Abnormal reorganization in focal hand dystonia - Sensory and motor training programs to retrain cortical function

NeuroRehabilitation

Volumn 23, Issue 1, 2008, Pages 43-53

  Zeuner, K E ^a   Molloy, F M ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b BEAUMONT HOSPITAL   (Ireland)

Author keywords

Abnormal reorganization; Focal hand dystonia; Maladaptive plasticity; Motor training; Sensory training

Indexed keywords

BACLOFEN; BENZODIAZEPINE DERIVATIVE; BOTULINUM TOXIN; CHOLINERGIC RECEPTOR BLOCKING AGENT;

BRAIN CORTEX; BRAIN FUNCTION; CLINICAL FEATURE; DYSTONIA; ELECTROENCEPHALOGRAPHY; FOCAL HAND DYSTONIA; HUMAN; MEDICAL RESEARCH; MODULATION; MOTOR CORTEX; MUSCLE CRAMP; MUSICIAN CRAMP; NERVE CELL PLASTICITY; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; SENSORIMOTOR FUNCTION; SENSORIMOTOR INTEGRATION; SENSORY DYSFUNCTION; TASK PERFORMANCE; TRANSCRANIAL MAGNETIC STIMULATION; WRITER CRAMP; ANIMAL; HAND; KINESIOTHERAPY; NERVE CELL INHIBITION; PHYSIOLOGY;

ANIMALS; CEREBRAL CORTEX; DYSTONIC DISORDERS; EXERCISE THERAPY; HAND; HUMANS; NEURAL INHIBITION; NEURONAL PLASTICITY;

EID: 44449135602     PISSN: 10538135     EISSN: None     Source Type: Journal    
DOI: 10.3233/nre-2008-23105     Document Type: Review

References (133)

1. G. Abbruzzese and A. Berardelli, Sensorimotor integration in movement disorders, Mov Disord 18 (2003), 231-240.
2. G. Abbruzzese, R. Marchese, A. Buccolieri, B. Gasparetto and C. Trompetto, Abnormalities of sensorimotor integration in focal dystonia: a transcranial magnetic stimulation study, Brain 124 (2001), 537-545.
3. G.E. Alexander and M.D. Crutcher, Functional architecture of basal ganglia circuits: neural substrates of parallel processing, Trends Neurosci 13 (1990), 266-271.
4. E. Altenmuller, Focal dystonia: advances in brain imaging and understanding of fine motor control in musicians, Hand Clin 19 (2003), 523-538, xi.
5. W. Bara-Jimenez, M.J. Catalan, M. Hallett and C. Gerloff, Abnormal somatosensory homunculus in dystonia of the hand, Ann Neurol 44 (1998), 828-831.
6. W. Bara-Jimenez, Shelton and M. Hallett, Spatial discrimination is abnormal in focal hand dystonia, Neurology 55 (2000), 1869-1873.
7. W. Bara-Jimenez, P. Shelton, T.D. Sanger and M. Hallett, Sensory discrimination capabilities in patients with focal hand dystonia, Ann Neurol 47 (2000), 377-380.
8. A. Berardelli, J.C. Rothwell, M. Hallett, P.D. Thompson, M. Manfredi and C.D. Marsden, The pathophysiology of primary dystonia, Brain 121 (1998), 1195-1212.
9. D. Berg, M.J. Herrmann, T.J. Muller, W.K. Strik, D. Aranda, T. Koenig, M. Naumann and A.J. Fallgatter, Cognitive response control in writer's cramp, Eur J Neurol 8 (2001), 587-594.
10. E.L. Bienenstock, L.N. Cooper and P.W. Munro, Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex, J Neurosci 2 (1982), 32-48.
11. D.T. Blake, N.N. Byl and M.M. Merzenich, Representation of the hand in the cerebral cortex, Behav Brain Res 135 (2002), 179-184.
12. S.B. Bressman, D. de Leon, D. Raymond, L.J. Ozelius, X.O. Breakefield, T.G. Nygaard, L. Almasy, N.J. Risch, P.L. Kramer, Clinical-genetic spectrum of primary dystonia, Adv Neurol 78 (1998), 79-91.
13. S.B. Bressman, G.A. Heiman, T.G. Nygaard, L.J. Ozelius, A.L. Hunt, M.F. Brin, M.F. Gordon, C.B. Moskowitz, D. de Leon, R.E. Burke et al., Astudy of idiopathic torsion dystonia in a non-Jewish family: evidence for genetic heterogeneity, Neurology 44 (1994), 283-287.
14. S.B. Bressman, A.L. Hunt, G.A. Heiman, M.F. Brin, R.E. Burke, S. Fahn, J.M. Trugman, D. de Leon, P.L. Kramer, K.C. Wilhelmsen et al., Exclusion of the DYT1 locus in a non-Jewish family with early-onset dystonia, Mov Disord 9 (1994), 626-632.
15. C.M. Butefisch, B. Boroojerdi, R. Chen, F. Battaglia and M. Hallett, Task-dependent intracortical inhibition is impaired in focal hand dystonia, Mov Disord 20 (2005), 545-551.
16. S. Butterworth, S. Francis, E. Kelly, F. McGlone, R. Bowtell and G.V. Sawle, Abnormal cortical sensory activation in dystonia: An fMRI study, Mov Disord 18 (2003), 673-682.
17. N. Byl, F. Wilson, M. Merzenich, M. Melnick, P. Scott, A. Oakes and A. McKenzie, Sensory dysfunction associated with repetitive strain injuries of tendinitis and focal hand dystonia: a comparative study, J Orthop Sports Phys Ther 23 (1996), 234-244.
18. N.N. Byl, Focal hand dystonia may result from aberrant neuroplasticity, Adv Neuro 94 (2004), 19-28.
19. N.N. Byl, What can we learn from animal models of focal hand dystonia? Rev Neurol (Paris) 159 (2003), 857-873.
20. N.N. Byl and A. McKenzie, Treatment effectiveness for patients with a history of repetitive hand use and focal hand dystonia: a planned, prospective follow-up study, J Hand Ther 13 (2000), 289-301.
21. N.N. Byl and A. McKenzie, Treatment effectiveness for patients with a history of repetitive hand use and focal hand dystonia: a planned, prospective follow-up study, J Hand Ther 13 (2000), 289-301.
22. N.N. Byl, A. McKenzie and S.S. Nagarajan, Differences in somatosensory hand organization in a healthy flutist and a flutist with focal hand dystonia: a case report, J Hand Ther 13 (2000), 302-309.
23. N.N. Byl, A. McKenzie and S.S. Nagarajan, Differences in somatosensory hand organization in a healthy flutist and a flutist with focal hand dystonia: a case report, J Hand Ther 13 (2000), 302-309.
24. N.N. Byl and M. Melnick, The neural consequences of repetition: clinical implications of a learning hypothesis, J Hand Ther 10 (1997), 160-174.
25. N.N. Byl, M.M. Merzenich, S. Cheung, P. Bedenbaugh, S.S. Nagarajan and W.M. Jenkins, A primate model for studying focal dystonia and repetitive strain injury: effects on the primary somatosensory cortex, Phys Ther 77 (1997), 269-284.
26. N.N. Byl, M.M. Merzenich and W.M. Jenkins, A primate genesis model of focal dystonia and repetitive strain injury: I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys, Neurology 47 (1996), 508-520.
27. N.N. Byl, S. Nagajaran and A.L. McKenzie, Effect of sensory discrimination training on structure and function in patients with focal hand dystonia: a case series, Arch Phys Med Rehabil 84 (2003), 1505-1514.
28. M.L. Byrnes, G.W. Thickbroom, S.A. Wilson, P. Sacco, J.M. Shipman, R. Stell and F.L. Mastaglia, The corticomotor representation of upper limb muscles in writer's cramp and changes following botulinum toxin injection, Brain 121 (1998), 977-988.
29. V. Candia, T. Elbert, E. Altenmuller, H. Rau, T. Schafer and E. Taub, Constraint-induced movement therapy for focal hand dystonia in musicians, Lancet 353 (1999), 42.
30. V. Candia, T. Schafer, E. Taub, H. Rau, E. Altenmuller, B. Rockstroh and T. Elbert, Sensory motor retuning: a behavioral treatment for focal hand dystonia of pianists and guitarists, Arch Phys Med Rehabil 83 (2002), 1342-1348.
31. V. Candia, C. Wienbruch, T. Elbert, B. Rockstroh and W. Ray, Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization, Proc Natl Acad Sci USA 100 (2003), 7942-7946.
32. A.O. Ceballos-Baumann, R.E. Passingham, T. Warner, E.D. Playford, C.D. Marsden and D.J. Brooks, Overactive prefrontal and underactive motor cortical areas in idiopathic dystonia, Ann Neurol 37 (1995), 363-372.
33. A.O. Ceballos-Baumann, G. Sheean, R.E. Passingham, C.D. Marsden and D.J. Brooks, Botulinum toxin does not reverse the cortical dysfunction associated with writer's cramp. A PET study, Brain 120 (1997), 571-582.
34. P. Chamagne, Functional dystonia in musicians: fundamental principles of the rehabilitation, Ann Chir Main Memb Super 12 (1993), 63-67.
35. R. Chen and M. Hallett, Focal dystonia and repetitive motion disorders, Clin Orthop (1998), 102-106.
36. R. Chen, E.M. Wassermann, M. Canos and M. Hallett, Impaired inhibition in writer's cramp during voluntary muscle activation, Neurology 49 (1997), 1054-1059.
37. L.G. Cohen and M. Hallett, Hand cramps: clinical features and electromyographic patterns in a focal dystonia, Neurology 38 (1988), 1005-1012.
38. C.P. Das, D. Dressler and M. Hallett, Botulinum toxin therapy of writer's cramp, Eur J Neurol 13(Suppl 1) (2006), 55-59.
39. G. Defazio, G. Abbruzzese, P. Livrea and A. Berardelli, Epidemiology of primary dystonia, Lancet Neurol 3 (2004), 673-678.
40. G. Defazio, A. Berardelli and M. Hallett, Do primary adult-onset focal dystonias share aetiological factors? Brain (2007).
41. G. Defazio, P. Livrea, G. Guanti, V. Lepore and E. Ferrari, Genetic contribution to idiopathic adult-onset blepharospasm and cranial-cervical dystonia, Eur Neurol 33 (1993), 345-350.
42. G. Deuschl, C. Toro, J. Matsumoto and M. Hallett, Movement-related cortical potentials in writer's cramp see comments, Ann Neurol 38 (1995), 862-868.
43. T. Elbert, V. Candia, E. Altenmuller, H. Rau, A. Sterr, B. Rockstroh, C. Pantev and E. Taub, Alteration of digital representations in somatosensory cortex in focal hand dystonia, Neuroreport 9 (1998), 3571-3575.
44. T. Elbert, C. Pantev, C. Wienbruch, B. Rockstroh and E. Taub, Increased cortical representation of the fingers of the left hand in string players, Science 270 (1995), 305-307.
45. S. Fahn, Assessment of the primary dystonias, in: Quantification of neurologic deficit, T. Munsat, ed., (Butterworths, Boston, London, Singapore, Sydney, Toronto, Wellington, 1989).
46. S.R. Filipovic, M. Ljubisavljevic, M. Svetel, S. Milanovic, A. Kacar and V.S. Kostic, Impairment of cortical inhibition in writer's cramp as revealed by changes in electromyographic silent period after transcranial magnetic stimulation, Neurosci Lett 222 (1997), 167-170.
47. M. Fiorio, M. Tinazzi and S.M. Aglioti, Selective impairment of hand mental rotation in patients with focal hand dystonia, Brain 129 (2006), 47-54.
48. M. Fiorio, M. Tinazzi, L. Bertolasi and S.M. Aglioti, Temporal processing of visuotactile and tactile stimuli in writer's cramp, Ann Neurol 53 (2003), 630-635.
49. E. Frasson, A. Priori, L. Bertolasi, F. Mauguiere, A. Fiaschi and M. Tinazzi, Somatosensory disinhibition in dystonia, Mov Disord 16 (2001), 674-682.
50. S.J. Frucht, Focal task-specific dystonia in musicians, Adv Neurol 94 (2004), 225-230.
51. P. Fuhr, R. Agostino and M. Hallett, Spinal motor neuron excitability during the silent period after cortical stimulation, Electroencephalogr Clin Neurophysiol 81 (1991), 257-262.
52. G. Garraux, A. Bauer, T. Hanakawa, T. Wu, K. Kansaku and M. Hallett, Changes in brain anatomy in focal hand dystonia, Ann Neurol 55 (2004), 736-739.
53. R.A. Grunewald, Y. Yoneda, J.M. Shipman and H.J. Sagar, Idiopathic focal dystonia: a disorder of muscle spindle afferent processing? Brain 120 (1997), 2179-2185.
54. M. Hallett, Disorder of movement preparation in dystonia, Brain 123 (2000), 1765-1766.
55. M. Hallett, Is dystonia a sensory disorder? Ann Neurol 38 (1995), 139-140.
56. M. Hallett, The neurophysiology of dystonia, Arch Neurol 55 (1998), 601-603.
57. M. Hallett, Pathophysiology of writer's cramp, Hum Mov Sci 25 (2006), 454-463.
58. M. Hallett, Physiology of basal ganglia disorders: An overview, Can J Neurol Sci 20 (1993), 177-183.
59. M. Hallett, Physiology of dystonia, Adv Neurol 78 (1998), 11-18.
60. T. Hamano, R. Kaji, M. Katayama, T. Kubori, A. Ikeda, H. Shibasaki, J. Kimura, Abnormal contingent negative variation in writer's cramp, Clin Neurophysiol 110 (1999), 508-515.
61. F. Hummel, F. Andres, E. Altenmuller, J. Dichgans and C. Gerloff, Inhibitory control of acquired motor programmes in the human brain, Brain 125 (2002), 404-420.
62. V. Ibanez, N. Sadato, B. Karp, M.P. Deiber and M. Hallett, Deficient activation of the motor cortical network in patients with writer's cramp, Neurology 53 (1999), 96-105.
63. K. Ikoma, A. Samii, B. Mercuri, E.M. Wassermann and M. Hallett, Abnormal cortical motor excitability in dystonia, Neurology 46 (1996), 1371-1376.
64. H.C. Jabusch, H. Vauth and E. Altenmuller, Quantification of focal dystonia in pianists using scale analysis, Mov Disord 19 (2004), 171-180.
65. H C. Jabusch, D. Zschucke, A. Schmidt, S. Schuele and E. Altenmuller, Focal dystonia in musicians: Treatment strategies and long-term outcome in 144 patients, Mov Disord 20 (2005), 1623-1626.
66. K.O. Johnson and J.R. Phillips, Tactile spatial resolution. I. Two-point discrimination, gap detection, grating resolution, and letter recognition, J Neurophysiol 46 (1981), 1177-1192.
67. R. Kaji, N. Kohara, M. Katayama, T. Kubori, T. Mezaki, H. Shibasaki and J. Kimura, Muscle afferent block by intramuscular injection of lidocaine for the treatment of writer's cramp, Muscle Nerve 18 (1995), 234-235.
68. R. Kaji, J.C. Rothwell, M. Katayama, T. Ikeda, T. Kubori, N. Kohara, T. Mezaki, H. Shibasaki and J. Kimura, Tonic vibration reflex and muscle afferent block in writer's cramp, Ann Neurol 38 (1995), 155-162.
69. M.S. Lee, J.O. Rinne, A. Ceballos-Baumann, P.D. Thompson and C.D. Marsden, Dystonia after head trauma, Neurology 44 (1994), 1374-1378.
70. A. Lerner, H. Shill, T. Hanakawa, K. Bushara, A. Goldfine and M. Hallett, Regional cerebral blood flow correlates of the severity of writer's cramp symptoms, Neuroimage 21 (2004), 904-913.
71. A.H. Lockwood, Medical problems of musicians, N Engl J Med 320 (1989), 221-227.
72. C. Lorenzano, M.A. Priori, A. Curra, F. Gilio, M. Manfredi and A. Berardelli, Impaired EMG inhibition elicited by tendon stimulation in dystonia, Neurology 55 (2000), 1789-1793.
73. N. Mai and C. Marquardt, Schreibtraining in der neurologischen Rehabilitation, E.K.N. (EKN), ed., Materialien fuer die Rehabilitation (Borgmann Publishing, Dortmund, ed. 2nd edition, 1999), pp. 1-87.
74. C. Marquardt and N. Mai, A computational procedure for movement analysis in handwriting, J Neurosci Methods 52 (1994), 39-45.
75. C.D. Marsden, J.A. Obeso, J.J. Zarranz and A.E. Lang, The anatomical basis of symptomatic hemidystonia, Brain 108(Pt 2) (1985), 463-483.
76. S. Meunier, L. Garnero, A. Ducorps, L. Mazieres, S. Lehericy, S.T. du Montcel, B. Renault and M. Vidailhet, Human brain mapping in dystonia reveals both endophenotypic traits and adaptive reorganization, Ann Neurol 50 (2001), 521-527.
77. S. Meunier, S. Lehericy, L. Garnero and M. Vidailhet, Dystonia: lessons from brain mapping, Neuroscientist 9 (2003), 76-81.
78. F.M. Molloy, T.D. Carr, K.E. Zeuner, J.M. Dambrosia and M. Hallett, Abnormalities of spatial discrimination in focal and generalized dystonia, Brain 126 (2003), 2175-2182.
79. N. Murase, R. Kaji, H. Shimazu, M. Katayama-Hirota, A. Ikeda, N. Kohara, J. Kimura, H. Shibasaki and J.C. Rothwell, Abnormal premovement gating of somatosensory input in writer's cramp, Brain 123 (2000), 1813-1829.
80. N. Murase, J. C. Rothwell, R. Kaji, R. Urushihara, K. Nakamura, N. Murayama, T. Igasaki, M. Sakata-Igasaki, T. Mima, A. Ikeda and H. Shibasaki, Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp, Brain 128 (2005), 104-115.
81. T. Odergren, N. Iwasaki, J. Borg and H. Forssberg, Impaired sensory-motor integration during grasping in writer's cramp, Brain 119 (1996), 569-583.
82. T. Odergren, S. Stone-Elander and M. Ingvar, Cerebral and cerebellar activation in correlation to the action-induced dystonia in writer's cramp, Mov Disord 13 (1998), 497-508.
83. T. Oga, M. Honda, K. Toma, N. Murase, T. Okada, T. Hanakawa, N. Sawamoto, T. Nagamine, J. Konishi, H. Fukuyama, R. Kaji and H. Shibasaki, Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp: an fMRI study, Brain 125 (2002), 895-903.
84. W.G. Ondo, J.M. Desaloms, J. Jankovic and R.G. Grossman, Pallidotomy for generalized dystonia, Mov Disord 13 (1998), 693-698.
85. M. Peller, K.E. Zeuner, A. Munchau, A. Quartarone, M. Weiss, A. Knutzen, M. Hallett, G. Deuschl and H.R. Siebner, The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp, Brain 129 (2006), 2697-2708.
86. A. Pesenti, S. Barbieri and A. Priori, Limb immobilization for occupational dystonia: a possible alternative treatment for selected patients, Adv Neurol 94 (2004), 247-254.
87. E.D. Playford, R.E. Passingham, C.D. Marsden and D.J. Brooks, Increased activation of frontal areas during arm movement in idiopathic torsion dystonia, Mov Disord 13 (1998), 309-318.
88. A. Priori, A. Pesenti, A. Cappellari, G. Scarlato and S. Barbieri, Limb immobilization for the treatment of focal occupational dystonia, Neurology 57 (2001), 405-409.
89. A. Quartarone, V. Rizzo, S. Bagnato, F. Morgante, A. Sant'Angelo, M. Romano, D. Crupi, P. Girlanda, J.C. Rothwell and H.R. Siebner, Homeostatic-like plasticity of the primary motor hand area is impaired in focal hand dystonia, Brain 128 (2005), 1943-1950.
90. A. Quartarone, H.R. Siebner and J.C. Rothwell, Task-specific hand dystonia: can too much plasticity be bad for you? Trends Neurosci 29 (2006), 192-199.
91. M.C. Ridding, G. Sheean, J.C. Rothwell, R. Inzelberg and T. Kujirai, Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia, J Neurol Neurosurg Psychiatry 59 (1995), 493-498.
92. T.D. Sanger, D. Tarsy and A. Pascual-Leone, Abnormalities of spatial and temporal sensory discrimination in writer's cramp, Mov Disord 16 (2001), 94-99.
93. A. Schmidt, H.C. Jabusch, E. Altenmuller, J. Hagenah, N. Bruggemann, K. Hedrich, R. Saunders-Pullman, S.B. Bressman, P.L. Kramer and C. Klein, Dominantly transmitted focal dystonia in families of patients with musician's cramp, Neurology 67 (2006), 691-693.
94. S. Schuele, H.C. Jabusch, R.J. Lederman and E. Altenmuller, Botulinum toxin injections in the treatment of musician's dystonia, Neurology 64 (2005), 341-343.
95. M.P. Sheehy and C.D. Marsden, Writers' cramp-a focal dystonia, Brain 105 (1982), 461-480.
96. H.R. Siebner, C. Auer, A. Ceballos-Baumann and B. Conrad, Has repetitive transcranial magnetic stimulation of the primary motor hand area a therapeutic application in writer's cramp? Electroencephalogr Clin Neurophysiol Suppl 51 (1999), 265-275.
97. H.R. Siebner, C. Auer and B. Conrad, Abnormal increase in the corticomotor output to the affected hand during repetitive transcranial magnetic stimulation of the primary motor cortex in patients with writer's cramp, Neurosci Lett 262 (1999), 133-136.
98. H.R. Siebner, N. Lang, V. Rizzo, M.A. Nitsche, W. Paulus, R.N. Lemon and J.C. Rothwell, Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex, J Neurosci 24 (2004), 3379-3385.
99. H.R. Siebner, J.M. Tormos, A.O. Ceballos-Baumann, C. Auer, M.D. Catala, B. Conrad and A. Pascual-Leone, Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer's cramp, Neurology 52 (1999), 529-537.
100. Y.H. Sohn and M. Hallett, Disturbed surround inhibition in focal hand dystonia, Ann Neurol 56 (2004), 595-599.
101. Y.H. Sohn and M. Hallett, Surround inhibition in human motor system, Exp Brain Res 158 (2004), 397-404.
102. Y. H. Sohn, H.Y. Jung, A. Kaelin-Lang and M. Hallett, Excitability of the ipsilateral motor cortex during phasic voluntary hand movement, Exp Brain Res 148 (2003), 176-185.
103. A. Sterr, M. Muller, T. Elbert, B. Rockstroh and E. Taub, Development of cortical reorganization in the somatosensory cortex of adult Braille students, Electroencephalogr Clin Neurophysiol Suppl 49 (1999), 292-298.
104. A. Sterr, M.M. Muller, T. Elbert, B. Rockstroh, C. Pantev and E. Taub, Changed perceptions in Braille readers, Nature 391 (1998), 134-135.
105. A. Sterr, M.M. Muller, T. Elbert, B. Rockstroh, C. Pantev and E. Taub, Perceptual correlates of changes in cortical representation of fingers in blind multifinger Braille readers, J Neurosci 18 (1998), 4417-4423.
106. C.M. Stinear and W.D. Byblow, Impaired modulation of intracortical inhibition in focal hand dystonia, Cereb Cortex 14 (2004), 555-561.
107. R.R. Tasker, T. Doorly and K. Yamashiro, Thalamotomy in generalized dystonia, Adv Neurol 50 (1988), 615-631.
108. E. Taub, G. Uswatte and R. Pidikiti, Constraint-Induced Movement Therapy: a new family of techniques with broad application to physical rehabilitation - a clinical review, J Rehabil Res Dev 36 (1999), 237-251.
109. L.W. Tempel and J.S. Perlmutter, Abnormal cortical responses in patients with writer's cramp published erratum appears in Neurology 44(12) (Dec. 1999), 2411;
110. Neurology 43 (1993), 2252-2257.
111. L.W. Tempel and J.S. Perlmutter, Abnormal vibration-induced cerebral blood flow responses in idiopathic dystonia, Brain 113(Pt 3) (1990), 691-707.
112. P.D. Thompson, J.P. Dick, B.L. Day, J.C. Rothwell, A. Berardelli, T. Kachi and C.D. Marsden, Electrophysiology of the corticomotoneurone pathways in patients with movement disorders, Mov Disord 1 (1986), 113-117.
113. M. Tinazzi, S. Farina, K. Bhatia, A. Fiaschi, G. Moretto, L. Bertolasi, S. Zarattini and N. Smania, TENS for the treatment of writer's cramp dystonia: a randomized, placebo-controlled study, Neurology 64 (2005), 1946-1948.
114. M. Tinazzi, E. Frasson, L. Bertolasi, A. Fiaschi and S. Aglioti, Temporal discrimination of somesthetic stimuli is impaired in dystonic patients, Neuroreport 10 (1999), 1547-1550.
115. M. Tinazzi, A. Priori, L. Bertolasi, E. Frasson, F. Mauguiere and A. Fiaschi, Abnormal central integration of a dual somatosensory input in dystonia. Evidence for sensory overflow, Brain 123(Pt 1) (2000), 42-50.
116. M. Tinazzi, T. Rosso and A. Fiaschi, Role of the somatosensory system in primary dystonia, Mov Disord 18 (2003), 605-622.
117. M. Tinazzi, S. Zarattini, M. Valeriani, S. Romito, S. Farina, G. Moretto, N. Smania, A. Fiaschi and G. Abbruzzese, Long-lasting modulation of human motor cortex following prolonged transcutaneous electrical nerve stimulation (TENS) of forearm muscles: evidence of reciprocal inhibition and facilitation, Exp Brain Res 161 (2005), 457-464.
118. M. Tinazzi, S. Zarattini, M. Valeriani, C. Stanzani, G. Moretto, N. Smania, A. Fiaschi and G. Abbruzzese, Effects of transcutaneous electrical nerve stimulation on motor cortex excitability in writer's cramp: neurophysiological and clinical correlations, Mov Disord 21 (2006), 1908-1913.
119. E.S. Tolosa and J.F.M. Marti, Adult-Onset Idiopathic Torsion Dystonia, in: Movement Disorders, R.L. Watts, W.C. Koller, eds, (McGraw Hill, New York, 2004), (vol. 1), pp. 511-525.
120. C. Toro, G. Deuschl and M. Hallett, Movement-related electroencephalographic desynchronization in patients with hand cramps: evidence for motor cortical involvement in focal dystonia, Ann Neurol 47 (2000), 456-461.
121. G.G. Turrigiano and S.B. Nelson, Hebb and homeostasis in neuronal plasticity, Curr Opin Neurobiol 10 (2000), 358-364.
122. G.G. Turrigiano and S.B. Nelson, Homeostatic plasticity in the developing nervous system, Nat Rev Neurosci 5 (2004), 97-107.
123. R.W. Van Boven, R.H. Hamilton, T. Kauffman, J.P. Keenan and A. Pascual-Leone, Tactile spatial resolution in blind braille readers, Neurology 54 (2000), 2230-2236.
124. R.W. Van Boven and K.O. Johnson, The limit of tactile spatial resolution in humans: grating orientation discrimination at the lip, tongue, and finger, Neurology 44 (1994), 2361-2366.
125. W. Van der Kamp, J.C. Rothwell, P.D. Thompson, B.L. Day and C.D. Marsden, The movement-related cortical potential is abnormal in patients with idiopathic torsion dystonia, Mov Disord 10 (1995), 630-633.
126. H.M. Waddy, N.A. Fletcher, A.E. Harding and C.D. Marsden, A genetic study of idiopathic focal dystonias, Ann Neurol 29 (1991), 320-324.
127. K.J. Werhahn, E. Kunesch, S. Noachtar, R. Benecke and J. Classen, Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans, J Physiol 517 (1999), 591-597.
128. J. Wissel, C. Kabus, R. Wenzel, S. Klepsch, U. Schwarz, A. Nebe, L. Schelosky, U. Scholz and W. Poewe, Botulinum toxin in writer's cramp: objective response evaluation in 31 patients, J Neurol Neurosurg Psychiatry 61 (1996), 172-175.
129. S. Yazawa, A. Ikeda, R. Kaji, K. Terada, T. Nagamine, K. Toma, T. Kubori, J. Kimura and H. Shibasaki, Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials, Brain 122(Pt 7) (1999), 1357-1366.
130. K. Yoshida, R. Kaji, N. Kohara, N. Murase, A. Ikeda, H. Shibasaki and T. Iizuka, Movement-related cortical potentials before jaw excursions in oromandibular dystonia, Mov Disord 18 (2003), 94-100.
131. K.E. Zeuner, W. Bara-Jimenez, P.S. Noguchi, S.R. Goldstein, J.M. Dambrosia and M. Hallett, Sensory training for patients with focal hand dystonia, Ann Neurol 51 (2002), 593-598.
132. K.E. Zeuner and M. Hallett, Sensory training as treatment for focal hand dystonia: a 1-year follow-up, Mov Disord 18 (2003), 1044-1047.
133. K.E. Zeuner, H.A. Shill, Y.H. Sohn, F.M. Molloy, B.C. Thornton, J.M. Dambrosia and M. Hallett, Motor training as treatment in focal hand dystonia, Mov Disord 20 (2005), 335-341.