Substituted furans as inhibitors of the PDE4 enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 323-326

  Perrier, Hélène ^a   Bayly, Christopher ^a   Laliberté, France ^a   Huang, Zheng ^a   Rasori, Roberta ^a   Robichaud, Annette ^a   Girard, Yves ^a   Macdonald, Dwight ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; CILOMILAST; FURAN DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; FERRETS; FURANS; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VOMITING;

EID: 0033535068     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00742-2     Document Type: Article

References (9)

1. (a) Peachell P. T.; Undem, B. D.; Schleimer, R. P.; MacGlashan, D. W., Jr.; Lichtenstein, L. M.; Cieslinski L. B.; Torphy, T. J. J. Immunol. 1992, 148, 2503.
2. (b) Dent G.; Giembycz, M. A.; Rabe, K. F.; Barnes, P. J. Br. J. Pharmacol. 1991, 103, 1339.
3. (a) Schwabe, U.; Miyake, M.; Ohga, Y.; Daly, J. W. Mol. Pharmacol. 1976, 12, 900.
4. (b) Nemoz, G.; Prigent, A. F.; Moueqqit, M.; Fougier, S.; Macovschi, O.; Pacheco, H. Biochem. Pharmacol. 1985, 34, 2997.
5. Hughes, B.; Howat, D.; Lisle, H.; Holbrook, M.; James, T.; Gozzard, N.; Blease, K.; Hughes, P.; Kingaby, R.; Warrellow, G.; Alexander, R.; Head, J.; Boyd, E.; Eaton, M.; Perry, M.; Wales, M.; Smith, B.; Owens, R.; Catterall, C.; Lumb, S.; Russell, A.; Allen, R.; Merriman, M.; Bloxham, D.; Higgs, G. Br. J. Pharmacol. 1996, 118, 1183.
6. Christensen, S. B.; Guider, A.; Forster, C. M.; Gleason, J. G.; Bender, P. E.; Karpinski, J. M.; DeWolf, W. E., Jr.; Barnette, M. S.; Underwood, D. C.; Griswold, D. E.; Cieslinski, L. B.; Burman, M.; Bochnowicz, S.; Osborn, R. R.; Manning, C. D.; Grous, M.; Hillegas, L. M.; Bartus, J. O.; Ryan, M. D.; Eggleston, D. S.; Haltiwanger, R. C.; Torphy, T. J. J. Med. Chem. 1998, 41, 821.
7. Kumar, A.; Boykin, D. W. Synth. Commun. 1995, 25, 2071, and references cited therein.
8. Girotra, N. N.; Biftu, T.; Ponpipom, M. M.; Acton, J. J.; Alberts, A. W.; Bach, T. N.; Ball, R. G.; Bugnianesi, R. L.; Parsons, W. H.; Chabala, J. C.; Davies, P.; Doebber, T.; Doherty, J.; Graham, D. W.; Hwang, S,-B.; Kuo, C.; Lam, M-H.; Luell, S., MacIntyre, D. E.; Meurer, R.; Roberts, C. D.; Sahoo, S. P.; Wu, M. S. J. Med. Chem. 1992, 35, 3474.
9. King, G. L. Can. J. Physio. Pharmacol. 1990, 68, 260.