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Volumn 4, Issue 4, 2004, Pages 595-605

Current clinical management of gastrointestinal stromal tumors

Author keywords

Gastrointestinal stromal tumor; Imatinib; Review; Therapy

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; BCR ABL PROTEIN; HYBRID PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE INHIBITOR; SEMAXANIB; STEM CELL FACTOR RECEPTOR;

EID: 4444316080     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.4.4.595     Document Type: Review
Times cited : (14)

References (85)
  • 1
    • 0035142836 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis
    • Miettinem M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis. Virchows Arch. 438, 1-12 (2001).
    • (2001) Virchows Arch. , vol.438 , pp. 1-12
    • Miettinem, M.1    Lasota, J.2
  • 2
    • 1842426806 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity
    • Debiec-Rychter M, Wasag B, Stul M et al. Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity. J. Pathol. 202, 430-438 (2004).
    • (2004) J. Pathol. , vol.202 , pp. 430-438
    • Debiec-Rychter, M.1    Wasag, B.2    Stul, M.3
  • 3
    • 3042646931 scopus 로고    scopus 로고
    • A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
    • Lasota J, Dansonka-Mieszkowska A, Sobin LH, Miettinen M. A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential. Lab. Invest. 84, 874-883 (2004).
    • (2004) Lab. Invest. , vol.84 , pp. 874-883
    • Lasota, J.1    Dansonka-Mieszkowska, A.2    Sobin, L.H.3    Miettinen, M.4
  • 4
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Medeiros F, Corless CL, Duensing A et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am. J. Surg. Pathol. 28, 889-894 (2004).
    • (2004) Am. J. Surg. Pathol. , vol.28 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 5
    • 3042538269 scopus 로고    scopus 로고
    • Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias
    • Blay P, Astudillo A, Buesa JM et al. Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. Clin. Cancer Res. 10, 4089-4095 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4089-4095
    • Blay, P.1    Astudillo, A.2    Buesa, J.M.3
  • 6
    • 3042594995 scopus 로고    scopus 로고
    • The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status
    • West RB, Corless CL, Chen X et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am. J. Pathol. 165, 107-113 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 107-113
    • West, R.B.1    Corless, C.L.2    Chen, X.3
  • 7
    • 4444361542 scopus 로고    scopus 로고
    • The Eisenberg article reviewed
    • Blanke CD. The Eisenberg article reviewed. Oncology 17(11), 1620-1623 (2003).
    • (2003) Oncology , vol.17 , Issue.11 , pp. 1620-1623
    • Blanke, C.D.1
  • 8
    • 0033772093 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Current diagnosis, biologic behavior, and management
    • Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF. Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann. Surg. Oncol. 7(9), 705-712 (2000).
    • (2000) Ann. Surg. Oncol. , vol.7 , Issue.9 , pp. 705-712
    • Pidhorecky, I.1    Cheney, R.T.2    Kraybill, W.G.3    Gibbs, J.F.4
  • 9
    • 0034956005 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor workshop
    • Berman J, O'Leary TJ. Gastrointestinal stromal tumor workshop. Hum. Pathol. 32(6), 578-582 (2001).
    • (2001) Hum. Pathol. , vol.32 , Issue.6 , pp. 578-582
    • Berman, J.1    O'Leary, T.J.2
  • 11
    • 0031848146 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumors with germline mutation of the KIT gene
    • Nishida T, Hirota S, Taniguchi M et al. Familial gastrointestinal stromal tumors with germline mutation of the KIT gene. Nature Genet. 19, 323-324 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 323-324
    • Nishida, T.1    Hirota, S.2    Taniguchi, M.3
  • 12
    • 0033971263 scopus 로고    scopus 로고
    • Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene
    • Hirota S, Okazaki T, Kitamura Y. Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene. Am. J. Surg. Pathol. 24, 326-327 (2000).
    • (2000) Am. J. Surg. Pathol. , vol.24 , pp. 326-327
    • Hirota, S.1    Okazaki, T.2    Kitamura, Y.3
  • 13
    • 0035425217 scopus 로고    scopus 로고
    • Germline mutation in the juxtamembrane domain of the KIT gene
    • Beghini A, Tibiletti M, Roversi G et al. Germline mutation in the juxtamembrane domain of the KIT gene. Cancer 92, 657-662 (2001).
    • (2001) Cancer , vol.92 , pp. 657-662
    • Beghini, A.1    Tibiletti, M.2    Roversi, G.3
  • 14
    • 0035174752 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumor with hyperpigmentation: Association with a germline mutation of the c-kit gene
    • Maeyama H, Hidaka E, Ota H et al. Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene. Gastroenterology 120, 210-215 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 210-215
    • Maeyama, H.1    Hidaka, E.2    Ota, H.3
  • 15
    • 0346025449 scopus 로고    scopus 로고
    • Absence of c-kit gene mutations in gastrointestinal stromal tumors from neurofibromatosis Type I patients
    • Kinoshita K, Hirota S, Isozaki K et al. Absence of c-kit gene mutations in gastrointestinal stromal tumors from neurofibromatosis Type I patients. J. Pathol. 202, 80-85 (2004).
    • (2004) J. Pathol. , vol.202 , pp. 80-85
    • Kinoshita, K.1    Hirota, S.2    Isozaki, K.3
  • 16
    • 0033064974 scopus 로고    scopus 로고
    • Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney triad): Natural history, adrenocortical component, and possible familial recurrence
    • Carney JA. Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney triad): natural history, adrenocortical component, and possible familial recurrence. Mayo Clin. Proc. 74, 543-552 (1999).
    • (1999) Mayo Clin. Proc. , vol.74 , pp. 543-552
    • Carney, J.A.1
  • 17
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279, 577-580 (1998).
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 18
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CDM, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum. Pathol. 33(6), 459-465 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.6 , pp. 459-465
    • Fletcher, C.D.M.1    Berman, J.J.2    Corless, C.3
  • 19
    • 0036769966 scopus 로고    scopus 로고
    • Pathology and diagnostic criteria of gastrointestinal stromal tumors (GIST): A review
    • Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GIST): a review. Eur. J. Cancer 38(5), S39-S51 (2002).
    • (2002) Eur. J. Cancer , vol.38 , Issue.5
    • Miettinen, M.1    Majidi, M.2    Lasota, J.3
  • 20
    • 0344305657 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Biology and treatment
    • Duffaud F, Blay JY. Gastrointestinal stromal tumors: biology and treatment. Oncology 65, 187-197 (2003).
    • (2003) Oncology , vol.65 , pp. 187-197
    • Duffaud, F.1    Blay, J.Y.2
  • 21
    • 0031850686 scopus 로고    scopus 로고
    • Interstitial cells of Cajal generate a rhythmic pacemaker current
    • Thomsen L, Robinson TL, Lee JC et al. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nature Med. 4, 848-851 (1998).
    • (1998) Nature Med. , vol.4 , pp. 848-851
    • Thomsen, L.1    Robinson, T.L.2    Lee, J.C.3
  • 22
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am. J. Pathol. 152(5), 1259-1269 (1998).
    • (1998) Am. J. Pathol. , vol.152 , Issue.5 , pp. 1259-1269
    • Kindblom, L.G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 23
    • 0032950650 scopus 로고    scopus 로고
    • Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal
    • Sakurai S, Fukasawa T, Chong JM, Tanaka A, Fukayama M. Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal. Am. J. Pathol. 154(1), 23-28 (1999).
    • (1999) Am. J. Pathol. , vol.154 , Issue.1 , pp. 23-28
    • Sakurai, S.1    Fukasawa, T.2    Chong, J.M.3    Tanaka, A.4    Fukayama, M.5
  • 25
    • 0036301863 scopus 로고    scopus 로고
    • Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review
    • Miettinen M, El-Rifai W, H L Sobin L, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum. Pathol. 33(5), 478-483 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.5 , pp. 478-483
    • Miettinen, M.1    El-Rifai, W.2    El-Rifai, H.L.3    Sobin, L.4    Lasota, J.5
  • 26
    • 9144268286 scopus 로고    scopus 로고
    • Molecular targets for tumour progression in gastrointestinal stromal tumors
    • Koon N, Schneider-Stock R, Sarlomo-Rikala M et al. Molecular targets for tumour progression in gastrointestinal stromal tumors. Gut 53(2), 235-240 (2004).
    • (2004) Gut , vol.53 , Issue.2 , pp. 235-240
    • Koon, N.1    Schneider-Stock, R.2    Sarlomo-Rikala, M.3
  • 27
    • 0033387158 scopus 로고    scopus 로고
    • Loss of heterozygosity at 1p36 predicts poor prognosis in gastrointestinal stromal/smooth muscle tumors
    • O'Leary T, Ernst S, Przygodzki R, Emory T, Sobin L. Loss of heterozygosity at 1p36 predicts poor prognosis in gastrointestinal stromal/smooth muscle tumors. Lab. Invest. 79(12), 1461-1467 (1999).
    • (1999) Lab. Invest. , vol.79 , Issue.12 , pp. 1461-1467
    • O'Leary, T.1    Ernst, S.2    Przygodzki, R.3    Emory, T.4    Sobin, L.5
  • 28
    • 0035332255 scopus 로고    scopus 로고
    • Consistent DNA losses on the short arm of chromosome 1 in a series of malignant gastrointestinal stromal tumors
    • Derre J, Lagace R, Terrier P, Sastre X, Aurias A. Consistent DNA losses on the short arm of chromosome 1 in a series of malignant gastrointestinal stromal tumors. Cancer Genet. Cytogenet. 127(1), 30-32 (2001).
    • (2001) Cancer Genet. Cytogenet. , vol.127 , Issue.1 , pp. 30-32
    • Derre, J.1    Lagace, R.2    Terrier, P.3    Sastre, X.4    Aurias, A.5
  • 29
    • 0034660868 scopus 로고    scopus 로고
    • DNA sequence copy number changes in gastrointestinal stromal tumors: Tumor progression and prognostic significance
    • El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M. DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cancer Res. 60(14), 3899-3903 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.14 , pp. 3899-3903
    • El-Rifai, W.1    Sarlomo-Rikala, M.2    Andersson, L.C.3    Knuutila, S.4    Miettinen, M.5
  • 30
    • 0344375087 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach
    • Takahashi R, Tanaka S, Kitadai Y et al. Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncology 64(3), 266-274 (2003).
    • (2003) Oncology , vol.64 , Issue.3 , pp. 266-274
    • Takahashi, R.1    Tanaka, S.2    Kitadai, Y.3
  • 31
    • 0343091240 scopus 로고    scopus 로고
    • Telomerase activity and expression of hTRT and hTR in gastrointestinal stromal tumors in comparison with extragastrointestinal sarcomas
    • Gentler T, Schneider-Stock R, Häckel C et al. Telomerase activity and expression of hTRT and hTR in gastrointestinal stromal tumors in comparison with extragastrointestinal sarcomas. Clin. Cancer Res. 6, 1811-1818 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1811-1818
    • Gentler, T.1    Schneider-Stock, R.2    Häckel, C.3
  • 32
    • 15144348712 scopus 로고    scopus 로고
    • Telomerase activity in gastrointestinal stromal tumors
    • Sakurai S, Fukayama M, Kaizaki Y et al. Telomerase activity in gastrointestinal stromal tumors. Cancer 83(10), 2060-2066 (1998).
    • (1998) Cancer , vol.83 , Issue.10 , pp. 2060-2066
    • Sakurai, S.1    Fukayama, M.2    Kaizaki, Y.3
  • 33
    • 0032953812 scopus 로고    scopus 로고
    • Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
    • Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M. Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am. J. Pathol. 154(1), 53-60 (1999).
    • (1999) Am. J. Pathol. , vol.154 , Issue.1 , pp. 53-60
    • Lasota, J.1    Jasinski, M.2    Sarlomo-Rikala, M.3    Miettinen, M.4
  • 34
    • 0033199890 scopus 로고    scopus 로고
    • Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
    • Taniguchi M, Nishida T, Hirota S et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res. 59(17), 4297-4300 (1999).
    • (1999) Cancer Res. , vol.59 , Issue.17 , pp. 4297-4300
    • Taniguchi, M.1    Nishida, T.2    Hirota, S.3
  • 35
    • 0033820064 scopus 로고    scopus 로고
    • Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases
    • Lasota J, Wozniak A, Sarlomo-Rikala M et al. Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases. Am. J. Pathol. 157(4), 1091-1095 (2000).
    • (2000) Am. J. Pathol. , vol.157 , Issue.4 , pp. 1091-1095
    • Lasota, J.1    Wozniak, A.2    Sarlomo-Rikala, M.3
  • 36
    • 0035066051 scopus 로고    scopus 로고
    • Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumors
    • Hirota S, Nishida T, Isozaki K et al. Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumors. J. Pathol. 193(4), 505-510 (2001).
    • (2001) J. Pathol. , vol.193 , Issue.4 , pp. 505-510
    • Hirota, S.1    Nishida, T.2    Isozaki, K.3
  • 37
    • 0034981645 scopus 로고    scopus 로고
    • Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese
    • Sakurai S, Oguni S, Hironaka M, Fukayama M, Morinaga S, Saito K. Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese. Jpn. J. Cancer Res. 92(5), 494-498 (2001).
    • (2001) Jpn. J. Cancer Res. , vol.92 , Issue.5 , pp. 494-498
    • Sakurai, S.1    Oguni, S.2    Hironaka, M.3    Fukayama, M.4    Morinaga, S.5    Saito, K.6
  • 38
    • 9144241089 scopus 로고    scopus 로고
    • KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin
    • Lasota J, Kopczynski J, Sarlomo-Rikala M et al. KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin. Hum. Pathol. 34, 1306-1312 (2003).
    • (2003) Hum. Pathol. , vol.34 , pp. 1306-1312
    • Lasota, J.1    Kopczynski, J.2    Sarlomo-Rikala, M.3
  • 39
    • 0346362402 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors with internal tandem duplications in 3′ end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course
    • Lasota J, Dansonka-Mieszkowska A, Stachura T et al. Gastrointestinal stromal tumors with internal tandem duplications in 3′ end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course. Mod. Pathol. 16, 1257-1264 (2003).
    • (2003) Mod. Pathol. , vol.16 , pp. 1257-1264
    • Lasota, J.1    Dansonka-Mieszkowska, A.2    Stachura, T.3
  • 40
    • 0028001294 scopus 로고
    • A YAC contig OK spanning a cluster of human Type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12
    • Spritz RA, Strunk KM, Lee ST et al. A YAC contig OK spanning a cluster of human Type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. Genomics 22(2), 431-436 (1994).
    • (1994) Genomics , vol.22 , Issue.2 , pp. 431-436
    • Spritz, R.A.1    Strunk, K.M.2    Lee, S.T.3
  • 41
    • 0029873587 scopus 로고    scopus 로고
    • JAK2 is associated with the c-kit protooncogene product and is phosphorylated in response to stem cell factor
    • Weiler SR, Mou S, DeBerry CS et al. JAK2 is associated with the c-kit protooncogene product and is phosphorylated in response to stem cell factor. Blood 87(9), 3688-3693 (1996).
    • (1996) Blood , vol.87 , Issue.9 , pp. 3688-3693
    • Weiler, S.R.1    Mou, S.2    DeBerry, C.S.3
  • 42
    • 0032518262 scopus 로고    scopus 로고
    • MAPK links the transcription factor Microphthalmia to c-Kit signaling in melanocytes
    • Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAPK links the transcription factor Microphthalmia to c-Kit signaling in melanocytes. Nature 391(6664), 298-301 (1998).
    • (1998) Nature , vol.391 , Issue.6664 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 43
    • 0033546145 scopus 로고    scopus 로고
    • STAT protein recruitment and activation in c-Kit deletion mutants
    • Brizzi MF, Dentelli P, Rosso A, Yarden Y, Pegoraro L. STAT protein recruitment and activation in c-Kit deletion mutants. J. Biol. Chem. 274(24), 16965-16972 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.24 , pp. 16965-16972
    • Brizzi, M.F.1    Dentelli, P.2    Rosso, A.3    Yarden, Y.4    Pegoraro, L.5
  • 44
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96(3), 925-932 (2000).
    • (2000) Blood , vol.96 , Issue.3 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 45
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum. Pathol. 33(5), 484-495 (2002).
    • (2002) Hum. Pathol. , vol.33 , Issue.5 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3    Fletcher, J.A.4
  • 46
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 61(22), 8118-8121 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.22 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3
  • 47
    • 0036092268 scopus 로고    scopus 로고
    • KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
    • Corless CL, McGreevey L, Haley A, Town A, Heinrich MC. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am. J. Pathol. 160(5), 1567-1572 (2002).
    • (2002) Am. J. Pathol. , vol.160 , Issue.5 , pp. 1567-1572
    • Corless, C.L.1    McGreevey, L.2    Haley, A.3    Town, A.4    Heinrich, M.C.5
  • 48
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am. J. Pathol. 156(3), 791-795 (2000).
    • (2000) Am. J. Pathol. , vol.156 , Issue.3 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3
  • 49
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299(5607), 708-710 (2003).
    • (2003) Science , vol.299 , Issue.5607 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 50
    • 0035893766 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile
    • Allander SV, Nupponen NN, Ringner M et al. Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile. Cancer Res. 61(24), 8624-8628 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.24 , pp. 8624-8628
    • Allander, S.V.1    Nupponen, N.N.2    Ringner, M.3
  • 51
    • 0033980085 scopus 로고    scopus 로고
    • Putative chromosomal deletions on 9P, 9Q and 22Q occur preferentially in malignant gastrointestinal stromal tumors
    • Kim NG, Kim JJ, Ahn JY et al. Putative chromosomal deletions on 9P, 9Q and 22Q occur preferentially in malignant gastrointestinal stromal tumors. Int. J. Cancer 85(5), 633-638 (2000).
    • (2000) Int. J. Cancer , vol.85 , Issue.5 , pp. 633-638
    • Kim, N.G.1    Kim, J.J.2    Ahn, J.Y.3
  • 52
    • 0038135029 scopus 로고    scopus 로고
    • High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors
    • Schneider-Stock R, Boltze C, Lasota J et al. High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors. J. Clin. Oncol. 21, 1688-1697 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1688-1697
    • Schneider-Stock, R.1    Boltze, C.2    Lasota, J.3
  • 53
    • 0037225829 scopus 로고    scopus 로고
    • Imatinib mesylate in the treatment of gastrointestinal stromal tumours
    • Croom KF, Perry CM. Imatinib mesylate in the treatment of gastrointestinal stromal tumours. Drugs 63(5), 513-522 (2003).
    • (2003) Drugs , vol.63 , Issue.5 , pp. 513-522
    • Croom, K.F.1    Perry, C.M.2
  • 54
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • Tuveson DA, Willis NA, Jacks T et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene 20(36), 5054-5058 (2001).
    • (2001) Oncogene , vol.20 , Issue.36 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3
  • 55
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N. Engl. J. Med. 344(14), 1052-1056 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.14 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 56
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A Phase I study
    • van Oosterom AT, Judson I, Verweij J et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a Phase I study. Lancet 358(9291), 1421-1423 (2001).
    • (2001) Lancet , vol.358 , Issue.9291 , pp. 1421-1423
    • van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 57
    • 0036769721 scopus 로고    scopus 로고
    • Update of Phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: A report of the EORTC Soft Tissue and Bone Sarcoma Group
    • van Oosterom AT, Judson IR, Verweij J et al. Update of Phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 38(Suppl. 5), S83-S87 (2002).
    • (2002) Eur. J. Cancer , vol.38 , Issue.SUPPL. 5
    • van Oosterom, A.T.1    Judson, I.R.2    Verweij, J.3
  • 59
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 347(7), 472-480 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , Issue.7 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 60
    • 11244267661 scopus 로고    scopus 로고
    • Long-term follow-up of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate
    • (Abstract 2)
    • Blanke C, H Joensuu H, Demetri G et al. Long-term follow-up of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate. Am. Soc. Clin. Oncol. Gastrointest. Cancer Symp. (2004) (Abstract 2).
    • (2004) Am. Soc. Clin. Oncol. Gastrointest. Cancer Symp.
    • Blanke, C.1    Joensuu, H.2    Demetri, G.3
  • 61
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571, Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group Phase II study
    • Verweij J, van Oosterom A, Blay JY et al. Imatinib mesylate (STI-571, Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group Phase II study. Eur. J. Cancer 39(14), 2006-2011 (2003).
    • (2003) Eur. J. Cancer , vol.39 , Issue.14 , pp. 2006-2011
    • Verweij, J.1    van Oosterom, A.2    Blay, J.Y.3
  • 62
    • 0003222976 scopus 로고    scopus 로고
    • KIT mutational status predicts clinical response to STI571 in patients with metastatic gastrointestinal stromal tumors (GISTs)
    • (Abstract 6)
    • Heinrich MC, Corless CL, Blande C et al. KIT mutational status predicts clinical response to STI571 in patients with metastatic gastrointestinal stromal tumors (GISTs). Proc. Am. Soc. Clin. Oncol. (2002) (Abstract 6).
    • (2002) Proc. Am. Soc. Clin. Oncol.
    • Heinrich, M.C.1    Corless, C.L.2    Blande, C.3
  • 63
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. 21(23), 4342-4349 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 64
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumors entered on Phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumors entered on Phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 40, 689-695 (2004).
    • (2004) Eur. J. Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 65
    • 0242691170 scopus 로고    scopus 로고
    • Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results
    • (Abstract 3271)
    • Benjamin RS, Rankin C, Fletcher C et al. Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3271).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Benjamin, R.S.1    Rankin, C.2    Fletcher, C.3
  • 66
    • 0242522370 scopus 로고    scopus 로고
    • Early efficacy comparison of two doses of imatinib for the treatment of advanced gastrointestinal stromal tumors (GIST): Interim results of a randomized Phase III trial from the EORTC-STBSG, ISG and AGITG
    • (Abstract 3272)
    • Verweij J, Casali PG, Zalcberg J et al. Early efficacy comparison of two doses of imatinib for the treatment of advanced gastrointestinal stromal tumors (GIST): interim results of a randomized Phase III trial from the EORTC-STBSG, ISG and AGITG. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3272).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 67
    • 0346210265 scopus 로고    scopus 로고
    • Prognostic factors of toxicity and efficacy in patients with gastrointestinal stromal tumors (GIST) treated with imatinib: A study of EORTC-STBSG, ISG and AGITG
    • (Abstract 3286)
    • van Glabbeke MM, Verweij J, Casali PG et al. Prognostic factors of toxicity and efficacy in patients with gastrointestinal stromal tumors (GIST) treated with imatinib: a study of EORTC-STBSG, ISG and AGITG. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3286).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • van Glabbeke, M.M.1    Verweij, J.2    Casali, P.G.3
  • 68
    • 0030853063 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
    • Deininger MW, Goldman JM, Lydon N, Melo JV. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 90(9), 3691-3698 (1997).
    • (1997) Blood , vol.90 , Issue.9 , pp. 3691-3698
    • Deininger, M.W.1    Goldman, J.M.2    Lydon, N.3    Melo, J.V.4
  • 69
    • 0033585504 scopus 로고    scopus 로고
    • In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
    • Le Coutre P, Mologni L, Cleris L et al. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J. Natl Cancer Inst. 91(2), 163-168 (1999).
    • (1999) J. Natl. Cancer Inst. , vol.91 , Issue.2 , pp. 163-168
    • Le Coutre, P.1    Mologni, L.2    Cleris, L.3
  • 70
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon FX, Deininger MW, Schultheis B et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 96(3), 1070-1079 (2000).
    • (2000) Blood , vol.96 , Issue.3 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 71
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293(5531), 876-880 (2001).
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 72
    • 0242691165 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST)
    • (Abstract 3275)
    • Fletcher JA, Corless CL, Dimitrijevic S et al. Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST). Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3275).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Fletcher, J.A.1    Corless, C.L.2    Dimitrijevic, S.3
  • 73
    • 0038312141 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
    • Sommer G, Agosti V, Ehlers I et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc. Natl. Acad. Sci. USA 100(11), 6706-6711 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.11 , pp. 6706-6711
    • Sommer, G.1    Agosti, V.2    Ehlers, I.3
  • 74
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • Smolich BD, Yuen HA, West KA, Giles FJ, Albitar M, Cherrington JM. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood 97(5), 1413-1421 (2001).
    • (2001) Blood , vol.97 , Issue.5 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3    Giles, F.J.4    Albitar, M.5    Cherrington, J.M.6
  • 75
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J. Clin. Oncol. 20(6), 1692-1703 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , Issue.6 , pp. 1692-1703
    • Heinrich, M.C.1    Blanke, C.D.2    Druker, B.J.3    Corless, C.L.4
  • 76
    • 0141993064 scopus 로고    scopus 로고
    • A Phase II clinical study of SU5416 in patients with refractory acute myeloid leukemia
    • Fiedler W, Mesters R, Tinnefeld H et al. A Phase II clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood 102(8), 2763-2767 (2003).
    • (2003) Blood , vol.102 , Issue.8 , pp. 2763-2767
    • Fiedler, W.1    Mesters, R.2    Tinnefeld, H.3
  • 77
    • 30344488355 scopus 로고    scopus 로고
    • Activity and tolerability of the multitargeted tyrosine kinase inhibitor SU011248 in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate
    • (Abstract 7)
    • Desai J, Maki R, Heinrich MC et al. Activity and tolerability of the multitargeted tyrosine kinase inhibitor SU011248 in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. Am. Soc. Clin. Oncol. Gastrointest. Cancer Symp. (2004) (Abstract 7).
    • (2004) Am. Soc. Clin. Oncol. Gastrointest. Cancer Symp.
    • Desai, J.1    Maki, R.2    Heinrich, M.C.3
  • 78
    • 10744226681 scopus 로고    scopus 로고
    • Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era
    • Wu PC, Langerman A, Ryan CW, Hart J, Swiger S, Posner MC. Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era. Surgery 134(4), 656-665 (2003).
    • (2003) Surgery , vol.134 , Issue.4 , pp. 656-665
    • Wu, P.C.1    Langerman, A.2    Ryan, C.W.3    Hart, J.4    Swiger, S.5    Posner, M.C.6
  • 79
    • 0242607135 scopus 로고    scopus 로고
    • Tumor resection following imatinib pretreatment in GI stromal tumors
    • (Abstract 3288)
    • Hohenberger P, Bauer S, Schneider U et al. Tumor resection following imatinib pretreatment in GI stromal tumors. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3288).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Hohenberger, P.1    Bauer, S.2    Schneider, U.3
  • 80
    • 0034256419 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors
    • Casper ES. Gastrointestinal stromal tumors. Curr. Treat. Options Oncol. 1, 267-273 (2000).
    • (2000) Curr. Treat. Options Oncol. , vol.1 , pp. 267-273
    • Casper, E.S.1
  • 81
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann. Surg. 231(1), 51-58 (2000).
    • (2000) Ann. Surg. , vol.231 , Issue.1 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.J.2    Leung, D.3    Mudan, S.S.4    Woodruff, J.M.5    Brennan, M.F.6
  • 82
    • 0029184054 scopus 로고
    • Primary gastrointestinal sarcomas: Analysis of prognostic variables
    • Conlon KC, Casper ES, Brennan MF. Primary gastrointestinal sarcomas: analysis of prognostic variables. Ann. Surg. Oncol. 2(1), 26-31 (1995).
    • (1995) Ann. Surg. Oncol. , vol.2 , Issue.1 , pp. 26-31
    • Conlon, K.C.1    Casper, E.S.2    Brennan, M.F.3
  • 83
    • 0036795899 scopus 로고    scopus 로고
    • Approval summary-imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
    • Dagher R, Cohen M, Williams G et al. Approval summary-imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin. Cancer Res. 8 (10), 3034-3038 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.10 , pp. 3034-3038
    • Dagher, R.1    Cohen, M.2    Williams, G.3
  • 84
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Med. 2(5), 561-566 (1996).
    • (1996) Nature Med. , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 85
    • 0036165807 scopus 로고    scopus 로고
    • FDA licences imatinib mesylate for CML
    • Habeck M. FDA licences imatinib mesylate for CML. Lancet Oncol. 3(1), 6 (2002).
    • (2002) Lancet Oncol. , vol.3 , Issue.1 , pp. 6
    • Habeck, M.1


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