Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR)

Journal of Steroid Biochemistry and Molecular Biology

Volumn 91, Issue 4-5, 2004, Pages 191-196

  Loinder, Kristina ^a   Söderström, Mats ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Coactivator; Corepressor; Differentiation; Nuclear receptor; Transcriptional regulation

Indexed keywords

CELL NUCLEUS RECEPTOR; NUCLEAR RECEPTOR COREPRESSOR; NUCLEIC ACID BINDING PROTEIN; RETINOIC ACID RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; MOLECULAR INTERACTION; NONHUMAN; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HUMANS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THYROID HORMONE RECEPTORS BETA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 4444371790     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2004.04.006     Document Type: Article

References (28)

1. C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev. 14 2 2000 121 141
2. A.J. Hörlein, A.M. Näär, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Söderström, and C.K. Glass Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor Nature 377 6548 1995 397 404
3. R. Kurokawa, M. Söderström, A. Hörlein, S. Halachmi, M. Brown, M.G. Rosenfeld, and C.K. Glass Polarity-specific activities of retinoic acid receptors determined by a co-repressor Nature 377 6548 1995 451 454
4. L. Nagy, H.Y. Kao, D. Chakravarti, R.J. Lin, C.A. Hassig, D.E. Ayer, S.L. Schreiber, and R.M. Evans Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase Cell 89 3 1997 373 380
5. T. Heinzel, R.M. Lavinsky, T.M. Mullen, M. Söderström, C.D. Laherty, J. Torchia, W.M. Yang, G. Brard, S.D. Ngo, J.R. Davie, E. Seto, R.N. Eisenman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression Nature 387 6628 1997 43 48
6. J.D. Chen, and R.M. Evans A transcriptional co-repressor that interacts with nuclear hormone receptors Nature 377 6548 1995 454 457
7. X. Hu, and M.A. Lazar The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors Nature 402 6757 1999 93 96
8. A.M. Näär, J.M. Boutin, S.M. Lipkin, V.C. Yu, J.M. Holloway, C.K. Glass, and M.G. Rosenfeld The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors Cell 65 7 1991 1267 1279
9. K. Umesono, and R.M. Evans Determinants of target gene specificity for steroid/thyroid hormone receptors Cell 57 1989 1139 1146
10. X.K. Zhang, B. Hoffmann, P.B. Tran, G. Graupner, and M. Pfahl Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors Nature 355 6359 1992 441 446
11. 3 signalling Nature 355 6359 1992 446 449
12. P. Germain, J. Iyer, C. Zechel, and H. Gronemeyer Co-regulator recruitment and the mechanism of retinoic acid receptor synergy Nature 415 6868 2002 187 192
13. J.J. Voegel, M.J. Heine, M. Tini, V. Vivat, P. Chambon, and H. Gronemeyer The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways EMBO J. 17 2 1998 507 519
14. D.M. Heery, E. Kalkhoven, S. Hoare, and M.G. Parker A signature motif in transcriptional co-activators mediates binding to nuclear receptors Nature 387 6634 1997 733 736
15. L. Nagy, H.Y. Kao, J.D. Love, C. Li, E. Banayo, J.T. Gooch, V. Krishna, K. Chatterjee, R.M. Evans, and J.W. Schwabe Mechanism of corepressor binding and release from nuclear hormone receptors Genes Dev. 13 24 1999 3209 3216
16. A.K. Shiau, D. Barstad, P.M. Loria, L. Cheng, P.J. Kushner, D.A. Agard, and G.L. Greene The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen Cell 95 7 1998 927 937
17. S. Westin, R. Kurokawa, R.T. Nolte, G.B. Wisely, E.M. McInerney, D.W. Rose, M.V. Milburn, M.G. Rosenfeld, and C.K. Glass Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators Nature 395 6698 1998 199 202
18. R.T. Nolte, G.B. Wisely, S. Westin, J.E. Cobb, M.H. Lambert, R. Kurokawa, M.G. Rosenfeld, T.M. Willson, C.K. Glass, and M.V. Milburn Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma Nature 395 6698 1998 137 143
19. W. Feng, R.C. Ribeiro, R.L. Wagner, H. Nguyen, J.W. Apriletti, R.J. Fletterick, J.D. Baxter, P.J. Kushner, and B.L. West Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors Science 280 5370 1998 1747 1749
20. B.D. Darimont, R.L. Wagner, J.W. Apriletti, M.R. Stallcup, P.J. Kushner, J.D. Baxter, R.J. Fletterick, and K.R. Yamamoto Structure and specificity of nuclear receptor-coactivator interactions Genes Dev. 12 21 1998 3343 3356
21. V. Perissi, L.M. Staszewski, E.M. McInerney, R. Kurokawa, A. Krones, D.W. Rose, M.H. Lambert, M.V. Milburn, C.K. Glass, and M.G. Rosenfeld Molecular determinants of nuclear receptor-corepressor interaction Genes Dev. 13 24 1999 3198 3208
22. P. Webb, C. Valentine, P. Nguyen, R.H. Price Jr., A. Marimuthu, B.L. West, J.D. Baxter, and P.J. Kushner ERb binds N-CoR in the presence of estrogens via an LXXLL-like motif in the N-CoR C-terminus Nucl. Recept. 1 1 2003 4
23. B. Liu, M. Gross, J. ten Hoeve, and K. Shuai A transcriptional corepressor of Stat1 with an essential LXXLL signature motif Proc. Natl. Acad. Sci. U.S.A. 98 6 2001 3203 3207
24. D. Li, F. Wang, and H.H. Samuels Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation Mol. Cell. Biol. 21 24 2001 8371 8384
25. G.B. Potter, G.M. Beaudoin III, C.L. DeRenzo, J.M. Zarach, S.H. Chen, and C.C. Thompson The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes Dev. 15 20 2001 2687 2701
26. I. Fernandes, Y. Bastien, T. Wai, K. Nygard, R. Lin, O. Cormier, H.S. Lee, F. Eng, N.R. Bertos, N. Pelletier, S. Mader, V.K. Han, X.J. Yang, and J.H. White Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms Mol. Cell 11 1 2003 139 150
27. H. Zhang, J.S. Thomsen, L. Johansson, J.Å. Gustafsson, and E. Treuter DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors J. Biol. Chem. 275 51 2000 39855 39859
28. X. Li, E.A. Kimbrel, D.J. Kenan, and D.P. McDonnell Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation Mol. Endocrinol. 16 7 2002 1482 1491