-
2
-
-
0034047375
-
The E4-6/7 protein functionally compensates for the loss of E1A expression in adenovirus infection
-
O'Connor RJ, Hearing P. The E4-6/7 protein functionally compensates for the loss of E1A expression in adenovirus infection. J Virol. 2000;74:5819-5824.
-
(2000)
J Virol
, vol.74
, pp. 5819-5824
-
-
O'Connor, R.J.1
Hearing, P.2
-
3
-
-
0030739355
-
Induction of DNA synthesis and apoptosis are separable functions of E2F-1
-
Phillips AC, Bates S, Ryan KM, Helin K, Vousden KH. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 1997;11:1853-1863.
-
(1997)
Genes Dev
, vol.11
, pp. 1853-1863
-
-
Phillips, A.C.1
Bates, S.2
Ryan, K.M.3
Helin, K.4
Vousden, K.H.5
-
4
-
-
0034927057
-
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
-
Kirn D, Martuza RL, Zwiebel J. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat Med. 2001;7:781-787.
-
(2001)
Nat Med
, vol.7
, pp. 781-787
-
-
Kirn, D.1
Martuza, R.L.2
Zwiebel, J.3
-
6
-
-
0027251720
-
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
-
Debbas M, Blanchette P, Yan Q, White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 1993;7:546-554.
-
(1993)
Genes Dev
, vol.7
, pp. 546-554
-
-
Debbas, M.1
Blanchette, P.2
Yan, Q.3
White, E.4
-
7
-
-
0027262606
-
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
-
Lowe SW, Ruley HE. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 1993;7:535-545.
-
(1993)
Genes Dev
, vol.7
, pp. 535-545
-
-
Lowe, S.W.1
Ruley, H.E.2
-
8
-
-
0025251915
-
Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins
-
Kao CC, Yew PR, Berk AJ. Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins. Virology. 1990;179:806-814.
-
(1990)
Virology
, vol.179
, pp. 806-814
-
-
Kao, C.C.1
Yew, P.R.2
Berk, A.J.3
-
9
-
-
0031901638
-
Adenovirus E1B 55K represses p53 activation in vitro
-
Martin ME, Berk AJ. Adenovirus E1B 55K represses p53 activation in vitro. J Virol. 1998;72:3146-3154.
-
(1998)
J Virol
, vol.72
, pp. 3146-3154
-
-
Martin, M.E.1
Berk, A.J.2
-
10
-
-
0028058784
-
Enhanced expression of p53 in human cells infected with mutant adenoviruses
-
Grand RJ, Grant ML, Gallimore PH. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology. 1994;203:229-240.
-
(1994)
Virology
, vol.203
, pp. 229-240
-
-
Grand, R.J.1
Grant, M.L.2
Gallimore, P.H.3
-
11
-
-
0035577765
-
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
-
Querido E, Blanchette P, Yan Q, et al. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev. 2001;15:3104-3117.
-
(2001)
Genes Dev
, vol.15
, pp. 3104-3117
-
-
Querido, E.1
Blanchette, P.2
Yan, Q.3
-
12
-
-
0032556920
-
The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells
-
Steegenga WT, Riteco N, Jochemsen AG, Fallaux FJ, Bos JL. The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells. Oncogene. 1998;16:349-357.
-
(1998)
Oncogene
, vol.16
, pp. 349-357
-
-
Steegenga, W.T.1
Riteco, N.2
Jochemsen, A.G.3
Fallaux, F.J.4
Bos, J.L.5
-
13
-
-
0026639932
-
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
-
Rao L, Debbas M, Sabbatini P, et al. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA. 1992;89:7742-7746.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7742-7746
-
-
Rao, L.1
Debbas, M.2
Sabbatini, P.3
-
14
-
-
0036226225
-
Bak and Bax function to limit adenovirus replication through apoptosis induction
-
Cuconati A, Degenhardt K, Sundararajan R, Anschel A, White E. Bak and Bax function to limit adenovirus replication through apoptosis induction. J Virol. 2002;76:4547-4558.
-
(2002)
J Virol
, vol.76
, pp. 4547-4558
-
-
Cuconati, A.1
Degenhardt, K.2
Sundararajan, R.3
Anschel, A.4
White, E.5
-
15
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff JR, Kim DH, Williams A, et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 1996;274:373-376.
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kim, D.H.2
Williams, A.3
-
16
-
-
0035134629
-
Clinical research results with d11520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: What have we learned?
-
Kirn D. Clinical research results with d11520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? Gene Therapy. 2001;8:89-98.
-
(2001)
Gene Therapy
, vol.8
, pp. 89-98
-
-
Kirn, D.1
-
17
-
-
0034990761
-
Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity
-
Nemunaitis J, Cunningham C, Buchanan A, et al. Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Therapy. 2001;8:746-759.
-
(2001)
Gene Therapy
, vol.8
, pp. 746-759
-
-
Nemunaitis, J.1
Cunningham, C.2
Buchanan, A.3
-
18
-
-
0036468548
-
Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts
-
Geoerger B, Grill J, Opolon P, et al. Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts. Cancer Res. 2002;62:764-772.
-
(2002)
Cancer Res
, vol.62
, pp. 764-772
-
-
Geoerger, B.1
Grill, J.2
Opolon, P.3
-
19
-
-
0037033736
-
ONYX-015: Mechanisms of action and clinical potential of a replication-selective adenovirus
-
Ries S, Korn WM. ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus. Br J Cancer. 2002;86:5-11.
-
(2002)
Br J Cancer
, vol.86
, pp. 5-11
-
-
Ries, S.1
Korn, W.M.2
-
20
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
-
Heise C, Sampson-Johannes A, Williams A, et al. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents (see comments). Nat Med. 1997;3:639-645.
-
(1997)
Nat Med
, vol.3
, pp. 639-645
-
-
Heise, C.1
Sampson-Johannes, A.2
Williams, A.3
-
21
-
-
0034161976
-
In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy
-
Rogulski KR, Freytag SO, Zhang K, et al. In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy. Cancer Res. 2000;60: 1193-1196.
-
(2000)
Cancer Res
, vol.60
, pp. 1193-1196
-
-
Rogulski, K.R.1
Freytag, S.O.2
Zhang, K.3
-
22
-
-
0031743945
-
Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
-
Rothmann T, Hengstermann A, Whitaker NJ, Scheffner M, zur Hausen H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J Virol. 1998;72:9470-9478.
-
(1998)
J Virol
, vol.72
, pp. 9470-9478
-
-
Rothmann, T.1
Hengstermann, A.2
Whitaker, N.J.3
Scheffner, M.4
Zur Hausen, H.5
-
23
-
-
0031798440
-
p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
-
Goodrum FD, Ornelles DA. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J Virol. 1998;72:9479-9490.
-
(1998)
J Virol
, vol.72
, pp. 9479-9490
-
-
Goodrum, F.D.1
Ornelles, D.A.2
-
24
-
-
0033022039
-
p53-Independent and -dependent requirements for E1B-55 K in adenovirus type 5 replication
-
Harada JN, Berk AJ. p53-Independent and -dependent requirements for E1B-55 K in adenovirus type 5 replication. J Virol. 1999;73:5333-5344.
-
(1999)
J Virol
, vol.73
, pp. 5333-5344
-
-
Harada, J.N.1
Berk, A.J.2
-
25
-
-
0036891811
-
Evidence that replication of the antitumor adenovirus onyx-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes
-
Edwards SJ, Dix BR, Myers CJ, et al. Evidence that replication of the antitumor adenovirus onyx-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes. J Virol. 2002;76:12483-12490.
-
(2002)
J Virol
, vol.76
, pp. 12483-12490
-
-
Edwards, S.J.1
Dix, B.R.2
Myers, C.J.3
-
26
-
-
0035015925
-
Does the antitumor adenovirus ONYX-015/d11520 selectively target cells defective in the p53 pathway?
-
Dix BR, Edwards SJ, Braithwaite AW. Does the antitumor adenovirus ONYX-015/d11520 selectively target cells defective in the p53 pathway? J Virol. 2001;75: 5443-5447.
-
(2001)
J Virol
, vol.75
, pp. 5443-5447
-
-
Dix, B.R.1
Edwards, S.J.2
Braithwaite, A.W.3
-
27
-
-
0037732474
-
Adenovirus with insertion-mutated E1A selectively propagates in liver cancer cells and destroys tumors in vivo
-
Zhao T, Rao XM, Xie X, et al. Adenovirus with insertion-mutated E1A selectively propagates in liver cancer cells and destroys tumors in vivo. Cancer Res. 2003;63: 3073-3078.
-
(2003)
Cancer Res
, vol.63
, pp. 3073-3078
-
-
Zhao, T.1
Rao, X.M.2
Xie, X.3
-
28
-
-
0033105423
-
Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: The importance of the adenoviral E1b-55kD gene
-
Hay JG, Shapiro N, Sauthoff H, et al. Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: the importance of the adenoviral E1b-55kD gene. Hum Gene Ther. 1999;10:579-590.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 579-590
-
-
Hay, J.G.1
Shapiro, N.2
Sauthoff, H.3
-
29
-
-
0034628552
-
Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector
-
Sauthoff H, Heitner S, Rom WN, Hay JG. Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector. Hum Gene Ther. 2000;11: 379-388.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 379-388
-
-
Sauthoff, H.1
Heitner, S.2
Rom, W.N.3
Hay, J.G.4
-
30
-
-
0034917855
-
Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved - Deletion of the viral E1b-19-kD gene increases the viral oncolytic effect
-
Harrison D, Sauthoff H, Heitner S, et al. Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved - deletion of the viral E1b-19-kD gene increases the viral oncolytic effect. Hum Gene Ther. 2001;12: 1323-1332.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1323-1332
-
-
Harrison, D.1
Sauthoff, H.2
Heitner, S.3
-
31
-
-
0036708228
-
Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy
-
Kim J, Cho JY, Kim JH, Jung KC, Yun CO. Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy. Cancer Gene Ther. 2002;9:725-736.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 725-736
-
-
Kim, J.1
Cho, J.Y.2
Kim, J.H.3
Jung, K.C.4
Yun, C.O.5
-
32
-
-
0017710978
-
Characteristics of a human cell line transformed by DNA from human adenovirus type 5
-
Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 1977;36:59-72.
-
(1977)
J Gen Virol
, vol.36
, pp. 59-72
-
-
Graham, F.L.1
Smiley, J.2
Russell, W.C.3
Nairn, R.4
-
33
-
-
0026397676
-
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines
-
Lehman TA, Benett WP, Metcalf RA, et al. p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res. 1991;51: 4090-4096.
-
(1991)
Cancer Res
, vol.51
, pp. 4090-4096
-
-
Lehman, T.A.1
Benett, W.P.2
Metcalf, R.A.3
-
34
-
-
0028559768
-
An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
-
Bett AJ, Haddara W, Prevec L, Graham FL. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci USA. 1994;91:8802-8806.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8802-8806
-
-
Bett, A.J.1
Haddara, W.2
Prevec, L.3
Graham, F.L.4
-
35
-
-
0002025785
-
Manipulation of adenovirus vectors
-
Murray EJ (ed). Clifton, NJ: The Humana Press Inc.
-
Graham FL. Manipulation of adenovirus vectors. In: Murray EJ (ed). Methods in Molecular Biology. Vol. 7 Clifton, NJ: The Humana Press Inc.; 1991 pp 109-128.
-
(1991)
Methods in Molecular Biology
, vol.7
, pp. 109-128
-
-
Graham, F.L.1
-
36
-
-
0029843063
-
Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted
-
Zhou H, O'Neal W, Morral N, Beaudet AL. Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted. J Virol. 1996;70:7030-7038.
-
(1996)
J Virol
, vol.70
, pp. 7030-7038
-
-
Zhou, H.1
O'Neal, W.2
Morral, N.3
Beaudet, A.L.4
-
37
-
-
0021059196
-
Light, fluorescent, and electron microscopic analysis of cultured breast tumor cells (T-47D) treated with 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride
-
Tseng MT, Safa AR. Light, fluorescent, and electron microscopic analysis of cultured breast tumor cells (T-47D) treated with 9,10- anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride. Cancer Res. 1983;43:5910-5914.
-
(1983)
Cancer Res
, vol.43
, pp. 5910-5914
-
-
Tseng, M.T.1
Safa, A.R.2
-
38
-
-
0034602188
-
Role of BAX in the apoptotic response to anticancer agents
-
Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science. 2000;290:989-992.
-
(2000)
Science
, vol.290
, pp. 989-992
-
-
Zhang, L.1
Yu, J.2
Park, B.H.3
Kinzler, K.W.4
Vogelstein, B.5
-
39
-
-
0037096737
-
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells
-
Theodorakis P, Lomonosova E, Chinnadurai G. Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells. Cancer Res. 2002;62:3373-3376.
-
(2002)
Cancer Res
, vol.62
, pp. 3373-3376
-
-
Theodorakis, P.1
Lomonosova, E.2
Chinnadurai, G.3
-
40
-
-
0026065049
-
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
-
Yu DH, Scorsone K, Hung MC. Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene. Mol Cell Biol. 1991;11:1745-1750.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1745-1750
-
-
Yu, D.H.1
Scorsone, K.2
Hung, M.C.3
-
41
-
-
0025301503
-
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products
-
Yu D, Suen TC, Yan DH, Chang LS, Hung MC. Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products. Proc Natl Acad Sci USA. 1990;87:4499-4503.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 4499-4503
-
-
Yu, D.1
Suen, T.C.2
Yan, D.H.3
Chang, L.S.4
Hung, M.C.5
-
42
-
-
0028823833
-
Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu
-
Yu D, Matin A, Xia W, et al. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu. Oncogene. 1995;11:1383-1388.
-
(1995)
Oncogene
, vol.11
, pp. 1383-1388
-
-
Yu, D.1
Matin, A.2
Xia, W.3
-
43
-
-
0025944105
-
Antioncogenic effect of adenovirus E1A in human tumor cells
-
Frisch SM. Antioncogenic effect of adenovirus E1A in human tumor cells. Proc Natl Acad Sci USA. 1991;88: 9077-9081.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9077-9081
-
-
Frisch, S.M.1
-
44
-
-
0032578861
-
Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo
-
Deng J, Xia W, Hung MC. Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo. Oncogene. 1998;17:2167-2175.
-
(1998)
Oncogene
, vol.17
, pp. 2167-2175
-
-
Deng, J.1
Xia, W.2
Hung, M.C.3
-
45
-
-
0034907553
-
Phase I trial of intratumoral liposome e1a gene therapy in patients with recurrent breast and head and neck cancer
-
Yoo GH, Hung MC, Lopez-Berestein G, et al. Phase I trial of intratumoral liposome e1a gene therapy in patients with recurrent breast and head and neck cancer. Clin Cancer Res. 2001;7:1237-1245.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1237-1245
-
-
Yoo, G.H.1
Hung, M.C.2
Lopez-Berestein, G.3
-
46
-
-
0036303883
-
A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma
-
Villaret D, Glisson B, Kenady D, et al. A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma. Head Neck. 2002;24:661-669.
-
(2002)
Head Neck
, vol.24
, pp. 661-669
-
-
Villaret, D.1
Glisson, B.2
Kenady, D.3
|