Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 6193-6206

  Castaño, Tania ^a   Encinas, Arantxa ^a   Pérez, Concepción ^a   Castro, Ana ^a   Campillo, Nuria E ^a   Gil, Carmen ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Artificial neural network; CODES; NOS; QSAR; Thiadiazole

Indexed keywords

4 AMINOCARBOHYDROXYMOYLMETHYL 5 BENZOYLIMINO 2 METHYL 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 4 BENZYL 2 (5 METHOXY 4 NITROPHENYL) 5 METHYLCARBAMOYLIMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 4 BENZYL 2 ETHYL 5 METHYLCARBAMOYLIMINO 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 4 BENZYL 2 ETHYL 5 METHYLCARBAMOYLIMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 4 BENZYL 2 TERT BUTYL 5 METHYLCARBAMOYLIMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 5 BENZOYLIMINO 2 METHYL 3 OXO 4 (N 1 PHENYLAMIDINOMETHYL) 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 5 BENZOYLIMINO 2,4 BIS(CYANOMETHYL) 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 5 BENZOYLIMINO 4 CYANOMETHYL 2 METHYL 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 5 BENZOYLIMINO 4 HYDROXYCARBONIMIDOYLMETHYL 2 METHYL 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; 5 BENZOYLIMINO 4 METHOXYCARBONIMIDOYLMETHYL 2 METHYL 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; BENZOYLIMINO 4 CYANOMETHYL 3 OXO 2,3,4,5 TETRAHYDRO 1,2,4 THIADIAZOLE; CITRULLINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; S ETHYL N PHENYLISOTHIOUREA; THIOUREA DERIVATIVE;

ARTICLE; ARTIFICIAL NEURAL NETWORK; DEGENERATIVE DISEASE; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NEUROPROTECTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; ISOENZYMES; NEURAL NETWORKS (COMPUTER); NITRIC OXIDE SYNTHASE TYPE I; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; THIOUREA;

EID: 44449138081     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.036     Document Type: Article

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