DNA-mediated fluctuations in ionic current through silicon oxide nanopore channels

Nano Letters

Volumn 4, Issue 8, 2004, Pages 1551-1556

  Chang, H ^a   Kosari, F ^c   Andreadakis, G ^c   Alam, M A ^a   Vasmatzis, G ^c   Bashir, R ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA; NUCLEIC ACID; OXIDE; POLYMER; SILICON DERIVATIVE; SINGLE STRANDED DNA;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; BIOSENSOR; CHANNEL GATING; ELECTRIC CONDUCTIVITY; ION CHANNEL; ION CURRENT; MEASUREMENT; MOLECULE;

EID: 4444348664     PISSN: 15306984     EISSN: None     Source Type: Journal    
DOI: 10.1021/nl049267c     Document Type: Article

References (24)

1. Bezrukov, S.; Vodyanoy, I.; Parsegian, V. A. Nature 1994, 370, 279-281.
2. Cornell, B. A.; Braach-Maksvytis, V. L. B.; King, L. G.; Osman, P. D. J.; Raguse, B.; Wiezorek, L.; Pace, R. J. Nature 1997, 387, 580-583.
3. Kasianowicz, J. J.; Brandin, E.; Branton, D.; Deamer, D. W. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 13770-13773.
4. Akeson, M.; Branton, D.; Kasianowicz, J. J.; Brandin, E.; Deamer, D. W. Biophys. J. 1999, 77, 3227-3233.
5. Meller, A.; Nivon, L.; Brandin, E.; Golovchenko, J.; Branton, D. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 1079-1084.
6. Vercoutere, W.; Winters-Hilt, S.; Olsen, H.; Deamer, D.; Haussler, D.; Akeson, M. Nature Biotechnol. 2001, 19, 248-252.
7. Meller, A.; Nivon, L.; Branton, D. Phys. Rev. Lett. 2001, 86, 3435-3438.
8. Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. Science 1996, 274, 1859-1865.
9. Li, J.; Stein, D.; McMullan, C.; Branton, D.; Aziz, M. J.; Golovchenko, J. A. Nature 2001, 412, 166-169.
10. Li, J.; Gershow, M.; Stein, D.; Brandin, E.; Golovchenko, J. Nature Materials 2003, 2, 611-615.
11. Branton, D.; Golovchenko, J. Nature 1999, 398, 660.
12. Gu, L. Q.; Braha, O.; Conlan, S.; Cheley, S.; Bayley, H. Nature 1999, 398, 686-689.
13. Gu, L. Q.; Serra, M. D.; Vincent, J. B.; Vigh, G.; Cheley, S.; Braha, O.; Bayley, H. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 3959-3964.
14. Gu, L. Q.; Cheley, S.; Bayley, H. Science 2001, 291, 636-640.
15. Storm, A. J.; Chen, J. H.; Ling, X. S.; Zandbergen, H. W.; Dekker, C. Nature Materials 2003, 2, 537-540.
16. Chang, H.; Kosari, F.; Andreadakis, G.; Vasmatzis, G.; Basgall, E.; King, A. H.; Bashir, R. Proceedings of the 2004 Hilton Head MEMS Conference, Hilton Head, SC, 2004.
17. Austin, R. H. Nature Materials 2003, 2, 567-568.
18. Parks, G. A. Chem. Rev. 1965, 65, 177-198.
19. Raiteri, R.; Margesin, B.; Grattarola, M. Sens. Actuators B 1998, 46, 126-132.
20. 19,21
21. Harame, D. L.; Bousse, L. J.; Shott, J. D.; Meindle, J. D. IEEE Trans. Electron Dev. 1987, 34, 1700-1706.
22. These currents and the dimensions of the channel correspond to resistivity of 45-58 Ωcm, and these values are close to the theoretical value of 78 Ωcm for 0.1 M KCl solution. In this calculation, we assume the voltage drop across the pore to be 0.67 of the voltage applied at the electrodes.
23. Daiguji, H.; Yang, P.; Majumdar, A. Nano Lett. 2004, 4, 137-142.
24. Since the mobility of potassium ions in the accumulated channel is known and can be expected to be 3-4x lower that the bulk mobility, the calculated accumulation current can range from ∼28 to 84 pA. Since the blocking current was calculated to be about 19 pA lower than the baseline, the total current could range from 9 to 65 pA. The value of mobility will be independently measured in future experiments.