메뉴 건너뛰기




Volumn 58, Issue 5, 2008, Pages 694-707

Cyclic GMP-Gated CNG Channels Function in Sema3A-Induced Growth Cone Repulsion

Author keywords

MOLNEURO

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; CYCLIC NUCLEOTIDE GATED CHANNEL; DILTIAZEM; ION CHANNEL; SEMAPHORIN 3A;

EID: 44649083709     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2008.03.017     Document Type: Article
Times cited : (70)

References (62)
  • 1
    • 3343017377 scopus 로고    scopus 로고
    • The Drosophila receptor guanylyl cyclase Gyc76C is required for Semaphorin-1a-Plexin A-mediated axonal repulsion
    • Ayoob J.C., Yu H., Terman J.R., and Kolodkin A.L. The Drosophila receptor guanylyl cyclase Gyc76C is required for Semaphorin-1a-Plexin A-mediated axonal repulsion. J. Neurosci. 24 (2004) 6639-6649
    • (2004) J. Neurosci. , vol.24 , pp. 6639-6649
    • Ayoob, J.C.1    Yu, H.2    Terman, J.R.3    Kolodkin, A.L.4
  • 2
    • 0033539598 scopus 로고    scopus 로고
    • Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin
    • Behar O., Mizuno K., Badminton M., and Woolf C.J. Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin. Proc. Natl. Acad. Sci. USA 96 (1999) 13501-13505
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13501-13505
    • Behar, O.1    Mizuno, K.2    Badminton, M.3    Woolf, C.J.4
  • 3
    • 38349057369 scopus 로고    scopus 로고
    • Semaphorin3A regulates axon growth independently of growth cone repulsion via modulation of TrkA signaling
    • Ben-Zvi A., Ben-Gigi L., Yagil Z., Lerman O., and Behar O. Semaphorin3A regulates axon growth independently of growth cone repulsion via modulation of TrkA signaling. Cell. Signal. 20 (2008) 467-479
    • (2008) Cell. Signal. , vol.20 , pp. 467-479
    • Ben-Zvi, A.1    Ben-Gigi, L.2    Yagil, Z.3    Lerman, O.4    Behar, O.5
  • 6
    • 33749429853 scopus 로고    scopus 로고
    • The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness
    • Brown R.L., Strassmaier T., Brady J.D., and Karpen J.W. The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness. Curr. Pharm. Des. 12 (2006) 3597-3613
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 3597-3613
    • Brown, R.L.1    Strassmaier, T.2    Brady, J.D.3    Karpen, J.W.4
  • 7
    • 0035924590 scopus 로고    scopus 로고
    • Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation
    • Campbell D.S., and Holt C.E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32 (2001) 1013-1026
    • (2001) Neuron , vol.32 , pp. 1013-1026
    • Campbell, D.S.1    Holt, C.E.2
  • 8
    • 0035503546 scopus 로고    scopus 로고
    • Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones
    • Campbell D.S., Regan A.G., Lopez J.S., Tannahill D., Harris W.A., and Holt C.E. Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones. J. Neurosci. 21 (2001) 8538-8549
    • (2001) J. Neurosci. , vol.21 , pp. 8538-8549
    • Campbell, D.S.1    Regan, A.G.2    Lopez, J.S.3    Tannahill, D.4    Harris, W.A.5    Holt, C.E.6
  • 9
    • 0342872023 scopus 로고    scopus 로고
    • Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
    • Chen H., Chédotal A., He Z., Goodman C.S., and Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19 (1997) 547-559
    • (1997) Neuron , vol.19 , pp. 547-559
    • Chen, H.1    Chédotal, A.2    He, Z.3    Goodman, C.S.4    Tessier-Lavigne, M.5
  • 11
    • 0030273625 scopus 로고    scopus 로고
    • A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans
    • Coburn C.M., and Bargmann C.I. A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron 17 (1996) 695-706
    • (1996) Neuron , vol.17 , pp. 695-706
    • Coburn, C.M.1    Bargmann, C.I.2
  • 12
    • 0022635692 scopus 로고
    • Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase
    • Corbin J.D., Ogreid D., Miller J.P., Suva R.H., Jastorff B., and Døskeland S.O. Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase. J. Biol. Chem. 261 (1986) 1208-1214
    • (1986) J. Biol. Chem. , vol.261 , pp. 1208-1214
    • Corbin, J.D.1    Ogreid, D.2    Miller, J.P.3    Suva, R.H.4    Jastorff, B.5    Døskeland, S.O.6
  • 14
    • 0029117775 scopus 로고
    • Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels
    • Frings S., Seifert R., Godde M., and Kaupp U.B. Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15 (1995) 169-179
    • (1995) Neuron , vol.15 , pp. 169-179
    • Frings, S.1    Seifert, R.2    Godde, M.3    Kaupp, U.B.4
  • 15
    • 31444455532 scopus 로고    scopus 로고
    • The molecular basis for calcium-dependent axon pathfinding
    • Gomez T.M., and Zheng J.Q. The molecular basis for calcium-dependent axon pathfinding. Nat. Rev. Neurosci. 7 (2006) 115-125
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 115-125
    • Gomez, T.M.1    Zheng, J.Q.2
  • 16
    • 0029092710 scopus 로고
    • Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor
    • Gordon S.E., Downing-Park J., and Zimmerman A.L. Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor. J. Physiol. 486 (1995) 533-546
    • (1995) J. Physiol. , vol.486 , pp. 533-546
    • Gordon, S.E.1    Downing-Park, J.2    Zimmerman, A.L.3
  • 19
    • 0032971038 scopus 로고    scopus 로고
    • Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors
    • Hackos D.H., and Korenbrot J.I. Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors. J. Gen. Physiol. 113 (1999) 799-817
    • (1999) J. Gen. Physiol. , vol.113 , pp. 799-817
    • Hackos, D.H.1    Korenbrot, J.I.2
  • 20
    • 0022544976 scopus 로고
    • Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane
    • Haynes L.W., Kay A.R., and Yau K.W. Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane. Nature 321 (1986) 66-70
    • (1986) Nature , vol.321 , pp. 66-70
    • Haynes, L.W.1    Kay, A.R.2    Yau, K.W.3
  • 21
    • 0037065995 scopus 로고    scopus 로고
    • Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system
    • He Z., Wang K.C., Koprivica V., Ming G.-L., and Song H.-J. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci. STKE 119 (2002) RE1
    • (2002) Sci. STKE , vol.119
    • He, Z.1    Wang, K.C.2    Koprivica, V.3    Ming, G.-L.4    Song, H.-J.5
  • 23
    • 10444267294 scopus 로고    scopus 로고
    • Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein
    • Henley J.R., Huang K.H., Wang D., and Poo M.M. Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein. Neuron 44 (2004) 909-916
    • (2004) Neuron , vol.44 , pp. 909-916
    • Henley, J.R.1    Huang, K.H.2    Wang, D.3    Poo, M.M.4
  • 25
    • 0033603256 scopus 로고    scopus 로고
    • A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
    • Hong K., Hinck L., Nishiyama M., Poo M.-m., Tessier-Lavigne M., and Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97 (1999) 927-941
    • (1999) Cell , vol.97 , pp. 927-941
    • Hong, K.1    Hinck, L.2    Nishiyama, M.3    Poo, M.-m.4    Tessier-Lavigne, M.5    Stein, E.6
  • 26
  • 27
    • 0037817750 scopus 로고    scopus 로고
    • Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance
    • Huber A.B., Kolodkin A.L., Ginty D.D., and Cloutier J.F. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu. Rev. Neurosci. 26 (2003) 509-563
    • (2003) Annu. Rev. Neurosci. , vol.26 , pp. 509-563
    • Huber, A.B.1    Kolodkin, A.L.2    Ginty, D.D.3    Cloutier, J.F.4
  • 28
    • 17144449224 scopus 로고    scopus 로고
    • 2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis
    • 2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis. Eur. J. Neurosci. 18 (2003) 2175-2187
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2175-2187
    • Jimenez-Gonzalez, C.1    McLaren, G.J.2    Dale, N.3
  • 29
    • 0036301043 scopus 로고    scopus 로고
    • Cyclic nucleotide-gated ion channels
    • Kaupp U.B., and Seifert R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82 (2002) 769-824
    • (2002) Physiol. Rev. , vol.82 , pp. 769-824
    • Kaupp, U.B.1    Seifert, R.2
  • 30
    • 0030273005 scopus 로고    scopus 로고
    • Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
    • Komatsu H., Mori I., Rhee J.S., Akaike N., and Ohshima Y. Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17 (1996) 707-718
    • (1996) Neuron , vol.17 , pp. 707-718
    • Komatsu, H.1    Mori, I.2    Rhee, J.S.3    Akaike, N.4    Ohshima, Y.5
  • 31
    • 0029916901 scopus 로고    scopus 로고
    • Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action
    • Kramer R.H., and Tibbs G.R. Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action. J. Neurosci. 16 (1996) 1285-1293
    • (1996) J. Neurosci. , vol.16 , pp. 1285-1293
    • Kramer, R.H.1    Tibbs, G.R.2
  • 32
    • 0032127530 scopus 로고    scopus 로고
    • Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers
    • Liu D.T., Tibbs G.R., Paoletti P., and Siegelbaum S.A. Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers. Neuron 21 (1998) 235-248
    • (1998) Neuron , vol.21 , pp. 235-248
    • Liu, D.T.1    Tibbs, G.R.2    Paoletti, P.3    Siegelbaum, S.A.4
  • 34
    • 0242721443 scopus 로고    scopus 로고
    • B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathways
    • Mann F., Miranda E., Weinl C., Harmer E., and Holt C.E. B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathways. J. Neurobiol. 57 (2003) 323-336
    • (2003) J. Neurobiol. , vol.57 , pp. 323-336
    • Mann, F.1    Miranda, E.2    Weinl, C.3    Harmer, E.4    Holt, C.E.5
  • 38
    • 0032215735 scopus 로고    scopus 로고
    • Neuropilin-1 extracellular domains mediate semaphoring D/III-induced growth cone collapse
    • Nakamura F., Tanaka M., Takahashi T., Falb R.G., and Strittmatter S.M. Neuropilin-1 extracellular domains mediate semaphoring D/III-induced growth cone collapse. Neuron 21 (1998) 1093-1100
    • (1998) Neuron , vol.21 , pp. 1093-1100
    • Nakamura, F.1    Tanaka, M.2    Takahashi, T.3    Falb, R.G.4    Strittmatter, S.M.5
  • 40
    • 44649109940 scopus 로고    scopus 로고
    • Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning
    • in press
    • Nishiyama M., von Schimmelmann M.J., Togashi K., Findley W.M., and Hong K. Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning. Nat. Neurosci. 11 (2008) in press
    • (2008) Nat. Neurosci. , vol.11
    • Nishiyama, M.1    von Schimmelmann, M.J.2    Togashi, K.3    Findley, W.M.4    Hong, K.5
  • 43
    • 0034611809 scopus 로고    scopus 로고
    • Semaphorin 3A is a chemoattractant for cortical apical dendrites
    • Polleux F., Morrow T., and Ghosh A. Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404 (2000) 567-573
    • (2000) Nature , vol.404 , pp. 567-573
    • Polleux, F.1    Morrow, T.2    Ghosh, A.3
  • 44
    • 0033782111 scopus 로고    scopus 로고
    • 2+ dependence of sensitivity modulation in cyclic GMP-gated currents of intact cone photoreceptors
    • 2+ dependence of sensitivity modulation in cyclic GMP-gated currents of intact cone photoreceptors. J. Gen. Physiol. 116 (2000) 521-534
    • (2000) J. Gen. Physiol. , vol.116 , pp. 521-534
    • Rebrik, T.I.1    Kotelnikova, E.A.2    Korenbrot, J.I.3
  • 45
    • 0023812979 scopus 로고
    • Development and characterization of commissural interneurones in the spinal cord of Xenopus laevis embryos revealed by antibodies to glycine
    • Roberts A., Dale N., Ottersen O.P., and Storm-Mathisen J. Development and characterization of commissural interneurones in the spinal cord of Xenopus laevis embryos revealed by antibodies to glycine. Development 103 (1988) 447-461
    • (1988) Development , vol.103 , pp. 447-461
    • Roberts, A.1    Dale, N.2    Ottersen, O.P.3    Storm-Mathisen, J.4
  • 46
    • 0036785879 scopus 로고    scopus 로고
    • Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway
    • Shewan D., Dwivedy A., Anderson R., and Holt C.E. Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway. Nat. Neurosci. 5 (2002) 955-962
    • (2002) Nat. Neurosci. , vol.5 , pp. 955-962
    • Shewan, D.1    Dwivedy, A.2    Anderson, R.3    Holt, C.E.4
  • 48
    • 0030877318 scopus 로고    scopus 로고
    • cAMP-induced switching in turning direction of nerve growth cones
    • Song H.J., Ming G.L., and Poo M.M. cAMP-induced switching in turning direction of nerve growth cones. Nature 388 (1997) 275-279
    • (1997) Nature , vol.388 , pp. 275-279
    • Song, H.J.1    Ming, G.L.2    Poo, M.M.3
  • 49
    • 0032483342 scopus 로고    scopus 로고
    • Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides
    • Song H.-j., Ming G., He Z., Lehmann M., McKerracher L., Tessier-Lavigne M., and Poo M. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 281 (1998) 1515-1518
    • (1998) Science , vol.281 , pp. 1515-1518
    • Song, H.-j.1    Ming, G.2    He, Z.3    Lehmann, M.4    McKerracher, L.5    Tessier-Lavigne, M.6    Poo, M.7
  • 50
    • 0035831296 scopus 로고    scopus 로고
    • Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex
    • Stein E., and Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 291 (2001) 1928-1938
    • (2001) Science , vol.291 , pp. 1928-1938
    • Stein, E.1    Tessier-Lavigne, M.2
  • 51
    • 0022456444 scopus 로고
    • Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem
    • Stern J.H., Kaupp U.B., and MacLeish P.R. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem. Proc. Natl. Acad. Sci. USA 83 (1986) 1163-1167
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 1163-1167
    • Stern, J.H.1    Kaupp, U.B.2    MacLeish, P.R.3
  • 52
    • 0037188897 scopus 로고    scopus 로고
    • MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
    • Terman J.R., Mao T., Pasterkamp R.J., Yu H.H., and Kolodkin A.L. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. Cell 109 (2002) 887-900
    • (2002) Cell , vol.109 , pp. 887-900
    • Terman, J.R.1    Mao, T.2    Pasterkamp, R.J.3    Yu, H.H.4    Kolodkin, A.L.5
  • 53
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne M., and Goodman C.S. The molecular biology of axon guidance. Science 274 (1996) 1123-1133
    • (1996) Science , vol.274 , pp. 1123-1133
    • Tessier-Lavigne, M.1    Goodman, C.S.2
  • 54
    • 33646916006 scopus 로고    scopus 로고
    • RanBPM contributes to Semaphorin3A signaling through Plexin-A receptors
    • Togashi H., Schmidt E.F., and Strittmatter S.M. RanBPM contributes to Semaphorin3A signaling through Plexin-A receptors. J. Neurosci. 26 (2006) 4961-4969
    • (2006) J. Neurosci. , vol.26 , pp. 4961-4969
    • Togashi, H.1    Schmidt, E.F.2    Strittmatter, S.M.3
  • 55
    • 0032125257 scopus 로고    scopus 로고
    • cAMP-mediated regulation of neurotrophin-induced collapse of nerve growth cones
    • Wang Q., and Zheng J.Q. cAMP-mediated regulation of neurotrophin-induced collapse of nerve growth cones. J. Neurosci. 18 (1998) 4973-4984
    • (1998) J. Neurosci. , vol.18 , pp. 4973-4984
    • Wang, Q.1    Zheng, J.Q.2
  • 56
    • 17244383526 scopus 로고    scopus 로고
    • Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones
    • Wang G.X., and Poo M.M. Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature 434 (2005) 898-904
    • (2005) Nature , vol.434 , pp. 898-904
    • Wang, G.X.1    Poo, M.M.2
  • 57
    • 22444433668 scopus 로고    scopus 로고
    • Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH
    • Wolin M.S., Ahmad M., and Gupte S.A. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am. J. Physiol. Lung Cell. Mol. Physiol. 289 (2005) L159-L173
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.289
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 58
    • 0026061044 scopus 로고
    • Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord
    • Yamada T., Placzek M., Tanaka H., Dodd J., and Jessell T.M. Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord. Cell 64 (1991) 635-647
    • (1991) Cell , vol.64 , pp. 635-647
    • Yamada, T.1    Placzek, M.2    Tanaka, H.3    Dodd, J.4    Jessell, T.M.5
  • 59
    • 0035514195 scopus 로고    scopus 로고
    • Dynamic regulation of axon guidance
    • Yu T.W., and Bargmann C.I. Dynamic regulation of axon guidance. Nat. Neurosci. 4 (2001) 1169-1176
    • (2001) Nat. Neurosci. , vol.4 , pp. 1169-1176
    • Yu, T.W.1    Bargmann, C.I.2
  • 60
    • 0033710345 scopus 로고    scopus 로고
    • Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit
    • Zheng C., Feinstein P., Bozza T., Rodriguez I., and Mombaerts P. Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron 26 (2000) 81-91
    • (2000) Neuron , vol.26 , pp. 81-91
    • Zheng, C.1    Feinstein, P.2    Bozza, T.3    Rodriguez, I.4    Mombaerts, P.5
  • 61
    • 0022496631 scopus 로고
    • Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores
    • Zimmerman A.L., and Baylor D.A. Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores. Nature 321 (1986) 70-72
    • (1986) Nature , vol.321 , pp. 70-72
    • Zimmerman, A.L.1    Baylor, D.A.2
  • 62
    • 0034604331 scopus 로고    scopus 로고
    • Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord
    • Zou Y., Stoeckli E., Chen H., and Tessier-Lavigne M. Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell 102 (2000) 363-375
    • (2000) Cell , vol.102 , pp. 363-375
    • Zou, Y.1    Stoeckli, E.2    Chen, H.3    Tessier-Lavigne, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.