Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.

Journal of medicinal chemistry

Volumn 41, Issue 3, 1998, Pages 266-270

  Kleinman, E F ^a   Campbell, E ^a   Giordano, L A ^a   Cohan, V L ^a   Jenkinson, T H ^a   Cheng, J B ^a   Shirley, J T ^a   Pettipher, E R ^a   Salter, E D ^a   Hibbs, T A ^a   DiCapua, F M ^a   Bordner, J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; HYDROXAMIC ACID; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; BINDING SITES; HYDROXAMIC ACIDS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; ROLIPRAM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

MLCS; MLOWN;

EID: 0032576647     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970685m     Document Type: Article

References (0)