. Nitric oxide and vascular smooth muscle cell proliferation. Cardiovasc. Res. 43 (1999) 658-665
39. Jeremy J.Y., Jones R.A., Kouparris A., Hotston M., Persad R., Angelini G.D., and Shukla N. Oxidative stress and erectile dysfunction: possible role of NADPH oxidase. Int. J. Impot. Res. 19 (2007) 265-280
40. Jeremy J.Y., Shukla N., Muzaffar S., and Angelini G.D. Reactive oxygen species, vascular disease and cardiovascular surgery. Curr. Vasc. Pharmacol. 2 (20004) 229-236
41. Hotston M., Jeremy J.Y., Kouparris A., Persad N., Angelini G.D., and Shukla N. Sildenafil (Viagra™) inhibits the upregulation of type 5 phosphodiesterase elicited with nicotine and tumour necrosing factor-α in cavernosal vascular smooth muscle cells: mediation by superoxide. Br. J. Urol. Int. 99 (2007) 612-618
42. Martinson E.A., Scheible S., Greinacher A., and Presek P. Platelet phospholipase D is activated by protein kinase C via an integrin alpha IIb beta 3-independent mechanism. Biochem. J. 310 (1995) 623-628
43. Jeremy J.Y., Mikhailidis D.P., and Dandona P. Excitatory receptor-prostanoid synthesis coupling in smooth muscle: mediation by calcium, protein kinase C and G proteins. Prostaglandins Leukot. Essent. Fatty Acids 34 (1988) 215-227
44. 2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway. Thromb. Haemost. 85 (2001) 341-348