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Volumn 96, Issue 2, 1999, Pages 167-181

VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T cells

Author keywords

Cytokines; Endotoxin; Immune cells; Neuroimmunomodulation; Neuropeptides

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033519349     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00023-5     Document Type: Article
Times cited : (159)

References (69)
  • 2
    • 0029885240 scopus 로고    scopus 로고
    • Functional and molecular characterization of VIP receptors and signal transduction in human and rodent systems
    • Calvo J.R., Pozo D., Guerrero J.M. Functional and molecular characterization of VIP receptors and signal transduction in human and rodent systems. Adv. Neuroimmunol. 6:1996;39-47.
    • (1996) Adv. Neuroimmunol. , vol.6 , pp. 39-47
    • Calvo, J.R.1    Pozo, D.2    Guerrero, J.M.3
  • 4
    • 0027240219 scopus 로고
    • Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells
    • D'Andrea A., Aste-Amezaga M., Valiante N.M., Ma X., Kubin M., Trinchieri G. Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J. Exp. Med. 178:1993;1041-1048.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 5
    • 0030639620 scopus 로고    scopus 로고
    • Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40
    • DeKruyff R.H., Gieni R.S., Umetsu D.T. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:1997;359-366.
    • (1997) J. Immunol. , vol.158 , pp. 359-366
    • DeKruyff, R.H.1    Gieni, R.S.2    Umetsu, D.T.3
  • 7
    • 0029949954 scopus 로고    scopus 로고
    • Characterization of gene expression of VIP and VIP1-receptor in rat peritoneal lymphocytes and macrophages
    • Delgado M., Pozo D., Martinez C., Garrido E., Leceta J., Calvo J.R., Gomariz R.P. Characterization of gene expression of VIP and VIP1-receptor in rat peritoneal lymphocytes and macrophages. Regul. Pept. 62:1996;161-166.
    • (1996) Regul. Pept. , vol.62 , pp. 161-166
    • Delgado, M.1    Pozo, D.2    Martinez, C.3    Garrido, E.4    Leceta, J.5    Calvo, J.R.6    Gomariz, R.P.7
  • 8
    • 0032553421 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit TNFα transcriptional activation by regulating NFkB and CREB/c-Jun
    • Delgado M., Munoz-Elias E.J., Kan Y., Gozes I., Fridkin M., Brenneman D.E., Gomariz R.P., Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit TNFα transcriptional activation by regulating NFkB and CREB/c-Jun. J. Biol. Chem. 273:1998;31427-31436.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31427-31436
    • Delgado, M.1    Munoz-Elias, E.J.2    Kan, Y.3    Gozes, I.4    Fridkin, M.5    Brenneman, D.E.6    Gomariz, R.P.7    Ganea, D.8
  • 9
    • 0033558092 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit endotoxin-induced TNFα production by macrophages: In vitro and in vivo studies
    • Delgado M., Pozo D., Martinez C., Leceta J., Calvo J.R., Ganea D., Gomariz R.P. Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit endotoxin-induced TNFα production by macrophages: in vitro and in vivo studies. J. Immunol. 162:1999;2358-2367.
    • (1999) J. Immunol. , vol.162 , pp. 2358-2367
    • Delgado, M.1    Pozo, D.2    Martinez, C.3    Leceta, J.4    Calvo, J.R.5    Ganea, D.6    Gomariz, R.P.7
  • 10
    • 0033555396 scopus 로고    scopus 로고
    • VIP and PACAP protect mice from lethal endotoxemia through the inhibition of TNFα and IL-6
    • Delgado M., Martinez C., Pozo D., Calvo J.R., Leceta J., Ganea D., Gomariz R.P. VIP and PACAP protect mice from lethal endotoxemia through the inhibition of TNFα and IL-6. J. Immunol. 162:1999;1200-1205.
    • (1999) J. Immunol. , vol.162 , pp. 1200-1205
    • Delgado, M.1    Martinez, C.2    Pozo, D.3    Calvo, J.R.4    Leceta, J.5    Ganea, D.6    Gomariz, R.P.7
  • 11
    • 0033083302 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide enhance IL-10 production by macrophages: In vitro and in vivo studies
    • Delgado M., Munoz-Elias E.J., Gomariz R.P., Gamea D. Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide enhance IL-10 production by macrophages: in vitro and in vivo studies. J. Immunol. 162:1999;1707-1716.
    • (1999) J. Immunol. , vol.162 , pp. 1707-1716
    • Delgado, M.1    Munoz-Elias, E.J.2    Gomariz, R.P.3    Gamea, D.4
  • 12
    • 0000274861 scopus 로고    scopus 로고
    • VIP and PACAP prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kB and interferon regulatory factor 1 activation
    • in press
    • Delgado, M., Munoz-Elias, E.J., Gomariz, R.P., Ganea, D., 1999d. VIP and PACAP prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kB and interferon regulatory factor 1 activation. J. Immunol., in press.
    • (1999) J. Immunol.
    • Delgado, M.1    Munoz-Elias, E.J.2    Gomariz, R.P.3    Ganea, D.4
  • 13
    • 0031892714 scopus 로고    scopus 로고
    • The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes
    • Dewit D., Gourlet P., Amraoui Z., Vertongen P., Willems F., Robberecht P., Goldman M. The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes. Immunol. Lett. 60:1998;57-60.
    • (1998) Immunol. Lett. , vol.60 , pp. 57-60
    • Dewit, D.1    Gourlet, P.2    Amraoui, Z.3    Vertongen, P.4    Willems, F.5    Robberecht, P.6    Goldman, M.7
  • 14
    • 0026661026 scopus 로고
    • Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha
    • Doherty G.M., Lange J.R., Langstein H.N., Alexander H.R., Buresh C.M., Norton J.A. Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha. J. Immunol. 149:1992;1666-1670.
    • (1992) J. Immunol. , vol.149 , pp. 1666-1670
    • Doherty, G.M.1    Lange, J.R.2    Langstein, H.N.3    Alexander, H.R.4    Buresh, C.M.5    Norton, J.A.6
  • 16
    • 0028943066 scopus 로고
    • Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha
    • Flesch I.E., Hess J.H., Huang S., Aguet M., Rothe J., Bluethmann H., Kufmann S.H. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J. Exp. Med. 181:1995;1615-1621.
    • (1995) J. Exp. Med. , vol.181 , pp. 1615-1621
    • Flesch, I.E.1    Hess, J.H.2    Huang, S.3    Aguet, M.4    Rothe, J.5    Bluethmann, H.6    Kufmann, S.H.7
  • 17
    • 0029994920 scopus 로고    scopus 로고
    • Regulatory effects of vasoactive intestinal peptide on cytokine production in central and peripheral lymphoid organs
    • Ganea D. Regulatory effects of vasoactive intestinal peptide on cytokine production in central and peripheral lymphoid organs. Adv. Neuroimmunol. 6:1996;61-74.
    • (1996) Adv. Neuroimmunol. , vol.6 , pp. 61-74
    • Ganea, D.1
  • 18
    • 0028215418 scopus 로고
    • Pituitary adenylate cyclase activating polypeptide (PACAP) immunolocalization in lymphoid tissues of the rat
    • Gaytan F., Martinez-Fuentes A.J., Gracia-Navarro F., Vaudry H., Aguilar E. Pituitary adenylate cyclase activating polypeptide (PACAP) immunolocalization in lymphoid tissues of the rat. Cell Tissue Res. 276:1994;223-227.
    • (1994) Cell Tissue Res. , vol.276 , pp. 223-227
    • Gaytan, F.1    Martinez-Fuentes, A.J.2    Gracia-Navarro, F.3    Vaudry, H.4    Aguilar, E.5
  • 20
    • 0028885561 scopus 로고
    • Fragments of the pituitary adenylate cyclase-activating polypeptide discriminate between type I and II recombinant receptors
    • Gourlet P., Vandermeers-Piret M.C., Rathe J., De Neef P., Robberecht P. Fragments of the pituitary adenylate cyclase-activating polypeptide discriminate between type I and II recombinant receptors. Eur. J. Pharmacol. 287:1995;7-11.
    • (1995) Eur. J. Pharmacol. , vol.287 , pp. 7-11
    • Gourlet, P.1    Vandermeers-Piret, M.C.2    Rathe, J.3    De Neef, P.4    Robberecht, P.5
  • 23
    • 0031427346 scopus 로고    scopus 로고
    • In vitro properties of a high affinity selective antagonist of the VIP1 receptor
    • Gourlet P., De Neef P., Cnudde J., Waelbroeck M., Robberecht P. In vitro properties of a high affinity selective antagonist of the VIP1 receptor. Peptides. 18:1997;1555-1560.
    • (1997) Peptides , vol.18 , pp. 1555-1560
    • Gourlet, P.1    De Neef, P.2    Cnudde, J.3    Waelbroeck, M.4    Robberecht, P.5
  • 26
    • 0028843942 scopus 로고
    • Immunosuppresive retroviral peptides: CAMP and cytokine patterns
    • Haraguchi S., Good R.A., Day N.K. Immunosuppresive retroviral peptides: cAMP and cytokine patterns. Immunol. Today. 16:1995;595-603.
    • (1995) Immunol. Today , vol.16 , pp. 595-603
    • Haraguchi, S.1    Good, R.A.2    Day, N.K.3
  • 27
    • 0028085437 scopus 로고
    • Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon
    • Heinzel F.P., Rerko R.M., Ling P., Hakimi J., Schoenhaut D.S. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 62:1994;4244-4249.
    • (1994) Infect. Immun. , vol.62 , pp. 4244-4249
    • Heinzel, F.P.1    Rerko, R.M.2    Ling, P.3    Hakimi, J.4    Schoenhaut, D.S.5
  • 28
    • 0030560659 scopus 로고    scopus 로고
    • Differential effects of gastrin-releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha production by whole blood cells from healthy young and old subjects
    • Hernanz A., Tato E., De la Fuente M., De Miguel E., Arnalich F. Differential effects of gastrin-releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha production by whole blood cells from healthy young and old subjects. J. Neuroimmunol. 75:1996;25-30.
    • (1996) J. Neuroimmunol. , vol.75 , pp. 25-30
    • Hernanz, A.1    Tato, E.2    De La Fuente, M.3    De Miguel, E.4    Arnalich, F.5
  • 29
    • 0027408695 scopus 로고
    • Interleukin 10 protects mice from lethal endotoxemia
    • Howard M., Muchamuel T., Andrade S., Menon S. Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177:1993;1205-1208.
    • (1993) J. Exp. Med. , vol.177 , pp. 1205-1208
    • Howard, M.1    Muchamuel, T.2    Andrade, S.3    Menon, S.4
  • 30
    • 0027336689 scopus 로고
    • Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., Murphy K.M. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:1993;547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 32
    • 0031092708 scopus 로고    scopus 로고
    • Substance P-induced IL-12 production by murine macrophages
    • Kincy-Cain T., Bost K.L. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158:1997;2334-2339.
    • (1997) J. Immunol. , vol.158 , pp. 2334-2339
    • Kincy-Cain, T.1    Bost, K.L.2
  • 33
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
    • Kobayashi M., Fitz L., Ryan M., Hewick R.M., Clark S.C., Chan S., Loudon R., Sherman F., Perussia B., Trinchieri G. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J. Exp. Med. 170:1989;827-846.
    • (1989) J. Exp. Med. , vol.170 , pp. 827-846
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 34
    • 0023818512 scopus 로고
    • Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression
    • Kunkel S.L., Spengler M., May M.A., Spengler R., Larrick J., Remick D. Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J. Biol. Chem. 263:1988;5380-5384.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5380-5384
    • Kunkel, S.L.1    Spengler, M.2    May, M.A.3    Spengler, R.4    Larrick, J.5    Remick, D.6
  • 35
    • 0028987883 scopus 로고
    • Macrophages and inflammatory mediators in tissue injury
    • Laskin D.L., Pendino J.K. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35:1995;655-677.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 655-677
    • Laskin, D.L.1    Pendino, J.K.2
  • 36
    • 0029889868 scopus 로고    scopus 로고
    • Expression of vasoactive intestinal peptide in lymphocytes: A possible endogenous role in the regulation of the immune system
    • Leceta J., Martinez C., Delgado M., Garrido E., Gomariz R.P. Expression of vasoactive intestinal peptide in lymphocytes: a possible endogenous role in the regulation of the immune system. Adv. Neuroimmunol. 6:1996;29-36.
    • (1996) Adv. Neuroimmunol. , vol.6 , pp. 29-36
    • Leceta, J.1    Martinez, C.2    Delgado, M.3    Garrido, E.4    Gomariz, R.P.5
  • 37
    • 0030891006 scopus 로고    scopus 로고
    • Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
    • Ma X., Neurath M., Gri G., Trinchieri G. Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J. Biol. Chem. 272:1997;10389-10395.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10389-10395
    • Ma, X.1    Neurath, M.2    Gri, G.3    Trinchieri, G.4
  • 39
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells
    • Manetti R., Parronchi P., Guidizi M.G., Piccinni M., Maggi E., Trinchieri G., Romagnani S. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1993;1199-1204.
    • (1993) J. Exp. Med. , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Guidizi, M.G.3    Piccinni, M.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 41
    • 0029935847 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide-38 inhibit IL-10 production in murine T lymphocytes
    • Martinez C., Delgado M., Gomariz R.P., Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide-38 inhibit IL-10 production in murine T lymphocytes. J. Immunol. 156:1996;4128-4136.
    • (1996) J. Immunol. , vol.156 , pp. 4128-4136
    • Martinez, C.1    Delgado, M.2    Gomariz, R.P.3    Ganea, D.4
  • 42
    • 2642701709 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide modulate endotoxin-induced IL-6 production by murine peritoneal macrophages
    • Martinez C., Delgado M., Pozo D., Leceta J., Calvo J.R., Ganea D., Gomariz R.P. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide modulate endotoxin-induced IL-6 production by murine peritoneal macrophages. J. Leukocyte Biol. 63:1998;591-601.
    • (1998) J. Leukocyte Biol. , vol.63 , pp. 591-601
    • Martinez, C.1    Delgado, M.2    Pozo, D.3    Leceta, J.4    Calvo, J.R.5    Ganea, D.6    Gomariz, R.P.7
  • 44
    • 0031030207 scopus 로고    scopus 로고
    • Maxadilan, the vasodilator peptide from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist
    • Moro O., Lerner E.A. Maxadilan, the vasodilator peptide from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J. Biol. Chem. 271:1996;966-970.
    • (1996) J. Biol. Chem. , vol.271 , pp. 966-970
    • Moro, O.1    Lerner, E.A.2
  • 47
    • 0025368105 scopus 로고
    • Somatostatin and vasoactive intestinal peptide reduce interferon gamma production by human peripheral blood mononuclear cells
    • Muscettola M., Grasso G. Somatostatin and vasoactive intestinal peptide reduce interferon gamma production by human peripheral blood mononuclear cells. Immunobiology. 180:1990;419-430.
    • (1990) Immunobiology , vol.180 , pp. 419-430
    • Muscettola, M.1    Grasso, G.2
  • 50
    • 0031566053 scopus 로고    scopus 로고
    • Functional characterization and mRNA expression of pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor in rat peritoneal macrophages
    • Pozo D., Delgado M., Martinez C., Gomariz R.P., Guerrero J.M., Calvo J.R. Functional characterization and mRNA expression of pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor in rat peritoneal macrophages. Biochim. Biophys. Acta. 1359:1997;250-262.
    • (1997) Biochim. Biophys. Acta , vol.1359 , pp. 250-262
    • Pozo, D.1    Delgado, M.2    Martinez, C.3    Gomariz, R.P.4    Guerrero, J.M.5    Calvo, J.R.6
  • 51
    • 0030027778 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase activating polypeptide and PACAP/vasoactive intestinal polypeptide receptors: Actions on the anterior pituitary gland
    • Rawlings S.R., Hezareh M. Pituitary adenylate cyclase activating polypeptide and PACAP/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland. Endocr. Rev. 17:1996;4-29.
    • (1996) Endocr. Rev. , vol.17 , pp. 4-29
    • Rawlings, S.R.1    Hezareh, M.2
  • 52
    • 0030051658 scopus 로고    scopus 로고
    • Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
    • Skeen M.J., Miller M.A., Shinnick T.M., Ziegler H.K. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1996;1196-1206.
    • (1996) J. Immunol. , vol.156 , pp. 1196-1206
    • Skeen, M.J.1    Miller, M.A.2    Shinnick, T.M.3    Ziegler, H.K.4
  • 53
    • 0030294517 scopus 로고    scopus 로고
    • - αβ T cells in the peritoneal cavity. Specific T cell-receptor mediated cytotoxicity and selective IFNg production against B cell leukemia and myeloma cells
    • - αβ T cells in the peritoneal cavity. Specific T cell-receptor mediated cytotoxicity and selective IFNg production against B cell leukemia and myeloma cells. J. Immunol. 157:1996;3925-3935.
    • (1996) J. Immunol. , vol.157 , pp. 3925-3935
    • Sugie, T.1    Kubota, H.2    Sato, M.3    Nakamura, E.4    Imamura, M.5    Minato, N.6
  • 55
    • 0030587817 scopus 로고    scopus 로고
    • Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production
    • Trepicchio W., Bozza M., Pedneault G., Dorner A. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J. Immunol. 157:1996;3627-3634.
    • (1996) J. Immunol. , vol.157 , pp. 3627-3634
    • Trepicchio, W.1    Bozza, M.2    Pedneault, G.3    Dorner, A.4
  • 56
    • 0028970060 scopus 로고
    • Interleukin 12: A proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin 12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:1995;251-278.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-278
    • Trinchieri, G.1
  • 57
    • 0031918989 scopus 로고    scopus 로고
    • Immunobiology of interleukin-12
    • Trinchieri G. Immunobiology of interleukin-12. Immunol. Res. 17:1998;269-278.
    • (1998) Immunol. Res. , vol.17 , pp. 269-278
    • Trinchieri, G.1
  • 58
    • 0031937388 scopus 로고    scopus 로고
    • Proinflammatory and immunoregulatory functions of interleukin-12
    • Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol. 16:1998;365-396.
    • (1998) Int. Rev. Immunol. , vol.16 , pp. 365-396
    • Trinchieri, G.1
  • 59
    • 0027530129 scopus 로고
    • Interleukin-12 and tumor necrosis factor-a are costimulators of interferon-g production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiological antagonist
    • Tripp C.S., Wolf S.F., Unanue E.R. Interleukin-12 and tumor necrosis factor-a are costimulators of interferon-g production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiological antagonist. Proc. Natl. Acad. Sci. U.S.A. 90:1993;3725-3729.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3725-3729
    • Tripp, C.S.1    Wolf, S.F.2    Unanue, E.R.3
  • 60
    • 0023726231 scopus 로고
    • Deactivation of macrophages by transforming growth factor β
    • Tsunawaki S., Sporn M., Ding A., Nathan C.F. Deactivation of macrophages by transforming growth factor β Nature. 334:1988;260-262.
    • (1988) Nature , vol.334 , pp. 260-262
    • Tsunawaki, S.1    Sporn, M.2    Ding, A.3    Nathan, C.F.4
  • 63
    • 0029883204 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide inhibits IL-4 production in murine T cells by a post-transcriptional mechanism
    • Wang H.Y., Xin Z., Tang H., Ganea D. Vasoactive intestinal peptide inhibits IL-4 production in murine T cells by a post-transcriptional mechanism. J. Immunol. 156:1996;3243-3253.
    • (1996) J. Immunol. , vol.156 , pp. 3243-3253
    • Wang, H.Y.1    Xin, Z.2    Tang, H.3    Ganea, D.4
  • 64
    • 0001141089 scopus 로고
    • Cell sources of natural killer cell stimulatory factor (NKSF/IL-12) transcripts and subunit expression
    • Wolf S., Seiburth D., Perussia B., Yetz-Adalpe J., D'Andrea A., Trinchieri G. Cell sources of natural killer cell stimulatory factor (NKSF/IL-12) transcripts and subunit expression. FASEB J. 6:1992;A1335.
    • (1992) FASEB J. , vol.6 , pp. 1335
    • Wolf, S.1    Seiburth, D.2    Perussia, B.3    Yetz-Adalpe, J.4    D'Andrea, A.5    Trinchieri, G.6
  • 65
    • 0028987562 scopus 로고
    • Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
    • Wysocka M., Kubin M., Vieira L.Q., Ozmen L., Garotta G., Scott P., Trinchieri G. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:1995;672-676.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 672-676
    • Wysocka, M.1    Kubin, M.2    Vieira, L.Q.3    Ozmen, L.4    Garotta, G.5    Scott, P.6    Trinchieri, G.7
  • 66
    • 0030975009 scopus 로고    scopus 로고
    • Novel cyclic peptide agonist of high potency and selectivity for the type II vasoactive intestinal peptide receptor
    • Xia M., Sreedharan S.P., Bolin D.R., Gaufo G.O., Goetzl E.J. Novel cyclic peptide agonist of high potency and selectivity for the type II vasoactive intestinal peptide receptor. J. Pharmacol. Exp. Ther. 281:1997;629-633.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 629-633
    • Xia, M.1    Sreedharan, S.P.2    Bolin, D.R.3    Gaufo, G.O.4    Goetzl, E.J.5
  • 67
    • 0032516760 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages
    • Xin Z., Sriram S. Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages. J. Neuroimmunol. 89:1998;206-212.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 206-212
    • Xin, Z.1    Sriram, S.2
  • 68
    • 0027942040 scopus 로고
    • Vasoactive intestinal peptide inhibits interleukin (IL)-2 and IL-4 production in murine thymocytes activated via TCR/CD3 complex
    • Xin Z., Tang H., Ganea D. Vasoactive intestinal peptide inhibits interleukin (IL)-2 and IL-4 production in murine thymocytes activated via TCR/CD3 complex. J. Neuroimmunol. 54:1994;59-68.
    • (1994) J. Neuroimmunol. , vol.54 , pp. 59-68
    • Xin, Z.1    Tang, H.2    Ganea, D.3


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