Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion

Pharmacology Biochemistry and Behavior

Volumn 79, Issue 1, 2004, Pages 155-164

  Yanpallewar, S U ^a   Rai, Sunita ^a   Kumar, Mohan ^a   Acharya, S B ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Cerebral hypoperfusion; Learning and memory; Ocimum sanctum; Oxidative stress; Reperfusion injury

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; NEUROPROTECTIVE AGENT; OCIMUM SANCTUM EXTRACT; SUPEROXIDE DISMUTASE; THIOL GROUP;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; COMMON CAROTID ARTERY; CONTROLLED STUDY; DEMENTIA; DRUG EFFECT; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; FOREBRAIN; GLIOSIS; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; LIPID PEROXIDATION; MALE; MAZE TEST; MEDICINAL PLANT; NEUROPROTECTION; NONHUMAN; OCIMUM SANCTUM; OPEN FIELD TEST; PLANT LEAF; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CAROTID STENOSIS; CHRONIC DISEASE; GROOMING; ISCHEMIC ATTACK, TRANSIENT; LIPID PEROXIDATION; MALE; MAZE LEARNING; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; OCIMUM; PHYTOTHERAPY; PLANT EXTRACTS; RATS; REPERFUSION INJURY; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; UP-REGULATION;

ANIMALIA; OCIMUM; OCIMUM TENUIFLORUM;

EID: 4544272940     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.07.008     Document Type: Article

References (60)

1. H. Abraham, and G. Lazar Early microglial reaction following mild forebrain ischemia induced by common carotid artery occlusion Brain Res. 862 2000 63 73
2. J.V. Bannister, W.H. Bannister, and G. Rotillio Aspects of structure, function and application of superoxide dismutase Crit. Rev. Biochem. 22 1987 111 180
3. F.C. Barone, L.M. Hillegans, and W.J. Price Polymorphonuclear leukocytes in cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification J. Neurosci. Res. 29 1991 331 345
4. M.F. Beal, B.T. Hyman, and W. Koroshetz Do defects in mitochondrial metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci. 16 1993 125 131
5. S.K. Bhattacharya B. Mukherjee Traditional medicine 1993 IBH Publishing New Delhi, India 320
6. S.K. Bhattacharya, and A.V. Muruganandam Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress Pharmacol. Biochem. Behav. 75 2003 547 555
7. S.K. Bhattacharya, A. Bhattacharya, K. Das, A.V. Muruganandam, and K. Sairam Further investigations on the antioxidant activity of Ocimum sanctum using different paradigms of oxidative stress in rats J. Nat. Rem. 1 2001 7 15
8. D.R. Blake, R.E. Allen, and J. Lunee Free radicals in biological systems: a review oriented to the inflammatory process Br. Med. Bull. 43 1987 371 385
9. F. Block, and M. Schwartz Correlation between hippocampal neuronal damage and spatial learning deficits due to global ischemia Pharmacol. Biochem. Behav. 56 1997 755 761
10. I.I. Brekhman, and I.V. Dardymox New substances of plant origin which increase non-specific resistance Annu. Rev. Pharmacol. Toxicol. 9 1969 419 439
11. G. Chaudhary, U. Sharma, N.R. Jagannathan, and Y.K. Gupta Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats Clin. Exp. Pharmacol. Physiol. 30 2003 399 404
12. O.J.L. Cooper, W.O. Pulsinelli, and T.E. Duffy Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain J. Neurochem. 35 1980 1242 1245
13. C.M. Davidson, B.A. Pappas, W.D. Stevens, T. Fortin, and S.A. Bennett Chronic cerebral hypoperfusion: loss of papillary reflex, visual impairment and retinal neurodegeneration Brain Res. 859 2000 96 103
14. P.U. Devi Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi) Indian J. Exp. Biol. 39 2000 185 190
15. P.U. Devi, and A. Ganasoundari Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury Indian J. Exp. Biol. 37 1999 262 268
16. P.U. Devi, A. Ganasoundari, B. Vrinda, K.K. Srinivasan, and M.K. Unnikrishnan Radiation protection by Ocimum flavonoids orientin and vicenin: mechanism of action Radiat. Res. 154 2000 455 460
17. I. Fridovich Superoxide radicals and superoxide dismutase Ann. Rev. Biochem. 44 1995 147 159
18. J.M. Gringo Reperfusion injury Transplant. Proc. 29 1997 59 61
19. B. Halliwell Reactive oxygen species in living system: source, biochemistry and role in human disease Am. J. Med. 99 1991 145 225
20. Y.C. Huang, B.N. Wu, Y.T. Lin, S.J. Chen, C.C. Chiu, and C.J. Cheng Eugenedilol: a third generation β-adrenoceptor blocker derived from eugenol, with α-adrenoceptor blocking and β 2-adrenoceptor agonist-associated vasorelaxant activities J. Cardiovasc. Pharmacol. 34 1999 10 20
21. A.J. Hunter, K.B. Mackay, and D.C. Rogers To what extent have functional studies of ischemia in animals have been useful in assessment of potential neuroprotective agent Trends Pharmacol. Sci. 19 1998 59 66
22. M. Ihara, H. Tomimoto, M. Kinoshita, O. Junseo, M. Noda, and H. Wakita Chronic cerebral hypoperfusion induces MMP2 but not MMP9 expression in the microglia and vascular endothelium in the white matter J. Cereb. Blood Flow Metab. 21 2001 828 834
23. Y. Iwasaki, S. Ito, M. Suzuki, T. Nagahori, T. Yamamoto, and H. Konno Forebrain ischemia induced by temporary bilateral common carotid artery occlusion in normotensive rats J. Neurol. Sci. 90 1989 155 165
24. P. Kakkar, B. Das, and P.N. Viswanathan A modified spectrophotometric assay of superoxide dismutase Indian J. Biochem. Biophys. 21 1984 130 132
25. M.A. Kelm, M.G. Nair, G.M. Strasburg, and D.L. De Witt Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn Phytomedicine 7 2000 7 13
26. R.R. Kritikar, and B.D. Basu B.J.F. Caius K.S. Bhaskar Indian Medicinal Plants vol. 3 1935 Bhishan Singh Mahendra Paul Singh Dehradun, India 19 65
27. Y.T. Lin, B.N. Wu, C.F. Horng, Y.C. Huang, S.J. Hong, and Y.C. Lo Isoeugenolol: a selective β1-adrenergic antagonist with tracheal and vascular smooth muscle properties Jpn. J. Pharmacol. 80 1999 127 136
28. J. Lister Ethologically based animal models of anxiety disorders Pharmacol. Ther. 46 1990 321 340
29. O.H. Lowry, N.J. Rosenborough, A.L. Farr, and R.J. Randal Protein measurement with folin phenol reagent J. Biol. Chem. 193 1951 265 275
30. G. Maulik, N. Maulik, V.E. Bhandari, S. Pakrashi, and D.K. Das Evaluation of antioxidant effectiveness of few herbal plants Free Radic. Res. 27 1997 22 28
31. P.K. Mediratta, K.K. Sharma, and S. Singh Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action J. Ethnopharmacol. 80 2002 15 20
32. R. Morris Development of a water maze procedure for studying spatial learning in the rat J. Neurosci. Methods 11 1984 47 60
33. K.M. Nadkarni Indian materia medica 1976 Popular Prakashan Mumbai, India 671
34. M. Nakashima, M. Niwa, T. Iwai, and T. Uematsu Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rats Free Radic. Biol. Med. 26 1999 722 729
35. J.M. Ni, H. Ohta, K. Matsumoto, and H. Watanabe Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats Brain Res. 653 1994 231 236
36. T. Nishijima, R. Uchida, K. Kamayama, N. Kawakami, T. Ohkubo, and K. Kitamura Mechanisms mediating vasorelaxing action of eugenol, a pungent oil, on rabbit arterial tissue Jpn. J. Pharmacol. 79 1999 327 334
37. F. Noll l-Lactic acid H.U. Bergmeyer Methods of enzymatic analysis 1984 Verlag Chemie Weinhem 582 588
38. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
39. B.A. Omar, and J.M. McCord The cardioprotective effect of Mn-superoxide dismutase is lost at high doses in the postischemic rabbit heart Free Radic. Biol. Med. 9 1990 473 478
40. S.T. Omaye, D.J. Turnball, and H.E. Samberlich Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids Methods Enzymol. 62 1979 3 11
41. B.A. Pappas, J.C. De La Torre, C.M. Davidson, M.T. Keyes, and T. Fortin Chronic reduction of cerebral blood flow in the adult rat: late emerging CA1 cell loss and memory dysfunction Brain Res. 708 1996 50 58
42. K. Plaschke, M. Grant, and M.O. Weigand Neuromodulatory effect of propentofylline on rat brain under acute transient and long-term hypoperfusion Br. J. Pharmacol. 133 2001 107 116
43. R.E. Ratych, R.S. Chuyknyiska, and G.B. Bulkley The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells Surgery 102 1987 122 131
44. T.N. Rege, U.M. Thatte, and S.A. Dahanukar Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine Phytother. Res. 13 1999 275 291
45. P.M. Reilly, H.J. Schiller, and G.B. Bulkley Pharmacological approaches to tissue injury mediated by free radicals and other reactive oxygen metabolites Am. J. Surg. 161 1991 488 503
46. Sairam, K. Experimental evaluation of some Ayurvedic rasayanas on peptic ulcer diathesis. PhD thesis. India: Institute of Medical Sciences, Banaras Hindu University, Varanasi; 2001.
47. C. Sarti, L. Pantoni, L. Bartolini, and D. Inzitari Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models J. Neurol. Sci. 203/204 2002 263 266
48. J. Sedlack, and R.H. Lindsay Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1968 192 205
49. P. Sen, P.C. Maiti, S. Puri, N.A. Andulov, and A.V. Valdman Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol, Tinospora malabarica in experimental animals Indian J. Exp. Biol. 30 1992 592 596
50. B.R. Shivakumar, V.R.S. Kolluri, and V. Ravindranath Glutathione homeostasis in brain during reperfusion following bilateral common carotid artery in rats Mol. Cell. Biochem. 111 1992 125 129
51. S. Singh, and D.K. Majumdar Effect of Ocimum sanctum fixed oil on vascular permeability and leukocyte migration Indian J. Exp. Biol. 37 1999 1136 1138
52. S. Singh, D.K. Majumdar, and H.M. Rehan Evaluation of anti-inflammatory potential of Ocimum sanctum (Holy basil) and its possible mechanism of action J. Ethnopharmacol. 54 1996 19 26
53. K.H. Sontag, C. Heim, and F. Block Cerebral oligemic hypoxia and forebrain ischemiaâ€"common and different long lasting consequences J. Krieglestein H. Oberpichler-Schwank Pharmacology of cerebral ischemia 1992 Wissenschaftliche Verlagsgeuschaft Stuttgart 417 419
54. V. Sorrenti, C. Di Giaxomo, M. Renis, A. Russo, C. La Della, and J.R. Perez-Polo Lipid peroxidation and survival in rats following cerebral post-ischemic reperfusion: effect of drugs with different molecular mechanisms Drugs Exp. Clin. Res. 20 1994 185 189
55. W.J. Streit, S.A. Walter, and N.A. Pennell Reactive microgliosis Prog. Neurobiol. 57 1999 563 581
56. J.A. Stoof, A. Winogrodzka, E.L. Vanmuiswinkel, E.C. Wolters, P. Voorn, and H.J. Gronewegen Leads for the development of neuroprotective treatments in Parkinson's disease and brain imaging methods for estimating treatment efficacy Eur. J. Pharmacol. 375 1999 75 86
57. Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for standards regarding preclinical neuroprotective and restorative drug development Stroke 30 1999 2752 2758
58. J.A. Thomas, B. Poland, and R. Honzatko Protein sulfhydryls and their role in antioxidant function of protein S-thiolation Arch. Biochem. Biophys. 319 1995 1 9
59. M. Tsuchiya, K. Sako, S. Yura, and Y. Yonemasu Cerebral blood flow and histopathological changes following permanent bilateral carotid artery ligation in Wistar rats Exp. Brain Res. 89 1992 87 92
60. M. Tsuchiya, K. Sako, S. Yura, and Y. Yonemasu Local cerebral glucose utilization following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow Exp. Brain Res. 53 1993 1 7