Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 8, 2006, Pages 2552-2558

  Zhao, Chunshen ^a   Zhao, Yanfang ^a   Chai, Huifang ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti hepatitis B virus activity; Ethyl 5 hydroxy 1H indole 3 carboxylates; Synthesis

Indexed keywords

1 ALKYL 2 (ARYLSULFONYLMETHYL) 5 HYDROXY 1H INDOLE 3 CARBOXYLATE; ANTIVIRUS AGENT; ETHYL 4 (1 IMIDAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(4 METHYLPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (1 TRIAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(4 FLUOROPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (1 TRIAZOLYLMETHYL) 5 HYDROXY 1 METHYL 2 [(3 METHOXYPHENYL) SULFINYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (2 METHYL 1 IMIDAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 (PHENYLSULFINYLMETHYL) 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (2 METHYL 1 IMIDAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(2 PYRIDINYL)SULFINYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (2 METHYL 1 IMIDAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(3,4 DIFLUOROPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (2 METHYL 1 IMIDAZOLYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(4 METHOXYPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (DIMETHYLAMINOMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 (PHENYLSULFINYLMETHYL) 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (DIMETHYLAMINOMETHYL) 5 HYDROXY 1 METHYL 2 [(3,4 DIMETHOXYPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (MORPHOLINOMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(2 FURANYLMETHYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (MORPHOLINOMETHYL) 5 HYDROXY 1 METHYL 2 [(3,4 DIMETHOXYPHENYL) SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PIPERIDINYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(2 FURANYLMETHYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(2 FURANYLMETHYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 CYCLOPROPYL 2 [(3,4 DIMETHOXYPHENYL)SULFINYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 METHYL 2 [(3 METHOXYPHENYL) SULFINYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 METHYL 2 [(3 METHOXYPHENYL) SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 METHYL 2 [(3,4 DIMETHOXYPHENYL)SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 METHYL 2 [(4 METHYLPHENYL) SULFINYLMETHYL] 1H INDOLE 3 CARBOXYLATE; ETHYL 4 (PYRROLIDINYLMETHYL) 5 HYDROXY 1 METHYL 2 [(4 METHYLPHENYL) SULFONYLMETHYL] 1H INDOLE 3 CARBOXYLATE; LAMIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IC 50; STATISTICAL SIGNIFICANCE;

ANTIVIRAL AGENTS; CELL LINE; DNA REPLICATION; HEPATITIS B VIRUS; INDOLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

HEPATITIS B VIRUS;

EID: 33644784714     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.11.033     Document Type: Article

References (13)

1. E. De clercq J. Clin. Virol. 30 2004 115 133
2. L.L. Ching, R. Vlad, Y. Man-Fung, and P. Thierry Lancet 362 2003 2089 2094
3. W.M. Lee N. Engl. J. Med. 337 1997 1733 1745
4. J.C. Humphries, and J.S. Dixon Intervirology 46 2003 413 420
5. D. Ganem, and A.M. Prince N. Engl. J. Med. 350 2004 1118 1129
6. Leneva, I. A.; Fadeeva, N. I.; Fedykina, I. T. Abstract 187, 7th International Conference on Antiviral Research, 1994.
7. Drugs Future 1992, 17, 1079-1081.
8. R.G. Glushkov, T.A. Guskova, and L. Krylova Vestn. Ross. Akad. Med. Nauk 3 1993 36 40
9. Chai, H. F.; Zhao, Y. F.; Zhao, C. S.; Gong, P. Bio. Med. Chem., in press. Available online: 23 September 2005.
10. S.A. Monti J. Org. Chem. 31 1966 2669
11. M.A. Sells, A.Z. Zelent, M. Shvartsman, and G. Acs J. Virol. 62 1988 2836 2844
12. B.E. Korba, and J.L. Gerin Antiviral Res. 19 1992 55 70
13. B.E. Korba, and J.L. Gerin Antiviral Res. 28 1995 225 242