Bystander responses in low dose irradiated cells treated with plasma from gamma irradiated blood

Journal of Physics: Conference Series

Volumn 101, Issue 1, 2008, Pages

  Acheva, Anna ^a   Georgieva, Radostina ^a   Rupova, Ivanka ^a   Boteva, Raina ^a   Lyng, Fiona ^b  

^a National Center of Radiobiology and Radiation Protection Bulgaria   (Bulgaria)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 44649109716     PISSN: 17426588     EISSN: 17426596     Source Type: Conference Proceeding    
DOI: 10.1088/1742-6596/101/1/012005     Document Type: Article

References (40)

1. Mothersill C, C Seymour 1997 Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells Int. J. Radiat. Biol. 71 421-427
2. Mothersill C and Seymour C 1998 Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keranocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149 256-262
3. Nagasawa H, JB Little 1992 Induction of sister chromatid exchanges by extremely low doses of alpha-particles Cancer Res. 52 6394-6396
4. Wojcik A and Streffer C 1994 Adaptive response to ionizing radiation in mammalian cells: a review. Biol. Zent, bl. 113 417-434
5. Wolff S 1998 The adaptive response in radiobiology: evolving insights and implications Environ. Health Persp. 106 (Suppl. 1) 277-283
6. Hickman A W, Jaramillo R J, Lechner J F and Johnson N F 1994 Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer Res. 54 5797-5800
7. Azzam E I, de Toledo S M, Gooding T and Little J B 1998 Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150 497-504
8. Prise K M, Belyakov O V, Folkard M and Michael B D 1998 Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74 793-798
9. Belyakov O V, Prise K M, Trott K R and Michael B D 1999 Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles. Int. J. Radiat. Biol. 75 985-993
10. Sawant S G, Randers-Pehrson G, Geard C R, Brenner D J and Hall E J 2001 The bystander effect in radiation oncogenesis: I Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155 397-401
11. Lyng F M, Seymour C B and Mothersill C 2000 Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. Br. J. Cancer 83 1223-1230
12. Lyng F M, Seymour C B and Mothersill C 2002 Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: A possible mechanism for bystander-induced genomic instability? Radiat. Res. 157 365-370
13. Nagasawa H and Little J B 1999 Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: Evidence for a bystander effect. Radiat. Res. 152 552-557
14. Zhou H, Randers-Pehrson G, Waldren C A, Vannais D, Hall E J and Hei T K 2000 Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97 2099-2104
15. Lorimore S A, Kadhim M A, Pocock D A, Papworth D, Stevens D L, Goodhead D T and E G Wright 1998 Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. USA 95 5730-5733
16. Seymour C B and Mothersill C 1997 Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat. Oncol. Investig. 5 106-110
17. Lehnert B, Goodwin E H and Deshpande A 1997 Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 57 2164-2171
18. Azzam E I, de Toledo S M and Little J B 2003 Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22 7050-7057
19. Emerit I, Khan S H and Cerutti P A 1985 Treatment of lymphocytecultures with a hypoxanthine-xanthine oxidase system induces the formation of transferable clastogenic material. J. Free Radic. Biol. Med. 1 51-57
20. Azzam E I, de Toledo S M, Spitz D R and Little J B 2002 Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62 5437-5442
21. Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C 2006 The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat Res. Apr 165(4) 400-9
22. Dent P, Yacoub A, Fisher P B, Hagan M P and Grant S 2003 MAPK pathways in radiation responses. Oncogene 22 5885-5896
23. Ballarini, F and Ottolenghi, A 2002 Low-dose radiation action: possible implications of bystander effects and adaptive response. J. Radiological Protection 22 A39 - A42
24. Iyer, R and Lehnert, B E 2002 Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiation Research 157 3-7
25. Iyer, R and Lehnert, B E 2002 Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutation Research 503 1-9
26. Clapham D E 1995 Intracellular calcium. Replenishing the stores. Nature 375 634-635
27. Bygrave F L and Roberts H R 1995 Regulation of cellular calcium through signaling crosstalk involves an intricate interplay between the actions of receptors, G-proteins, and second messengers. FASEB J. 9 1297-1303
28. Rego A C and Oliveira C R 2003 Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases. Neurochem. Res. 28 1563-1574
29. Rigaud, O and Moustacchi, E 1996 Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutation Research 358 127-134
30. Stecca, C and Gerber, G B 1998 Adaptive response to DNAdamagingage nts: a review of potential mechanisms. Biochemical Pharmacology 55 941-951
31. Sasaki, M S, Ejima Y, Tachibana, A, Yamada, T, Ishizaki, K, Shimizu, T and Nomura, T 2002 DNA damage response pathway in radioadaptive response. Mutation Research 504 101-118
32. Mothersill C, Seymour CB 2002 Bystander and delayed effects after fractionated radiation exposure. Radiat Res 158 626-633
33. Maguire M, Mothersill C, Seymour CB and Lyng FM An adaptive response following exposure of cultures to medium from cells irradiated to low doses of cobalt 60 gamma rays. Radiation Research in press.
34. Lyng FM, Seymour CB, Mothersill C 2002 Early events in the apoptotic cascade initiated in cells treated with medium from the progeny of irradiated cells. Radiat Prot Dosimetry 99 169-172
35. Puck, T T and Marcus, P I 1956 Action of X-rays on mammalian cells. J. Experimental Medicine 103 653-666
36. Ferlini C, Di Cesare S, Rainaldi G, Malorni W, Samoggia P, Biselli R and Fattorossi A 1996 Flow cytometric analysis of the early phases of apoptosis by cellular and nuclear techniques. Cytometry 24 106-115
37. Iyer R, Lehnert B E and Swensson R 2000 Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60 1290-1298
38. Shao C, Aoki M and Furusawa Y 2003 Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation 2002 Radiat. Environ. Biophys. 42 183-187
39. Iyer R and Lehnert B E Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiat. Res. 157 3-7
40. Mitchell S A, Marino S A, Brenner D J and Hall E J 2004 Bystander effect and adaptive response in C3H 10T(1/2) cells. Int. J. Radiat. Biol. 80 465-472