WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for α1-adrenoreceptor subtypes and 5-HT(1A) receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4214-4224

  Bolognesi, Maria L ^a   Budriesi, Roberta ^a   Cavalli, Andrea ^a   Chiarini, Alberto ^a   Gotti, Roberto ^a   Leonardi, Amedeo ^b   Minarini, Anna ^a   Poggesi, Elena ^b   Recanatini, Maurizio ^a   Rosini, Michela ^a   Tumiatti, Vincenzo ^a   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Recordati SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; [(2,3 DIHYDRO 1,4 BENZODIOXIN 2 YLMETHYL)AMINO] 5 PHENOXYCYCLOPENTAN 1 OL; ALPHA 1 ADRENERGIC RECEPTOR; BENZODIOXAN DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; RECEPTOR AFFINITY; STEREOISOMERISM; SYNTHESIS;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AORTA, THORACIC; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DIOXANES; HELA CELLS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0033533802     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991065j     Document Type: Article

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