Utilizing a -100 °C microplate CCD Imager, yttrium silicate coated 384-microplates and ultra-performance liquid chromatography for improved profiling of radiolabeled drug metabolites in complex biological samples

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 868, Issue 1-2, 2008, Pages 49-57

  Dear, G J ^a   Patel, N ^a   Weightman, Alan ^a   Pirard, Hans ^b   Talvitie, Miika ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b PERKINELMER INC   (United States)

Author keywords

Drug metabolism; LumaPlate 384; Metabolite profiling; UPLC; ViewLux

Indexed keywords

CHARGE COUPLED DEVICES; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; YTTRIUM COMPOUNDS;

BIOLOGICAL SAMPLES; DRUG METABOLITES; MICROPLATE CCD IMAGERS;

METABOLITES;

DRUG METABOLITE; YTTRIUM SILICATE Y 90; DRUG; RADIOISOTOPE;

ARTICLE; CAMERA; DRUG DETERMINATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGING SYSTEM; ISOTOPE LABELING; PRIORITY JOURNAL; ANIMAL; BILE; CHEMISTRY; COLD; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; METHODOLOGY; RAT; STANDARD;

ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; COLD; LIVER; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; RADIOISOTOPES; RATS; REFERENCE STANDARDS;

EID: 44449134642     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.04.013     Document Type: Article

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