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Volumn 34, Issue 2, 2004, Pages 388-397

An MHC anchor-substituted analog of myelin oligodendrocyte glycoprotein 35-55 induces IFN-γ and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis

Author keywords

Autoantibodies; CD4+ T cells; EAE; Optic neuritis; Peptides

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN 35-55; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; GLYCOPROTEIN; HISTOCOMPATIBILITY ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 2; INTERLEUKIN 4; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35 55); MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE; PEPTIDE FRAGMENT;

EID: 1642312993     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324502     Document Type: Article
Times cited : (19)

References (45)
  • 1
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L., Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996. 85: 299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 3
    • 0036219003 scopus 로고    scopus 로고
    • T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    • Kuchroo, V. K., Anderson, A. C., Waldner, H., Munder, M., Bettelli, E. and Nicholson, L. B., T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 2002. 20: 101-123.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 101-123
    • Kuchroo, V.K.1    Anderson, A.C.2    Waldner, H.3    Munder, M.4    Bettelli, E.5    Nicholson, L.B.6
  • 5
    • 0029038922 scopus 로고
    • A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: Fine specificity and T cell receptor V beta expression of encephalitogenic T cells
    • Mendel, I., Kerlero de Rosbo, N. and Ben-Nun, A., A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 1995. 25: 1951-1959.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1951-1959
    • Mendel, I.1    Kerlero de Rosbo, N.2    Ben-Nun, A.3
  • 6
    • 0345628025 scopus 로고    scopus 로고
    • Optic neuritis: Prognosis for multiple sclerosis from MRI, CSF, and HLA findings
    • Soderstrom, M., Ya-Ping, J., Hillert, J. and Link, H., Optic neuritis: prognosis for multiple sclerosis from MRI, CSF, and HLA findings. Neurology 1998. 50: 708-714.
    • (1998) Neurology , vol.50 , pp. 708-714
    • Soderstrom, M.1    Ya-Ping, J.2    Hillert, J.3    Link, H.4
  • 7
    • 0032859137 scopus 로고    scopus 로고
    • Long-term follow-up of isolated optic neuritis: The risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests
    • Ghezzi, A., Martinelli, V., Torri, V., Zaffaroni, M., Rodegher, M., Comi, G., Zibetti, A. and Canal, N., Long-term follow-up of isolated optic neuritis: the risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests. J. Neurol. 1999. 246: 770-775.
    • (1999) J. Neurol. , vol.246 , pp. 770-775
    • Ghezzi, A.1    Martinelli, V.2    Torri, V.3    Zaffaroni, M.4    Rodegher, M.5    Comi, G.6    Zibetti, A.7    Canal, N.8
  • 8
    • 0031859926 scopus 로고    scopus 로고
    • Microvascular and cellular responses in the optic nerve of rats with acute experimental allergic encephalomyelitis (EAE)
    • Hu, P., Pollard, J., Hunt, N., Taylor, J. and Chan-Ling, T., Microvascular and cellular responses in the optic nerve of rats with acute experimental allergic encephalomyelitis (EAE). Brain Pathol. 1998. 8: 475-486.
    • (1998) Brain Pathol. , vol.8 , pp. 475-486
    • Hu, P.1    Pollard, J.2    Hunt, N.3    Taylor, J.4    Chan-Ling, T.5
  • 9
    • 0031941202 scopus 로고    scopus 로고
    • Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: Demyelination and fast axonal transport changes in disease
    • O'Neill, J. K., Baker, D., Morris, M. M., Gschmeissner, S. E., Jenkins, H. G., Butt, A. M., Kirvell, S. L. and Amor, S., Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: demyelination and fast axonal transport changes in disease. J. Neuroimmunol. 1998. 82: 210-218.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 210-218
    • O'Neill, J.K.1    Baker, D.2    Morris, M.M.3    Gschmeissner, S.E.4    Jenkins, H.G.5    Butt, A.M.6    Kirvell, S.L.7    Amor, S.8
  • 10
    • 0018883441 scopus 로고
    • Optic neuritis and chronic relapsing experimental allergic encephalomyelitis: Relationship to clinical course and comparison with multiple sclerosis
    • Raine, C. S., Traugott, U., Nussenblatt, R. B. and Stone, S. H., Optic neuritis and chronic relapsing experimental allergic encephalomyelitis: relationship to clinical course and comparison with multiple sclerosis. Lab. Invest. 1980. 42: 327-335.
    • (1980) Lab. Invest. , vol.42 , pp. 327-335
    • Raine, C.S.1    Traugott, U.2    Nussenblatt, R.B.3    Stone, S.H.4
  • 11
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A. and Kuchroo, V. K., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 2003. 197: 1073-1081.
    • (2003) J. Exp. Med. , vol.197 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 12
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster, J. and Allen, P. M., Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 1996. 14: 1-27.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 13
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T cell functions stimulated by altered peptide ligands
    • Evavold, B. D., Sloan-Lancaster, J. and Allen, P. M., Tickling the TCR: selective T cell functions stimulated by altered peptide ligands. Immunol. Today 1993. 14: 602-609.
    • (1993) Immunol. Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 14
    • 0024325672 scopus 로고
    • Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy
    • Wraith, D. C., Smilek, D. E., Mitchell, D. J., Steinman, L. and McDevitt, H. O., Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 1989. 59: 247-255.
    • (1989) Cell , vol.59 , pp. 247-255
    • Wraith, D.C.1    Smilek, D.E.2    Mitchell, D.J.3    Steinman, L.4    McDevitt, H.O.5
  • 15
    • 0028956146 scopus 로고
    • Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
    • Windhagen, A., Scholz, C., Hollsberg, P., Fukaura, H., Sette, A. and Hafler, D. A., Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995. 2: 373-380.
    • (1995) Immunity , vol.2 , pp. 373-380
    • Windhagen, A.1    Scholz, C.2    Hollsberg, P.3    Fukaura, H.4    Sette, A.5    Hafler, D.A.6
  • 16
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D. and Allen, P. M., Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991. 252: 1308-1310.
    • (1991) Science , vol.252 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 17
    • 0027174663 scopus 로고
    • Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides
    • Evavold, B. D., Sloan-Lancaster, J., Hsu, B. L. and Allen, P. M., Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 1993. 150: 3131-3140.
    • (1993) J. Immunol. , vol.150 , pp. 3131-3140
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Hsu, B.L.3    Allen, P.M.4
  • 18
    • 0030797568 scopus 로고    scopus 로고
    • A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens
    • Nicholson, L. B., Murtaza, A., Hafler, B. P., Sette, A. and Kuchroo, V. K., A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc. Natl. Acad. Sci. USA 1997. 94: 9279-9284.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9279-9284
    • Nicholson, L.B.1    Murtaza, A.2    Hafler, B.P.3    Sette, A.4    Kuchroo, V.K.5
  • 20
    • 0027964523 scopus 로고
    • A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
    • Kuchroo, V. K., Greer, J. M., Kaul, D., Ishioka, G., Franco, A., Sette, A., Sobel, R. A. and Lees, M. B., A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 1994. 153: 3326-3336.
    • (1994) J. Immunol. , vol.153 , pp. 3326-3336
    • Kuchroo, V.K.1    Greer, J.M.2    Kaul, D.3    Ishioka, G.4    Franco, A.5    Sette, A.6    Sobel, R.A.7    Lees, M.B.8
  • 21
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B. and Kuchroo, V. K., An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995. 2: 397-405.
    • (1995) Immunity , vol.2 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 22
    • 0042847235 scopus 로고    scopus 로고
    • Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of MOG 35-55
    • Ford, M. L. and Evavold, B. D., Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of MOG 35-55. J. Immunol. 2003. 171: 1247-1254.
    • (2003) J. Immunol. , vol.171 , pp. 1247-1254
    • Ford, M.L.1    Evavold, B.D.2
  • 24
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • The Altered Peptide Ligand in Relapsing MS Study Group
    • Kappos, L., Comi, G., Panitch, H., Oger, J., Antel, J., Conlon, P. and Steinman, L., Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat. Med. 2000. 6: 1176-1182.
    • (2000) Nat. Med. , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 25
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova, B., Goodwin, B., Richert, N., Cortese, I., Kondo, T., Afshar, G., Gran, B., Eaton, J., Antel, J., Frank, J. A., McFarland, H. F. and Martin, R., Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 2000. 6: 1167-1175.
    • (2000) Nat. Med. , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 26
    • 0033038933 scopus 로고    scopus 로고
    • Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells
    • Anderton, S. M., Kissler, S., Lamont, A. G. and Wraith, D. C., Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells. Eur. J. Immunol. 1999. 29: 1850-1857.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1850-1857
    • Anderton, S.M.1    Kissler, S.2    Lamont, A.G.3    Wraith, D.C.4
  • 28
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz, R. H., Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 1996. 184: 1-8.
    • (1996) J. Exp. Med. , vol.184 , pp. 1-8
    • Schwartz, R.H.1
  • 29
    • 0033846948 scopus 로고    scopus 로고
    • Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis. Overexpression of chemokine receptor CCR5
    • Zang, Y. C., Samanta, A. K., Halder, J. B., Hong, J., Tejada-Simon, M. V., Rivera, V. M. and Zhang, J. Z., Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis. Overexpression of chemokine receptor CCR5. Brain 2000. 123: 1874-1882.
    • (2000) Brain , vol.123 , pp. 1874-1882
    • Zang, Y.C.1    Samanta, A.K.2    Halder, J.B.3    Hong, J.4    Tejada-Simon, M.V.5    Rivera, V.M.6    Zhang, J.Z.7
  • 30
    • 0042138931 scopus 로고    scopus 로고
    • Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis
    • discussion 843-774, 855-760
    • Begolka, W. S. and Miller, S. D., Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis. Res. Immunol. 1998. 149: 771-781; discussion 843-774, 855-760.
    • (1998) Res. Immunol. , vol.149 , pp. 771-781
    • Begolka, W.S.1    Miller, S.D.2
  • 31
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D. and Fathman, C. G., Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996. 156: 5-7.
    • (1996) J. Immunol. , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 32
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu, C. Q., Wittmer, S. and Dalton, D. K., Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 2000. 192: 123-128.
    • (2000) J. Exp. Med. , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 34
    • 0037442191 scopus 로고    scopus 로고
    • Cutting edge: Both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity
    • Robbie-Ryan, M., Tanzola, M. B., Secor, V. H. and Brown, M. A., Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity. J. Immunol. 2003. 170: 1630-1634.
    • (2003) J. Immunol. , vol.170 , pp. 1630-1634
    • Robbie-Ryan, M.1    Tanzola, M.B.2    Secor, V.H.3    Brown, M.A.4
  • 35
    • 0036318944 scopus 로고    scopus 로고
    • A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination
    • Svensson, L., Abdul-Majid, K. B., Bauer, J., Lassmann, H., Harris, R. A. and Holmdahl, R., A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination. Eur. J. Immunol. 2002. 32: 1939-1946.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1939-1946
    • Svensson, L.1    Abdul-Majid, K.B.2    Bauer, J.3    Lassmann, H.4    Harris, R.A.5    Holmdahl, R.6
  • 36
    • 0032209673 scopus 로고    scopus 로고
    • B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • Hjelmstrom, P., Juedes, A. E., Fjell, J. and Ruddle, N. H., B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J. Immunol. 1998. 161: 4480-4483.
    • (1998) J. Immunol. , vol.161 , pp. 4480-4483
    • Hjelmstrom, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 37
    • 0032729174 scopus 로고    scopus 로고
    • B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide
    • Lyons, J. A., San, M., Happ, M. P. and Cross, A. H., B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide. Eur. J. Immunol. 1999. 29: 3432-3439.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3432-3439
    • Lyons, J.A.1    San, M.2    Happ, M.P.3    Cross, A.H.4
  • 38
    • 0025282658 scopus 로고
    • Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein
    • Kerlero de Rosbo, N., Honegger, P., Lassmann, H. and Metthieu, J. M., Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein. J. Neurochem. 1990. 55: 583-587.
    • (1990) J. Neurochem. , vol.55 , pp. 583-587
    • Kerlero de Rosbo, N.1    Honegger, P.2    Lassmann, H.3    Metthieu, J.M.4
  • 39
    • 0026758968 scopus 로고
    • Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody
    • Linington, C., Engelhardt, B., Kapocs, G. and Lassman, H., Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. J. Neuroimmunol. 1992. 40: 219-224.
    • (1992) J. Neuroimmunol. , vol.40 , pp. 219-224
    • Linington, C.1    Engelhardt, B.2    Kapocs, G.3    Lassman, H.4
  • 41
    • 0027427223 scopus 로고
    • Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis
    • Kuchroo, V. K., Martin, C. A., Greer, J. M., Ju, S. T., Sobel, R. A. and Dorf, M. E., Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol. 1993. 151: 4371-4382.
    • (1993) J. Immunol. , vol.151 , pp. 4371-4382
    • Kuchroo, V.K.1    Martin, C.A.2    Greer, J.M.3    Ju, S.T.4    Sobel, R.A.5    Dorf, M.E.6
  • 45
    • 0031974120 scopus 로고    scopus 로고
    • Persistence of peptide-induced CD4+ T cell anergy in vitro
    • Ryan, K. R. and Evavold, B. D., Persistence of peptide-induced CD4+ T cell anergy in vitro. J. Exp. Med. 1998. 187: 89-96.
    • (1998) J. Exp. Med. , vol.187 , pp. 89-96
    • Ryan, K.R.1    Evavold, B.D.2


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