-
1
-
-
58149191995
-
-
For example, see
-
(l) For example, see:
-
-
-
-
2
-
-
0028138378
-
-
(a) Todo, Y.; Takagi, H.; lino, F.; Fukuoka, Y.; Ikeda, Y.; Tanaka, K.; Saikawa, I.; Narita, H. Chem. Pharm. Bull. 1994, 42, 2049-2054.
-
(1994)
Chem. Pharm. Bull
, vol.42
, pp. 2049-2054
-
-
Todo, Y.1
Takagi, H.2
lino, F.3
Fukuoka, Y.4
Ikeda, Y.5
Tanaka, K.6
Saikawa, I.7
Narita, H.8
-
4
-
-
30344462386
-
-
(a) Chai, H.; Zhao, Y.; Zhao, C; Gong, P. Bioorg. Med. Chem. 2006, 14, 911-917.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 911-917
-
-
Chai, H.1
Zhao, Y.2
Zhao, C.3
Gong, P.4
-
5
-
-
33644784714
-
-
(b) Zhao, C; zhao, Y.; Chai, H.; Gong, P. Bioorg. Med. Chem. 2006, 14, 2552-2558.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 2552-2558
-
-
Zhao, C.1
zhao, Y.2
Chai, H.3
Gong, P.4
-
6
-
-
18244398450
-
-
(a) Li, Q.; Woods, K. W.; Claiborne, A.; Gwaltney, S. L., II; Barr, K. J.; Liu, G.; Gehrke, L.; Credo, R. B.; Hui, Y. H.; Lee, J.; Warner, R. B.; Kovar, P.; Nukkala, M. A.; Zielinski, N. A.; Tahir, S. K.; Fitzgerald, M.; Kim, K. H.; Marsh, K.; Frost, D.; Ng, S. C; Rosenberg, S.; Sham, H. Bioorg. Med. Chem. Lett. 2002, 12, 465-469.
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 465-469
-
-
Li, Q.1
Woods, K.W.2
Claiborne, A.3
Gwaltney II, S.L.4
Barr, K.J.5
Liu, G.6
Gehrke, L.7
Credo, R.B.8
Hui, Y.H.9
Lee, J.10
Warner, R.B.11
Kovar, P.12
Nukkala, M.A.13
Zielinski, N.A.14
Tahir, S.K.15
Fitzgerald, M.16
Kim, K.H.17
Marsh, K.18
Frost, D.19
Ng, S.C.20
Rosenberg, S.21
Sham, H.22
more..
-
7
-
-
0035959970
-
-
(b) Swann, E.; Barraja, P.; Oberlander, A. M.; Gardipee, W. T.; Hudnott, A. R.; Beall, H. D.; Moody, C. J. J. Med. Chem. 2001, 44, 3311-3319.
-
(2001)
J. Med. Chem
, vol.44
, pp. 3311-3319
-
-
Swann, E.1
Barraja, P.2
Oberlander, A.M.3
Gardipee, W.T.4
Hudnott, A.R.5
Beall, H.D.6
Moody, C.J.7
-
8
-
-
0029133493
-
-
Yoshimura, H.; Nagai, M.; Hibi, S.; Kikichi, K.; Abe, S.; Hida, T.; Higashi, S.; Hishimura, I.; Yamanaka, T. J. Med. Chem. 1995, 38, 3163-3173.
-
(1995)
J. Med. Chem
, vol.38
, pp. 3163-3173
-
-
Yoshimura, H.1
Nagai, M.2
Hibi, S.3
Kikichi, K.4
Abe, S.5
Hida, T.6
Higashi, S.7
Hishimura, I.8
Yamanaka, T.9
-
10
-
-
0029132257
-
-
(b) Gillaspy, M. L.; Lefker, B. A.; Hada, W. A.; Hoover, D. J. Tetrahedron Lett. 1995, 36, 7399 -7402.
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 7399-7402
-
-
Gillaspy, M.L.1
Lefker, B.A.2
Hada, W.A.3
Hoover, D.J.4
-
11
-
-
0242659913
-
-
(c) Yoshida, Y.; Umeza, K.; Hamada, Y.; Atsumi, N.; Tabuchi, F. Synlett 2003, 2139-2142.
-
(2003)
Synlett
, pp. 2139-2142
-
-
Yoshida, Y.1
Umeza, K.2
Hamada, Y.3
Atsumi, N.4
Tabuchi, F.5
-
12
-
-
33645965855
-
-
(d) Satoh, T.; Miura, M.; Sakai, K.; Yokoyama, Y. Tetrahedron 2006, 62, 4253-4261.
-
(2006)
Tetrahedron
, vol.62
, pp. 4253-4261
-
-
Satoh, T.1
Miura, M.2
Sakai, K.3
Yokoyama, Y.4
-
13
-
-
33846093068
-
-
Gagnon, A.; St-Onge, M.; Little, K.; Duplessis, M.; Barabé, F. J. Am. Chem. Soc. 2007, 129, 44-45.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 44-45
-
-
Gagnon, A.1
St-Onge, M.2
Little, K.3
Duplessis, M.4
Barabé, F.5
-
14
-
-
58149190565
-
-
Though there are a few reports of nucleophilic substitution of amide nitrogen atom with cycopropyl bromide, only one or two examples are mentioned and the yield was not clearly mentioned
-
Though there are a few reports of nucleophilic substitution of amide nitrogen atom with cycopropyl bromide, only one or two examples are mentioned and the yield was not clearly mentioned:
-
-
-
-
15
-
-
33847632984
-
-
(a) Liang, G.-B.; Qian, X.; Feng, D.; Biftu, T.; Eiermann, G.; He, H.; Leiting, B.; Lyons, K.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Thornberry, N. A.; Weber, A. E. Bioorg. Med. Chem. Lett. 2007, 17, 1903-1907.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 1903-1907
-
-
Liang, G.-B.1
Qian, X.2
Feng, D.3
Biftu, T.4
Eiermann, G.5
He, H.6
Leiting, B.7
Lyons, K.8
Petrov, A.9
Sinha-Roy, R.10
Zhang, B.11
Wu, J.12
Zhang, X.13
Thornberry, N.A.14
Weber, A.E.15
-
16
-
-
3843124412
-
-
(b) Tran, T. P.; Ellsworth, E. L.; Stier, M. A.; Domagala, J. M.; Showalter, H. D. H.; Gracheck, S. J.; Shapiro, M. A.; Joannides, T. E.; Singh, R. Bioorg. Med. Chem. Lett. 2004, 14, 4405 -4409.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 4405-4409
-
-
Tran, T.P.1
Ellsworth, E.L.2
Stier, M.A.3
Domagala, J.M.4
Showalter, H.D.H.5
Gracheck, S.J.6
Shapiro, M.A.7
Joannides, T.E.8
Singh, R.9
-
17
-
-
34548296982
-
-
For reviews, see
-
For reviews, see: Kienle, M.; Dubbaka, S. R.; Brade, K.; Knochel, P. Eur. J. Org. Chem. 2007, 4166-4176.
-
(2007)
Eur. J. Org. Chem
, pp. 4166-4176
-
-
Kienle, M.1
Dubbaka, S.R.2
Brade, K.3
Knochel, P.4
-
20
-
-
0345329013
-
-
(c) Lindley, J. Tetrahedron 1984, 40, 1433-1456.
-
(1984)
Tetrahedron
, vol.40
, pp. 1433-1456
-
-
Lindley, J.1
-
21
-
-
0033515805
-
-
(d) Kiyomori, A.; Marcoux, J.-F.; Buchwald, S. L. Tetrahedron Lett. 1999, 40, 2657 -2640.
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 2657-2640
-
-
Kiyomori, A.1
Marcoux, J.-F.2
Buchwald, S.L.3
-
22
-
-
0034609669
-
-
and references cited therein
-
Elliott, G. I.; Konopelski, J. P. Org. Lett. 2000, 2, 3055-3057 and references cited therein.
-
(2000)
Org. Lett
, vol.2
, pp. 3055-3057
-
-
Elliott, G.I.1
Konopelski, J.P.2
-
23
-
-
0034680613
-
-
and references cited therein
-
Sorenson, R. J. J. Org. Chem. 2000, 65,7747-7749 and references cited therein.
-
(2000)
J. Org. Chem
, vol.65
, pp. 7747-7749
-
-
Sorenson, R.J.1
-
24
-
-
0034625934
-
-
(a) Lam, P. Y. S.; Deudon, S.; Averill, K. M.; Li, R.; He, M. Y.; DeShong, P.; Clark, C. G. J. Am. Chem. Soc. 2000, 122, 7600-7601.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 7600-7601
-
-
Lam, P.Y.S.1
Deudon, S.2
Averill, K.M.3
Li, R.4
He, M.Y.5
DeShong, P.6
Clark, C.G.7
-
25
-
-
34848822489
-
-
(b) Song, R.-J.; Deng, C.-L.; Xie, Y.-X.; Li, J.-H. Tetrahedron Lett. 2007, 48, 7845-7848.
-
(2007)
Tetrahedron Lett
, vol.48
, pp. 7845-7848
-
-
Song, R.-J.1
Deng, C.-L.2
Xie, Y.-X.3
Li, J.-H.4
-
27
-
-
0034115347
-
-
Lam, P. Y. S.; Clark, C. G.; Saubern, S.; Adams, J.; Averill, K. M.; Chan, D. M. T.; Combs, A. Synlett 2000, 674-676.
-
(2000)
Synlett
, pp. 674-676
-
-
Lam, P.Y.S.1
Clark, C.G.2
Saubern, S.3
Adams, J.4
Averill, K.M.5
Chan, D.M.T.6
Combs, A.7
-
28
-
-
0032493017
-
-
(a) Lam, P. Y. S.; Clark, C. G.; Saubern, S.; Adams, J.; Winters, M. P.; Chan, D. M. T.; Combs, A. Tetrahedron Lett. 1998, 39, 2941-2944.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 2941-2944
-
-
Lam, P.Y.S.1
Clark, C.G.2
Saubern, S.3
Adams, J.4
Winters, M.P.5
Chan, D.M.T.6
Combs, A.7
-
29
-
-
0032492942
-
-
(b) Chan, D. M. T.; Monaco, K. L.; Wang, R.-P.; Winters, M. P. Tetrahedron Lett. 1998, 39, 2933-2936.
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 2933-2936
-
-
Chan, D.M.T.1
Monaco, K.L.2
Wang, R.-P.3
Winters, M.P.4
-
33
-
-
33947123181
-
-
(d) Txschucke, C. C; Murphy, J. M.; Hartwig, J. F. Org. Lett. 2007, 9, 761-764.
-
(2007)
Org. Lett
, vol.9
, pp. 761-764
-
-
Txschucke, C.C.1
Murphy, J.M.2
Hartwig, J.F.3
-
34
-
-
0037163328
-
-
Suzuki-Miyaura coupling reactions of cyclopropylboronic acid and aryl halides had already been reported. Wallace, D. J, Chen, C. Tetrahedron Lett. 2002, 43, 6987-6990
-
Suzuki-Miyaura coupling reactions of cyclopropylboronic acid and aryl halides had already been reported. Wallace, D. J.; Chen, C. Tetrahedron Lett. 2002, 43, 6987-6990.
-
-
-
-
35
-
-
38549118405
-
-
Yamamoto, Y.; Takizawa, M.; Yu, X.-Q.; Miyaura, N. Angew. Chem., Int. Ed. 2008, 47, 928-931.
-
(2008)
Angew. Chem., Int. Ed
, vol.47
, pp. 928-931
-
-
Yamamoto, Y.1
Takizawa, M.2
Yu, X.-Q.3
Miyaura, N.4
-
36
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58149179314
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In the case of indole and 5-methoxyindole, starting material was consumed completely, while starting material remained in the case of other substrates. An insoluble black tar emerged during the extractive operation in the former case
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In the case of indole and 5-methoxyindole, starting material was consumed completely, while starting material remained in the case of other substrates. An insoluble black tar emerged during the extractive operation in the former case.
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