Aminoacyl-tRNA synthetase complexes: Beyond translation

Journal of Cell Science

Volumn 117, Issue 17, 2004, Pages 3725-3734

  Lee, Sang Won ^a   Cho, Byeong Hoon ^a   Park, Sang Gyu ^a   Kim, Sunghoon ^a  

^a Seoul National University   (South Korea)

Author keywords

Aminoacyl tRNA synthase; Macromolecular protein complex; Multi functionality; Protein network; Protein synthesis

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; ARGININE TRANSFER RNA LIGASE; ISOLEUCINE TRANSFER RNA LIGASE; METHIONINE TRANSFER RNA LIGASE; PROTEIN P18; PROTEIN P43; SYNAPTOPHYSIN;

CATALYSIS; CHROMOSOMAL LOCALIZATION; ENZYME BINDING; MACROMOLECULE; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION;

AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ARGININE-TRNA LIGASE; CYTOKINES; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; HUMANS; ISOLEUCINE-TRNA LIGASE; METHIONINE-TRNA LIGASE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 4444369924     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01342     Document Type: Review

References (127)

1. Ahn, H. C., Kim, S. and Lee, B. J. (2003). Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43. FEBS Lett. 542, 119-124.
2. Akins, R. A. and Lambowitz, A. M. (1987). A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof. Cell 50, 331-345.
3. Arenberg, D. A., Polverini, P. J., Kunkel, S. L., Shanafelt, A., Hesselgesser, J., Horuk, R. and Strieter, R. M. (1997). The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer. J. Leukoc. Biol. 62, 554-562.
4. Asano, K., Merrick, W. C. and Hershey, J. W. (1997). The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. J. Biol. Chem. 272, 23477-23480.
5. Barbarese, E., Koppel, D. E., Deutscher, M. P., Smith, C. L., Ainger, K., Morgan, F. and Carson, J. H. (1995). Protein translation components are colocalized in granules in oligodendrocytes. J. Cell Sci. 108, 2781-2790.
6. Barnett, G., Jakobsen, A. M., Tas, M., Rice, K., Carmichael, J. and Murray, J. C. (2000). Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress. Cancer Res. 60, 2850-2857.
7. Bec, G., Kerjan, P., Zha, X. D. and Waller, J. P. (1989). Valyl-tRNA synthetase from rabbit liver. 1. Purification as a heterotypic complex in association with elongation factor 1. J. Biol. Chem. 264, 21131-21137.
8. Bec, G., Kerjan, P. and Waller, J. P. (1994). Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. J Biol. Chem. 269, 2086-2092.
9. Benkovic, S. J., Valentine, A. M. and Salinas, F. (2001). Replisome-mediated DNA replication. Annu. Rev. Biochem. 70, 181-208.
10. Brandsma, M., Kerjan, P., Dijk, J., Janssen, G. M. and Moller, W. (1995). Valyl-tRNA synthetase from Artemia. Purification and association with elongation factor 1. Eur. J. Biochem. 233, 277-282.
11. Brevet, A., Geffrotin, C. and Kellermann, O. (1982). Macromolecular complex of aminoacyt-tRNA synthetases from sheep liver. Identification of the methionyl-tRNA synthetase component by affinity labeling. Eur. J. Biochem. 124, 483-488.
12. Brunel, C., Romby, P., Moine, H., Caillet, J., Grunberg-Manago, M., Springer, M., Ehresmann, B. and Ehresmann, C. (1993). Translational regulation of the Escherichia coli threonyl-tRNA synthetase gene: structural and functional importance of the thrS operator domains. Biochimie 75, 1167-1179.
13. Burbaum, J. J. and Schimmel, P. (1991). Structural relationships and the classification of aminoacyl-tRNA synthetases. J. Biol. Chem. 266, 16965-16968.
14. Cahuzac, B., Berthonneau, E., Birlirakis, N., Guittet, E. and Mirande, M. (2000). A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases. EMBO J. 19, 445-452.
15. Calado, A., Treichel, N., Muller, E. C., Otto, A. and Kutay, U. (2002). Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J. 21, 6216-6224.
16. Cherniack, A. D., Garriga, G., Kittle, J. D., Jr, Akins, R. A. and Lambowitz, A. M. (1990). Function of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases. Cell 62, 745-755.
17. Cirakoglu, B. and Waller, J. P. (1985). Multiple forms of arginyl- and lysyl-tRNA synthetases in rat liver: a re-evaluation. Biochim. Biophys: Acta 829, 173-179.
18. Clark-Lewis, I., Schumacher, C., Baggiolini, M. and Moser, B. (1991). Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities. J. Biol. Chem. 266, 23128-23134.
19. Clark-Lewis, I., Dewald, B., Geiser, T., Moser, B. and Baggiolini, M. (1993). Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg. Proc. Natl. Acad. Sci. USA 90, 3574-3577.
20. Conaway, J. W., Bradsher, J. N., Tan, S. and Conaway, R. C. (1993). Transcription factor SIII: a novel component of the RNA polymerase II elongation complex. Cell Mol. Biol. Res. 39, 323-329.
21. Cusack, S., Hartlein, M. and Leberman, R. (1991). Sequence, structure and evolutionary relationships between class 2 aminoacyl-tRNA synthetases. Nucleic Acids Res. 19, 3489-3498.
22. Damuni, Z., Caudwell, F. B. and Cohen, P. (1982). Regulation of the aminoacyl-tRNA synthetase complex of rat liver by phosphorylation/dephosphorylation in vitro and in vivo. Eur. J. Biochem. 129, 57-65.
23. Dang, C. V. and Yang, D. C. H. (1979). Disassembly and gross structure of particulate aminoacyl-tRNA synthetases from rat liver. Isolation and the structural relationship of synthetase complexes. J. Biol. Chem. 254, 5350-5356.
24. Dang, C. V., Yang, D. C. H. and Pollard, T. D. (1983). Association of methionyl-tRNA synthetase with detergent-insoluble components of the rough endoplasmic reticulum. J. Cell Biol. 96, 1138-1147.
25. Deinert, K., Fasiolo, F., Hurt, E. C. and Simos, G. (2001). Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs. J. Biol. Chem. 276, 6000-6008.
26. Eriani, G., Delarue, M., Poch, O., Gangloff, J. and Moras, D. (1990). Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347, 203-206.
27. Francin, M. and Mirande, M. (2003). Functional dissection of the eukaryotic-specific tRNA-interacting factor of lysyl-tRNA synthetase. J. Biol. Chem. 278, 1472-1479.
28. Francin, M., Kaminska, M., Kerjan, P. and Mirande, M. (2002). The N-terminal domain of mammalian lysyl-tRNA synthetase is a functional tRNA-binding domain. J. Biol. Chem. 277, 1762-1769.
29. Frugier, M., Moulinier, L. and Giege, R. (2000). A domain in the N-terminal extension of class IIb eukaryotic aminoacyl-tRNA synthetases is important for tRNA binding. EMBO J. 19, 2371-2380.
30. Galani, K., Grosshans, H., Deinert, K., Hurt, E. C. and Simos, G. (2001). The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J. 20, 6889-6898.
31. Gimbrone, M. A., Jr, Nagel, T. and Topper, J. N. (1997). Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J. Clin. Invest. 100, S61-S65.
32. Glickman, M. H., Rubin, D. M., Coux, O., Wefes, I., Pfeifer, G., Cjeka, Z., Baumeister, W., Fried, V. A. and Finley, D. (1998). A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94, 615-623.
33. Goldgur, Y. and Safro, M. (1994). Aminoacyl-tRNA synthetases from Haloarcula marismortui: an evidence for a multienzyme complex in a procaryotic system. Biochem. Mol. Biol. Int. 32, 1075-1083.
34. Goldgur, Y., Mosyak, L., Reshetnikova, L., Ankilova, V., Lavrik, O., Khodyreva, S. and Safro, M. (1997). The crystal structure of phenylalanyl-tRNA synthetase from Thermus thermophilus complexed with cognate tRNAPhe. Structure 5, 59-68.
35. Grosshans, H., Hurt, E. and Simos, G. (2000a). An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes Dev. 14, 830-840.
36. Grosshans, H., Simos, G. and Hurt, E. (2000b). Review: transport of tRNA out of the nucleus - direct channeling to the ribosome? J. Struct. Biol. 129, 288-294.
37. Han, J. M., Kim, J. Y. and Kim, S. (2003). Molecular network and functional implications of macromolecular tRNA synthetase complex. Biochem. Biophys. Res. Commun. 303, 985-993.
38. Herbert, C. J., Dujardin, G., Labouesse, M. and Slonimski, P. P. (1988). Divergence of the mitochondrial leucyl tRNA synthetase genes in two closely related yeasts Saccharomyces cerevisiae and Saccharomyces douglasii: a paradigm of incipient evolution. Mol. Gen. Genet. 213, 297-309.
39. Hopper, A. K. and Phizicky, E. M. (2003). tRNA transfers to the limelight. Genes Dev. 17, 162-180.
40. Ibba, M. and Soil, D. (2001). The renaissance of aminoacyl-tRNA synthesis. EMBO Rep. 2, 382-387.
41. Jeffery, C. J. (1999). Moonlighting proteins. Trends Biochem. Sci. 24, 8-11.
42. Jeong, E. J., Hwang, G. S., Kim, K. H., Kim, M. J., Kim, S. and Kim, K. S. (2000). Structural analysis of multi-functional peptide motifs present in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. Biochemistry 39, 15775-15782.
43. Johnson, D. L., Dang, C. V. and Yang, D. C. H. (1980). Purification and characterization of lysyl-tRNA synthetase after dissociation of the particulate aminoacyl-tRNA synthetases from rat liver. J Biol. Chem. 255, 4362-4366.
44. Kaminska, M., Shalak, V. and Mirande, M. (2001). The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. Biochemistry 40, 14309-14316.
45. Kang, J., Kim, T., Ko, Y. G., Rho, S. B., Park, S. G., Kim, M. J., Kwon, H. J. and Kim, S. (2000). Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. J. Biol. Chem. 275, 31682-31688.
46. Kao, J., Ryan, J., Brett, J., Chen, J., Shen, H., Fan, Y. G., Godman, G., Familletti, P. C., Wang, F., Pan, Y. C. et al. (1992). Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host response mechanisms. J. Biol. Chem. 267, 20239-20247.
47. Kellermann, O., Tonetti, H., Brevet, A., Mirande, M., Pailliez, J. P. and Waller, J. P. (1982). Macromolecular complexes from sheep and rabbit containing seven aminoacyl-tRNA synthetases. I. Species specificity of the polypeptide composition. J. Biol. Chem. 257, 11041-11048.
48. Kerjan, P., Triconnet, M. and Waller, J. P. (1992). Mammalian prolyl-tRNA synthetase corresponds to the approximately 150 kDa subunit of the high-M(r) aminoacyl-tRNA synthetase complex. Biochimie 74, 195-205.
49. Kerjan, P., Cerini, C., Semeriva, M. and Mirande, M. (1994). The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Biochim. Biophys. Acta 1199, 293-297.
50. Kim, J. E., Kim, K. H., Lee, S. W., Seol, W., Shiba, K. and Kim, S. (2000). An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. Nucleic Acids Res. 28, 2866-2872.
51. Kim, J. Y., Kang, Y. S., Lee, J. W., Kim, H. J., Ahn, Y. H., Park, H., Ko, Y. G. and Kim, S. (2002). p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc. Natl. Acad. Sci. USA 99, 7912-7916.
52. Kim, M. J., Park, B. J., Kang, Y. S., Kim, H. J., Park, J. H., Kang, J. W., Lee, S. W., Han, J. M., Lee, H. W. and Kim, S. (2003). Downregulation of fuse-binding protein and c-myc by tRNA synthetase cofactor, p38, is required for lung differentiation. Nat. Genet. 34, 330-336.
53. Kim, S., Landro, J. A., Gale, A. J. and Schimmel, P. (1993). C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation. Biochemistry 32, 13026-13031.
54. Kim, T., Park, S. G., Kim, J. E., Seol, W., Ko, Y. G. and Kim, S. (2000). Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex. J. Biol. Chem. 275, 21768-21772.
55. Kim, Y., Shin, J., Li, R., Cheong, C., Kim, K. and Kim, S. (2000). A novel anti-tumor cytokine contains an RNA-binding motif present in aminoacyl-tRNA synthetases. J. Biol. Chem. 275, 27062-27068.
56. Kimball, S. R. (2001). Regulation of translation initiation by amino acids in eukaryotic cells. Prog. Mol. Subcell. Biol. 26, 155-184.
57. Kise, Y., Lee, S. W., Park, S. G., Fukai, S., Sengoku, T., Ishii, R., Yokoyama, S., Kim, S. and Nureki, O. (2004). A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. Nat. Struct. Mol. Biol. 11, 149-156.
58. Kisselev, L. L. and Wolfson, A. D. (1994). Aminoacyl-tRNA synthetase from higher eukaryotes. Prog. Nucleic Acid Res. Mol. Biol. 48, 83-142.
59. Knies, U. E., Behrensdorf, H. A., Mitchell, C. A., Deutsch, U., Risau, W., Drexler, H. C. A. and Cluass, M. (1998). Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc. Natl. Acad. Sci. USA 95, 12322-12327.
60. Ko, Y. G., Kang, Y. S., Kim, E. K., Park, S. G. and Kim, S. (2000). Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J. Cell Biol. 149, 567-574.
61. Ko, Y. G., Kim, E. Y., Kim, T., Park, H., Park, H. S., Choi, E. J. and Kim, S. (2001a). Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276, 6030-6036.
62. Ko, Y. G., Park, H., Kim, T., Lee, J. W., Park, S. G., Seol, W., Kint, J. E., Lee, W. H., Kim, S. H., Park, J. E. et al. (2001b). A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. J. Biol. Chem. 276, 23028-23033.
63. Ko, Y. G., Park, H. and Kim, S. (2002). Novel regulatory interactions and activities of mammalian tRNA synthetases. Proteomics 2, 1304-1310.
64. Kornelyuk, A. I., Klimenko, I. V. and Odynets, K. A. (1995). Conformational change of mammalian tyrosyl-tRNA synthetase induced by tyrosyl adenylate formation. Biochem. Mol. Biol. Int. 35, 317-322.
65. Labouesse, M. (1990). The yeast mitochondrial leucyl-tRNA synthetase is a splicing factor for the excision of several group I introns. Mol. Gen. Genet. 224, 209-221.
66. Lee, J. S., Park, S. G., Park H., Seol, W., Lee, S. W. and Kim, S. (2002). Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. Biochem. Biophys. Res. Commun. 291, 158-164.
67. Lipman, R. S., Sowers, K. R. and Hou, Y. M. (2000). Synthesis of cysteinyl-tRNA(Cys) by a genome that lacks the normal cysteine-tRNA synthetase. Biochemistry 39, 7792-7798.
68. Lipman, R. S., Chen, J., Evilia, C., Vitseva, O. and Hou, Y. M. (2003). Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaea. Biochemistry 42, 7487-7496.
69. Lund, E. and Dahlberg, J. E. (1998). Proofreading and aminoacylation of tRNAs before export from the nucleus. Science 282, 2082-2085.
70. Martinis, S. A., Plateau, P., Cavarelli, J. and Florentz, C. (1999). Aminoacyl-tRNA synthetases: a family of expanding functions. EMBO J. 18, 4591-4596.
71. Mirande, M. (1991). Aminoacyl-tRNA synthetase family from prokaryotes and eukaryotes: structural domains and their implications. Prog. Nucleic Acid Res. Mol. Biol. 40, 95-142.
72. Mirande, M., Kellermann, O. and Waller, J. P. (1982). Macromolecular complexes from sheep and rabbit containing seven aminoacyl-tRNA synthetases. II. Structural characterization of the polypeptide components and immunological identification of the methionyl-tRNA synthetase subunit. J. Biol. Chem. 257, 11049-11055.
73. Mirande, M., le Corre, D., Louvard, D., Reggio, H., Pailliez, J. P. and Waller, J. P. (1985a). Association of an aminoacyl-tRNA synthetase complex and of phenylalanyl-tRNA synthetase with the cytoskeletal framework fraction from mammalian cells. Exp. Cell Res. 156, 91-102.
74. Mirande, M., le Corre, D. and Waller, J. P. (1985b). A complex from cultured Chinese hamster ovary cells containing nine aminoacyl-tRNA synthetases. Thermolabile leucyl-tRNA synthetase from the tsH1 mutant cell line is an integral component of this complex. Eur. J. Biochem. 147, 281-289.
75. Morales, A. J., Swairjo, M. A. and Schimmel, P. (1999). Structure-specific tRNA-binding protein from the extreme thermophile Aquifex aeolicus. EMBO J. 18, 3475-3483.
76. Mosyak, L., Reshetnikova, L., Goldgur, Y., Delarue, M. and Safro, M. G. (1995). Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. Nat. Struct. Biol. 2, 537-547.
77. Mucha, P. (2002). Aminoacyl-tRNA synthetases and aminoacylation of tRNA in the nucleus. Acta. Biochim. Pol. 49, 1-10.
78. Nathanson, L. and Deutscher, M. P. (2000). Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex. J. Biol. Chem. 275, 31559-31562.
79. Negrutskii, B. S. and Deutscher, M. P. (1991). Channeling of aminoacyl-tRNA for protein synthesis in vivo. Proc. Natl. Acad. Sci. USA 88, 4991-4995.
80. Negrutskii, B. S. and Deutscher, M. P. (1992). A sequestered pool of aminoacyl-tRNA in mammalian cells. Proc. Natl. Acad. Sci. USA 89, 3601-36044.
81. Negrutskii, B. S., Stapulionis, R. and Deutscher, M. P. (1994). Supramolecular organization of the mammalian translation system. Proc. Natl. Acad. Sci. USA 91, 964-968.
82. Negrutskii, B. S., Budkevich, T. V., Shalak, V. F., Turkovskaya, G. V. and El'skaya, A. V. (1996). Rabbit translation elongation factor 1 alpha stimulates the activity of homologous aminoacyl-tRNA synthetase. FEBS Lett. 382, 18-20.
83. Negrutskii, B. S., Shalak, V. F., Kerjan, P., El'skaya, A. V. and Mirande, M. (1999). Functional interaction of mammalian valyl-tRNA synthetase with elongation factore EF-1alpha in the complex with EF-1H. J. Biol. Chem. 274, 4545-4550.
84. Norcum, M. T. (1989). Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells. J. Biol. Chem. 264, 15043-15051.
85. Norcum, M. T. (1991). Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents. J. Biol. Chem. 266, 15398-15405.
86. Norcum, M. T. and Boisset, N. (2002). Three-dimensional architecture of the eukaryotic multisynthetase complex determined from negatively stained and cryoelectron micrographs. FEBS Lett. 512, 298-302.
87. Norcum, M. T. and Warrington, J. A. (1998). Structural analysis of the multienzyme aminoacyl-tRNA synthetase complex: a three-domain model based on reversible chemical crosslinking. Protein Sci. 7, 79-87.
88. Norcum, M. T. and Warrington, J. A. (2000). The cytokine portion of p43 occupies a central position within the eukaryotic multisynthetase complex. J. Biol. Chem. 275, 17921-17924.
89. Onesti, S., Desogus, G., Brevet, A., Chen, J., Plateau, P., Blanquet, S. and Brick, P. (2000). Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding. Biochemistry 39, 12853-12861.
90. Otani, A., Slike, B. M., Dorrell, M. I., Hood, J., Kinder, K., Ewalt, K. L., Cheresh, D., Schimmel, P. and Friedlander, M. (2002). A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proc. Natl. Acad. Sci. USA 99, 178-183.
91. Park, H., Park, S. G., Lee, J. W., Kim, T., Kim, G., Ko, Y. G. and Kim, S. (2002). Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase associated factor, p43: identification of the related adhesion molecules and signal pathways. J. Leukoc. Biol. 71, 223-230.
92. Park, S. G., Jung, K. H., Lee, J. S., Jo, Y. J., Motegi, H., Kim, S. and Shiba, K. (1999). Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J. Biol. Chem. 274, 16673-16676.
93. Park, S. G., Kang, Y. S., Ahn, Y. H., Lee, S. H., Kim, K. R., Kim, K. W., Koh, G. Y., Ko, Y. G. and Kim, S. (2002). Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J. Biol. Chem. 277, 45243-45248.
94. Pendergast, A. M. and Traugh, J. A. (1985). Alteration of aminoacyl-tRNA synthetase activities by phosphorylation with casein kinase I. J. Biol. Chem. 260, 11769-11774.
95. Pendergast, A. M., Venema, R. C. and Traugh, J. A. (1987). Regulation of phosphorylation of aminoacyl-tRNA synthetases in the high molecular weight core complex in reticulocytes. J. Biol. Chem. 262, 5939-5942.
96. Petrushenko, Z. M., Negrutskii, B. S., Ladokhin, A. S., Budkevich, T. V., Shalak, V. F. and El'skaya, A. V. (1997). Evidence for the formation of an unusual ternary complex of rabbit liver EF-1alpha with GDP and deacylated tRNA. FEBS Lett. 407, 13-17.
97. Putney, S. D. and Schimmel, P. (1981). An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription. Nature 291, 632-635.
98. Quevillon, S. and Mirande, M. (1996). The p18 component of the multisynthetase complex shares a protein motif with the beta and gamma subunits of eukaryotic elongation factor 1. FEBS Lett. 395, 63-67.
99. Quevillon, S., Agou, F., Robinson, J. C. and Mirande, M. (1997). The p43 component of the mammalina multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 272, 32573-32579.
100. Quevillon, S., Robinson, J. C., Berthonneau, E., Siatecka, M. and Mirande, M. (1999). Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J. Mol. Biol. 285, 183-195.
101. Ramakrishnan, V. and White, S. W. (1998). Ribosomal protein structures: insights into the architecture, machinery and evolution of the ribosome. Trends Biochem. Sci. 23, 208-212.
102. Reed, V. S. and Yang, D. C. H. (1994). Characterization of a novel N-terminal peptide in human aspartyl-tRNA synthetase. Roles in the transfer of aminoacyl-tRNA from aminoacyl-tRNA synthetase to the elongation factor 1 alpha. J. Biol. Chem. 269, 32937-32941.
103. Renault, L., Kerjan, P., Pasqualato, S., Menetrey, J., Robinson, J. C., Kawaguchi, S., Vassylyev, D. G., Yokoyama, S., Mirande, M. and Cherfils, J. (2001). Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry. EMBO J. 20, 570-578.
104. Rho, S. B., Lee, K. H., Kim, J. W., Shiba, K., Jo, Y. J. and Kim, S. (1996). Interaction between human tRNA synthetases involves repeated sequence elements. Proc. Natl. Acad. Sci. USA 93, 10128-10133.
105. Rho, S. B., Lee, J. S., Jeong, E. J., Kim, K. S., Kim, Y. G. and Kim, S. (1998). A multifunctional repeated motif is present in human bifunctional tRNA synthetase. J. Biol. Chem. 273, 11267-11273.
106. Rho, S. B., Kim, M. J., Lee, J. S., Seol, W., Motegi, H., Kim, S. and Shiba, K. (1999). Genetic dissection of protein-protein interactions in multi-tRNA syntherase complex. Proc. Natl. Acad. Sci. USA 96, 4488-4493.
107. Robinson, J. C., Kerjan, P. and Mirande, M. (2000). Macromolecular assemblage of aminoacyl-tRNA synthetases: quantitative analysis of protein-protein interactions and mechanism of complex assembly. J. Mol. Biol. 304, 983-994.
108. Rojiani, M. V., Jakubowski, H. and Goldman, E. (1990). Relationship between protein synthesis and concentrations of charged and uncharged tRNATrp in Escherichia coli. Proc. Natl. Acad. Sci. USA 87, 1511-1515.
109. Romby, P., Caillet, J., Ebel, C., Sacerdot, C., Graffe, M., Eyermann, F., Brunel, C., Moine, H., Ehresmann, C., Ehresmann, B. et al. (1996). The expression of E. coli threonyl-tRNA synthetase is regulated at the translational level by symmetrical operator-repressor interactions. EMBO J. 15, 5976-5987.
110. Sanders, J., Brandsma, M., Janssen, G. M. C., Dijk, J. and Moller, W. (1996). Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. J. Cell Sci. 109, 1113-1117.
111. Shalak, V., Kaminska, M., Mitnacht-Kraus, R., Vandenabeele, P., Clauss, M. and Mirande, M. (2001). The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. J. Biol. Chem. 276, 23769-23776.
112. Sihag, R. K. and Deutscher, M. P. (1983). Perturbation of the ammoacyl-tRNA syntherase complex by salts and detergents. Importance of hydrophobic interactions and possible involvement of lipids. J. Biol. Chem. 258, 11846-11850.
113. Simos, G., Segref, A., Fasiolo, F., Hellmuth, K., Shevchenko, A., Mann, M. and Hurt, E. C. (1996). The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J. 5, 5437-5448.
114. Simos, G., Sauer, A., Fasiolo, F. and Hurt, E. C. (1998). A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases. Mol. Cell 1, 235-242.
115. Simos, G., Grosshans, H. and Hurt, E. (2002). Nuclear export of tRNA. Results Probl. Cell Differ. 35, 115-131.
116. Sivaram, P. and Deutscher, M. P. (1990). Existence of two forms of rat liver arginyl-tRNA synthetase suggests channeling of aminoacyl-tRNA for protein synthesis. Proc. Natl. Acad. Sci. USA 87, 3665-3669.
117. Srere, P. A. (1987). Complexes of sequential metabolic enzymes. Annu. Rev. Biochem. 56, 89-124.
118. Stapulionis, R. and Deutscher, M. P. (1995). A channeled tRNA cycle during mammalian protein synthesis. Proc. Natl. Acad. Sci. USA 92, 7158-7161.
119. Swairjo, M. A., Morales, A. J., Wang, C. C., Ortiz, A. R. and Schimmel, P. (2000). Crystal structure of trbp111: a structure-specific tRNA-binding protein. EMBO J. 19, 6287-6298.
120. Valenzuela, D. and Schulman, L. H. (1986). Identification of peptide sequences at the tRNA binding site of Escherichia coli methionyl-tRNA synthetase. Biochemistry 25, 4555-4561.
121. Venema, R. C. and Traugh, J. A. (1991). Protein kinase C phosphorylates glutamyl-tRNA synthetase in rabbit reticulocytes stimulated by tumor promoting phorbol esters. J. Biol. Chem. 266, 5298-5302.
122. Wakasugi, K. and Schimmel, P. (1999a). Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. J. Biol. Chem. 274, 23155-23159.
123. Wakasugi, K. and Schimmel, P. (1999b). Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science 284, 147-151.
124. Wakasugi, K., Slike, B. M., Hood, J., Ewalt, K. L., Cheresh, D. A. and Schimmel, P. (2002a). Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase. J. Biol. Chem. 277, 20124-20126.
125. Wakasugi, K., Slike, B. M., Hood, J., Otani, A., Ewalt, K. L., Friedlander, M., Cheresh, D. A. and Schimmel, P. (2002b). A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc. Natl. Acad. Sci. USA 99, 173-177.
126. Wolfe, C. L., Warrington, J. A., Davis, S., Green, S. and Norcum, M. T. (2003). Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII. Protein Sci. 12, 2282-2290.
127. Yang, D. C. H. (1996). Mammalian aminoacyl-tRNA synthetases. Curr. Top. Cell. Regul. 34, 101-136.