Antioxidants inhibit endothelin-1 (1–31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1)

Biochemical Pharmacology

Volumn 64, Issue 10, 2002, Pages 1521-1531

  Kyaw, Moe ^a   Yoshizumi, Masanori ^a   Tsuchiya, Koichiro ^a   Kirima, Kazuyoshi ^a   Suzaki, Yuki ^a   Abe, Shinji ^a   Hasegawa, Toyoshi ^a   Tamaki, Toshiaki ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Antioxidants; Endothelin 1 (1 31); Human chymase; Mitogen activated protein kinases; Rat aortic smooth muscle cell; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; DIPHENYLENEIODONIUM CHLORIDE; DNA; ENDOTHELIN 1 DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; SYNAPTOPHYSIN; THYMIDINE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ANIMAL CELL; AORTA; ARTICLE; CELL ASSAY; CELL CULTURE; CELL FREE SYSTEM; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL DIVISION; CYCLIC N-OXIDES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELINS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; ONIUM COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

EID: 0037111941     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01349-7     Document Type: Article

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