Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme

Biochemistry

Volumn 36, Issue 20, 1997, Pages 6207-6217

  Lo Bello, Mario ^a   Oakley, Aaron J ^b   Battistoni, Andrea ^a   Mazzetti, Anna P ^a   Nuccetelli, Marzia ^a   Mazzarese, Giampiero ^a   Rossjohn, Jamie ^b   Parker, Michael W ^b   Ricci, Giorgio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; MUTANT PROTEIN;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

4-CHLORO-7-NITROBENZOFURAZAN; CRYSTALLOGRAPHY, X-RAY; DINITROCHLOROBENZENE; ETHACRYNIC ACID; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; KINETICS; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TYROSINE; VISCOSITY;

FELIS CATUS; SIGANUS;

EID: 0030923311     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962813z     Document Type: Article

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