-
1
-
-
0024416485
-
Development of hirudin as an antithrombotic agent
-
Markwardt F: Development of hirudin as an antithrombotic agent. Semin Thromb Hemost 15:269, 1991
-
(1991)
Semin Thromb Hemost
, vol.15
, pp. 269
-
-
Markwardt, F.1
-
2
-
-
0024445042
-
Antistasin, a leech-derived inhibitor of factor Xa: Kinetic analysis of enzyme inhibition and identification of the reactive site
-
Dunwiddie CT, Thornberry N, Bull H, Sardana M, Friedman P, Jacobs J, Simpson E: Antistasin, a leech-derived inhibitor of factor Xa: Kinetic analysis of enzyme inhibition and identification of the reactive site. J Biol Chem 264:16694, 1989
-
(1989)
J Biol Chem
, vol.264
, pp. 16694
-
-
Dunwiddie, C.T.1
Thornberry, N.2
Bull, H.3
Sardana, M.4
Friedman, P.5
Jacobs, J.6
Simpson, E.7
-
3
-
-
0025375504
-
Tick anticoagulant peptide is a novel inhibitor of factor Xa
-
Waxman L, Smith DE, Arcuri KE, Vlasuk GP: Tick anticoagulant peptide is a novel inhibitor of factor Xa. Science 248:593, 1990
-
(1990)
Science
, vol.248
, pp. 593
-
-
Waxman, L.1
Smith, D.E.2
Arcuri, K.E.3
Vlasuk, G.P.4
-
4
-
-
0028812448
-
Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmondus rotundus)
-
Apitz-Castro R, Béguin S, Tablante A, Bartoli F, Holt JC, Hemker HC: Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmondus rotundus). Thromb Haemost 73:94, 1994
-
(1994)
Thromb Haemost
, vol.73
, pp. 94
-
-
Apitz-Castro, R.1
Béguin, S.2
Tablante, A.3
Bartoli, F.4
Holt, J.C.5
Hemker, H.C.6
-
5
-
-
0025887032
-
A GP Hb-IIIa-specific integrin antagonist from the venom of Sistrurus M. barbouri
-
Scarborough RM, Rose JW, Hsu MA, Phillips DR, Fried VA, Campbell AM, Nannizzi L, Charo IF: A GP Hb-IIIa-specific integrin antagonist from the venom of Sistrurus M. barbouri. J Biol Chem 266:9359, 1991
-
(1991)
J Biol Chem
, vol.266
, pp. 9359
-
-
Scarborough, R.M.1
Rose, J.W.2
Hsu, M.A.3
Phillips, D.R.4
Fried, V.A.5
Campbell, A.M.6
Nannizzi, L.7
Charo, I.F.8
-
6
-
-
0022760451
-
Isolation and characterization of hirudin isoinhibitors and sequence analysis of hirudin PA
-
Dodt T, Machleidt W, Seemueller U, Machlev R, Fritz H: Isolation and characterization of hirudin isoinhibitors and sequence analysis of hirudin PA. Biol Chem Hoppe Seyler 367:803, 1986
-
(1986)
Biol Chem Hoppe Seyler
, vol.367
, pp. 803
-
-
Dodt, T.1
Machleidt, W.2
Seemueller, U.3
Machlev, R.4
Fritz, H.5
-
7
-
-
0022521744
-
Kinetics of the inhibition of thrombin by hirudin
-
Stone RS, Hofsteenge J: Kinetics of the inhibition of thrombin by hirudin. Biochemistry 25:4622, 1986
-
(1986)
Biochemistry
, vol.25
, pp. 4622
-
-
Stone, R.S.1
Hofsteenge, J.2
-
8
-
-
0025329390
-
The structure of a complex of recombinant hirudin and human-a-thrombin
-
Rydel TJ, Ravichrandran KG, Tulinsky A, Bode W, Huber R, Fenton JW, Roitsch C: The structure of a complex of recombinant hirudin and human-a-thrombin. Science 249:277, 1990
-
(1990)
Science
, vol.249
, pp. 277
-
-
Rydel, T.J.1
Ravichrandran, K.G.2
Tulinsky, A.3
Bode, W.4
Huber, R.5
Fenton, J.W.6
Roitsch, C.7
-
9
-
-
0024590497
-
Purification and biochemical characterization of recombinant hirudin produced by Saccharomyces cerevisiaie
-
Riehl-Bellon N, Carvallo D, Acker M, van Dorsselaer A, Marquet M, Loison G, Lemoine Y, Brown SW, Courtney M, Roitsch C: Purification and biochemical characterization of recombinant hirudin produced by Saccharomyces cerevisiaie. Biochemistry 28:2941, 1989
-
(1989)
Biochemistry
, vol.28
, pp. 2941
-
-
Riehl-Bellon, N.1
Carvallo, D.2
Acker, M.3
Van Dorsselaer, A.4
Marquet, M.5
Loison, G.6
Lemoine, Y.7
Brown, S.W.8
Courtney, M.9
Roitsch, C.10
-
10
-
-
0024451152
-
Biology of recombinant hirudin (CGP 39393). a new prospect in the treatment of thrombosis
-
Talbot MD: Biology of recombinant hirudin (CGP 39393). A new prospect in the treatment of thrombosis. Semin Thromb Hemost 15:293, 1989
-
(1989)
Semin Thromb Hemost
, vol.15
, pp. 293
-
-
Talbot, M.D.1
-
11
-
-
0023216618
-
Studies on the pharmacokinetics of hirudin
-
Markwardt F, Nowak G, Sturzebecher U, Walsmann P: Studies on the pharmacokinetics of hirudin. Biomed Biochim Acta 46:237, 1987
-
(1987)
Biomed Biochim Acta
, vol.46
, pp. 237
-
-
Markwardt, F.1
Nowak, G.2
Sturzebecher, U.3
Walsmann, P.4
-
12
-
-
0023779072
-
Evidence for the identity of hirudin isolated after kidney passage with the starting material
-
Henschen A, Markwardt F, Walsmann P: Evidence for the identity of hirudin isolated after kidney passage with the starting material. Folia Haematol 115:59, 1988
-
(1988)
Folia Haematol
, vol.115
, pp. 59
-
-
Henschen, A.1
Markwardt, F.2
Walsmann, P.3
-
14
-
-
0025667847
-
Preparation of dextran-bound recombinant hirudin and ils pharmacokinetic behaviour
-
Markwardt M, Richter P, Walsmann G, Riesener G, Paintz M: Preparation of dextran-bound recombinant hirudin and ils pharmacokinetic behaviour. Biomed Biochim Acta 49:1103, 1990
-
(1990)
Biomed Biochim Acta
, vol.49
, pp. 1103
-
-
Markwardt, M.1
Richter, P.2
Walsmann, G.3
Riesener, G.4
Paintz, M.5
-
15
-
-
0027479693
-
The effect of a long-lasting recombinant hirudin (PEG-hirudin) on experimental disseminated intravascular coagulation (DIG) in rabbits
-
Zawilska K, Zozulinska M, Turowiecka Z, Blahut M, Drobnik L, Vinazzer H: The effect of a long-lasting recombinant hirudin (PEG-hirudin) on experimental disseminated intravascular coagulation (DIG) in rabbits. Thromb Res 69:315, 1993
-
(1993)
Thromb Res
, vol.69
, pp. 315
-
-
Zawilska, K.1
Zozulinska, M.2
Turowiecka, Z.3
Blahut, M.4
Drobnik, L.5
Vinazzer, H.6
-
16
-
-
0029835392
-
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
-
GUSTO lib Investigators: A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 335:775, 1996
-
(1996)
N Engl J Med
, vol.335
, pp. 775
-
-
-
18
-
-
0003185280
-
Gene synthesis: Assembly of target sequences using mutually priming long oligonucleotides
-
in Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds): Media, PA, Wiley
-
Moore DD: Gene synthesis: Assembly of target sequences using mutually priming long oligonucleotides, in Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds): Current Protocols in Molecular Biology. Media, PA, Wiley, 1987, p 3.5.8
-
(1987)
Current Protocols in Molecular Biology.
, pp. 358
-
-
Moore, D.D.1
-
19
-
-
0025830274
-
Maximizing sensitivity and specificity of PCR by preamplification heating
-
D'Aquila RT, Bechtel LJ, Videler JA, Eron JJ, Gorczyca P, Kaplan JC: Maximizing sensitivity and specificity of PCR by preamplification heating. Nucleic Acids Res 19:3749, 1991
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 3749
-
-
D'Aquila, R.T.1
Bechtel, L.J.2
Videler, J.A.3
Eron, J.J.4
Gorczyca, P.5
Kaplan, J.C.6
-
20
-
-
0004136246
-
-
Cold Spring Harbor, NY, Cold Spring Harbor Laboratory
-
Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
-
(1989)
Molecular Cloning: a Laboratory Manual (Ed 2).
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
21
-
-
0026696565
-
Molecular cloning and expression of rabbit antithrombin III
-
Sheffield WP, Brothers AB, Hatton MWC, Clarke BJ, Blajchman MA: Molecular cloning and expression of rabbit antithrombin III. Blood 79:2330, 1992
-
(1992)
Blood
, vol.79
, pp. 2330
-
-
Sheffield, W.P.1
Brothers, A.B.2
Hatton, M.W.C.3
Clarke, B.J.4
-
22
-
-
0028362250
-
Molecular cloning and expression of rabbit heparin cofactor II: A plasma thrombin inhibitor highly conserved between species
-
Sheffield WP, Schuyler PD, Blajchman MA: Molecular cloning and expression of rabbit heparin cofactor II: A plasma thrombin inhibitor highly conserved between species. Thromb Haemost 71:778, 1994
-
(1994)
Thromb Haemost
, vol.71
, pp. 778
-
-
Sheffield, W.P.1
Schuyler, P.D.2
-
23
-
-
0026315433
-
Receptor-mediated gene delivery in vivo: Partial correction of genetic analbuminemia in rats
-
Wu GY, Wilson GM, Shabby F, Grossman M, Shafritz DA, Wu CH: Receptor-mediated gene delivery in vivo: Partial correction of genetic analbuminemia in rats. J Biol Chem 266:14338, 1991
-
(1991)
J Biol Chem
, vol.266
, pp. 14338
-
-
Wu, G.Y.1
Wilson, G.M.2
Shabby, F.3
Grossman, M.4
Shafritz, D.A.5
Wu, C.H.6
-
24
-
-
0021253525
-
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
-
Henikoff S: Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene 28:351, 1984
-
(1984)
Gene
, vol.28
, pp. 351
-
-
Henikoff, S.1
-
25
-
-
0024283936
-
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering
-
Green S, Isseman I, Sheer E: A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res 16:369, 1988
-
(1988)
Nucleic Acids Res
, vol.16
, pp. 369
-
-
Green, S.1
Isseman, I.2
Sheer, E.3
-
27
-
-
0028037888
-
Amino acid substitutions of the P2 residue of antithrombin that either enhance or impair function
-
Sheffield WP, Blajchman MA: Amino acid substitutions of the P2 residue of antithrombin that either enhance or impair function. Thromb Res 75:293, 1994
-
(1994)
Thromb Res
, vol.75
, pp. 293
-
-
Sheffield, W.P.1
Blajchman, M.A.2
-
28
-
-
0018406314
-
Use of kinetic analysis and mathematical modeling in the study of metabolic pathways in vivo
-
Carson ER, Jones EA: Use of kinetic analysis and mathematical modeling in the study of metabolic pathways in vivo. N Engl J Med 300:1016, 1979
-
(1979)
N Engl J Med
, vol.300
, pp. 1016
-
-
Carson, E.R.1
Jones, E.A.2
-
29
-
-
0021265717
-
In vivo behaviour of radioiodinated rabbit antithrombin III. Demonstration of a non-circulating vascular compartment
-
Carlson TH, Atencio AC, Simon TB: In vivo behaviour of radioiodinated rabbit antithrombin III. Demonstration of a non-circulating vascular compartment. J Clin Invest 74:191, 1984
-
(1984)
J Clin Invest
, vol.74
, pp. 191
-
-
Carlson, T.H.1
Atencio, A.C.2
Simon, T.B.3
-
30
-
-
0022003081
-
Comparison of the behaviour in vivo of two molecular forms of antithrombin III
-
Carlson TH, Atencio AC, Simon TH: Comparison of the behaviour in vivo of two molecular forms of antithrombin III. Biochem J 225:557, 1985
-
(1985)
Biochem J
, vol.225
, pp. 557
-
-
Carlson, T.H.1
Atencio, A.C.2
Simon, T.H.3
-
31
-
-
0028858172
-
Intracellular events determine the fate of antithrombin Utah
-
Sheffield WP, Castillo JE, Blajchman MA: Intracellular events determine the fate of antithrombin Utah. Blood 86:3461, 1995
-
(1995)
Blood
, vol.86
, pp. 3461
-
-
Sheffield, W.P.1
Castillo, J.E.2
Blajchman, M.A.3
-
32
-
-
0027438174
-
CX-397, a novel recombinant hirudin analog having a hybrid sequence of hirudin variants-1 and -3
-
Komatsu Y, Noda A, Misawa S, Sukesada A, Hiyasa H: CX-397, a novel recombinant hirudin analog having a hybrid sequence of hirudin variants-1 and -3. Biochem Biophys Res Commun 196:773, 1993
-
(1993)
Biochem Biophys Res Commun
, vol.196
, pp. 773
-
-
Komatsu, Y.1
Noda, A.2
Misawa, S.3
Sukesada, A.4
Hiyasa, H.5
-
33
-
-
0008915717
-
Nucleotide sequence and the encoded amino acids of human serum albumin mRNA
-
Dugiaczyk A, Law SW, Dennison OE: Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sei USA 79:71, 1982
-
(1982)
Proc Natl Acad Sei USA
, vol.79
, pp. 71
-
-
Dugiaczyk, A.1
Law, S.W.2
Dennison, O.E.3
-
34
-
-
0027219371
-
X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27 nm resolution
-
Ho JX, Holowachuk EW, Norton EJ, Twigg PD, Carter DC: X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27 nm resolution. Eur J Biochem 215:205, 1993
-
(1993)
Eur J Biochem
, vol.215
, pp. 205
-
-
Ho, J.X.1
Holowachuk, E.W.2
Norton, E.J.3
Twigg, P.D.4
Carter, D.C.5
-
35
-
-
0015900723
-
Selective removal of albumin from plasma by affinity chromatography
-
Travis J, Pannell R: Selective removal of albumin from plasma by affinity chromatography. Clin Chim Acta 49:49, 1973
-
(1973)
Clin Chim Acta
, vol.49
, pp. 49
-
-
Travis, J.1
Pannell, R.2
-
36
-
-
0028202551
-
Radiolabeled r-hirudin as a measure of thrombin activity at, or within, the rabbit aorta wall in vitro and in vivo
-
Hatton MWC, Ross-Ouellet B: Radiolabeled r-hirudin as a measure of thrombin activity at, or within, the rabbit aorta wall in vitro and in vivo. Thromb Haemost 71:499, 1994
-
(1994)
Thromb Haemost
, vol.71
, pp. 499
-
-
Hatton, M.W.C.1
Ross-Ouellet, B.2
-
37
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia colt
-
Huston JS, Levinson D, Mudgett-Hunter M, Tai M-S, Novotny J, Margolies MN, Ridge RJ, Bruccoleri RE, Haber E, Crea R, Oppermann H: Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia colt. Proc Natl Acad Sei USA 85:5879, 1988
-
(1988)
Proc Natl Acad Sei USA
, vol.85
, pp. 5879
-
-
Huston, J.S.1
Levinson, D.2
Mudgett-Hunter, M.3
Tai, M.-S.4
Novotny, J.5
Margolies, M.N.6
Ridge, R.J.7
Bruccoleri, R.E.8
Haber, E.9
Crea, R.10
Oppermann, H.11
-
38
-
-
0023766115
-
Use of sitedirected mutagenesis to investigate the basis for the specificity of hirudin
-
Braun PJ, Dennis S, Hofsteenge J, Stone SR: Use of sitedirected mutagenesis to investigate the basis for the specificity of hirudin. Biochemistry 27:6517, 1988
-
(1988)
Biochemistry
, vol.27
, pp. 6517
-
-
Braun, P.J.1
Dennis, S.2
Hofsteenge, J.3
Stone, S.R.4
-
39
-
-
0027217174
-
On glucose transport and non-enzymic glycation of proteins in vivo
-
Hatton MWC, Richardson M, Winocour PD: On glucose transport and non-enzymic glycation of proteins in vivo. J Theor Biol 161:481, 1993
-
(1993)
J Theor Biol
, vol.161
, pp. 481
-
-
Hatton, M.W.C.1
Richardson, M.2
Winocour, P.D.3
-
40
-
-
0028255957
-
Covalent linkage of streptokinase to recombinant hirudin: A novel thrombolytic agent with antithrombotic properties
-
Phaneuf MD, Ozaki CK, Johnstone MT, Loza J-P, Quist WC, LoGerfo FW: Covalent linkage of streptokinase to recombinant hirudin: A novel thrombolytic agent with antithrombotic properties. Thromb Haemost 71:481, 1994
-
(1994)
Thromb Haemost
, vol.71
, pp. 481
-
-
Phaneuf, M.D.1
Ozaki, C.K.2
Johnstone, M.T.3
Loza, J.-P.4
Quist, W.C.5
Logerfo, F.W.6
-
41
-
-
0027953821
-
Synthesis and characterization of a recombinant hirudin-albumin complex
-
Phaneuf MD, Ito RK, LoGerfo FW: Synthesis and characterization of a recombinant hirudin-albumin complex. Blood Coagul Fibrin 5:641, 1994
-
(1994)
Blood Coagul Fibrin
, vol.5
, pp. 641
-
-
Phaneuf, M.D.1
Ito, R.K.2
Logerfo, F.W.3
-
42
-
-
0027964241
-
Direct thrombin inhibition with rec-hirudin (COP 39393) as prophylaxis of thromboembolic complications after total hip replacement
-
Eriksson BI, Kalebo P, Ekman S, Lindbratt S, Kerry R, Close P: Direct thrombin inhibition with rec-hirudin (COP 39393) as prophylaxis of thromboembolic complications after total hip replacement. Thromb Haemost 72:227, 1994
-
(1994)
Thromb Haemost
, vol.72
, pp. 227
-
-
Eriksson, B.I.1
Kalebo, P.2
Ekman, S.3
Lindbratt, S.4
Kerry, R.5
Close, P.6
-
43
-
-
0028092111
-
Hirudin in myocardial infarction. Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI-9A) trial
-
Antman E, for the TIMI-9A Investigators: Hirudin in myocardial infarction. Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI-9A) trial. Circulation 90:1638, 1994
-
(1994)
Circulation
, vol.90
, pp. 1638
-
-
Antman, E.1
-
44
-
-
0028037517
-
Randomised trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
-
GUSTO Ha Investigators: Randomised trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 90:1631, 1994
-
(1994)
Circulation
, vol.90
, pp. 1631
-
-
|