General facile synthesis of 2,5-diarylheteropentalenes

Tetrahedron Letters

Volumn 45, Issue 38, 2004, Pages 7157-7161

  Vachal, Petr ^a   Toth, Leslie M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

2,5 Diarylheteropentalenes; Bromination; Catalysis; Heterocycles; Suzuki

Indexed keywords

FURAN DERIVATIVE; HETEROCYCLIC COMPOUND; HETEROPENTALENE; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PYRROLE DERIVATIVE; THIADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CHEMICAL REACTION; DRUG SYNTHESIS; PHARMACOPHORE; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

LATEOLABRAX JAPONICUS;

EID: 4444361567     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.07.132     Document Type: Article

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50. 4 (0.1 mmol) was added and the mixture was degassed with argon for 2 min after which it was heated under argon to 85 A°C for 3 h. The reaction mixture was combined with 1 M hydrochloric acid (100 mL) and ethyl acetate (200 mL). The organic layer was separated, washed sequentially with 1 M hydrochloric acid (50 mL) and brine (50 mL), and dried over sodium sulfate. The desired product was obtained by column chromatography on silica gel (eluent: hexanes/ethyl acetate)