Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: Novel series of PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 653-658

  Andres J Ignacio ^a   Alonso, José M ^a   Díaz, Adolfo ^a   Fernández, Javier ^a   Iturrino, Laura ^a   Martínez, Pedro ^a   Matesanz, Encarna ^a   Freyne, Eddy J ^b   Deroose, Frederik ^b   Boeckx, Gustaaf ^b   Petit, Davy ^b   Diels, Gaston ^b   Megens, Anton ^b   Somers, Marijke ^b   Wauwe, Jean Van ^b   Stoppie, Paul ^b   Cools, Marina ^b   Clerck, Fred De ^b   Peeters, Danielle ^b   De Chaffoy, Didier ^b  

^a Division of Janssen Cilag SA   (Spain)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOL 2 ONE DERIVATIVE; IMIDAZOLE DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ANTIINFLAMMATORY AGENT; ENZYME INHIBITOR; IMIDAZOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; ANIMAL; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; EAR DISEASE; IC 50; INFLAMMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TOPICAL DRUG ADMINISTRATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EAR DISEASES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INFLAMMATION; INHIBITORY CONCENTRATION 50; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8444225357     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00817-4     Document Type: Article

References (23)