SCOPUS 정보 검색 플랫폼

Volumn 12, Issue 19, 2004, Pages 5063-5078

Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors

(12) Ochiai, Hiroshi a Odagaki, Yoshihiko a Ohtani, Tazumi a Ishida, Akiharu a Kusumi, Kensuke a Kishikawa, Katuya a Yamamoto, Susumu a Takeda, Hiroshi a Obata, Takaaki a Kobayashi, Kaoru a Nakai, Hisao a Toda, Masaaki a

a ONO PHARMACEUTICAL CO (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYBUTANAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYPROPANAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]BUTANOIC ACID; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]PROPANOIC ACID; 3 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYPROPANAMIDE; 3 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]PROPANOIC ACID; 4 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYPROPANAMIDE; 4 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]BUTANOIC ACID; 5 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 1,3A,4,5,6,6A HEXAHYDROPENTALENE 2 CARBOXYLIC ACID; 5 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] N HYDROXY 1,3A,4,5,6,6A HEXAHYDROPENTALENE 2 CARBOXAMIDE; 5 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] N HYDROXYOCTAHYDROPENTALENE 2 CARBOXAMIDE; 5 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]OCTAHYDROPENTALENE 2 CARBOXYLIC ACID; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; BINDING SITES; BRONCHOCONSTRICTION; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; FERRETS; GASTRIC EMPTYING; GUINEA PIGS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALE; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA; VOMITING;

EID: 4444323214 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2004.07.040 Document Type: Article

Times cited : (6)

References (29)

1
- 0034009080
- S.H. Sondering, and J.A. Beavo Curr. Opin. Cell Biol. 12 2000 174
- (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 174
- Sondering, S.H.¹ Beavo, J.A.²

2
- 0035224418
- M.D. Houslay Prog. Nucleic Acid Res. Mol. Biol. 69 2001 249
- (2001) Prog. Nucleic Acid Res. Mol. Biol. , vol.69 , pp. 249
- Houslay, M.D.¹

3
- 0031914520
- T. Torphy J. Am. J. Respir. Crit. Care Med. 157 1998 351
- (1998) J. Am. J. Respir. Crit. Care Med. , vol.157 , pp. 351
- Torphy, T.¹

4
- 0035188826
- D.M. Essayan J. Allergy Clin. Immunol. 108 2001 671
- (2001) J. Allergy Clin. Immunol. , vol.108 , pp. 671
- Essayan, D.M.¹

5
- 0030984966
- M.M. Teixeira, R.W. Gristwood, N. Cooper, and P.G. Hellewell Trends Pharmacol. Sci. 18 1997 164
- (1997) Trends Pharmacol. Sci. , vol.18 , pp. 164
- Teixeira, M.M.¹ Gristwood, R.W.² Cooper, N.³ Hellewell, P.G.⁴

6
- 4444328883
- A.M. Doherty Curr. Opin. Chem. Biol. 8 1999 65
- (1999) Curr. Opin. Chem. Biol. , vol.8 , pp. 65
- Doherty, A.M.¹

7
- 14444268769
- S.B. Christensen, A. Guider, C.F. Forster, J.G. Gleason, P.E. Bender, J.M. Karponski, W.E. Dewolf, M.S. Barnette, D.C. Underwood, D.E. Griswold, L.B. Cieslinski, M. Burman, S. Bochnowicz, R.R. Osborn, C.D. Manning, M. Grous, L.M. Hillegas, J.O. Bartus, M.D. Ryan, D.S. Eggleston, R.C. Haltiwanger, and T.J. Torphy J. Med. Chem. 41 1998 821
- (1998) J. Med. Chem. , vol.41 , pp. 821
- Christensen, S.B.¹ Guider, A.² Forster, C.F.³ Gleason, J.G.⁴ Bender, P.E.⁵ Karponski, J.M.⁶ Dewolf, W.E.⁷ Barnette, M.S.⁸ Underwood, D.C.⁹ Griswold, D.E.¹⁰ Cieslinski, L.B.¹¹ Burman, M.¹² Bochnowicz, S.¹³ Osborn, R.R.¹⁴ Manning, C.D.¹⁵ Grous, M.¹⁶ Hillegas, L.M.¹⁷ Bartus, J.O.¹⁸ Ryan, M.D.¹⁹ Eggleston, D.S.²⁰ more..

8
- 0037234521
- D.J. Hele, and M.G. Belvisi Exp. Opin. Investig. Drugs 12 2003 5
- (2003) Exp. Opin. Investig. Drugs , vol.12 , pp. 5
- Hele, D.J.¹ Belvisi, M.G.²

9
- 0034942625
- M.A. Giembycz Exp. Opin. Investig. Drugs 10 2001 1361
- (2001) Exp. Opin. Investig. Drugs , vol.10 , pp. 1361
- Giembycz, M.A.¹

10
- 0348147636
- H. Ochiai, T. Ohtani, A. Ishida, K. Kusumi, M. Kato, H. Kohno, K. Kishikawa, T. Obata, H. Nakai, and M. Toda Bioorg. Med. Chem. Lett. 14 2004 207
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 207
- Ochiai, H.¹ Ohtani, T.² Ishida, A.³ Kusumi, K.⁴ Kato, M.⁵ Kohno, H.⁶ Kishikawa, K.⁷ Obata, T.⁸ Nakai, H.⁹ Toda, M.¹⁰

11
- 1242271419
- H. Ochiai, T. Ohtani, A. Ishida, K. Kishikawa, T. Obata, H. Nakai, and M. Toda Bioorg. Med. Chem. Lett. 14 2004 1323
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1323
- Ochiai, H.¹ Ohtani, T.² Ishida, A.³ Kishikawa, K.⁴ Obata, T.⁵ Nakai, H.⁶ Toda, M.⁷

12
- 0002022623
- I. Vaulont, H.J. Gais, N. Reuter, E. Schmitz, and R.K.L. Ossenkamp Eur. J. Org. Chem. 1998 805
- (1998) Eur. J. Org. Chem. , pp. 805
- Vaulont, I.¹ Gais, H.J.² Reuter, N.³ Schmitz, E.⁴ Ossenkamp, R.K.L.⁵

13
- 0018352751
- M. Shibasaki, J. Ueda, and S. Ikegami Tetrahedron Lett. 20 1979 433
- (1979) Tetrahedron Lett. , vol.20 , pp. 433
- Shibasaki, M.¹ Ueda, J.² Ikegami, S.³

14
- 33845551063
- G. Stork, and D.E. Kahne J. Am. Chem. Soc. 105 1983 1072
- (1983) J. Am. Chem. Soc. , vol.105 , pp. 1072
- Stork, G.¹ Kahne, D.E.²

15
- 0006141543
- D.A. Evans, and M.M. Morrissey J. Am. Chem. Soc. 106 1984 3866
- (1984) J. Am. Chem. Soc. , vol.106 , pp. 3866
- Evans, D.A.¹ Morrissey, M.M.²

16
- 0033575442
- M. Lautens, and T. Rovis Tetrahedron 55 1999 8967
- (1999) Tetrahedron , vol.55 , pp. 8967
- Lautens, M.¹ Rovis, T.²

17
- 0026996701
- T.J. Torphy, H. Zhou, and L.B. Cieslinski J. Pharmacol. Exp. Ther. 263 1992 1195
- (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 1195
- Torphy, T.J.¹ Zhou, H.² Cieslinski, L.B.³

18
- 0032576647
- E.F. Kleinman, E. Campbell, L.A. Giordano, V.L. Cohan, T.H. Jenkinson, J.B. Cheng, J.T. Shirley, E.R. Pettipher, E.D. Salter, T.A. Hibbs, F.M. Dicapua, and J. Bordner J. Med. Chem. 41 1998 266
- (1998) J. Med. Chem. , vol.41 , pp. 266
- Kleinman, E.F.¹ Campbell, E.² Giordano, L.A.³ Cohan, V.L.⁴ Jenkinson, T.H.⁵ Cheng, J.B.⁶ Shirley, J.T.⁷ Pettipher, E.R.⁸ Salter, E.D.⁹ Hibbs, T.A.¹⁰ Dicapua, F.M.¹¹ Bordner, J.¹²

19
- 84986512474
- B.R. Brooks, R.E. Bruccoleri, B.D. Olafson, D.J. States, S. Swaminathan, and M. Karplus J. Comput. Chem. 4 1983 187
- (1983) J. Comput. Chem. , vol.4 , pp. 187
- Brooks, B.R.¹ Bruccoleri, R.E.² Olafson, B.D.³ States, D.J.⁴ Swaminathan, S.⁵ Karplus, M.⁶

20
- 0035964174
- S. Liu, F. Laliberte, B. Bobechko, A. Bartlett, P. Lario, E. Gorseth, J.V. Hamme, M.J. Gresser, and Z. Huang Biochemistry 40 2001 10179
- (2001) Biochemistry , vol.40 , pp. 10179
- Liu, S.¹ Laliberte, F.² Bobechko, B.³ Bartlett, A.⁴ Lario, P.⁵ Gorseth, E.⁶ Hamme, J.V.⁷ Gresser, M.J.⁸ Huang, Z.⁹

21
- 0034625541
- R.X. Xu, A.M. Hassell, D. Vanderwall, M.H. Lambert, W.D. Holmes, M.A. Luther, W.J. Rocque, M.V. Milburn, Y. Zhao, H. Ke, and R.T. Nolte Science 288 2000 1822
- (2000) Science , vol.288 , pp. 1822
- Xu, R.X.¹ Hassell, A.M.² Vanderwall, D.³ Lambert, M.H.⁴ Holmes, W.D.⁵ Luther, M.A.⁶ Rocque, W.J.⁷ Milburn, M.V.⁸ Zhao, Y.⁹ Ke, H.¹⁰ Nolte, R.T.¹¹

22
- 0037163858
- M.E. Lee, J. Markowitz, J.O. Lee, and H. Lee FEBS Lett. 530 2002 53
- (2002) FEBS Lett. , vol.530 , pp. 53
- Lee, M.E.¹ Markowitz, J.² Lee, J.O.³ Lee, H.⁴

23
- 0038154006
- Q. Huai, H. Wang, Y. Sun, H.Y. Kim, Y. Liu, and H. Ke Structure 11 2003 865
- (2003) Structure , vol.11 , pp. 865
- Huai, Q.¹ Wang, H.² Sun, Y.³ Kim, H.Y.⁴ Liu, Y.⁵ Ke, H.⁶

24
- 0028244816
- K.J. Tracey, and A. Cerami Annu. Rev. Med. 45 1994 491
- (1994) Annu. Rev. Med. , vol.45 , pp. 491
- Tracey, K.J.¹ Cerami, A.²

25
- 0027096564
- N. Nakagawa, T. Obata, T. Kobayashi, Y. Okada, F. Nambu, T. Terawaki, and H. Aishita Jpn. J. Pharmacol. 60 1992 217
- (1992) Jpn. J. Pharmacol. , vol.60 , pp. 217
- Nakagawa, N.¹ Obata, T.² Kobayashi, T.³ Okada, Y.⁴ Nambu, F.⁵ Terawaki, T.⁶ Aishita, H.⁷

26
- 0027310777
- N. Nakagawa, T. Obata, T. Kobayashi, Y. Okada, F. Nambu, T. Terawaki, T. Furuya, K. Muryobayashi, M. Sawada, and H. Aishita Eur. J. Pharmacol. 235 1993 211
- (1993) Eur. J. Pharmacol. , vol.235 , pp. 211
- Nakagawa, N.¹ Obata, T.² Kobayashi, T.³ Okada, Y.⁴ Nambu, F.⁵ Terawaki, T.⁶ Furuya, T.⁷ Muryobayashi, K.⁸ Sawada, M.⁹ Aishita, H.¹⁰

27
- 0032934381
- C. Brideau, C.V. Staden, A. Sthyler, I.W. Rodger, and C.C. Chan Br. J. Pharmacol. 126 1999 979
- (1999) Br. J. Pharmacol. , vol.126 , pp. 979
- Brideau, C.¹ Staden, C.V.² Sthyler, A.³ Rodger, I.W.⁴ Chan, C.C.⁵

28
- 8444225357
- J.I. Andres, J.M. Alonso, A. Diaz, J. Fernandez, L. Iturrino, P. Martinez, E. Matesanz, E.J. Freyne, F. Deroose, G. Boeckx, D. Petit, G. Diels, A. Megens, M. Somers, J.V. Wauwe, P. Stoppie, M. Cools, F.D. Clerck, D. Peeters, and D.D. Chaffoy Bioorg. Med. Chem. Lett. 12 2002 653
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 653
- Andres, J.I.¹ Alonso, J.M.² Diaz, A.³ Fernandez, J.⁴ Iturrino, L.⁵ Martinez, P.⁶ Matesanz, E.⁷ Freyne, E.J.⁸ Deroose, F.⁹ Boeckx, G.¹⁰ Petit, D.¹¹ Diels, G.¹² Megens, A.¹³ Somers, M.¹⁴ Wauwe, J.V.¹⁵ Stoppie, P.¹⁶ Cools, M.¹⁷ Clerck, F.D.¹⁸ Peeters, D.¹⁹ Chaffoy, D.D.²⁰ more..

29
- 0023088944
- M.L. Reeves, B.K. Leigh, and P.J. England Biochem. J. 241 1987 535
- (1987) Biochem. J. , vol.241 , pp. 535
- Reeves, M.L.¹ Leigh, B.K.² England, P.J.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.