Orally active PDE4 inhibitors with therapeutic potential

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 5, 2004, Pages 1323-1327

  Ochiai, Hiroshi ^a   Ohtani, Tazumi ^a   Ishida, Akiharu ^a   Kishikawa, Katuya ^a   Obata, Takaaki ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Bicyclo 3 3 0 octane; Orally active; PDE4 inhibitor; Three pharmacophores

Indexed keywords

CILOMILAST; PHOSPHODIESTERASE IV INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; GUINEA PIG; HUMAN; IC 50; NONHUMAN; PHARMACOPHORE; RAT; SPECIES DIFFERENCE; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION;

EID: 1242271419     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.018     Document Type: Article

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