DDPH: Improving cognitive deficits beyond its α1-adrenoceptor antagonism in chronic cerebral hypoperfused rats

European Journal of Pharmacology

Volumn 588, Issue 2-3, 2008, Pages 178-188

  He, Zhi ^a   Huang, Lin ^a   Wu, Yan ^a   Wang, Jianzhi ^a   Wang, Hongxing ^a   Guo, Lianjun ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

1 Adrenoceptor antagonist; Chronic cerebral hypoperfusion; DDPH; Learning and memory; Long term potentiation; Morris water maze; NR2B; Oxidative stress

Indexed keywords

1 (2,6 DIMETHYLPHENOXY) 2 (3,4 DIMETHOXYPHENYLETHYLAMINO)PROPANE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY LIGATION; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; GLIA CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; LONG TERM POTENTIATION; LOW DRUG DOSE; MALE; MAZE TEST; MEMORY; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; NUCLEAR SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WESTERN BLOTTING;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CHRONIC DISEASE; COGNITION DISORDERS; GLUTATHIONE PEROXIDASE; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MALONDIALDEHYDE; MAZE LEARNING; PHENETHYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 44649189750     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.060     Document Type: Article

References (64)

1. Adibhatla R.M., and Hatcher J.F. Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic. Bio. Med. 40 (2006) 376-387
2. Agar E., Bosnak M., Amanvermez R., Demir S., Ayyildiz M., and Celik C. The effect of ethanol on lipid peroxidation and glutathione level in the brain stem of rat. Neuroreport 10 (1999) 1799-1801
3. 2 agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure. Brain Res. 913 (2001) 133-139
4. Armstrong D., and Browne R. The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds related to oxidative stress as applied to the clinical chemistry laboratory. Adv. Exp. Med. Biol. 366 (1994) 43-58
5. Bartlett T.E., Bannister N.J., Collett V.J., Dargan S.L., Massey P.V., Bortolotto Z.A., Fitzjohn S.M., Bashir Z.I., Collingridge G.L., and Lodge D. Differential roles of NR2A and NR2B-containing NMDA receptors in long-term potentiation and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology 52 (2007) 60-70
6. Berberich S., Punnakkal P., Jensen V., Pawlak V., Seeburg P.H., Hvalby O., and Köhr G. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J. Neurosci. 25 (2005) 6907-6910
7. Bliss T.V.P., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361 (1993) 31-39
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
9. Cada A., Torre J.C., and Gonzalez L.F. Chronic cerebrovascular ischemia in aged rats: effects on brain metabolic capacity and behavior. Neurobiol. Aging 21 (2000) 225-233
10. Charles D. Vascular factors in dementia: an overview. J. Neurol. Sci. 226 (2004) 19-23
11. Chong Z.Z., Li F., and Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog. Neurobiol. 75 (2005) 207-246
12. 2-adrenoceptor antagonist, dexefaroxan, against spatial memory deficit induced by cortical devascularization in the adult rat. Exp. Neurol. 185 (2004) 198-200
13. David W.D. Vascular dementia. Clin. Neurosci. Res. 3 (2004) 437-448
14. 2-adrenoceptors. Eur. J. Pharmacol. 361 (1998) 1-15
15. Farkas E., Institoris A., Domoki F., Mihaly A., and Bari F. The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat. Brain Res. 1087 (2006) 168-174
16. Farkas E., Luiten P.G.M., and Baric F. Permanent bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res. Rev. 54 (2007) 162-180
17. Gao C., Wang J.Z., and Chen M.E. Effects of intravenous administration of marrow stromal cells on long-term potentiation induction of vascular dementia rats. Chinese J. Clin. Rehabil. 16 (2003) 2268-2269
18. Goto W., Ichikawa M., Tanaka E., Hara H., and Araie M. Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures. Brain Res. 1003 (2004) 130-137
19. Guang H.M., and Du G.H. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Eur. J. Pharmacol. 542 (2006) 77-83
20. Gunstad J., Brickman A.M., Paul R.H., Browndyke J., Moser D.J., Ott B.R., Gordon N., Haque O., and Cohen R.A. Progressive morphometries and cognitive changes in vascular dementia. Arch. Clin. Neuropsychol. 20 (2005) 229-241
21. Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am. J. Med. 91 (1991) 14S-22S
22. Han J.S. Principal of Neuroscience (1999), Press of Peking medical university, Peking
23. Hu G.S., and Huang X.J. Inhibitory effects of DDPH on contraction of isolated tracheal smooth muscle of guinea pigs induced by some mediators. J. China Mod. App. Pharmacy. 15 (1998) 11-14
24. Jennifer M.L., and Aaron J. The N-methyl-d-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. Pharmacol. Therapeut 97 (2003) 55-85
25. 2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur. J. Pharmacol. 372 (1999) 31-36
26. Kašparová S., Brezová V., Valko M., Horecký J., Mlynárik V., Liptaj T., Vančová O., Ulična O., and Dobrota D. Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem. Int. 46 (2005) 601-611
27. Kobayashi M. Differential regulation of synaptic transmission by adrenergic agonists via protein kinase A and protein kinase C in layer V pyramidal neurons of rat cerebral bortex. Neuroscience 146 (2007) 1772-1784
28. Lai S.K., Wong C.K.C., Yang M.S., and Yung K.K.L. Changes in expression of N-methyl-d-aspartate receptor subunits in the rat neostriatum after a single dose of antisense oligonucleotide specific for N-methyl-d-aspartate receptor 1 subunit. Neuroscience 98 (2000) 493-500
29. Lee B., Choi Y.K., Kim H., Kim S., Hahm D.Y., Lee H.J., and Shim I. Protective effects of methanol extract of Acori graminei rhizome and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and cognitive impairments in the rat. Life Sci. 74 (2003) 435-450
30. Liao Y., Wang R., and Tang X.C. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Acta Pharmacol. Sin. 25 (2004) 1590-1596
31. Liu J., Jin D.Z., Xiao L., and Zhu X.Z. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. Brain Res. 1089 (2006) 162-170
32. Li X.P., Wang W.T., Yu P.X., Guo L.J., and Qian J.Q. Neuroprotective effects of DDPH on incomplete cerebral ischemia in rats. Chinese Pharmacol. Bull. 17 (2001) 345-347
33. Lu J., Ni P.Z., Zhou J.M., Tang W.F., Fu J.H., and Xia L. Synthesis and antihypertensive activity of a1-andrenoceptor antagonist DDPH putative metabolites. Chinese J. Med. Chem. 110 (2000) 101-106
34. Lu Z.Z., Zhong Y.Y., Xia L., and Hann Q.D. Antagonistic characterization of 1-(2, 6-dimethylphenoxy)-2-(3, 4-dimethoxyphenylethylamine) propane hydrochloride on α1-adrenoceptor. Acta Pharmaceu. Sin. 35 (2000) 739-742
35. Ma D.Q., Hussein M., Rajakumaraswamy N., Artiad M., Sanders R.D., Franks N.P., and Maze M. Dexmedetomidine produces its neuroprotective effect via the α2A-adrenoceptor subtype. Eur. J. Pharmacol. 502 (2004) 87-97
36. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free. Radical. Bio. Med. 23 (1997) 134-147
37. Mast H., Totemic T.K., and Mohr J.P. Chronic brain ischemia: the contributions of Otto Binswanger and Aloes Alzheimer to the mechanisms of vascular dementia. J. Neurol. Sci. 132 (1995) 4-10
38. McCord J.M., and Fridovich I. Superoxide dismutase: the first twenty years (1968-1988). Free Radic. Biol. Med. 5 (1988) 363-369
39. 3H]noradrenaline in response to oxidative stress combined with mitochondrial dysfunction in rat hippocampal slices. Neuroscience 120 (2003) 771-781
40. Mori K., Togashi H., Ichi K., Ueno, Matsumoto M., and Yoshioka M. Amino guanidine prevented the impairment behavior and hippocampal long-term potentiation following transient cerebral ischemia. Behav. Brain Res. 120 (2001) 159-169
41. Ni J.W., Matsumoto K., Li H.B., Murakami Y., and Watanabe H. Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat. Brain Res. 673 (1995) 290-296
42. Ni P.Z., Sun H.B., Pen J.H., Xia L., and Qian J.Q. Resolution of a1-adrenoceptor antagonist (±)-DDPH and pharmacological activity of (-)-DDPH. J. Chinese Pharmaceu. Sci. 6 (1997) 51-53
43. Ohta K., Fukuuchi Y., Shimazu K., Komatsumoto S., Ichijo M., Araki N., and Shibata M. Presynaptic glutamate receptors facilitate release of norepinephrine and 5-hydroxytryptamine as well as dopamine in the normal and ischemic striatum. J. Auton. Nerv. Syst. 49 (1994) 195-202
44. Paxinos G., and Watson C. The rat brain in sterotaxic coordinates (1986), Academic Press, New York
45. Picconi B., Tortiglione A., Barone I., Centonze D., Gardoni F., Gubellini P., Bonsi P., Pisani A., Bernardi G., Di Luca M., and Calabresi P. NR2B subunit exerts a critical role in postischemic synaptic plasticity. Stroke 37 (2006) 1895-1901
46. Qu L., Wang E.X., Guo L.J., Wang W.T., and Qian J.Q. Study on the protective effects and mechanism of DDPH on brain ischemia. Acta. Univ. Med. Tongji. 29 (2000) 394-396
47. Qu L., Wang W.T., Guo L.J., Wang F., Lv Q., and Qian J.Q. Protective effects of DDPH on brain ischemia injury in rats. Acta Pharmaceu. Sin. 38 (2003) 725-727
48. Rajakumaraswamy N., Ma D.Q., Hossain M., Sanders R.D., Franks N.P., and Maze M. Neuroprotective interaction produced by xenon anddexmedetomidine on in vitro and in vivo neuronal injury models. Neurosci. Lett. 409 (2006) 128-133
49. Roman G.C. Vascular dementia revisited: diagnosis, pathogenesis, treatment, and prevention. Med. Clin. North. Am. 86 (2002) 477-499
50. Roman G.C. Vascular dementia may be the most common form of dementia in the elderly. J. Neurol. Sci. 203-204 (2002) 7-10
51. Shibata S., Kodama K., Tominaga K., Ueki S., and Watanabe S. Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices. Eur. J. Pharmacol. 221 (1992) 255-260
52. 1A receptors and a1-adrenoceptors. Neurosci. Lett. 357 (2004) 91-94
53. Tang Y.P., Shimizu E., Dube G.R., Rampon C., Kerchner G.A., Zhuo M., Liu G., and Tsien J.Z. Genetic enhancement of learning and memory in mice. Nature. 401 (1999) 63-69
54. Tang Y.P., Wang H., Feng R., Kyin M., and Tsien J.Z. Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 41 (2001) 779-790
55. 3H]dopamine release. Eur. J. Pharmacol. 336 (1997) 275-281
56. Wang L.M., Han Y.F., and Tang X.C. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur. J. Pharmacol. 398 (2000) 65-72
57. Wang W.T., Guo L.J., Qu L., Wang F., Lv Q., and Qian J.Q. Neuroprotective effects of DDPH on cerebral ischemia and reperfusion in mice. Chinese J. Pharmacol. Toxicol. 15 (2001) 137-140
58. White B.C., Sullivan J.M., DeGracia D.J., O'Neil B.J., Neumar R.W., Grossman L.I., Rafols J.A., and Krause J.S. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 179 (2000) 1-33
59. 1-adrenocepter antagonist DDPH and its analogues. Chinese J. Struct. Chem. 23 (2004) 962-968
60. Yanpallewara S.U., Raib S., Kumarb M., and Acharyaa S.B. Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion. Pharmacol. Biochem. Be. 79 (2004) 155-164
61. Zhang Y. Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat. Neuroscience 125 (2004) 625-631
62. Zhao M.G., Toyoda H., Lee Y.S., Wu L.J., Ko S.W., Zhang X.H., Jia Y., Shum F., Xu H., Li B.M., Kaang B.K., and Zhuo M. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47 (2005) 859-872
63. 1-adrenoceptors. J. Acta. Univ. Med. Tongji. 30 (2001) 522-524
64. Zhong H.Y., and Minneman K.P. α-Adrenoceptor subtypes. Eur. J. Pharmacol. 375 (1999) 261-276