Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or α-particles

International Journal of Radiation Biology

Volumn 75, Issue 8, 1999, Pages 985-993

  Belyakov, O V ^a,b   Prise, K M ^a   Trott, K R ^a,b   Michael, B D ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; APOPTOSIS; ARTICLE; CELL SURVIVAL; CLONOGENESIS; FIBROBLAST; HUMAN; HUMAN CELL; LETHALITY; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION DOSE; X IRRADIATION;

ALPHA PARTICLES; APOPTOSIS; CELL DIVISION; CELL LINE; CELL SURVIVAL; CLONE CELLS; FIBROBLASTS; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; PHOSPHATIDYLSERINES; RADIATION DOSAGE; TIME FACTORS; X-RAYS;

EID: 0032804183     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099139746     Document Type: Article

References (35)

1. ALMASSAY, Z., KREPINSKY, A. B., BIANCO, A. and KOTELES, C. J., 1987, The present state and perspectives of micronucleus assay in radiation protection. International Journal of Radiation and Applied Instrumentation, 38, 241-249.
2. CHANG, W. P. and LITTLE, J. B., 1992, Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: associations with delayed reproductive phenotype. Mutation Research, 270, 191-199.
3. CORNFORTH, M. N. and GOODWIN, E. H., 1991, Transmission of radiation-induced acentric chromosomal fragments to micronuclei in normal human fibroblasts. Radiation Research, 126, 210-217.
4. 1 arrest and long-term induction of CIP1 in normal human fibroblasts. Genes and Development, 8, 2540-2551.
5. ENNS, L., BARLEY, R. D., PATERSON, M. C. and MIRZAYANS, R., 1998, Radiosensitivity in ataxia telangiectasia fibroblasts is not associated with deregulated apoptosis. Radiation Research, 150, 11-16.
6. FENECH, M., 1997, The advantages and disadvantages of the cytokinesis-block micronucleus method. Mutation Research, 392, 11-18.
7. FENECH, M. and MORLEY, A. A., 1989, Kinetochore detection in micronuclei: an alternative method for measuring chromosome loss. Mutagenesis, 4, 98-104.
8. FOLKARD, M., PRISE, K. M., VOJNOVIC, B., NEWMAN, H. C., ROPER, M. J. and MICHAEL, B. D., 1996, Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions. International Journal of Radiation Biology, 69, 729-738.
9. GEARD, C. R. and CHEN, Y. C., 1990, Micronuclei and clonogenicity following low-and high-dose-rate gamma irradiation of normal human fibroblasts. Radiation Research, 124, S56-61.
10. GORGOJO, L. and LITTLE, J. B., 1989, Expression of lethal mutations in progeny of irradiated mammalian cells. International Journal of Radiation Biology, 55, 619-630.
11. HARPER, K., LORIMORE, S. A. and WRIGHT, E. G., 1997, Delayed appearance of radiation-induced mutation at the HPRT locus in murine haemopoietic cells. Experimental Hematology, 25, 263-269.
12. HOLMBERG, K., FALT, S., JOHANSSON, A. and LAMBERT, B., 1993, Chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutation Research, 286, 321-330.
13. HOLMBERG, K., MEIJER, A. E., AUER, G. and LAMBERT, B., 1995, Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation. International Journal of Radiation Biology, 68, 245-255.
14. HOLMBERG, K., MEIJER, A. E., HARMS-RINGDAHL, M. and LAMBERT, B., 1998, Chromosomal instability in human lymphocytes after low dose rate γ-irradiation and delayed mitogen Stimulation. International Journal of Radiation Biology, 73, 21-34.
15. JAMALI, M. and TROTT, K.-R., 1996, Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells. International Journal of Radiation Biology, 69, 301-307.
16. KADHIM, M. A., LORIMORE, S. A., TOWNSEND, K. M. S., GOODHEAD, D. T., BUCKLE, V. J. and WRIGHT, E. G., 1995, Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. International Journal of Radiation Biology, 67, 287-293.
17. KADHIM, M. A., MACDONALD, D. A., GOODHEAD, D. T., LORIMORE, S. A., MARSDEN, S. J. and WRIGHT, E. G., 1992, Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature, 355, 738-740.
18. KADHIM, M. A., MARSDEN, S. J. and WRIGHT, E. G., 1998, Radiation-induced chromosomal instability in human fibroblasts: temporal effects and the influence of radiation quality. International Journal of Radiation Biology, 73, 143-148.
19. KERR, J. F., WYLLIE A. H. and CURRIE A. R., 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26, 239-257.
20. LENGAUER, C., KINZLER, K. W. and VOGELSTEIN, B., 1998, Genetic instability in human cancers. Nature, 396, 643-649.
21. LINKE, S. P., CLARKIN, K. C. and WAHL, G. M., 1997, p53 mediates permanent arrest over multiple cell cycles in response to γ-irradiation. Cancer Research, 57, 1171-1179.
22. LITTLE, J, B., GORGOJO, L. and VETROVS, H. 1990, Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. International Journal of Radiation Oncology, Biology and Physics, 19, 1425-1429.
23. MANTI, L., JAMALI, M., PRISE, K. M., MICHAEL, B. D. and TROTT, K.-R., 1997, Genomic instability in Chinese hamster cells after exposure to X rays or alpha particles of different mean linear energy transfer. Radiation Research, 147, 22-28.
24. MARDER, B. A. and MORGAN, W. F., 1993, Delayed chromosomal instability induced by DNA damage. Molecular Cellular Biology, 13, 6667-6677.
25. MARTINS, M. B., SABATIER, L. O., RICOUL, M., PINTON, A. and DUTRILLAUX, B., 1993, Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts. Mutation Research, 285, 229-237.
26. MORGAN, W. F., DAY, J. P., KAPLAN, M. I., MCGHEE, E. M. and LIMOLI, C. L., 1996, Genomic instability induced by ionizing radiation. Radiation Research, 146, 247-258.
27. PAMPFER, S. and STREFFER, C., 1989, Increased chromosomal aberration levels in cells from mouse fetuses after zygote X-irradiation. International Journal of Radiation Biology, 55, 85-92.
28. PONNAIYA, B., CORNFORTH, M. N. and ULLRICH, R. L., 1997a, Induction of chromosomal instability in human mammary cells by neutrons and gamma rays. Radiation Research, 147, 288-294.
29. PONNAIYA, B., CORNFORTH, M. N. and ULLRICH, R. L., 1997b, Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white. Radiation Research, 147, 121-125.
30. PRISE, K. M., FOLKARD, M., VOJNOVIC, B., DAVIES, S., ROPER, M. J. and MICHAEL, B. D., 1990, The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part II: Measurement of oxygen enhancement ratios and DNA damage. International Journal of Radiation Biology, 58, 261-277.
31. RAJU, M. R., EISEN, Y., CARPENTER, S., JARRETT, K. and HARVEY, W. F., 1993, Radiobiology of α-particles IV. Cell inactivation by α-particles of energies 0.4-3.5 MeV. Radiation Research, 133, 289-296.
32. SAVAGE, J. R. K. and PAPWORTH, D. G., 1982, Frequency and distribution studies of asymmetrical versus symmetrical chromosome aberrations. Mutation Research, 95, 7-18.
33. SEYMOUR, C. B., MOTHERSILL, C. and ALPER, T., 1986, High yields of mutations in somatic mammalian cells that survive ionizing radiation. International Journal of Radiation Biology, 50, 167-179.
34. VAN ENGELAND, M., RAMAEKERS, F. C. S., SCHUTTE, B. and REUTELINGSPERGER, C. P. M., 1996, A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry, 24, 131-139.
35. WATSON, G. E., LORIMORE, S. A., CLUTTON, S. M., KADHIM, M. A. and WRIGHT, E. G., 1997, Genetic factors influencing α-particle-induced chromosomal instability. International Journal of Radiation Biology, 71, 497-503.