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Volumn 180, Issue 7, 2008, Pages 4451-4457

Loss of IFN-γ enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 17; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; HISTOCOMPATIBILITY ANTIGEN; INTERFERON RECEPTOR; MYELIN ASSOCIATED GLYCOPROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN;

EID: 44449165047     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4451     Document Type: Article
Times cited : (44)

References (37)
  • 1
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14: 602-609.
    • (1993) Immunol. Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 2
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363: 156-159.
    • (1993) Nature , vol.363 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 5
    • 0042847235 scopus 로고    scopus 로고
    • Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55
    • Ford, M. L., and B. D. Evavold. 2003. Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55. J. Immunol. 171: 1247-1254.
    • (2003) J. Immunol , vol.171 , pp. 1247-1254
    • Ford, M.L.1    Evavold, B.D.2
  • 6
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova, B., B. Goodwin, N. Richert, I. Cortese, T. Kondo, G. Afshar, B. Gran, J. Eaton, J. Antel, J. A. Frank, et al. 2000. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 6: 1167-1175.
    • (2000) Nat. Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10
  • 7
    • 0036046080 scopus 로고    scopus 로고
    • Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand
    • Kim, H. J., J. P. Antel, P. Duquette, D. G. Alleva, P. J. Conlon, and A. Bar-Or. 2002. Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand. Clin. Immunol. 104: 105-114.
    • (2002) Clin. Immunol , vol.104 , pp. 105-114
    • Kim, H.J.1    Antel, J.P.2    Duquette, P.3    Alleva, D.G.4    Conlon, P.J.5    Bar-Or, A.6
  • 8
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson, L. B., J.M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3: 397-405.
    • (1995) Immunity , vol.3 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 9
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a nonencephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial: The altered peptide ligand in relapsing MS study group
    • Kappos, L., G. Comi, H. Panitch, J. Oger, J. Antel, P. Conlon, and L. Steinman. 2000. Induction of a nonencephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial: the altered peptide ligand in relapsing MS study group. Nat. Med. 6: 1176-1182.
    • (2000) Nat. Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 10
    • 14844346786 scopus 로고    scopus 로고
    • Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151
    • Margot, C. D., M. L. Ford, and B. D. Evavold. 2005. Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151. J. Immunol. 174: 3352-3358.
    • (2005) J. Immunol , vol.174 , pp. 3352-3358
    • Margot, C.D.1    Ford, M.L.2    Evavold, B.D.3
  • 11
    • 1642312993 scopus 로고    scopus 로고
    • An MHC anchor-substituted analog of myelin oligodendrocyte glycoprotein 35-55 induces IFN-γ and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis
    • Ford, M. L., and B. D. Evavold. 2004. An MHC anchor-substituted analog of myelin oligodendrocyte glycoprotein 35-55 induces IFN-γ and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis. Eur. J. Immunol. 34: 388-397.
    • (2004) Eur. J. Immunol , vol.34 , pp. 388-397
    • Ford, M.L.1    Evavold, B.D.2
  • 12
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomy- elitis (EAE)
    • Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomy- elitis (EAE). J. Immunol. 156: 5-7.
    • (1996) J. Immunol , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 13
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-y confers resistance to experimental allergic encephalomyelitis
    • Krakowski, M., and T. Owens. 1996. Interferon-y confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26: 1641-1646.
    • (1996) Eur. J. Immunol , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 14
    • 0030587910 scopus 로고    scopus 로고
    • IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg, D. O., S. Fordham, C. C. Bernard, W. B. Cowden, and I. A. Ramshaw. 1996. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157: 3223-3227.
    • (1996) J. Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 15
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu, C. Q., S. Wittmer, and D. K. Dalton. 2000. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 192:123-128.
    • (2000) J. Exp. Med , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 16
    • 0034162486 scopus 로고    scopus 로고
    • Interferon-γ shapes immune invasion of the central nervous system via regulation of chemokines
    • Tran, E. H., E. N. Prince, and T. Owens. 2000. Interferon-γ shapes immune invasion of the central nervous system via regulation of chemokines. J. Immunol. 164: 2759-2768.
    • (2000) J. Immunol , vol.164 , pp. 2759-2768
    • Tran, E.H.1    Prince, E.N.2    Owens, T.3
  • 19
    • 34248355132 scopus 로고    scopus 로고
    • Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models
    • Fabis, M. J., G. S. Scott, R. B. Kean, H. Koprowski, and D. C. Hooper. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc. Natl. Acad. Sci. USA 104: 5656-5661.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5656-5661
    • Fabis, M.J.1    Scott, G.S.2    Kean, R.B.3    Koprowski, H.4    Hooper, D.C.5
  • 20
    • 35649000947 scopus 로고    scopus 로고
    • IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis
    • Xiao, B., C. Ma, L. Xu, H. Link, and C. Lu. 2008. IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis. Mol. Immunol. 45: 1191-1196.
    • (2008) Mol. Immunol , vol.45 , pp. 1191-1196
    • Xiao, B.1    Ma, C.2    Xu, L.3    Link, H.4    Lu, C.5
  • 22
    • 0035005706 scopus 로고    scopus 로고
    • The "cleavage" activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring "2A-like" sequences
    • Donnelly, M. L., L. E. Hughes, G. Luke, H. Mendoza, E. Ten Dam, D. Gani, and M. D. Ryan. 2001. The "cleavage" activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring "2A-like" sequences. J. Gen. Virol. 82: 1027-1041.
    • (2001) J. Gen. Virol , vol.82 , pp. 1027-1041
    • Donnelly, M.L.1    Hughes, L.E.2    Luke, G.3    Mendoza, H.4    Ten Dam, E.5    Gani, D.6    Ryan, M.D.7
  • 23
    • 0039310043 scopus 로고
    • Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coli
    • Schatz, P. J. 1993. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli. Biotechnology 11: 1138-1143.
    • (1993) Biotechnology , vol.11 , pp. 1138-1143
    • Schatz, P.J.1
  • 26
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • Hofstetter, H. H., S. M. Ibrahim, D. Koczan, N. Kruze, A. Weishaupt, K. V. Toyka, and R. Gold. 2005. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 237:123-130.
    • (2005) Cell. Immunol , vol.237 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruze, N.4    Weishaupt, A.5    Toyka, K.V.6    Gold, R.7
  • 28
  • 30
    • 33845961158 scopus 로고    scopus 로고
    • Feedback regulation of murine autoimmunity via dominant anti-inflammatory effects of interferon-γ
    • Minguela, A., S. Pastor, W. Mi, J. A. Richardson, and E. S. Ward. 2007. Feedback regulation of murine autoimmunity via dominant anti-inflammatory effects of interferon-γ. J. Immunol. 178: 134-144.
    • (2007) J. Immunol , vol.178 , pp. 134-144
    • Minguela, A.1    Pastor, S.2    Mi, W.3    Richardson, J.A.4    Ward, E.S.5
  • 31
    • 0033571331 scopus 로고    scopus 로고
    • IFN-γ is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: A possible role for nitric oxide
    • Willenborg, D. O., S. A. Fordham, M. A. Staykova, I. A. Ramshaw, and W. B. Cowden. 1999. IFN-γ is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J. Immunol. 163.
    • (1999) J. Immunol , pp. 163
    • Willenborg, D.O.1    Fordham, S.A.2    Staykova, M.A.3    Ramshaw, I.A.4    Cowden, W.B.5
  • 32
    • 0034600788 scopus 로고    scopus 로고
    • Inter-feron γ eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells
    • Dalton, D. K., L. Haynes, C. Q. Chu, S. L. Swain, and S. Wittmer. 2000. Inter-feron γ eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J. Exp. Med. 192: 117-122.
    • (2000) J. Exp. Med , vol.192 , pp. 117-122
    • Dalton, D.K.1    Haynes, L.2    Chu, C.Q.3    Swain, S.L.4    Wittmer, S.5
  • 33
    • 23444449846 scopus 로고    scopus 로고
    • Indolamine 2,3- dioxygenase is expressed in the CNS and downregulates autoimmune inflammation
    • Kwidzinski, E., J. Bunse, O. Aktas, D. Richter, L. Mutlu, F. Zipp, R. Nitsch, and I. Bechman. 2005. Indolamine 2,3- dioxygenase is expressed in the CNS and downregulates autoimmune inflammation. FASEB J. 19: 1347-1349.
    • (2005) FASEB J , vol.19 , pp. 1347-1349
    • Kwidzinski, E.1    Bunse, J.2    Aktas, O.3    Richter, D.4    Mutlu, L.5    Zipp, F.6    Nitsch, R.7    Bechman, I.8
  • 34
    • 0037037582 scopus 로고    scopus 로고
    • Interferon γ is required for activation-induced death of T lymphocytes
    • Refaeli, Y., L. van Parijs, S. I. Alexander, and A. K. Abbas. 2002. Interferon γ is required for activation-induced death of T lymphocytes. J. Exp. Med. 196:999-1005.
    • (2002) J. Exp. Med , vol.196 , pp. 999-1005
    • Refaeli, Y.1    van Parijs, L.2    Alexander, S.I.3    Abbas, A.K.4
  • 35
    • 0025991518 scopus 로고
    • Immune modulation within the brain: Recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ
    • Sethna, M. P., and L. A. Lampson. 1991. Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ. J. Neuroimmunol. 34: 121-132.
    • (1991) J. Neuroimmunol , vol.34 , pp. 121-132
    • Sethna, M.P.1    Lampson, L.A.2
  • 36
    • 33846811702 scopus 로고    scopus 로고
    • The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
    • Lin, W., S. L. Bailey, H. Ho, H. P. Harding, D. Ron, S. D. Miller, and B. Popko. 2007. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J. Clin. Invest. 117: 448 -456.
    • (2007) J. Clin. Invest , vol.117 , pp. 448-456
    • Lin, W.1    Bailey, S.L.2    Ho, H.3    Harding, H.P.4    Ron, D.5    Miller, S.D.6    Popko, B.7
  • 37
    • 33847223756 scopus 로고    scopus 로고
    • Interferon-γ-oligodendrocyte interaction in the regulation of experimental autoimmune encephalomyelitis
    • Balabanov, R., K. Strand, R. Goswami, E. McMahon, W. Bogolka, S. D. Miller, and B. Popko. 2007. Interferon-γ-oligodendrocyte interaction in the regulation of experimental autoimmune encephalomyelitis. J. Neurosci. 27: 2013-2024.
    • (2007) J. Neurosci , vol.27 , pp. 2013-2024
    • Balabanov, R.1    Strand, K.2    Goswami, R.3    McMahon, E.4    Bogolka, W.5    Miller, S.D.6    Popko, B.7


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