Phospholamban ablation by RNA interference increases Ca2+uptake into rat cardiac myocyte sarcoplasmic reticulum

Journal of Molecular and Cellular Cardiology

Volumn 37, Issue 3, 2004, Pages 691-698

  Watanabe, Atai ^a   Arai, Masashi ^a   Yamazaki, Miki ^a   Koitabashi, Norimichi ^a   Wuytack, Frank ^b   Kurabayashi, Masahiko ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Calcium; Gene expression; haemagglutinating virus of Japan; HVJ; Phospholamban; phospholamban; PLB; RNA interference; RNAi; sarcoplasmic reticulum; SERCA2; siRNA; small interfering RNA; SR; SR Ca2+ ATPase 2

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALSEQUESTRIN; HYDROGEN PEROXIDE; MESSENGER RNA; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM ADENOSINE TRIPHOSPHATASE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS VECTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; GENE EXPRESSION; GENETIC TRANSFECTION; HEART FAILURE; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SARCOPLASMIC RETICULUM; VIRUS ENVELOPE; VIRUS HEMAGGLUTINATION;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; GENE EXPRESSION REGULATION; MYOCYTES, CARDIAC; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TRANSFECTION;

EID: 4444377434     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2004.06.009     Document Type: Article

References (30)

1. Hobai I.A., O'Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation. 103:2001;1577-1584
2. Beuckelmann D.J., Nabauer M., Erdmann E. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation. 85:1992;1046-1055
3. 2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res. 83:1998;1205-1214
4. 2+-ATPase. Circ Res. 83:1998;889-897
5. Koss K.L., Kranias E.G. Phospholamban: a prominent regulator of myocardial contractility. Circ Res. 79:1996;1059-1063
6. Luo W., Grupp I.L., Harrer J., Ponniah S., Grupp G., Duffy J.J., et al. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res. 75:1994;401-409
7. Minamisawa S., Hoshijima M., Chu G., Ward C.A., Frank K., Gu Y., et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99:1999;313-322
8. del Monte F., Harding S.E., Dec G.W., Gwathmey J.K., Hajjar R.J. Targeting phospholamban by gene transfer in human heart failure. Circulation. 105:2002;904-907
9. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811
10. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498
11. Miyagishi M., Hayashi M., Taira K. Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev. 13:2003;1-7
12. Kaneda Y., Nakajima T., Nishikawa T., Yamamoto S., Ikegami H., Suzuki N., et al. Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system. Mol Ther. 6:2002;219-226
13. Yokoyama T., Sekiguchi K., Tanaka T., Tomaru K., Arai M., Suzuki T., et al. Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts. Am J Physiol. 276:1999;H1968-H1976
14. 2+-ATPase gene. J Biol Chem. 263:1988;15024-15031
15. Arai M., Alpert N.R., Periasamy M. Cloning and characterization of the gene encoding rabbit cardiac calsequestrin. Gene. 109:1991;275-279
16. Eggermont J.A., Wuytack F., Verbist J., Casteels R. Expression of endoplasmic-reticulum Ca(2+)-pump isoforms and of phospholamban in pig smooth-muscle tissues. Biochem J. 271:1990;649-653
17. 2+ transport by cyclic 3′,5′-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochim Biophys Acta. 844:1985;193-199
18. Ide T., Tsutsui H., Kinugawa S., Suematsu N., Hayashidani S., Ichikawa K., et al. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res. 86:2000;152-157
19. Arai M., Alpert N.R., MacLennan D.H., Barton P., Periasamy M. Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circ Res. 72:1993;463-469
20. Mercadier J.J., Lompre A.M., Duc P., Boheler K.R., Fraysse J.B., Wisnewsky C., et al. Altered sarcoplasmic reticulum Ca(2+)-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest. 85:1990;305-309
21. Toyofuku T., Kurzydlowski K., Tada M., MacLennan D.H. Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban. J Biol Chem. 269:1994;22929-22932
22. Hoshijima M., Ikeda Y., Iwanaga Y., Minamisawa S., Date M.O., Gu Y., et al. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 8:2002;864-871
23. Periasamy M., Reed T.D., Liu L.H., Ji Y., Loukianov E., Paul R.J., et al. Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 274:1999;2556-2562
24. Luo W., Wolska B.M., Grupp I.L., Harrer J.M., Haghighi K., Ferguson D.G., et al. Phospholamban gene dosage effects in the mammalian heart. Circ Res. 78:1996;839-847
25. Sato Y., Kiriazis H., Yatani A., Schmidt A.G., Hahn H., Ferguson D.G., et al. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J Biol Chem. 276:2001;9392-9399
26. Song Q., Schmidt A.G., Hahn H.S., Carr A.N., Frank B., Pater L., et al. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 111:2003;859-867
27. Miyagishi M., Taira K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol. 20:2002;497-500
28. Paul C.P., Good P.D., Winer I., Engelke D.R. Effective expression of small interfering RNA in human cells. Nat Biotechnol. 20:2002;505-508
29. Bekeredjian R., Chen S., Frenkel P.A., Grayburn P.A., Shohet R.V. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation. 108:2003;1022-1026
30. Beeri R., Guerrero J.L., Supple G., Sullivan S., Levine R.A., Hajjar R.J. New efficient catheter-based system for myocardial gene delivery. Circulation. 106:2002;1756-1759