The cognitive enhancer SGS742 does not involve major known signaling cascades in OF1 mice

Neurochemical Research

Volumn 33, Issue 7, 2008, Pages 1384-1392

  Sunyer, Berta ^a   Shim, Ki Shuk ^a   Höger, Harald ^a   Lubec, Gert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cognitive enhancer; GABA(B) receptor; Immunoblotting; SGS742

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DREBRIN; EARLY GROWTH RESPONSE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; IMMUNOBLOTTING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; BLOTTING, WESTERN; CUES; MAZE LEARNING; MICE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; ORGANOPHOSPHORUS COMPOUNDS; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; SPACE PERCEPTION;

MUS;

EID: 44549083192     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9596-x     Document Type: Article

References (45)

1. Helm KA, Haberman RP, Dean SL et al (2005) GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus. Neuropharmacology 48:956-964
2. Tully T, Bourtchouladze R, Scott R et al (2003) Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov 2:267-277 Review
3. Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87-136 Review
4. Martin SJ, Morris RG (2002) New life in an old idea: the synaptic plasticity and memory hypothesis revisited. Hippocampus 12:609-636 Review
5. Malenka RC, Kauer JA, Perkel DJ et al (1989) An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340:554-557
6. Silva AJ, Stevens CF, Tonegawa S et al (1992) Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257:201-206
7. Giese KP, Fedorov NB, Filipkowski RK et al (1998) Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279:870-873
8. Elgersma Y, Fedorov NB, Ikonen S et al (2002). Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron 36:493-505
9. Ehrlich I, Malinow R (2004) Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci 24:916-927
10. McGahon B, Maguire C, Kelly A et al (1999) Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino- cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes. Neuroscience 90:1167-1175
11. Blum S, Moore AN, Adams F et al (1999) A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosci 19:3535-3544
12. Gooney M, Shaw K, Kelly A et al (2002) Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor. Behav Neurosci 116:455-463
13. Tully T (1997) Regulation of gene expression and its role in long-term memory and synaptic plasticity. Proc Natl Acad Sci USA 94:4239-4241
14. Guzowski JF, McGaugh JL (1997) Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc Natl Acad Sci USA 94:2693-2698
15. Pittenger C, Huang YY, Paletzki RF et al (2002) Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34:447-462
16. Mizuno M, Yamada K, Maekawa N et al (2002) CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res 133:135-141
17. Cole AJ, Saffen DW, Baraban JM et al (1989) Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340:474-476
18. Wisden W, Errington ML, Williams S et al (1990). Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4:603-614
19. Abraham WC, Dragunow M, Tate WP (1991) The role of immediate early genes in the stabilization of long-term potentiation. Mol Neurobiol 5:297-314 Review
20. Jones MW, Errington ML, French PJ et al (2001). A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci 4:289-296
21. Tyler WJ, Alonso M, Bramham CR et al (2002) From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 9:224-237 Review
22. Bramham CR, Messaoudi E (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76:99-125 Review
23. Davies B, Kearns IR, Ure J et al (2001) Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci 21:6993-7000
24. Mizuno M, Yamada K, Olariu A et al (2000) Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J Neurosci 20:7116-7121
25. Linnarsson S, Bjorklund A, Ernfors P (1997) Learning deficit in BDNF mutant mice. Eur J Neurosci 9:2581-2587
26. Weitzdoerfer R, Dierssen M, Fountoulakis M et al (2001) Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. J Neural Transm Suppl 61:59-70
27. Shim KS, Lubec G (2002) Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett 324:209-212
28. Froestl W, Gallagher M, Jenkins H et al (2004) SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol 68:1479-1487
29. Carletti R, Libri V, Bowery NG (1993) The GABA-B antagonist CGP36742 enhances spatial learning performance and antagonises baclofen-induced amnesia in mice. Br J Pharmacol 109:74
30. Nakagawa Y, Takashima T (1997) The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats. Brain Res 766:101-106
31. Mondadori C, Jaekel J, Preiswerk G (1993) CGP 36742: the first orally active GABAb blocker improves the cognitive performance of mice, rats, and rhesus monkeys. Behav Neural Biol 60:62-68
32. Sunyer B, Patil S, Frischer C, Hoger H et al (2007) Strain-dependent effects of SGS742 in the mouse. Behav Brain Res 181:64-75
33. Nehring RB, Horikawa HP, El Far O et al (2007) The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. J Biol Chem 275:35185-35191
34. Vernon E, Meyer G, Pickard L et al (2001) GABA (B) receptors couple directly to the transcription factor ATF4. Mol Cell Neurosci 17:637-645
35. White JH, McIllhinney RA, Wis A et al (2000) The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci USA 97:13967-13972
36. Pittaluga A, Feligioni M, Ghersi C et al (2001) Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABA(B) receptor antagonists. Neuropharmacology 41:301-310
37. Nyitrai G, Kekesi KA, Emri Z et al (2003) GABA(B) receptor antagonist CGP-36742 enhances somatostatin release in the rat hippocampus in vivo and in vitro. Eur J Pharmacol 478:111-119
38. Boehm S, Betz H (1997) Somatostatin inhibits excitatory transmission at rat hippocampal synapses via presynaptic receptors. J Neurosci 17:4066-4075
39. Kaneko S, Maeda T, Satoh M (1997) Cognitive enhancers and hippocampal long-term potentiation in vitro. Behav Brain Res 83:45-49
40. Pizarro JM, Haro LS, Barea-Rodriguez EJ (2003) Learning associated increase in heat shock cognate 70 mRNA and protein expression. Neurobiol Learn Mem 79:142-151
41. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
42. Pollak DD, Herkner K, Hoeger H, Lubec G (2005) Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice. Behav Brain Res 163:128-135
43. Sananbenesi F, Fischer A, Schrick C et al (2003) Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci 23:11436-11443
44. Heese K, Otten U, Mathivet P et al (2000) GABA(B) receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats. Neuropharmacology 39:449-462
45. Bonanno G, Carita F, Cavazzani P et al (1999) Selective block of rat and human neocortex GABA(B) receptors regulating somatostatin release by a GABA(B) antagonist endowed with cognition enhancing activity. Neuropharmacology 38:1789-1795