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Akaneya Y., Tsumoto T., Hatanaka H. Brain-derived neurotrophic factor enhances long-term potentiation in rat visual cortex. J Neurophysiol. 76:1997;4198-4201.
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Akaneya, Y.1
Tsumoto, T.2
Hatanaka, H.3
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42
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0031028559
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BDNF and NGF potentiate excitatory synaptic transmission in the rat visual cortex
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Carmignoto G., Pizzorusso T., Tia S., Vicini S. BDNF and NGF potentiate excitatory synaptic transmission in the rat visual cortex. J Physiol. 498:1997;153-164.
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Carmignoto, G.1
Pizzorusso, T.2
Tia, S.3
Vicini, S.4
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43
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0033213270
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Essential role for TrkB receptors in hippocampus-mediated learning
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Using a CNS-targeted knockout of TrkB receptors that occurs postnatally, the authors assess the effects of TrkB loss on hippocampal LTP and spatial memory tasks. Homozygotes show an almost complete loss of LTP and are impaired in spatial memory tasks. Interestingly, heterozygotes show a significant reduction in LTP that is almost as severe as the homozygotes, yet show no behavioral impairments. These data suggest either that very low levels of LTP are sufficient for spatial memory or that there is a strong dissociation between LTP and spatial memory.
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Minichiello L., Korte M., Wolfer D., Kuhn K., Unkicker K., Cestari V., Rossi Arnaud C., Lipp H-P., Bonhoeffer T., Klein R. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 24:1999;401-414. Using a CNS-targeted knockout of TrkB receptors that occurs postnatally, the authors assess the effects of TrkB loss on hippocampal LTP and spatial memory tasks. Homozygotes show an almost complete loss of LTP and are impaired in spatial memory tasks. Interestingly, heterozygotes show a significant reduction in LTP that is almost as severe as the homozygotes, yet show no behavioral impairments. These data suggest either that very low levels of LTP are sufficient for spatial memory or that there is a strong dissociation between LTP and spatial memory.
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(1999)
Neuron
, vol.24
, pp. 401-414
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Minichiello, L.1
Korte, M.2
Wolfer, D.3
Kuhn, K.4
Unkicker, K.5
Cestari, V.6
Rossi Arnaud, C.7
Lipp, H.-P.8
Bonhoeffer, T.9
Klein, R.10
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44
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0033200089
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Activation of a TRPC3-dependent cation current through the neurotrophin BDNF
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Li H-S., Xu X-Z.S., Montell C. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24:1999;261-273.
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(1999)
Neuron
, vol.24
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Li, H.-S.1
Xu, X.-Z.S.2
Montell, C.3
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45
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0033613422
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Neurotrophin-evoked rapid excitation through TrkB receptors
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This paper (see also [44]) expands the already significant array of effects BDNF can have on central neurons by demonstrating that brief puffs of BDNF can directly depolarize a variety of central neurons. This effect is rapid (milliseconds) - too fast to be mediated by the receptor tyrosine kinase phosphorylation thought to underlie most other effects of BDNF. This effect is only seen with high concentrations of BDNF (greater than 20 ng/ml), and does not appear to saturate at concentrations (100-200 ng/ml) at which other effects of BDNF saturate.
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Kafitz K.W., Rose C.R., Thoenen H., Konnerth A. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature. 401:1999;918-921. This paper (see also [44]) expands the already significant array of effects BDNF can have on central neurons by demonstrating that brief puffs of BDNF can directly depolarize a variety of central neurons. This effect is rapid (milliseconds) - too fast to be mediated by the receptor tyrosine kinase phosphorylation thought to underlie most other effects of BDNF. This effect is only seen with high concentrations of BDNF (greater than 20 ng/ml), and does not appear to saturate at concentrations (100-200 ng/ml) at which other effects of BDNF saturate.
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(1999)
Nature
, vol.401
, pp. 918-921
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Kafitz, K.W.1
Rose, C.R.2
Thoenen, H.3
Konnerth, A.4
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46
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0028858681
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Neurotrophins regulate dendritic growth in developing visual cortex
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McAllister A.K., Lo D.C., Katz L.C. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron. 15:1995;791-803.
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(1995)
Neuron
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McAllister, A.K.1
Lo, D.C.2
Katz, L.C.3
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47
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0032168158
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Opposite effects of BDNF on the quantal amplitude of pyramidal and interneuron excitatory synapses
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Rutherford L.C., Nelson S.B., Turrigiano G.G. Opposite effects of BDNF on the quantal amplitude of pyramidal and interneuron excitatory synapses. Neuron. 21:1998;521-530.
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(1998)
Neuron
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Rutherford, L.C.1
Nelson, S.B.2
Turrigiano, G.G.3
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48
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0032854908
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BDNF regulates the intrinsic excitability of cortical neurons
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••], and that these synaptic changes are mediated through the activity-dependent release of BDNF [47]. Here, they show that the changes in intrinsic excitability produced by activity blockade are also mediated by BDNF. Application of BDNF during the period of activity deprivation prevented - while preventing endogenously released BDNF from activating TrkB receptors mimicked - the effects of activity blockade. This suggests that BDNF produces coordinated changes in intrinsic and synaptic properties that act synergistically to regulate firing rates.
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••], and that these synaptic changes are mediated through the activity-dependent release of BDNF [47]. Here, they show that the changes in intrinsic excitability produced by activity blockade are also mediated by BDNF. Application of BDNF during the period of activity deprivation prevented - while preventing endogenously released BDNF from activating TrkB receptors mimicked - the effects of activity blockade. This suggests that BDNF produces coordinated changes in intrinsic and synaptic properties that act synergistically to regulate firing rates.
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(1999)
Learn Memory
, vol.6
, pp. 284-291
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Desai, N.S.1
Rutherford, L.C.2
Turrigiano, G.G.3
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49
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17344369060
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Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus
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Gottschalk W., Pozzo-Miller L.T., Figurov A., Lu B. Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus. J Neurosci. 18:1998;6830-6839.
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(1998)
J Neurosci
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Gottschalk, W.1
Pozzo-Miller, L.T.2
Figurov, A.3
Lu, B.4
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50
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0030612039
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A synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus
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A synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. J Neurosci. 17:1997;2959-2966.
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(1997)
J Neurosci
, vol.17
, pp. 2959-2966
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Tanaka, T.1
Saito, H.2
Matsuki, N.3
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51
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0032429305
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Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus
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Frerking M., Malenka R.C., Nicoll R.A. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. J Neurophysiol. 80:1998;3383-3386.
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(1998)
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Frerking, M.1
Malenka, R.C.2
Nicoll, R.A.3
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52
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0031008630
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BDNF mediates the activity-dependent regulation of inhibition in neocortical cultures
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Rutherford L.C., DeWan A., Lauer H., Turrigiano G.G. BDNF mediates the activity-dependent regulation of inhibition in neocortical cultures. J Neurosci. 17:1997;4527-4535.
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(1997)
J Neurosci
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Rutherford, L.C.1
Dewan, A.2
Lauer, H.3
Turrigiano, G.G.4
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53
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0033567012
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Long-term enhancement of central synaptic transmission by chronic BDNF treatment
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Sherwood N.T., Lo D.C. Long-term enhancement of central synaptic transmission by chronic BDNF treatment. J Neurosci. 19:1999;7025-7036.
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(1999)
J Neurosci
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Sherwood, N.T.1
Lo, D.C.2
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54
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0033578688
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BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
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Huang Z.J., Kirkwood A., Pizzorusso T., Porciatti V., Morales B., Bear M.F., Maffei L., Tonegawa S. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 98:1999;1-20.
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(1999)
Cell
, vol.98
, pp. 1-20
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Huang, Z.J.1
Kirkwood, A.2
Pizzorusso, T.3
Porciatti, V.4
Morales, B.5
Bear, M.F.6
Maffei, L.7
Tonegawa, S.8
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